11-deoxycorticosterone

11-Deoxycorticosterone-d8 is a deuterated compound of 11-Deoxycorticosterone. 11-Deoxycorticosterone has a CAS number of 64-85-7. Deoxycorticosterone is a steroid metabolite produced by the adrenal gland. Deoxycorticosterone is an aldosterone precursor and possesses mineralocorticoid activity.

Tetrahydro 11-Deoxycorticosterone-d3 is a deuterated compound of Tetrahydro 11-Deoxycorticosterone. Tetrahydro 11-Deoxycorticosterone has a CAS number of 567-03-3.

11-Deoxycorticosterone-D8 (Standard) is a reference standard of 11-Deoxycorticosterone-D8 intended for quantitative analysis, quality control, and related biochemical research applications. 11-Deoxycorticosterone-d8 is a deuterated compound of 11-Deoxycorticosterone. 11-Deoxycorticosterone has a CAS number of 64-85-7. Deoxycorticosterone is a steroid metabolite produced by the adrenal gland. Deoxycorticosterone is an aldosterone precursor and possesses mineralocorticoid activity.

Tetrahydro 11-Deoxycorticosterone-D3 (Standard) is a reference standard of Tetrahydro 11-Deoxycorticosterone-D3 intended for quantitative analysis, quality control, and related biochemical research applications. Tetrahydro 11-Deoxycorticosterone-d3 is a deuterated compound of Tetrahydro 11-Deoxycorticosterone. Tetrahydro 11-Deoxycorticosterone has a CAS number of 567-03-3.

Deoxycorticosterone acetate (DOCA) is a steroid hormone produced by the adrenal glands, possessing mineralocorticoid activity and serving as a precursor to aldosterone. As an agonist of the mineralocorticoid receptor, DOCA can induce severe kidney damage, including inflammation, fibrosis, glomerular injury, and proteinuria. It is commonly used to establish animal models of chronic kidney injury and hypertension.

Tetrahydrodeoxycorticosterone(Tetrahydro-11-deoxycorticosterone) is a potent GABAA receptor orthosteric modulator (PAM) with neuroprotective activity that selectively inhibits neurosteroid-mediated enhancement of GABA-induced currents at the GABAA receptor, and can be used in the study of neurological disorders.

18-Hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid produced by the zona fasciculata of the adrenal gland, with its biosynthesis regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. This regulation heightens 18-OH-DOC production in isolated human adrenal glomerulosa cells and allows for its formation from 11-deoxy corticosterone (DOC) in human SK-MEL188 melanoma cells. As an intermediate in progesterone metabolism, 18-OH-DOC can be converted to aldosterone in rat adrenal glands' capsular portion. Its continuous infusion (200 μg/rat per day) has been shown to raise systolic blood pressure in uninephrectomized saline-drinking rats, and elevated plasma levels of 18-OH-DOC have been observed in the adb/db mouse model of type 2 diabetes.

Metyrapol is a competitive inhibitor of 11-deoxycorticosterone hydroxylation by 11β-hydroxylase.

Tetrahydrodeoxycorticosterone (Standard) is a reference standard for research and analysis in studies involving Tetrahydrodeoxycorticosterone. Tetrahydrodeoxycorticosterone(Tetrahydro-11-deoxycorticosterone) is a potent GABAA receptor orthosteric modulator (PAM) with neuroprotective activity that selectively inhibits neurosteroid-mediated enhancement of GABA-induced currents at the GABAA receptor, and can be used in the study of neurological disorders.

21-Deoxy Cortisone (21-Desoxycortisone; NSC 38722) is a corticosteroid metabolite of 11-ketoprogesterone. It is generated from 11-ketoprogesterone by the cytochrome P450 (CYP) isoform CYP17A1, and can also be produced by oxidation via 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) from 21-deoxycorticosterone. In patients with congenital adrenal hyperplasia, a metabolic disorder characterized by a deficiency of 21-hydroxylase, levels of 21-Deoxy Cortisone are elevated.