1-oleoyl lysophosphatidic acid

1-Oleoyl Lysophosphatidic Acid (1-Oleoyl LPA) is a biologically active phospholipid that can exert multiple biological effects in various disease states of the kidney by activating a complex network of at least six homologous G protein-coupled receptors and their heterotrimeric G proteins. 1-Oleoyl Lysophosphatidic Acid promotes polarization of BV-2 and primary murine microglia toward an M1-like phenotype and can be used to study cancer and atherosclerosis.

1-Oleoyl lysophosphatidic acid sodium (1-Oleoyl lysophosphatidic acid sodium salt) salt is an Endogenous agonist of LPA1 and LPA2

1-Oleoyl-sn-glycero-2,3-cyclic-phosphate ammonium (18:1 Cyclic LPA) is a cyclic lysophosphatidic acid used in lipid vesicle (liposome) formation.

Oleoyl 3-carbacyclic Phosphatidic Acid are naturally occurring lysophosphatidic acid (LPA) analogs characterized by a five-membered ring formed between the sn-2 hydroxy group and the sn-3 phosphate moiety. Oleoyl 3-Carbacyclic Phosphatidic Acid (3-ccPA 18:1) contains the 18:1 fatty acid oleate at the sn-1 position of the glycerol backbone and functions as a cyclic lysophosphatidic acid analog. At a concentration of 25 μM, Oleoyl 3-Carbacyclic Phosphatidic Acid (3-ccPA 18:1) inhibits MM1 cell transcellular migration through mesothelial cell monolayers induced by fetal bovine serum by 90.1% and by lysophosphatidic acid by 99.9%, without affecting cell proliferation. Furthermore, Oleoyl 3-Carbacyclic Phosphatidic Acid (3-ccPA 18:1), at concentrations ranging from 0.1 to 1.0 μM, markedly suppresses autotaxin, a key regulator of cancer cell survival, growth, migration, invasion, and metastasis. These findings support the application of Oleoyl 3-Carbacyclic Phosphatidic Acid (3-ccPA 18:1) in studies of lysophospholipid signaling, cancer cell biology, cell migration, and autotaxin-mediated molecular mechanisms.