αconotoxinvc1.1

α-Conotoxin Vc1.1 are potent, short peptide neurotoxins derived from the venom of marine cone snails that selectively and competitively block nicotinic acetylcholine receptors (nAChRs) in the nervous system, serving as highly specific molecular probes to dissect nAChR subtype function and as promising drug discovery leads for pain management, oncology research, and neurological disorder studies by precisely modulating neurotransmission, inhibiting nerve signal propagation, and inducing controlled paralysis in experimental systems.

α-Conotoxin Vc1.1 TFA is a peptide isolated from Conus victoriae and a selective nAChR antagonist that inhibits α3α5β2, α3β2 and α3β4, reversing mechanical allodynia in neuropathic pain models and can be used to study neuropathic chronic pain. α-Conotoxin Vc1.1 TFA inhibits human dorsal root ganglion nerve excitability and mouse colon nociception via GABA(B) receptors.