(z)-tamoxifen

Tamoxifen is an orally active selective estrogen receptor modulator (SERM) that acts as an estrogen antagonist in breast cells and an agonist in bone, liver, and uterine cells. It can be used to induce gene knockout and liver injury models in mice, and also exhibits multiple biological activities, including activation of Hsp90, induction of autophagy and apoptosis, and inhibition of EBOV and MARV viral infections.

4-Hydroxytamoxifen (ICI 79280) is the active metabolite of Tamoxifen, an estrogen receptor modulator (SERM) with selective and oral potency. 4-Hydroxytamoxifen has antitumor activity and may be used in breast cancer research.

Tamoxifen Citrate is an orally active selective estrogen receptor modulator (SERM) that blocks estrogen activity in breast cells while activating estrogen signaling in cells such as those of the bone, liver, and uterus. As an Hsp90 activator, it enhances the ATPase activity of the Hsp90 chaperone complex, induces autophagy and apoptosis, and can be used to generate gene knockout models in CreER(T2) transgenic mice as well as liver injury models.

Tamoxifen-​D5 is a deuterium labeled Tamoxifen. Tamoxifen (T6906) is a selective modulator of estrogen receptor (SERM). Tamoxifen (T6906) is a potent activator of Hsp90 and enhances the Hsp90 molecular chaperone ATPase activity.

(E/Z)-MitoTam (iodide, hydriodide) is a mixture of E/Z isomers of MitoTam iodide, hydriodide. This compound, a derivative of tamoxifen, acts as an electron transport chain (ETC) inhibitor, preventing changes in mitochondrial membrane potential and affecting mitochondrial morphology in aging cells. It is an effective anticancer agent, impeding the formation of respiratory complex I (CI- respiration) and supercomplexes (SCs) in breast cancer cells, and can induce apoptosis (apoptosis).

Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase activity.

Endoxifen E-isomer hydrochloride (E-Endoxifen hydrochloride), a tamoxifen metabolite, is an effective and specific Estrogen Response Modifier (SERM).

(E/Z)-Endoxifen ((E/Z)-Endoxifen) is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has an approximately 100-fold greater affinity for estrogen receptors than tamoxifen. As the efficient conversion of tamoxifen to endoxifen depends on CYP2D6, polymorphisms in this CYP isoform can impact the effectiveness of TMX treatment.

Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.

Endoxifen-d5 (Z-isomer) is the deuterium-labeled form of Endoxifen (Z-isomer). Endoxifen (Z-isomer) is an orally active metabolite of Tamoxifen, which exerts antiestrogenic effects in ERα-expressing breast cancer cells. It inhibits hERG in a concentration-dependent manner, with an IC50 of 1.6 μM.

Tamoxifen (Standard) is a reference standard of tamoxifen, suitable for quantitative analysis, quality control, and related research such as biochemical experiments. Tamoxifen is an orally active selective estrogen receptor modulator (SERM) that acts as an antagonist to estrogen in mammary cells and as an agonist in bone, liver, and uterine cells. Tamoxifen (Standard) can be used to induce gene knockout and liver injury models in mice, and possesses various biological activities, including the activation of Hsp90, inducing autophagy and apoptosis, and inhibiting EBOV (IC50 = 0.1 μM) and MARV (IC50 = 1.8 μM) viral infections.