(r)thalidomide

(R)-Thalidomide is a COX 1/2 inhibitor that induces apoptosis in MCF-7, IM-9, HS-Sultan, KB and other cancer cells.

(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 serves as the E3 ubiquitin ligase ligand and linker for PROTAC(R)-NX-2127, utilized in cancer research.

(S)-Deoxy-thalidomide-(R)-pyrrolidine-3-carbaldehyde is a compound that functions as an E3 ligase ligand-linker conjugate. It includes a CRBN-based ligand and a linker, and is utilized in the synthesis of PROTACs.

Thalidomide-PIP-(R)C-pyrrolidine-boc is a conjugate comprising an E3 ligase ligand and a linker, specifically containing Thalidomide and its corresponding linker. This compound functions as a Cereblon ligand, facilitating the recruitment of the CRBN protein, and is a crucial intermediate in synthesizing complete PROTAC molecules.

(S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and a linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding Linker. It functions as a Cereblon ligand to recruit CRBN protein and serves as a crucial intermediate for synthesizing complete PROTACs molecules.

(1R,5S)-Thalidomide-3,8-diazabicyclo[3.2.1]octane-(1R,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding linker. This compound serves as a Cereblon ligand to recruit CRBN protein and acts as a crucial intermediate in the synthesis of complete PROTAC molecules.

(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding linker. It acts as a Cereblon ligand, recruiting CRBN proteins, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.

Thalidomide-((3R)-3-pyrrolidinemethanol) is a compound that acts as an E3 ligase ligand-linker conjugate, consisting of a CRBN-based ligand and a linker, designed for PROTAC synthesis.

Thalidomide-(1-(3R-pyrrolidinylmethyl)piperazine)-Boc is an E3 ligase ligand-linker conjugate, which includes a CRBN-based ligand and a linker, and can be utilized for the synthesis of PROTACs.

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a short PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was Thalidomide - linker 11 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC8 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was Thalidomide amide-alkylC8-amine PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).

Thalidomide 5'-amine-alkylC6-amine serves as a specialized cereblon ligand for PROTAC research and development, combining an E3 ligase ligand and an alkylC6 linker with a terminal amine for target protein ligand conjugation. It is among a series of functionalized tool molecules designed for PROTAC R&D.