(3r,8s)-falcarindiol

1. (+)-(3R,8S)-Falcarindiol is a potential new anticancer agent that exerts its activity through inducing ER stress and apoptosis. 2. Falcarindiol induces immunosuppressive effects in vitro and in vivo and might be a novel therapy for autoimmune or allergic diseases. 3. Falcarindiol has protective effect against CCl(4) toxicity , in part, be explained by anti-lipid peroxidation activity associated with the induction of the GSTs including GSTA4.

Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ, enhancing ABCA1 expression [a cholesterol transporter], and induces apoptosis and autophagy, exhibiting anti-inflammatory, antifungal, anticancer, and antidiabetic properties.