Millettia

1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesity-related transcription through a feedback mechanism that regulates the expression of adiponectin, adipoR1, adipoR2, and AMPK. 3. Prunetin and biochanin A are potent reducers of NF-κB and ERK activation, zonula occludens 1 tyrosine phosphorylation, and metalloproteinase-mediated shedding activity, which may account for the barrier-improving ability of these isoflavones. 4. Prunetin significantly suppresses ATP-induced mucin secretion from cultured RTSE cells; Prunetin inhibits the production of MUC5AC mucin protein induced by EGF or PMA from NCI-H292 cells; Prunetin also inhibits the expression of MUC5AC mucin gene induced by EGF or PMA from NCI-H292 cells.

Colutehydroquinone is an antifungal isoflavonoid from Colutea arborescens.

2',4',5'-TriMethoxy-2'',2''-diMethylpyrano[5'',6'':6,7]isoflavone is a natural product used in life sciences research. The catalog number is TN2708, and the CAS number is 211799-56-3.

Odoriflavene has antioxidant activity, and it also shows inhibition effects on the decrease of glutathione level of rat lens induced by UV irradiation. Odoriflavene shows cytotoxic activity against a SH-SY5Y cell line in vitro.

Pendulone could be a valuable chemopreventive agent, it shows strong inhibition on the effect of the cell cycle induced by TPA and shows potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test.

Millewanins H shows antiestrogenic activity.

2'-Hydroxy-3,4,4',6'-Tetramethoxychalcone is a natural chalcone exhibiting anticancer activity against MCF7 cells and BCRP inhibitory activity.

Millewanin G shows antiestrogenic activity.