Centipeda

Microhelenin C has significant antileukemic activity.

Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 μM) in Cancer Cells.Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.antitumour

Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner. Arnicolide D exerts strong cytotoxic activity on the human colon carcinoma HT-29 cell line.

Minimolide F, isolated from Centipeda minima, shows antiproliferative activity against human nasopharyngeal cancer cells with an IC50 of 17.4 μM.

Arnicolide C (Isobutyroylplenolin) is a sesquiterpene lactone metabolite naturally found in Centipeda minima and Arnica montana. Arnicolide C is reported to possess diverse biological activities, including anti-inflammatory, antiallergy, antitumor, anticancer, and antiprotozoal properties, making it a multifunctional natural product.