Calophyllaceae

2-Hydroxyxanthone is a naturally occurring flavonoid that inhibits the activity of Plasmodium falciparum K1, a potential inhibitor of PKCζ and MAO-A, and inhibits the proliferation of K562 cells.

Tovopyrifolin C is a naturally occurring flavonoid found in a variety of plants that inhibits monoamine oxidase (IC50=2.7 µM).

Calanolide E2 has anti-HIV activity.

Pyranojacareubin is a natural product from Calophyllum inophyllum.

Mesuaxanthone A and mesuaxanthone B are two yellow pigments.They produce varying degrees of C.N.S. depression characterised by ptosis, sedation, decreased spontaneous motor activity, loss of muscle tone, potentiation of pentobarbitone sleeping time and et

Canophyllal shows antiplasmodial activity against the W2 strain of Plasmodium falciparum which is resistant to chloroquine and other antimalarial drugs.

Pancixanthone A may have antimalarial activity, it also shows a significant antileishmanial activity against the promastigote forms of Leishmania mexicana and L. infantum and against the amastigote forms of L. infantum.

Mesuol has antioxidant activity, it shows very high scavenging activity against DPPH radical; it also has immunomodulatory activity, can potentiate percentage neutrophil adhesion in neutrophil adhesion test in rats and phagocytosis in carbon clearance assay. Mesuol can suppress HIV-1 replication in Jurkat T cells, it inhibits TNFα-induced HIV-1-LTR transcriptional activity by targeting the nuclear factor-κB (NF-κB) pathway.

Isoapetalic acid and apetalic acid exhibit cytotoxic activities towards both cancer cell lines(human breast cancer (MCF-7) and human lung carcinoma (A-549) cell lines) and both Gram-positive bacteria(two Gram-positive bacteria, S. aureus and B. subtilis a