Araucariales

Secoisolariciresinol is an enterolignan precursor, it has antioxidant, and estrogen-like activities, it can significantly suppress triglyceride (TG) accumulation in 3T3-L1 adipocytes.

Podocarpusflavone A is a DNA topoisomerase I inhibitor with moderate anti-proliferative activity that induces cell apoptosis in MCF-7.

Prunin (Naringenin 7-0-glucoside) possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-resistant HepG2 cells; it also can stimulate growth of Pseudomonas aeruginosa and different Bacilllus sp. Prunin exhibits a markedly enhanced solubility compared to naringenin and naringin while maintaining the in vitro inhibition of HMG-CoA reductase.

Totarol ((+)-Totarol) shows antibacterial effects against several pathogenic Gram-positive bacteria, mycobacterium tuberculosis.

Isocupressic acid ((+)-Isocupressic acid) is an abortifacient isolated from pine needles and bark that blocks progesterone production in bovine corpus luteum cells.

9,13β-Epidioxy-8(14)-abieten-18-oic acid has anti-inflammatory activities, it exhibits moderate activities on NO levels in LPS-stimulated murine microglia BV2 cells, with IC50 values of 57.3 ± 0.2 uM. It is also a potential antitumor-promoting diterpenoid, it shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate. 9 α ,13 β -Epidioxyabeit-8(14)en-18-oic acid may contribute to the growth inhibitory effect of the pine needles and may play an important role in the allelopathy of red pine.

Acetylisocupressic acid is a natural product of Araucaria, Araucariaceae. The catalog number is TN3343 and the CAS number is 52992-82-2. Acetylisocupressic acid can be used as a reference standard.

Nagilactone C and phyllanthoside are novel protein synthesis inhibitors, they are specific for the eukaryotic translation apparatus, function in vivo and in vitro, and interfere with translation elongation. Nagilactone C shows high insecticidal activity against second-instar nymphs of Eocanthecona furcellata. Nagilactone C possesses potent antiproliferative activity against human fibrosarcoma and murine colon carcinoma tumor cell lines exhibiting ED50 values of 2.3 and 1.2 microg/ml, respectively.

2,3-Dihydroamentoflavone 7,4'-dimethyl ether exhibits cytotoxicity (ED50 values < 4 microg/mL) against P-388 and HT-29 cell lines in vitro.

2,3-Dihydroheveaflavone is a natural product for research related to life sciences. The catalog number is TN2696 and the CAS number is 110382-42-8.

4 beta-Carboxy-19-nortotarol can inhibit microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ NADH, it inhibits linoleic acid autoxidation but not generation of superoxide anion.

5,5'-Dimethoxysecoisolariciresinol is a natural product from Podocarpus spicata.

2,3-dihydrosciadopitysin is a natural product of Podocarpus, Podocarpaceae. The catalog number is TN2700 and the CAS number is 34421-19-7. 2,3-dihydrosciadopitysin can be used as a reference standard.

2,3-Dihydropodocarpusflavone A (Catalog Number: TN2699, CAS: 852875-96-8) is a natural product used in life sciences research.