Dihydroevocarpine (1-methyl-2-tridecylquinolin-4-one) induces AML cytotoxicity, apoptosis and G0/G1 blockade, and inhibits tumor growth by inhibiting mTORC1/2 activity and the mTOR pathway in an acute myeloid leukemia (AML) xenograft model.

(±)-Evodiamine is an alkaloid isolated from Evodiae fructus and a topoisomerase I inhibitor. It also inhibits adipocyte differentiation and diabetes by downregulating IGF-1/HIF-1α and IL-6/STAT pathways. As an inhibitor of NF-κB activation, it suppresses invasion, promotes apoptosis, and inhibits TNF-induced Akt activation.

1-Methyl-2-pentyl-4(1H)-quinolinone, a low toxic natural product containing a quinoline structure, is a specific inhibitor of Plasmodium falciparum type II NADH dehydrogenase (PfNDH2), significantly inhibits Plasmodium falciparum development in the mosquito stage and blocks malaria transmission.