Dihydroevocarpine (1-methyl-2-tridecylquinolin-4-one) induces AML cytotoxicity, apoptosis and G0 G1 blockade, and inhibits tumor growth by inhibiting mTORC1 2 activity and the mTOR pathway in an acute myeloid leukemia (AML) xenograft model.
1-Methyl-2-pentyl-4(1H)-quinolinone, a low toxic natural product containing a quinoline structure, is a specific inhibitor of Plasmodium falciparum type II NADH dehydrogenase (PfNDH2), significantly inhibits Plasmodium falciparum development in the mosquito stage and blocks malaria transmission.