Glycozolidal is a carbazole alkaloid isolated from the leaves or stems of Clausena lansium (Lour.) Skeels. It exhibits potent antibacterial activity against Porphyromonas gingivalis, a keystone pathogen involved in the pathogenesis of chronic periodontitis. In vitro studies have also characterized its cytotoxic profile, with IC50 values of 120.86 µg/mL against human gingival fibroblasts (HGFs) and 97.74 µg/mL against U937 monocytes. This bioactive secondary metabolite serves as a significant scaffold for exploring novel antimicrobial agents targeting oral infections and studying the structure-activity relationships of carbazole derivatives.