Plantainoside D (Isoplantamajoside) shows potent antioxidative effects as those of ascorbic acid, it shows angiotensin-converting enzyme (ACE) inhibitory inhibitory activity in vitro with the IC(50) value of 2.17 mM, it also shows inhibitory activity against PKCalpha with the IC50 value14.8microM.

Plantamajoside (Y0160) has anti-hepatotoxic, anti-inflammatory, antinociceptive activities, improving sexual function and antioxidant activity.

Martynoside is an active glycoside extracted from Rehmannia, with anti-estrogen, anticancer, cytotoxic, hematopoietic, antioxidant, and anti-metastatic properties. It increases IGFBP3 levels through the ER pathway.

Plantaginin is a naturally derived flavonoid glycoside known to inhibit MMP-2 activity, indicating its potential role in regulating extracellular matrix remodeling. This activity provides a biochemical basis for its investigation in inflammation, metastasis suppression, and tissue-repair research where MMP-2 modulation is mechanistically relevant.