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Dysosma

  • Etoposide
    T013233419-42-0
    Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM). Etoposide has antitumor activity and induces apoptosis and autophagy.
    • $33
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  • Picropodophyllol
    TN20703811-15-2
    Picropodophyllol is a natural product isolated from the roots of Dysosma versipellis
    • $57
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  • Picropodophyllin
    T6943477-47-4
    Picropodophyllin (Picropodophyllin (PPP)) (PPP) is a specific IGF-1R inhibitor (IC50: 1 nM). Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT).
    • $58
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  • Acetylepipodophyllotoxin
    TN13571180-35-4
    Acetylepipodophyllotoxin has insecticidal activity.
    • $540
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  • 4'-Demethylpodophyllotoxin
    T2S002940505-27-9
    4'-Demethylpodophyllotoxin is isolated from the herb of Dysosma pleiantha (Hance) Woodson with remarkable cytotoxic potential in diverse cancer cell lines.
    • $39
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  • Picropodophyllone
    TN2071477-48-5
    Picropodophyllone is one of the lignans from the roots of D. aurantiocaulis and D. pleianthum.
    • $64
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  • 4'-Demethylepipodophyllotoxin
    T29376559-91-7
    4'-Demethylepipodophyllotoxin (DMEP) is a potent inhibitor of microtubule assembly.
    • $33
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  • Podophyllotoxone
    T8188477-49-6
    Podophyllotoxinone, a natural compound found in Dysosma versipellis, shows inhibitory activity against L1210 leukemia and KB cells in vitro.
    • $91
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  • Picropodophyllotoxin
    T3S002717434-18-3
    Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllotoxin (AXL 1717) specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT). This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis. IGF1R, a receptor tyrosine kinase overexpressed in a variety of human cancers, plays a critical role in the growth and survival of many types of cancer cells.
    • $32
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  • Deoxypodophyllotoxin
    TN108719186-35-7
    Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities.
    • $116
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  • Podophyllol
    TN209078339-51-2
    Podophyllol is a natural product
    • $250
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  • Podophyllotoxin 4-O-glucoside
    TN481316481-54-2
    Podophyllotoxin 4-O-glucoside is a natural product of Dysosma, Berberidaceae. The catalog number is TN4813 and the CAS number is 16481-54-2. Podophyllotoxin 4-O-glucoside can be used as a reference standard.
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    • Podofilox
      T1121518-28-5
      Podofilox ((+)-Shikonin) is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
      • $66
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