Epimedokoreanin B (EKB), an isoprenylated flavonoid isolated from Korean Epimedium, exhibited anticancer activity in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells.Epimedokoreanin B also possesses anti-inflammatory and antibacterial activities, and may have scavenging activity against DPPH radicals, inhibiting the proliferation of MCF-7 and HepG2 in a dose-dependent manner. Epimedokoreanin B also exhibits anti-inflammatory and antibacterial activity, with DPPH radical scavenging activity, and inhibits the proliferation of MCF-7 and HepG2 in a dose-dependent manner.Epimedokoreanin B significantly inhibits the formation of N (α)-(carboxymethyl)lysine (CML) and N (Ï)-(carboxymethyl)arginine (CMA), and prevents clinical complications of diabetes mellitus through the inhibition of advanced glycation end-products (AGEs).

Icariin (Ieariline) belongs to the flavonol glycoside group of natural products, can inhibit PDE5 and PDE4 activity (IC50=432 73.50 μM), is also a PPARα activator. Icariin can increase cardiovascular and cerebrovascular blood flow, promote hematopoiesis, immunity and bone metabolism.

Epimedin A1 (Hexandraside F)(Hexandraside F) is a flavonoid extracted from Herba Epimedii which is one of commonly used Chinese medicines.

Icariside I (Lcariside I) is isolated from Epimedium herb. It can stimulate osteogenic differentiation of BMSCs and inhibit bone resorption activity of osteoclasts.

Icaritin (Anhydroicaritin) has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation. Icaritin has anti-multiple myeloma activity, mainly mediated by inhibiting IL-6 JAK2 STAT3 signaling. Icaritin at low concentration (4 or 8 μMol L) can promote rat chondrocyte proliferation and inhibit cell apoptosis, while the effect of Icaritin on rat chondrocyte at high concentration was reversed.

Epimedoside A has significant antioxidant activity in vitro.

1. β-Anhydroicaritin exhibits immunosuppressive effect on the mouse macrophages stimulated by LPS. 2. β-Anhydroicaritin phytosomes can inhibit enhanced bone turnover induced by ovariectomy, improve BMD the biomechanical properties of vertebrae, without any stimulation on uterus. 3. β-Anhydroicaritin possesses significant protective effects on the zymosan-induced peritonitis mice, which might be associated with the regulation of Ca(2+); influx in macrophages and iNOS expression.

1. Epimedin B (Epmedin B) has potential activity against osteoporosis by stimulating osteoblasts.

Epmedin C (Baohuoside-VI) was metabolized via desugarization, dehydrogenation, hydrogenation, dehydroxylation, hydroxylation, demethylation and glucuronidation pathways in vivo. It has potential activity against osteoporosis by stimulating osteoblasts.

Baohuoside I (Icariside-II) is a component of Epimedium koreanum, exhibits anti-inflammatory activity and anti-osteoporosis activities.

Noricaritin, a flavonoid derived from Epimedium root, induces cell proliferation in lung tissue and inhibits the production of pro-inflammatory cytokines and chemokines in human lung epithelial cells.

Epimedin A has anti-osteoporosis activities in vivo.

Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.

2''-O-Rhamnosylicariside II is beneficial for improving postmenopausal osteoporosis and demonstrates potent antioxidant activity, with IC50 values of 90.5 µM [90.5 uM].

Sagittatoside C is a natural product

8,3'-Diprenylapigenin is a natural product for research related to life sciences. The catalog number is TN3264 and the CAS number is 955135-37-2.

Epimedin K is a natural product from Epimedium koreanum NAKAI (Berberidaceae).

Korepimedoside A is a natural product from Epimedium koreanum.

Baohuoside V is a natural product

Icariside E5 may have antioxidant property that strengthen the importance of peppers in the Mediterranean diet.

Epimedin B1 is a natural product for research related to life sciences. The catalog number is TN3970 and the CAS number is 133137-58-3.

Ikarisoside F and epimedin A can bind to AdoHcy hydrolase, inhibit the activity of AdoHcy hydrolase, thus regulating the cellular biomethylation as well as reducing cellular Hcy level.

Sutchuenmedin A is a natural product from Epimedium sutchuenense.

Isoanhydroicaritin is a natural product from Epimedium brevicornu Maxim.

Baohuoside aglycone possesses cardioprotective effect in prevention of ischemia reperfusion injury and reduce the myocardial infraction, the mechnism is due to the reduction of the injury of free radicals. Baohuoside VII in vivo exhibits significant anti

Sagittatoside B is a natural product from Epimedium brevicornu Maxim.

Sagittatoside A selectively activates estrogen response element (ERE)-luciferase activity via ERα.

Brevicornin is a natural product from Epimedium brevicornu Maxim.

Caohuoside E is a natural product from Epimedium sagittatum.

Iso-sagittatoside A is a natural product for research related to life sciences. The catalog number is TN4259 and the CAS number is 503456-08-4.