lysosomal-autophagy — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T23004	ML-SA1	Mucolipin synthetic agonist 1	Others , TRP/TRPV Channel
	ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV...		Others , TRP/TRPV Channel
T7944	VPS34 inhibitor 1 (Compound 19, PIK-III analogue)	PIK-III analogue	PI3K
	VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)		PI3K
T3436	LYS01	lys05 (free base)	Autophagy
	LYS01 free base is a new lysosomal autophagy inhibitor.		Autophagy
T3437	Lys05	Lys01 trihydrochloride	lysosomal autophagy , Autophagy
	Lys05, or Lys01 trihydrochloride, is a potent, water soluble lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compa...		lysosomal autophagy , Autophagy
T5538	DC661		Apoptosis , Autophagy
	DC661 is a palmitoyl-protein thioesterase 1 (PPT1) inhibitor that acts as an anti-lysosomal agent by inhibiting autophagy, demonstrating anti-cancer activity.		Apoptosis , Autophagy
T11191	EN6		Proton pump , Autophagy
	EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative ...		Proton pump , Autophagy
T21992	Vacuolin-1		PI3K , Autophagy
	Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. It acts by inhibiting release of lysosomal content.vacuolin‐1 is a potent and selective PIKfyve inhibitor and inhibits ...		PI3K , Autophagy
T60202	MMRi62	7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol	Ferroptosis
	MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol), a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity aga...		Ferroptosis
T63476	ARN5187 trihydrochloride
	ARN5187 trihydrochloride is a lysosomal REV-ERBβ ligand that inhibits REV-ERB-mediated transcriptional regulation and autophagy. ARN5187 trihydrochloride has lysosomal potency and cytotoxicity and induces apoptosis.
T61883	ARN5187
	ARN5187 is a lysosomal compound, REV-ERB β Ligand. ARN5187 inhibits REV-ERB-mediated transcriptional regulation and autophagy. ARN5187 shows lysosomal efficacy and cytotoxicity, and can induce apoptosis.
T74615	NAMPT degrader-1
	NAMPT Degrader-1 (Compound A3), a nicotinamide phosphoribosyltransferase (NAMPT) degrader, exhibits potent antitumor activity in cells by specifically inducing the degradation of NAMPT via the autophagy-lysosomal pathway...
T79147	KRAS degrader-1
	KRAS degrader-1 (compound 1) is a potent agent that selectively targets KRAS proteins for destruction via the autophagy-lysosomal degradation pathway [1].
T62331	Autophagy-IN-1
	Autophagy-IN-1 is a potent inhibitor of autophagy/mitophagy, blocking autophagosomal-lysosomal fusion in cancer cells while selectively increasing autophagic flux. Autophagy-IN-1 significantly inhibits tumour growth in t...
T81820	Meso-Benzothiazole-BODIPY 505/515
	Meso-Benzothiazole-BODIPY 505/515, a boron dipyrromethene (BODIPY)-based fluorescent probe, is utilized in autophagy research, particularly for studying Alzheimer's disease, lysosomal storage disorders, and neurodegenera...
T73544	MPM-1
	MPM-1, a mimic of marine Eusynstyelamides, serves as an effective anticancer agent. It swiftly induces a necrosis-like death in cancer cells in vitro, facilitates immunogenic cell death, and disrupts autophagy, leading t...

Compounds

ML-SA1

T23004

Synonym: Mucolipin synthetic agonist 1

Target: Others, TRP/TRPV Channel

VPS34 inhibitor 1 (Compound 19, PIK-III analogue)

T7944

Synonym: PIK-III analogue

Target: PI3K

LYS01

T3436

Synonym: lys05 (free base)

Target: Autophagy

Lys05

T3437

Synonym: Lys01 trihydrochloride

Target: lysosomal autophagy, Autophagy

DC661

T5538

Synonym:

Target: Apoptosis, Autophagy

EN6

T11191

Synonym:

Target: Proton pump, Autophagy

Vacuolin-1

T21992

Synonym:

Target: PI3K, Autophagy

MMRi62

T60202

Synonym: 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol

Target: Ferroptosis

ARN5187 trihydrochloride

meso-Benzothiazole-BODIPY 505/515

Cat No.	Product Name	Targets
T5689	20-DEOXYINGENOL	Others , Autophagy
	20-DEOXYINGENOL is a natual product.
TN1711	Gossypetin	Antioxidant , p38 MAPK , MAPK , Antibacterial
	Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signaling pathway.Gossypetin exhibits antimutagenic, antiatherosc...

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-01710	Mucolipin-1/MCOLN1 Protein, Human, Recombinant (His)	Human	in vitro E. coli expression system
	Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to t...
TMPH-02282	Ubiquilin-1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pa...

Mucolipin-1/MCOLN1 Protein, Human, Recombinant (His)

TMPH-01710

Species: Human

Expression System: in vitro E. coli expression system

Ubiquilin-1 Protein, Human, Recombinant (His & Myc)

TMPH-02282

Species: Human

Expression System: E. coli

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Compounds

Natural Products

Recombinant Proteins

Compounds

Natural Products

Recombinant Proteins