Home Tools
Log in
Cart

c-Kit

Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR). Multiple transcript variants encoding different isoforms have been found for this gene.KIT is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. Altered forms of this receptor may be associated with some types of cancer. KIT is a receptor tyrosine kinase type III, which binds to stem cell factor (a substance that causes certain types of cells to grow), also known as "steel factor" or "c-kit ligand".
Cat. No. Product name CAS No. Purity Chemical Structure
T22256 C-Kit-IN-5-1 1003311-62-3 98%
AMG-25 is a novel selective and potent c-Kit inhibitor.
TQ0080 SU14813 maleate 849643-15-8 98%
SU14813 maleate is an inhibitor of multi-targeted receptor tyrosine kinases (IC50s: 2, 50, 4, 15 nM for VEGFR1, VEGFR2, PDGFRβ, and KIT).
T1925 PLX647 873786-09-5 98%
PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).
T10801 CHMFL-ABL/KIT-155 2081093-21-0 98%
CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM). It arrests cell cycle progression and induce...
T10650 C-Kit-IN-2 2121515-37-3 98%
c-Kit-IN-2 is a c-KIT inhibitor (IC50: 82 nM), shows superior antiproliferative activities against all the three GIST cell lines, GIST430, GIST882, and GIST48 (G...
T6193 Dovitinib Dilactic Acid 852433-84-2 98%
Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with ...
T12145 N-Desethyl Sunitinib 356068-97-8 98%
N-Desethyl Sunitinib is a sunitinib metabolite.
T14928 Agerafenib hydrochloride 1227678-26-3 98%
Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).
T22303 Dasatinib hydrochloride 854001-07-3 98%
Dasatinib hydrochloride (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. ...
T6091 CP-673451 343787-29-1 98%
CP-673451 is a specific inhibitor of PDGFRα/β (IC50: 10/1 nM) with antiangiogenic and antitumor activity and the selectivity is higher 450-fold than other angiog...
T2609 Masitinib 790299-79-5 98%
Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has ...
T2446 KI8751 228559-41-9 98%
KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.
T1448 Dasatinib 302962-49-8 98%
Dasatinib is a potent inhibitor of the Bcr-Abl and Src family (IC50s: 0.6, 0.8, 79 and 37 nM for Abl, Src, c-Kit, and c-KitD816V, respectively).
T2341 KW-2449 1000669-72-6 98%
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R...
T1792 Regorafenib 755037-03-7 98%
Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor (IC50s: 1.5/2.5/4.2/7/13/22 nM for RET/C-RAF/VEGFR2/c-Kit/VEGFR1/PDGFRβ).
T0097L Pazopanib 444731-52-6 98%
Pazopanib, a small molecule inhibitor, inhibits multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits VEGFR-1,...
T6196 PP1 172889-26-8 98%
PP1, a specific and effective Src inhibitor, is with IC50 for Lck/Fyn is 5 nM/ 6 nM, respectively.
T7861 Flumatinib mesylate 895519-91-2 98%
Flumatinib mesylate is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.
T0093 Sorafenib tosylate 475207-59-1 98%
Sorafenib is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).
T2500 Cediranib 288383-20-0 98%
Cediranib (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (IC50: 5 nM/...
c-Kit-IN-5-1
T22256
AMG-25 is a novel selective and potent c-Kit inhibitor.
SU14813 maleate
TQ0080
SU14813 maleate is an inhibitor of multi-targeted receptor tyrosine kinases (IC50s: 2, 50, 4, 15 nM for VEGFR1, VEGFR2, PDGFRβ, and KIT).
PLX647
T1925
PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).
CHMFL-ABL/KIT-155
T10801
CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM). It arrests cell cycle progression and induce...
c-Kit-IN-2
T10650
c-Kit-IN-2 is a c-KIT inhibitor (IC50: 82 nM), shows superior antiproliferative activities against all the three GIST cell lines, GIST430, GIST882, and GIST48 (G...
Dovitinib Dilactic Acid
T6193
Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with ...
N-Desethyl Sunitinib
T12145
N-Desethyl Sunitinib is a sunitinib metabolite.
Agerafenib hydrochloride
T14928
Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).
Dasatinib hydrochloride
T22303
Dasatinib hydrochloride (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. ...
CP-673451
T6091
CP-673451 is a specific inhibitor of PDGFRα/β (IC50: 10/1 nM) with antiangiogenic and antitumor activity and the selectivity is higher 450-fold than other angiog...
Masitinib
T2609
Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has ...
KI8751
T2446
KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.
Dasatinib
T1448
Dasatinib is a potent inhibitor of the Bcr-Abl and Src family (IC50s: 0.6, 0.8, 79 and 37 nM for Abl, Src, c-Kit, and c-KitD816V, respectively).
KW-2449
T2341
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R...
Regorafenib
T1792
Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor (IC50s: 1.5/2.5/4.2/7/13/22 nM for RET/C-RAF/VEGFR2/c-Kit/VEGFR1/PDGFRβ).
Pazopanib
T0097L
Pazopanib, a small molecule inhibitor, inhibits multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits VEGFR-1,...
PP1
T6196
PP1, a specific and effective Src inhibitor, is with IC50 for Lck/Fyn is 5 nM/ 6 nM, respectively.
Flumatinib mesylate
T7861
Flumatinib mesylate is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.
Sorafenib tosylate
T0093
Sorafenib is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).
Cediranib
T2500
Cediranib (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (IC50: 5 nM/...
1 2 3 4 5