c-Kit

Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR). Multiple transcript variants encoding different isoforms have been found for this gene.KIT is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. Altered forms of this receptor may be associated with some types of cancer. KIT is a receptor tyrosine kinase type III, which binds to stem cell factor (a substance that causes certain types of cells to grow), also known as "steel factor" or "c-kit ligand".

Cat. No.	Product name	CAS No.	Purity
T22256	C-Kit-IN-5-1	1003311-62-3	98%
T22256	AMG-25 is a novel selective and potent c-Kit inhibitor.
TQ0080	SU14813 maleate	849643-15-8	98%
TQ0080	SU14813 maleate is an inhibitor of multi-targeted receptor tyrosine kinases (IC50s: 2, 50, 4, 15 nM for VEGFR1, VEGFR2, PDGFRβ, and KIT).
T1925	PLX647	873786-09-5	98%
T1925	PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).
T10801	CHMFL-ABL/KIT-155	2081093-21-0	98%
T10801	CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM). It arrests cell cycle progression and induce...
T10650	C-Kit-IN-2	2121515-37-3	98%
T10650	c-Kit-IN-2 is a c-KIT inhibitor (IC50: 82 nM), shows superior antiproliferative activities against all the three GIST cell lines, GIST430, GIST882, and GIST48 (G...
T6193	Dovitinib Dilactic Acid	852433-84-2	98%
T6193	Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with ...
T12145	N-Desethyl Sunitinib	356068-97-8	98%
T12145	N-Desethyl Sunitinib is a sunitinib metabolite.
T14928	Agerafenib hydrochloride	1227678-26-3	98%
T14928	Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).
T22303	Dasatinib hydrochloride	854001-07-3	98%
T22303	Dasatinib hydrochloride (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. ...
T6091	CP-673451	343787-29-1	98%
T6091	CP-673451 is a specific inhibitor of PDGFRα/β (IC50: 10/1 nM) with antiangiogenic and antitumor activity and the selectivity is higher 450-fold than other angiog...
T2609	Masitinib	790299-79-5	98%
T2609	Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has ...
T2446	KI8751	228559-41-9	98%
T2446	KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.
T1448	Dasatinib	302962-49-8	98%
T1448	Dasatinib is a potent inhibitor of the Bcr-Abl and Src family (IC50s: 0.6, 0.8, 79 and 37 nM for Abl, Src, c-Kit, and c-KitD816V, respectively).
T2341	KW-2449	1000669-72-6	98%
T2341	KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R...
T1792	Regorafenib	755037-03-7	98%
T1792	Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor (IC50s: 1.5/2.5/4.2/7/13/22 nM for RET/C-RAF/VEGFR2/c-Kit/VEGFR1/PDGFRβ).
T0097L	Pazopanib	444731-52-6	98%
T0097L	Pazopanib, a small molecule inhibitor, inhibits multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits VEGFR-1,...
T6196	PP1	172889-26-8	98%
T6196	PP1, a specific and effective Src inhibitor, is with IC50 for Lck/Fyn is 5 nM/ 6 nM, respectively.
T7861	Flumatinib mesylate	895519-91-2	98%
T7861	Flumatinib mesylate is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.
T0093	Sorafenib tosylate	475207-59-1	98%
T0093	Sorafenib is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).
T2500	Cediranib	288383-20-0	98%
T2500	Cediranib (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (IC50: 5 nM/...