T22256 |
C-Kit-IN-5-1
|
1003311-62-3
|
98%
|
|
AMG-25 is a novel selective and potent c-Kit inhibitor.
|
TQ0080 |
SU14813 maleate
|
849643-15-8
|
98%
|
|
SU14813 maleate is an inhibitor of multi-targeted receptor tyrosine kinases (IC50s: 2, 50, 4, 15 nM for VEGFR1, VEGFR2, PDGFRβ, and KIT).
|
T1925 |
PLX647
|
873786-09-5
|
98%
|
|
PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).
|
T10801 |
CHMFL-ABL/KIT-155
|
2081093-21-0
|
98%
|
|
CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM). It arrests cell cycle progression and induce...
|
T10650 |
C-Kit-IN-2
|
2121515-37-3
|
98%
|
|
c-Kit-IN-2 is a c-KIT inhibitor (IC50: 82 nM), shows superior antiproliferative activities against all the three GIST cell lines, GIST430, GIST882, and GIST48 (G...
|
T6193 |
Dovitinib Dilactic Acid
|
852433-84-2
|
98%
|
|
Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with ...
|
T12145 |
N-Desethyl Sunitinib
|
356068-97-8
|
98%
|
|
N-Desethyl Sunitinib is a sunitinib metabolite.
|
T14928 |
Agerafenib hydrochloride
|
1227678-26-3
|
98%
|
|
Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).
|
T22303 |
Dasatinib hydrochloride
|
854001-07-3
|
98%
|
|
Dasatinib hydrochloride (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. ...
|
T6091 |
CP-673451
|
343787-29-1
|
98%
|
|
CP-673451 is a specific inhibitor of PDGFRα/β (IC50: 10/1 nM) with antiangiogenic and antitumor activity and the selectivity is higher 450-fold than other angiog...
|
T2609 |
Masitinib
|
790299-79-5
|
98%
|
|
Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has ...
|
T2446 |
KI8751
|
228559-41-9
|
98%
|
|
KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.
|
T1448 |
Dasatinib
|
302962-49-8
|
98%
|
|
Dasatinib is a potent inhibitor of the Bcr-Abl and Src family (IC50s: 0.6, 0.8, 79 and 37 nM for Abl, Src, c-Kit, and c-KitD816V, respectively).
|
T2341 |
KW-2449
|
1000669-72-6
|
98%
|
|
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R...
|
T1792 |
Regorafenib
|
755037-03-7
|
98%
|
|
Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor (IC50s: 1.5/2.5/4.2/7/13/22 nM for RET/C-RAF/VEGFR2/c-Kit/VEGFR1/PDGFRβ).
|
T0097L |
Pazopanib
|
444731-52-6
|
98%
|
|
Pazopanib, a small molecule inhibitor, inhibits multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits VEGFR-1,...
|
T6196 |
PP1
|
172889-26-8
|
98%
|
|
PP1, a specific and effective Src inhibitor, is with IC50 for Lck/Fyn is 5 nM/ 6 nM, respectively.
|
T7861 |
Flumatinib mesylate
|
895519-91-2
|
98%
|
|
Flumatinib mesylate is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.
|
T0093 |
Sorafenib tosylate
|
475207-59-1
|
98%
|
|
Sorafenib is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).
|
T2500 |
Cediranib
|
288383-20-0
|
98%
|
|
Cediranib (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (IC50: 5 nM/...
|