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Tyrosine Kinase/Adaptors c-Fms

c-Fms

Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation 115), is a cell-surface protein encoded, in humans, by the CSF1R gene (known also as c-FMS). It is a receptor for a cytokine called colony stimulating factor 1.
Cat No. product name
T11734 K-80003 K-80003 is a potent inhibitor of cancer cell growth and tRXRα-dependent Akt activation.
T4376 Nampt-IN-1 Nampt-IN-1 (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.
T6104 Cerdulatinib hydrochloride Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and S...
T2116 AEE788 AEE788 has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.
T6930 Pazopanib HCl Pazopanib HCl (GW786034 HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 7...
T2609 Masitinib Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has ...
T2659 GW 2580 GW2580 is a specific, oral-bioavailable CSF-1R inhibitor for c-FMS.
T1925 PLX647 PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).
T6028 PF477736 PF-477736 is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes.
T4315 Ki20227 Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRβ(IC50: 45...
T10648 C-Fms-IN-9 c-Fms-IN-9 is a c-FMS inhibitor extracted from patent WO2014145023A1 (Example 7). It inhibits unphosphorylated c-FMS kinase (uFMS) and uKIT (IC50s: <0.01 μM and...
T5172 AZ304 AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).
T5586 CFMS Receptor Inhibitor II cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor
T12505 PLX5622 hemifumarate PLX5622 hemifumarate is a highly selective brain penetrant and oral active inhibitor of CSF1R(Ki of 5.9 nM).
T10894 CSF1R-IN-1 CSF1R-IN-1 is a CSF1R inhibitor with IC50 of 0.5 nM.
T13194 CSF1R-IN-2 CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).
T10775 C-Fms-IN-2 c-Fms-IN-2 is an inhibitor of FMS kinase (IC50: 0.024 μM).
T10645 C-Fms-IN-6 c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50: > 1 μM).
T3351 CC223 CC-223 is an orally available mTOR inhibitor with potential antitumor activity. CC-223 inhibits the activity of mTOR, which may result in the induction of tumor ...
K-80003
T11734CAS 1292821-90-9
K-80003 is a potent inhibitor of cancer cell growth and tRXRα-dependent Akt activation.
Nampt-IN-1
T4376CAS 1698878-14-6
Nampt-IN-1 (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.
Cerdulatinib hydrochloride
T6104CAS 1369761-01-2
Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and S...
AEE788
T2116CAS 497839-62-0
AEE788 has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.
Pazopanib HCl
T6930CAS 635702-64-6
Pazopanib HCl (GW786034 HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 7...
Masitinib
T2609CAS 790299-79-5
Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has ...
GW 2580
T2659CAS 870483-87-7
GW2580 is a specific, oral-bioavailable CSF-1R inhibitor for c-FMS.
PLX647
T1925CAS 873786-09-5
PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).
PF477736
T6028CAS 952021-60-2
PF-477736 is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes.
Ki20227
T4315CAS 623142-96-1
Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRβ(IC50: 45...
c-Fms-IN-9
T10648CAS 1628574-50-4
c-Fms-IN-9 is a c-FMS inhibitor extracted from patent WO2014145023A1 (Example 7). It inhibits unphosphorylated c-FMS kinase (uFMS) and uKIT (IC50s: <0.01 μM and...
AZ304
T5172CAS 942507-42-8
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).
cFMS Receptor Inhibitor II
T5586CAS 959860-85-6
cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor
PLX5622 hemifumarate
T12505CAS T12505
PLX5622 hemifumarate is a highly selective brain penetrant and oral active inhibitor of CSF1R(Ki of 5.9 nM).
CSF1R-IN-1
T10894CAS 2095849-04-8
CSF1R-IN-1 is a CSF1R inhibitor with IC50 of 0.5 nM.
CSF1R-IN-2
T13194CAS 2271119-26-5
CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).
c-Fms-IN-2
T10775CAS 791587-67-2
c-Fms-IN-2 is an inhibitor of FMS kinase (IC50: 0.024 μM).
c-Fms-IN-6
T10645CAS 1628574-81-1
c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50: > 1 μM).
CC223
T3351CAS 1228013-30-6
CC-223 is an orally available mTOR inhibitor with potential antitumor activity. CC-223 inhibits the activity of mTOR, which may result in the induction of tumor ...