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Search Results for " advanced-glycation-end-products "

Targets

9

Compounds

7

Natural Products

10

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T7369L Gemigliptin Tartrate(911637-19-9 free base) LC15-0444 tartrate Proteasome , DPP-4
Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4). It has an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate exhibit...
T2507 Azeliragon TTP488 Beta Amyloid , advanced glycation end products
Azeliragon (TTP488) is an antagonist at the Receptor for Advanced Glycation End products; is evaluated as a potential treatment for patients with mild-to-moderate Alzheimer_acute_s disease (AD).
TP1935L1 RAGE antagonist peptide acetate Beta Amyloid
RAGE antagonist peptide acetate is an advanced antagonist of glycation end products (RAGE). RAGE antagonist peptide acetate possesses anti-tumor and anti-inflammatory activities. RAGE antagonist peptide acetate prevents ...
T39115 ABR-238901 TLR
ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end products) and TLR4 (toll-like receptor 4). ABR-238901 has potential a...
T9948 NecroX-7 LC-280126,LC28-0126,LC28 0126 NADPH-oxidase
NecroX-7 (LC-280126) is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing ...
T35890 Pentosidine
Advanced glycation end products (AGEs) are compounds formed by non-enzymatic chemical reactions following the bonding of sugars to proteins or lipids during diabetes, uremia, aging, rheumatic arthritis, and other conditi...
TP1935 RAGE antagonist peptide
Receptor for advanced glycation end products (RAGE) antagonist. Blocks S100P, S100A4 and HMGB-1 mediated RAGE activation in vitro and in vivo. Inhibits growth and metastasis of rat glioma tumors. Reduces cell growth and ...
T73818 Homocarnosine TFA
Homocarnosine TFA, a unique dipeptide of γ-aminobutyric acid (GABA) and histidine found in the brain, acts as an inhibitory neuromodulator synthesized from GABA within neurons. It exhibits anticonvulsant effects [1], and...
T72824 RAGE/SERT-IN-1
RAGE/SERT-IN-1 is a potent, orally active inhibitor of advanced glycation end products (RAGE) and serotonin transporter (SERT), with IC50 values of 8.26 μM and 31.09 nM, respectively. It demonstrates a significant neurop...
Cat No. Product Name Synonyms Targets
TN1471 Cassiaside C Toralactone 9-O-β-D-gentiobioside Others , Endogenous Metabolite
Cassiaside C (Toralactone 9-O-β-D-gentiobioside), a naphthopyrone extracted from Cassia tora seeds, exhibits in vitro inhibitory activity against the formation of advanced glycation end products (AGE).
T12588 Pyridoxylamine pyridoxamine Endogenous Metabolite
Pyridoxylamine (pyridoxamine) is an inhibitor of advanced glycation end production (AGEs) and lipoxidation end products (ALEs).
TN2165 Rubrofusarin gentiobioside Rubrofusarin-6-O-beta-D-gentiobioside ERK , NF-κB , TGF-beta/Smad
Rubrofusarin gentiobioside (Rubrofusarin-6-O-beta-D-gentiobioside) can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA binding activity, suggests that it has potential as a preventive...
TN1042 Chebulic acid Others
Chebulic acid, a phenolcarboxylic acid compound isolated from Terminalia chebula, has potent anti-oxidant activity,which breaks the cross-links of proteins induced by advanced glycation end-products (AGEs) and inhibits t...
TN3972 Epimedokoreanin B Apoptosis , Others , Antibacterial
Epimedokoreanin B (EKB), an isoprenylated flavonoid isolated from Korean Epimedium, exhibited anticancer activity in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells.Epimedokoreanin B also possesses anti-...
TN2894 3,5-Di-O-caffeoylquinic acid methyl ester HSV
3,5-Di-O-caffeoylquinic acid methyl ester exhibits potent inhibitory activities against the formation of advanced glycation end products (AGEs); it exhibits cytotoxicity actions against human cervix carcinoma HeLa cells....
T81905 Lucidin-ω-Me ether
Lucidin-ω-Me ether (Compound 2), extracted from Knoxia valerianoides roots, demonstrates inhibitory activity against the formation of advanced glycation end products (AGEs) with an IC50 of 62.79 μM in vitro [1].

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-02881 RAGE Protein, Human, Recombinant Human HEK293
Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certai...
TMPY-02927 RAGE Protein, Human, Recombinant (His) Human HEK293
Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certai...
TMPK-00479 AGER Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
The receptor for advanced glycation end products (AGER) is an oncogenic transmembranous receptor up-regulated in various human cancers. AGER promotes proliferation, migration, and inhibits apoptosis of squamous cervical ...
TMPY-01675 RAGE Protein, Mouse, Recombinant (His) Mouse HEK293
Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certai...
TMPY-01716 RAGE Protein, Human, Recombinant (hFc) Human HEK293
Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certai...
TMPJ-00292 CD36 Protein, Human, Recombinant (hFc) Human Human Cells
Platelet Glycoprotein 4 (CD36) is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types including microvascular endothelium, adipocytes, skeletal ...
TMPJ-00379 AOC3 Protein, Human, Recombinant (hFc) Human Human Cells
Membrane primary amine oxidase(AOC3), also known as vascular adhesion protein (VAP-1) and HPAO, this protein is a member of the semicarbazide-sensitive amine oxidase (SSAO) family. VAP-1 is a type 1 membrane-bound glycop...
TMPY-00913 S100B Protein, Human, Recombinant (hFc) Human HEK293
S100B is a member of the S100 family of proteins containing two EF-hand-type calcium-binding motifs. S100B exerts both intracellular and extracellular functions. Intracellular S100B acts as a stimulator of cell prolifera...
TMPY-02531 S100B Protein, Human, Recombinant (His) Human E. coli
S100B is a member of the S100 family of proteins containing two EF-hand-type calcium-binding motifs. S100B exerts both intracellular and extracellular functions. Intracellular S100B acts as a stimulator of cell prolifera...
TMPY-03020 S100B Protein, Mouse, Recombinant (hFc) Mouse HEK293
S100B is a member of the S100 family of proteins containing two EF-hand-type calcium-binding motifs. S100B exerts both intracellular and extracellular functions. Intracellular S100B acts as a stimulator of cell prolifera...
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