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Vasopressin Receptor

The actions of vasopressin are mediated by stimulation of tissue-specific G protein-coupled receptors (GPCRs) called vasopressin receptors that are classified into the V1 (V1A), V2, and V3 (V1B) receptor subtypes. These three subtypes differ in localization, function and signal transduction mechanisms.

  • Nelivaptan
    T28153439687-69-1In house
    Nelivaptan (SR 149415) is a vasopressin V1b receptor antagonist.
    • $71
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  • Fuscoside
    T4355131631-89-5
    Fuscoside (OPC 21268) is a non-peptide Arginine vasopressin(AVP) Receptor V antagonist.
    • $52
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  • d[Cha4]-AVP acetate(500170-27-4 free base)
    TP2082L
    d[Cha4]-AVP acetate is a potent and selective human vasopressin V1B receptor agonist (Ki values are 1.2, 151, 240 and 750 nM for V1B, V1A, Oxytocin and V2 receptors respectively). Stimulates ACTH and corticosterone secretion and exhibits negligible vasopr
    • $100
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  • d[Leu4,Lys8]-VP acetate
    TP1927L1
    d[Leu4,Lys8]-VP acetate is a selective vasopressin V1b receptor agonist. The Kis for rat, human and mouse V1b receptors are 0.16 nM, 0.52 nM and 0.1.38 nM, respectively. d[Leu4,Lys8]-VP acetate exhibits weak antidiuretic, vasopressor and oxytocic activiti
    • $39
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  • Desmopressin
    T501916679-58-6
    Desmopressin (DDAVP)(DDAVP) is the synthetic analogue of the antidiuretic hormone arginine vasopressin.Vasopressin Receptor The antidiuretic properties of desmopressin have led to its use in polyuric conditions including primary nocturnal enuresis, nocturia, and diabetes insipidus. Desmopressin works by limiting the amount of water that is eliminated in the urine. Desmopressin binds to V2 receptors in renal collecting ducts, increasing water reabsorption. It also stimulates release of von Willebrand factor from endothelial cells by acting on the V2 receptor.
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    • Conopressin S acetate(111317-90-9 free base)
      TP1192L
      Conopressin S acetate(111317-90-9 free base) (Con-S acetate) is a natural product isolated from Conus striatus, shows high affinity with vasopressin V1b receptor (AVPR1B), with a Ki of 8.3 nM.
      • $50
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    • OPC-51803
      T28257192514-54-8In house
      OPC-51803 is an orally available nonapeptidylpressor (AVP) V(2) receptor selective agonist for the treatment of urinary incontinence and nocturia.
      • $350
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    • Desmopressin acetate (16679-58-6 free base)
      T514462288-83-9
      Desmopressin acetate (16679-58-6 free base) (DDAVP) is the synthetic analog of the antidiuretic hormone arginine vasopressin. Vasopressin Receptor The antidiuretic properties of desmopressin have led to its use in polyuric conditions including primary nocturnal enuresis, nocturia, and diabetes insipidus. Desmopressin acetate (16679-58-6 free base) works by limiting the amount of water that is eliminated in the urine. Desmopressin acetate (16679-58-6 free base) binds to V2 receptors in renal collecting ducts, increasing water reabsorption. It also stimulates the release of von Willebrand factor from endothelial cells by acting on the V2 receptor.
      • $45
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      TargetMol | Citations Cited
    • Balovaptan
      T144941228088-30-9
      Balovaptan (RG7314) is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors. It is used for the research of autism.
      • $60
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    • [Deamino-Pen1,Val4,D-Arg8]-vasopressin
      T8350164158-84-5
      [Deamino-Pen1,Val4,D-Arg8]-vasopressin (AVP-A) is an antagonist of arginine-vasopressin (AVP). It effectively reduces plasma aldosterone concentration in rats and is utilized in studying the growth and steroidogenic capacity of the rat adrenal zona glomerulosa [1].
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    • Vasopressin Dimer (anti-parallel) (TFA)
      T80198
      Vasopressin Dimer (anti-parallel) TFA, an anti-parallel dimer form of vasopressin, has the capability to activate four G protein-coupled receptors: V1aR, V1bR, V2R, and OTR [1].
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    • Fedovapagon
      T15273347887-36-9
      Fedovapagon (VA106483) is a selective and potent agonist of the vasopressin V2 receptor (V2R) that inhibits the growth of intersegmental vessels in zebrafish. Fedovapagon can be used to study overactive bladder, nocturia, and painful bladder syndromes.
      • $113
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    • Tolvaptan
      T2326150683-30-0
      Tolvaptan (OPC-41061) is an orally bioavailable, selective, arginine vasopressin receptor 2 (V2, AVPR2) antagonist that can be used to treat hyponatremia.
      • $32
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    • Atosiban acetate
      T5148914453-95-5
      Atosiban acetate (RW22164) is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban acetate (RW22164) inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a result, there is reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, Atosiban acetate (RW22164) suppresses oxytocin-mediated release of PGE and PGF from the decidua. In human pre-term labor, atosiban, at the recommended dosage, antagonizes uterine contractions and induces uterine quiescence. The onset of uterus relaxation following atosiban is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence.
      • $67
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    • L-371,257
      T15682162042-44-6
      L-371,257 is a competitive antagonist of oxytocin receptor with pA2 of 8.4 and Ki of 19 nM. L-371,257 shows a Ki of 3.7 nM for vasopressin receptor 1a.
      • $34
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    • Conivaptan hydrochloride
      T6453168626-94-6
      Conivaptan hydrochloride (Vaprisol) is an orally active vasopressin V2 and V1A receptor antagonist, used in the therapy of hypervolemic hyponatremia and euvolemic.
      • $37
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    • Mozavaptan
      T6288137975-06-5
      Mozavaptan (OPC-31260) is a competitive vasopressin receptor antagonist for both V1 and V2 receptors with IC50 of 1.2 μM and 14 nM, respectively.
      • $48
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    • Argipressin
      T7434113-79-1
      Argipressin (Vasopressin) is a peptide hormone with vasoconstrictive and antidiuretic activities that binds to the vascular arginine vasopressin receptor, V1, with Kd values of 1.31 and 1.44 nM in A7r5 rat aortic smooth muscle cells and neonatal rat cardiomyocytes, respectively.
      • $46
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    • (D-Arg8)-Inotocin
      T80138745816-74-4
      '(D-Arg8)-Inotocin is a potent, selective, and competitive antagonist of the vasopressin receptor (V 1a R), exhibiting a binding affinity (K i) of 1.3 nM. It demonstrates over 3000-fold selectivity for the human V1aR compared to the OTR, V1bR, and V2R subtypes [1].'
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    • Vasopressin Dimer (parallel) (TFA)
      T80197
      Vasopressin Dimer (parallel) TFA, a parallel dimer of Vasopressin, has the capability to activate four G protein-coupled receptors—namely, V1aR, V1bR, V2R, and OTR [1].
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    • RG7713
      T4141920022-47-5
      RG7713 (RO 5028442) has been used in trials studying Autistic Disorder.
      • $54
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    • Felypressin
      T256856-59-7
      Felypressin (Octapressin) is a synthetic analog of LYPRESSIN with a PHENYLALANINE substitution at residue 2. Felypressin is a vasoconstrictor with reduced antidiuretic activity.
      • $31
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    • Invopressin
      T802701488411-60-4
      Invopressin (Compound 42), a vasopressin V1A receptor partial agonist (EC50: 1.0 nM), is utilized in research related to cirrhosis conditions such as bacterial peritonitis, HRS2, and refractory ascites [1].
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    • Val9-Oxytocin
      T801361021701-88-1
      Val9-Oxytocin, an Oxytocin analog where Gly9 is substituted with Val9 [1], functions as a complete antagonist of the vasopressin (V1a) receptor.
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    • Felypressin acetate
      T2568L914453-97-7
      Felypressin acetate (PLV-2) is an agonist of vasopressin 1 and acts on all arginine vasopressin receptors 1AS. Felypressin acetate can be used in dental procedures.
      • $39
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    • Atosiban
      T499690779-69-4
      Atosiban (RW22164) is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a result, there is reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua. In human pre-term labor, atosiban, at the recommended dosage, antagonizes uterine contractions and induces uterine quiescence. The onset of uterus relaxation following atosiban is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence.
      • $62
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    • Terlipressin Acetate
      T13920L1884420-36-3
      Terlipressin Acetate, a highly selective vasopressin V1 receptor agonist, on oxygen and glucose deprivation/re-oxygenation (OGD/R)-induced damage in intestinal epithelial cells (IEC-6).Terlipressin acetate exerts anti-inflammatory and anti-oxidative effects. Terlipressin acetate has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research.
      • $41
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    • Dp[Tyr(methyl)2,Arg8]-Vasopressin
      T8007367269-08-3
      Dp[Tyr(Me)2,Arg8]-Vasopressin is a non-selective antagonist of the peptide arginine vasopressin V1b receptor [1].
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    • (d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin
      T80137176714-12-8
      (d(CH2)5[Tyr(Me)2, Dab5]AVP), a vasopressin V1a receptor-specific antagonist, demonstrates a pA2 value of 6.71 [1].
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    • LIXIVAPTAN
      T7303168079-32-1
      Lixivaptan (VPA-985) is an orally active and selective vasopressin receptor V2 antagonist(Ki = 2.3 nM)
      • $36
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    • TASP0390325
      T289261642187-96-9
      TASP0390325 is an orally active and high affinity arginine pressin receptor 1B (V1B receptor) antagonist that shows antidepressant and anxiolytic activity in animal studies and blocks V1B receptors in the anterior pituitary gland in vivo.
      • $52
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