trypanosoma brucei brucei — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T27135	DDD85646	DDD 85646,DDD-85646	Parasite
	DDD85646 is an inhibitor of T. brucei N-myristoyltransferase with a Ki of 1.44 nM, an IC50 of 2 nM and an EC50 of 2 nM. The IC50 of hNMT is 4 nM.		Parasite
T63059	CRK12-IN-1		Antibiotic
	CRK12-IN-1 is a potent CRK12 inhibitor.CRK12-IN-1 has insecticidal activity, with inhibitory effects on Trypanosoma brucei (T.b. brucei) and Trypanosoma congolense (T. congolense) with EC50s of 1.3 and 18 nM, respectivel...		Antibiotic
T10340	Antitrypanosomal agent 2		Parasite
	Antitrypanosomal agent 2 shows potent and specific antiparasite activities against Trypanosoma brucei.		Parasite
T23973	DDD100097	DDD 100097,DDD-100097	Others
	DDD100097 is a potent N-myristoyltransferase inhibitor with potential inhibitory effects on Trypanosoma brucei, which can be used to study neurological disorders.		Others
T77551	6'-hydroxydihydrocinchonidine		Antibiotic , Drug Metabolite
	6'-hydroxydihydrocinchonidine is a metabolite of quinine, with antimicrobial and antitumor activity, and inhibitory effect on Trypanosoma brucei and Streptococcus pneumoniae.		Antibiotic , Drug Metabolite
T77645	JC-229		TRP/TRPV Channel
	JC-229 is a potent and selective TbRPA1 inhibitor that can inhibit RPA1 in Trypanosoma brucei. JC-229 can be used to study human African Trypanosomiasis (HAT).		TRP/TRPV Channel
T2112	Fexinidazole	HOE 239	Others , Parasite
	Fexinidazole (HOE 239) is an antiparasitic agent. It has activity against Trypanosoma cruzi, Tritrichomonas foetus, Trichomonas vaginalis, Entamoeba histolytica, Trypanosoma brucei, and Leishmania donovani. The biologica...		Others , Parasite
T23132	Pentamidine dihydrochloride	MP-601205 dihydrochloride	Phosphatase , Antibacterial , Antibiotic , Parasite , Antifungal
	Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi...
T69764	NPD-008
	NPD-008 is an inhibitor of trypanosoma brucei phosphodiesterase B1 (TbrPDEB1).
T69765	NPD-039
	NPD-039 is an inhibitor of trypanosoma brucei phosphodiesterase B1 (TbrPDEB1).
T6769	Elaiophylin	Efomycin E,Gopalamicin,Salbomycin,Azalomycin B	Others , Autophagy
	Elaiophylin (Salbomycin) shows antiprotozoal activity against Plasmodium falciparum K1a and Trypanosoma brucei brucei GUTat 3.1 strains with IC50 of 0.36 μM and 0.45 μM, respectively.		Others , Autophagy
T13223	Tuberculosis inhibitor 1		Others
	Tuberculosis inhibitor 1 is a potent and non-cytotoxic inhibitor of trypanosoma brucei growth (EC50: 5 nM).		Others
T61912	TbPTR1 inhibitor 1
	TbPTR1 inhibitor 1 (compound 5d) is an effective inhibitor of kinetochore pteridine reductase 1 (PTR1). The IC50 of TbPTR1 inhibitor 1 inhibits Trypanosoma brucei PTR1 (TbPTR1) is <0.1 nM, EC50 of TbPTR1 inhibitor 1 inhi...
T69313	Ascofuranone
	Ascofuranone is an inhibitor of the ubiquinol oxidase activity of Trypanosoma brucei mitochondrial alternative oxidase (TAO), as well as an inhibitor of HsDHODH.
T74192	Z-Leu-Arg-AMC
	Z-Leu-Arg-AMC, a carboxybenzoyl (Z) leucine derivative featuring a 4-methylcoumarinyl-7-amide (AMC), serves as the active site for the cysteine proteinase trypanopain-Tb in Trypanosoma brucei brucei [1].
T62372	Antitrypanosomal agent 8
	Antitrypanosomal agent 8 (compound 3b) showed a strong antitrypanosomal effect against Trypanosoma brucei (IC50: 0.79 μM). The IC50 value was 80.95 μM.
T11711	Jaspamycin	7-CN-7-C-Ino	JAK
	Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity. Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in T...		JAK
T79253	HAT-IN-8		Parasite
	HAT-IN-8 (Compound 38), a blood-brain barrier-permeable inhibitor of Trypanosoma brucei with an EC50 of 0.18 μM, is utilized in the study of Human African trypanosomiasis [1].		Parasite
T83025	Antiparasitic agent-19
	Antiparasitic Agent-19 (Compound 40) is a broad-spectrum antiparasitic with minimal toxicity to Trypanosoma brucei, Leishmania infantum, and Trypanosoma cruzi [1].
T79390	Antileishmanial agent-23		Parasite
	Antileishmanial agent-23 (compound G1/9), a potent and selective trypanothione reductase (TR) inhibitor, exhibits an IC50 of 2.24 ± 0.52 μM. It effectively inhibits the growth of Leishmania, Trypanosoma cruzi, and Trypan...		Parasite
T79457	PEX5-PEX14 PPI-IN-1
	PEX5-PEX14 PPI-IN-1 (Compound 8) is a PEX14-PEX5 protein-protein interaction (PPI) inhibitor that disrupts the interaction between PEX5 and TbPEX14 with an inhibitory constant (Ki) of 53 μM. It effectively inhibits the b...
T62710	Antitrypanosomal agent 6
	Antitrypanosomal agent 6 (compound 18a) is a potent antitrypanosomal agent showing good ADME properties. Antitrypanosomal agent 6 is more than twice as active as Nifurtimox against Trypanosoma brucei (T. brucei) with an ...
T12250	NPD-1335		Others
	NPD1335, a potent inhibitor of Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1), exhibits submicromolar activity against T. brucei parasites and an improved cytotoxicity profile. By elevating intracellular cAMP levels,...		Others
T62212	Antitrypanosomal agent 4
	Antitrypanosomal agent 4 (compound 19) is a potent antitrypanosomal agent that crosses the blood-brain barrier and shows good resistance to Trypanosoma cruzi and T. b. brucei with IC50 values of 1.2 μM and 70 nM respecti...
T23102	OBAA		Others
	OBAA is a potent inhibitor of phospholipase A2 (PLA2) with an IC 50 of 70 nM. OBAA blocks Melittin-induced Ca 2+ influx in Trypanosoma brucei with an IC 50 of 0.4 μM [1] [2] [3].		Others
T63738	Purine phosphoribosyltransferase-IN-2
	Purine phosphoribosyltransferase-IN-2 is a potent inhibitor of Plasmodium falciparum (Pf), Plasmodium vivax (Pv), and Trypanosoma brucei (Tbr) 6-oxopurine phosphoribosyltransferase (PRT) with Ki values of 30, 20, and 2 n...
T63737	Purine phosphoribosyltransferase-IN-1
	Purinephosphoribosyltransferase-IN-1 (Compound (S,R)-48) is a potent inhibitor of Plasmodium falciparum (Pf), Plasmodium vivax (Pv) and Trypanosoma brucei (Tbr) 6-oxopurine phosphate ribosyltransferase (PRT) with Ki valu...
T37154	7-Methylguanosine 5'-diphosphate sodium
	7-Methylguanosine 5’-diphosphate (7-Methyl-GDP) sodium, a cap analog, is utilized in the synthesis of mRNA cap analogues[1].

Compounds

DDD85646

T27135

Synonym: DDD 85646,DDD-85646

Antitrypanosomal agent 2

Synonym: DDD 100097,DDD-100097

Target: Others

6'-hydroxydihydrocinchonidine

T77551

Synonym:

Target: Antibiotic, Drug Metabolite

JC-229

T77645

Synonym:

Target: TRP/TRPV Channel

Fexinidazole

T2112

Synonym: HOE 239

Target: Others, Parasite

Pentamidine dihydrochloride

T23132

Synonym: MP-601205 dihydrochloride

Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal

Synonym: Efomycin E,Gopalamicin,Salbomycin,Azalomycin B

Target: Others, Autophagy

Tuberculosis inhibitor 1

Antitrypanosomal agent 8

Synonym: 7-CN-7-C-Ino

Antiparasitic agent-19

T83025

Synonym:

Target:

Antileishmanial agent-23

Antitrypanosomal agent 6

Antitrypanosomal agent 4

Purine phosphoribosyltransferase-IN-2

T63738

Synonym:

Target:

Purine phosphoribosyltransferase-IN-1

T63737

Synonym:

Target:

7-Methylguanosine 5'-diphosphate sodium

T37154

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
T4S0590	Columbin		Phospholipase , COX , Parasite
	1. Columbin has anti-inflammatory activity. 2. Columbin has chemopreventive ability against human colon cancer. 3. Columbin inhibits PLA2 hydrolysis of ghost RBC in a dose-dependent fashion.		Phospholipase , COX , Parasite
T3792	Ajugol	Leonuride	Parasite
	Ajugol (Leonuride) shows some trypanocidal potential against Trypanosoma brucei rhodesiense (IC50 values 29.3–73.0 ug/ml).		Parasite
T2S1792	Lycobetaine	Ungeremine	Antibacterial
	1. Lycobetaine (Ungeremine) is a potential biofungicide against Penicillium roqueforti and Aspergillus niger.2. Lycobetaine have strong antibacterial activity against Flavobacterium columnare . 3. Lycobetaine effectively...		Antibacterial
TN3220	7',8'-Dihydroobolactone		Antifection
	7',8'-Dihydroobolactone can inhibit Trypanosoma brucei brucei with an IC(50) of 2.8 microM.		Antifection
TN2485	1,2-Dihydrotanshinone	1,2-Dihydrotanshinquinone	Antifection
	1,2 Dihydrotanshinquinone is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum.		Antifection
T12286	Obtusifoliol		Others
	Obtusifoliol is a specific inhibitor of CYP51(Trypanosoma brucei (TB) and human CYP51 with Kd values of 1.2 µM and 1.4 µM, respectively).		Others
TN5588	Kolavenol
	Kolavenol shows a trypanocidal activity with an IC50 value of 2.5 microg/ml (8.6 microM) against Trypanosoma brucei rhodesiense, the causing agent of the acute form of human African trypanosomiasis.
TN1930	Methylenetanshinquinone		Antifection
	Methylenetanshinquinone shows antiplasmodial and antitrypanosomal activity, it is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum.		Antifection
TN4578	Monomethyl kolavate		Antifection
	Monomethyl kolavate is a power Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) inhibitor, with an IC50 value of 12uM.		Antifection
TN4041	Eupatoriopicrin		Others
	Eupatoriopicrin shows anti-trypanosomal activity and cytotoxicity against Trypanosoma brucei rhodesiense. Eupatoriopicrin-induced DNA damage may play a role in the observed cytotoxicity, it shows a weak sensitizing capac...		Others