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Search Result

Search Results for " thyroid hormone receptor "

Targets

Thyroid hormone receptor(THR) TSH Receptor

33

Compounds

4

Natural Products

18

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T12073 ML-109 TSH Receptor
ML-109 is a potent agonist of thyroid stimulating hormone receptor (TSHR) (EC50 of 40 nM)
T12192 NCGC00229600 Others , TSH Receptor
NCGC00229600 is an allosteric inverse thyrotropin receptor (TSHR) agonist. NCGC00229600 inhibits both TSH and stimulating antibody activation of TSHRs endogenously and can be used in Graves' disease studies.
T5360 Eprotirome KB2115 Thyroid hormone receptor(THR)
Eprotirome (KB2115), a synthetic thyroid hormone mimetic, is a thyroid hormone receptor agonist.
T40548 NH-3 Thyroid hormone receptor(THR)
NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the...
T1604 Tiratricol 3,3',5-Triiodothyroacetic acid Thyroid hormone receptor(THR)
Tiratricol (3,3',5-Triiodothyroacetic acid) is a metabolite of T3 and T4 thyroid hormones; promoted for hyperlipidemia, localized lipodystrophy, and obesity. Tiratricol has been used in trials studying the treatment of A...
T5383 D3-βArr NCGC00379308 TSH Receptor
D3-βArr (NCGC00379308) is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSHR activation.
T13072 Taltirelin acetate TA-0910 acetate Thyroid hormone receptor(THR)
Taltirelin acetate (TA-0910 acetate) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R)(IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release)).
T3595 Resmetirom VIA-3196,MGL3196 Thyroid hormone receptor(THR)
Resmetirom (VIA-3196) is a highly selective thyroid hormone receptor β (THR-β) agonist.
T5313 Sobetirome IACS-010759,QRX-431 Thyroid hormone receptor(THR)
Sobetirome (IACS-010759) is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM).
T13492 3,5-Diiodothyropropionic acid C082182,Ditpa cpd Thyroid hormone receptor(THR)
3,5-Diiodothyropropionic acid (C082182) is a thyroid hormone analog. It induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (Ka: 2.40/M and 4.06/M for TRα1 and TRβ1).
T7578 REVERSE T3 3,3',5'-triiodo-L-thyronine Thyroid hormone receptor(THR)
Reverse T3 (3,3',5'-triiodo-L-thyronine) inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes.
TP1022 Protirelin Acetate TSH-RF Acetate,TRH Acetate,TRF Acetate Thyroid hormone receptor(THR) , Endogenous Metabolite
Protirelin Acetate (TRH Acetate) is a thyrotropin-releasing hormone, stimulating the release of thyrotropin and prolactin from the anterior pituitary.
T1669 Liothyronine sodium 3,3',5-Triiodo-L-thyronine sodium,Triostat,T3 Sodium salt,Sodium L-3,3',5-triiodothyronine,Cytomel Thyroid hormone receptor(THR)
Liothyronine Sodium is the sodium salt form of liothyronine, a synthetic form of the levorotatory isomer of the naturally occurring thyroid hormone triiodothyronine (T3). Liothyronine sodium (3,3',5-Triiodo-L-thyronine s...
T22355 L-Thyroxine sodium LT4 sodium,Levothyroxine sodium,L-T4 sodium Thyroid hormone receptor(THR)
L-Thyroxine sodium (LT4 sodium), the major hormone derived from the thyroid gland, is the agonist of Thyroid hormone receptor alpha and beta.
T7590 Taltirelin TA-0910 Thyroid hormone receptor(THR)
Taltirelin (TA-0910) is at thyrotropin-releasing hormone receptor (TRH-R) superagonist (IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release))[1].
T15699 L-Thyroxine sodium salt pentahydrate Sodium levothyroxine pentahydrate,Levothyroxine Thyroid hormone receptor(THR)
L-Thyroxine sodium salt pentahydrate, also known as Levothyroxine, is a synthetic hormone utilized in the study of hypothyroidism. It is biologically activated into Triiodothyronine (T3) from its original form, L-Thyroxi...
T23673 AH-3960 AH3960 Thyroid hormone receptor(THR)
AH-3960 is an thyroid hormone receptor-1 (PTHR1) agonist.
T8672 2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE BisOPP-A Thyroid hormone receptor(THR)
2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE is targets the thyroid stimulating hormone receptor (human)
T13435 TR antagonist 1 Thyroid hormone receptor(THR)
TR antagonist 1 is a highly potent thyroid hormone receptor (TR) antagonist (IC50 of 36 and 22 nM for TRα and TRβ, respectively) that can be used to study diseases caused by endocrine abnormalities.
T27714 KB-141
KB-141 is an agonist of thyroid hormone receptor.
T79089 THR-β modulator-1
THR-β Modulator-1 (Compound 1a) is a potent modulator of the thyroid hormone receptor β, utilized in the study of thyroid hormone receptor-associated disorders [1].
T29011 Triiodothyronine Sulfate Thyroid hormone receptor(THR) , Endogenous Metabolite
Triiodothyronine Sulfate is a prodrug to the Conventional Hormone Therapy of Hypothyroidism. Triiodothyronine sulfate is the main metabolite of thyroid hormone triiodothyronine (T3). Triiodothyronine is an active form of...
T11376 GC 14 Others
GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 200 nM and 35 nM for hTRα and hTRβ, respectively.
T11954 MB-07344 Others
MB-07344 has additive cholesterol lowering activity in combination with Atorvastatin in rabbits, dogs and monkeys. MB-07344 is a potent thyroid hormone receptor (TR)-β agonist with a Ki of 2.17 nM.
T16756 Risarestat CT 112 Reductase
Risarestat (CT-112) is a potent aldose reductase inhibitor and thyroid hormone receptor (TR) antagonist for the treatment of hypoglycemia.
T16403 Org41841 Org-41841 TSH Receptor
Org41841 is an agonist of luteinising hormone/chorionic gonadotropin receptor and thyroid stimulating hormone receptor (EC50s: 0.2 and 7.7 μM, respectively) and can be used to study hyperthyroidism.
T63876 TRβ agonist 1
TRβ Agonist 1, a selective and mutation-sensitive thyroid hormone receptor β (TRβ) agonist, demonstrates an EC50 value of 21 nM. It is useful in the research of dyslipidemia, nonalcoholic steatohepatitis (NASH), and resi...
T11954L MB-07344 sodium Others
MB-07344 sodium has additive cholesterol lowering activity in combination with Atorvastatin in rabbits, dogs and monkeys. MB-07344 sodium is a potent thyroid hormone receptor (TR)-β agonist with a Ki of 2.17 nM.
TP1677 Calcitonin (8-32), salmon
Calcitonin (8-32), salmon is a highly selective amylin receptor antagonist.Calcitonin is a hormone known to participate in calcium and phosphorus metabolism. In mammals, the major source of calcitonin is from the parafol...
T35839 3-Iodothyronamine (hydrochloride)
3-Iodothyronamine is derived from the deiodination and decarboxylation of endogenous thyroxine. It activates the G protein-coupled receptor known as trace amine-associated receptor 1 at nanomolar concentrations whereupon...
T62570 THR-β agonist 1
THRβ Agonist 1 is a potent and selective THRβ agonist. THRβ Agonist 1 has the potential to be used in studies of thyroid hormone receptor related disorders.
T74785 THR-β agonist 6
THR-β Agonist 6, a selective and orally active compound targeting the thyroid hormone receptor β (THR-β), demonstrates specificity with EC50 values of 0.03 μM for THR-β and 0.22 μM for THR-α. This compound boasts a remar...
T35712 Debutyldronedarone hydrochloride SR35021 hydrochloride
N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbut...

Compounds

ML-109
T12073
Synonym:
Target: TSH Receptor
NCGC00229600
T12192
Synonym:
Target: Others, TSH Receptor
Eprotirome
T5360
Synonym: KB2115
Target: Thyroid hormone receptor(THR)
NH-3
T40548
Synonym:
Target: Thyroid hormone receptor(THR)
Tiratricol
T1604
Synonym: 3,3',5-Triiodothyroacetic acid
Target: Thyroid hormone receptor(THR)
D3-βArr
T5383
Synonym: NCGC00379308
Target: TSH Receptor
Taltirelin acetate
T13072
Synonym: TA-0910 acetate
Target: Thyroid hormone receptor(THR)
Resmetirom
T3595
Synonym: VIA-3196,MGL3196
Target: Thyroid hormone receptor(THR)
Sobetirome
T5313
Synonym: IACS-010759,QRX-431
Target: Thyroid hormone receptor(THR)
3,5-Diiodothyropropionic acid
T13492
Synonym: C082182,Ditpa cpd
Target: Thyroid hormone receptor(THR)
REVERSE T3
T7578
Synonym: 3,3',5'-triiodo-L-thyronine
Target: Thyroid hormone receptor(THR)
Protirelin Acetate
TP1022
Synonym: TSH-RF Acetate,TRH Acetate,TRF Acetate
Target: Thyroid hormone receptor(THR), Endogenous Metabolite
Liothyronine sodium
T1669
Synonym: 3,3',5-Triiodo-L-thyronine sodium,Triostat,T3 Sodium salt,Sodium L-3,3',5-triiodothyronine,Cytomel
Target: Thyroid hormone receptor(THR)
L-Thyroxine sodium
T22355
Synonym: LT4 sodium,Levothyroxine sodium,L-T4 sodium
Target: Thyroid hormone receptor(THR)
Taltirelin
T7590
Synonym: TA-0910
Target: Thyroid hormone receptor(THR)
L-Thyroxine sodium salt pentahydrate
T15699
Synonym: Sodium levothyroxine pentahydrate,Levothyroxine
Target: Thyroid hormone receptor(THR)
AH-3960
T23673
Synonym: AH3960
Target: Thyroid hormone receptor(THR)
2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE
T8672
Synonym: BisOPP-A
Target: Thyroid hormone receptor(THR)
TR antagonist 1
T13435
Synonym:
Target: Thyroid hormone receptor(THR)
KB-141
T27714
Synonym:
Target:
THR-β modulator-1
T79089
Synonym:
Target:
Triiodothyronine Sulfate
T29011
Synonym:
Target: Thyroid hormone receptor(THR), Endogenous Metabolite
GC 14
T11376
Synonym:
Target: Others
MB-07344
T11954
Synonym:
Target: Others
Risarestat
T16756
Synonym: CT 112
Target: Reductase
Org41841
T16403
Synonym: Org-41841
Target: TSH Receptor
TRβ agonist 1
T63876
Synonym:
Target:
MB-07344 sodium
T11954L
Synonym:
Target: Others
Calcitonin (8-32), salmon
TP1677
Synonym:
Target:
3-Iodothyronamine (hydrochloride)
T35839
Synonym:
Target:
THR-β agonist 1
T62570
Synonym:
Target:
THR-β agonist 6
T74785
Synonym:
Target:
Debutyldronedarone hydrochloride
T35712
Synonym: SR35021 hydrochloride
Target:
Cat No. Product Name Synonyms Targets
T6956 Protirelin Lopremone,pGlu-His-Pro-NH2,Synthetic thyrotropin-releasing hormone,Thyroliberin,TRH,TRF Thyroid hormone receptor(THR) , Endogenous Metabolite
Protirelin (Thyroliberin) is a tripeptide that stimulates the release of thyrotropin and prolactin.
T0864 L-Thyroxine Levothyroxine,NSC 36397,T4 Thyroid hormone receptor(THR) , Endogenous Metabolite
L-Thyroxine (NSC 36397) is the major hormone derived from the thyroid gland. L-Thyroxine (NSC 36397) is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in...
T1653 Liothyronine Tresitope,O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine,Triiodothyronine,L-3,3',5-Triiodothyronine,3,3',5-Triiodo-L-thyronine,Lyothyronine Thyroid hormone receptor(THR) , Endogenous Metabolite
Liothyronine (Tresitope) is an active form of thyroid hormone, binding to β1 thyroid hormone receptor (TRβ1), and activates its activity.
T16442 PCO371 2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl- Thyroid hormone receptor(THR)
PCO371 (2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-) is an orally active full agonist of parathyroid hormon...

Natural Products

Protirelin
T6956
Synonym: Lopremone,pGlu-His-Pro-NH2,Synthetic thyrotropin-releasing hormone,Thyroliberin,TRH,TRF
Target: Thyroid hormone receptor(THR), Endogenous Metabolite
L-Thyroxine
T0864
Synonym: Levothyroxine,NSC 36397,T4
Target: Thyroid hormone receptor(THR), Endogenous Metabolite
Liothyronine
T1653
Synonym: Tresitope,O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine,Triiodothyronine,L-3,3',5-Triiodothyronine,3,3',5-Triiodo-L-thyronine,Lyothyronine
Target: Thyroid hormone receptor(THR), Endogenous Metabolite
PCO371
T16442
Synonym: 2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-
Target: Thyroid hormone receptor(THR)

Recombinant Proteins

Species：
Human (15)
Mouse (3)
Expression System：
E. coli (8)
HEK293 (5)
Baculovirus-Insect Cells (4)
Yeast (1)
Tag：
His (6)
N-terminal 6xHis-SUMO-tagged (3)
C-6His,N-T7 tag (1)
C-terminal 6xHis-tagged (1)
GST (1)
His,GST (1)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (1)
N-terminal 6xHis-Myc-tagged (1)
N-terminal 6xHis-tagged (1)
hFc (1)
Cat No. Product Name Species Expression System
TMPY-04127 CIp4 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
CIp4 Protein, Human, Recombinant (His) is expressed in Baculovirus-Insect Cells with His tag. The predicted molecular weight is 64 kDa. Accession number: Q15642-2
TMPY-06821 THRB Protein, Human, Recombinant (His) Human E. coli
Thyroid hormone receptor beta (THRB), also known as TRbeta and NR1A2, belongs to the nuclear hormone receptor family. Featuring an N-terminal transactivation domain, a central DNA-binding domain, and a hormone/ligand-bin...
TMPH-02203 THRA Protein, Human, Recombinant (His) Human E. coli
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.; Does not bind thyroid hormone and functions as a...
TMPH-02684 GPHB5 Protein, Mouse, Recombinant (His) Mouse Yeast
Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid ce...
TMPH-02685 GPHB5 Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid ce...
TMPH-02204 THRB Protein, Human, Recombinant (His & SUMO) Human E. coli
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
TMPH-01794 NR2F6 Protein, Human, Recombinant (His & Myc) Human HEK293
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are a...
TMPH-01795 NR2F6 Protein, Human, Recombinant (His & SUMO) Human E. coli
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are a...
TMPY-00186 GHRH Protein, Human, Recombinant (hFc) Human HEK293
The role of hypothalamic growth hormone-releasing hormone (GHRH) in the release of growth hormone (GH) from the pituitary is well established. Extra-hypothalamic growth hormone-releasing hormone (GHRH) plays an important...
TMPJ-00705 BCAS2 Protein, Human, Recombinant (His, T7) Human E. coli
Breast Carcinoma-Amplified Sequence 2 (BCAS2) is a member of the SPF27 family. BCAS2 is a nuclear protein and widely expressed in many rtissues. BCAS2 is identified as being overexpressed in various breast cancer cell li...
TMPY-03784 GPHA2 Protein, Human, Recombinant (His) Human HEK293
GPHA2 is a member of the glycoprotein hormones subunit alpha family. Glycoprotein hormones consist of two subunits, the common alpha- and specific beta-subunits, which associate noncovalently to form a heterodimer. The a...
TMPY-03812 GPHA2 Protein, Human, Recombinant (mFc) Human HEK293
GPHA2 is a member of the glycoprotein hormones subunit alpha family. Glycoprotein hormones consist of two subunits, the common alpha- and specific beta-subunits, which associate noncovalently to form a heterodimer. The a...
TMPY-02883 C1D Protein, Human, Recombinant (GST) Human E. coli
C1D nuclear receptor corepressor belongs to the C1D family. It is a DNA binding and apoptosis-inducing protein.C1D nuclear receptor corepressorinteracts with TSNAX and DNA-PKcs. It acts as a corepressor for the thyroid h...
TMPH-02221 TRIM24 Protein, Human, Recombinant (His & SUMO) Human E. coli
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the high...
TMPY-02987 Vitamin D Receptor/VDR Protein, Mouse, Recombinant (His) Mouse Baculovirus-Insect Cells
VDR (vitamin D (1,25- dihydroxyvitamin D3) receptor), also known as NR1I1, belongs to the NR1I family, NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal...
TMPY-02706 Vitamin D Receptor/VDR Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
VDR (vitamin D (1,25- dihydroxyvitamin D3) receptor), also known as NR1I1, belongs to the NR1I family, NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal...
TMPY-02270 RET Protein, Human, Recombinant (His) Human HEK293
RET proto-oncogene, also known as RET, is a cell-surface molecule that transduce signals for cell growth and differentiation. It contains 1 cadherin domain and 1 protein kinase domain. RET proto-oncogene belongs to the p...
TMPY-04418 RET Protein, Human, Recombinant (aa 658-1114, His & GST) Human Baculovirus-Insect Cells
RET proto-oncogene, also known as RET, is a cell-surface molecule that transduce signals for cell growth and differentiation. It contains 1 cadherin domain and 1 protein kinase domain. RET proto-oncogene belongs to the p...
CIp4 Protein, Human, Recombinant (His)
TMPY-04127
Species: Human
Expression System: Baculovirus-Insect Cells
THRB Protein, Human, Recombinant (His)
TMPY-06821
Species: Human
Expression System: E. coli
THRA Protein, Human, Recombinant (His)
TMPH-02203
Species: Human
Expression System: E. coli
GPHB5 Protein, Mouse, Recombinant (His)
TMPH-02684
Species: Mouse
Expression System: Yeast
GPHB5 Protein, Mouse, Recombinant (His & Myc)
TMPH-02685
Species: Mouse
Expression System: E. coli
THRB Protein, Human, Recombinant (His & SUMO)
TMPH-02204
Species: Human
Expression System: E. coli
NR2F6 Protein, Human, Recombinant (His & Myc)
TMPH-01794
Species: Human
Expression System: HEK293
NR2F6 Protein, Human, Recombinant (His & SUMO)
TMPH-01795
Species: Human
Expression System: E. coli
GHRH Protein, Human, Recombinant (hFc)
TMPY-00186
Species: Human
Expression System: HEK293
BCAS2 Protein, Human, Recombinant (His, T7)
TMPJ-00705
Species: Human
Expression System: E. coli
GPHA2 Protein, Human, Recombinant (His)
TMPY-03784
Species: Human
Expression System: HEK293
GPHA2 Protein, Human, Recombinant (mFc)
TMPY-03812
Species: Human
Expression System: HEK293
C1D Protein, Human, Recombinant (GST)
TMPY-02883
Species: Human
Expression System: E. coli
TRIM24 Protein, Human, Recombinant (His & SUMO)
TMPH-02221
Species: Human
Expression System: E. coli
Vitamin D Receptor/VDR Protein, Mouse, Recombinant (His)
TMPY-02987
Species: Mouse
Expression System: Baculovirus-Insect Cells
Vitamin D Receptor/VDR Protein, Human, Recombinant (His)
TMPY-02706
Species: Human
Expression System: Baculovirus-Insect Cells
RET Protein, Human, Recombinant (His)
TMPY-02270
Species: Human
Expression System: HEK293
RET Protein, Human, Recombinant (aa 658-1114, His & GST)
TMPY-04418
Species: Human
Expression System: Baculovirus-Insect Cells
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