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Membrane transporter/Ion channel TRP/TRPV Channel

TRP/TRPV Channel

TRPV is a family of transient receptor potential cation channels (TRP channels) in animals. All TRPVs are highly calcium selective. TRP channels are a large group of ion channels consisting of six protein families, located mostly on the plasma membrane of numerous human and animal cell types, and in some fungi.
Cat No. product name
T9247 Vanilloid receptor antagonist 1 Vanilloid receptor antagonist 1 is a potent vanilloid receptor TRPV1 antagonist.
T4699 Hexamethylene amiloride HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 µM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013...
T3727 Methyl syringate Methyl syringate has a unique inhibitory activity toward aflatoxin production with a different mode of action from that of gallic acid. Methyl syringate from K. ...
T6848 GSK1016790A GSK1016790A (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34 nM in choroid plexus epithelial cells.
T4385 PF4840154 PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 2...
T4028 ML329 ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.
T6977 SB366791 SB-366791 is a new and selective cinnamide TRPV1 antagonist.
T3865 Beta-Eudesmol β-Eudesmol is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a variety of plants, inclu...
T4693 2-APB 2-Aminoethoxydiphenyl borate (2-APB) is a chemical that acts to inhibit both IP3 receptors and TRP channels (although it activates TRPV1, TRPV2, & TRPV3 at highe...
T4680 HC067047 HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .
T6379 AMG517 AMG 517 is an effective and specific TRPV1 antagonist, antagonizes proton (IC50: 0.76 nM), capsaicin (IC50: 0.62 nM), and heat activation (IC50: 1.3 nM) of TRPV1...
T5479 AMG-333 AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.
T5640 GSK2193874 GSK2193874 was identified as a selective, orally active TRPV4 blocker.
T5786 TETRAHYDROPIPERINE TETRAHYDROPIPERINE is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.
T5698 TRPM8 antagonist 2 TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes.
T5962 N-Ethyl-p-menthane-3-carboxamide N-Ethyl-p-menthane-3-carboxamide is an agonist of TRPM8( EC50 : 3.7 μM).
T7205 A 967079 A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively....
T7177 Capsazepine Capsazepine is an antagonist of TRPV1 receptor ( IC50 : 562 nM). Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of ...
T7102 BCTC BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 (IC50 of 35 and 6 nM, respectively)
T2952 Camphor Camphor is a bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infec...
T0647 Tryptamine Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It ...
T7416 WS-12 WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM)
T2807 Caffeic Acid Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activi...
T0399 Methyl salicylate Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. For acute ...
T0399 Methyl salicylate Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. For acute ...
T2007 RQ00203078 RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist.
T2170 SKF-96365 hydrochloride SKF-96365, a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 can induce cyt...
T2994 Cardamonin Cardamomin (also known as cardamonin) is a chalconoid that has been isolated from several plants including Alpinia katsumadai and Alpinia conchigera. It is a nov...
T1321 Nonivamide Nonivamide is found in herbs and spices. Nonivamide is an alkaloid from Capsicum species Nonivamide is a flavoring ingredient. Nonivamide is an organic compound ...
T1109 Zucapsaicin Zucapsaicin is a medication used to treat osteoarthritis of the knee and Others neuropathic pain.Zucapsaicin is a synthetic cis isomer of natural capsaicin that ...
T2711 TCS 5861528 TCS5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM, respectively.
T0457 Probenecid Probenecid is a benzoic acid derivative with antihyperuricemic property.
T6617 Optovin Optovin is a TRPA1 activator, which is reversibly photoactivated.
T6530 HC030031 HC-030031 is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2±0.2 and 5.3±0.2 μM, respectively.
T1814 ICILIN Icilin(AG 3-5) is a synthetic TRPM8 ion channel super-agonist.
T1062 Capsaicin Capsaicin is an active component of chili peppers. It selectively binds to TRPV1 which is a heat-activated calcium channel. Capsaicin causes the channel to open ...
T0882 D-Camphor (+)-Camphor is the oil extracted from the wood of the Camphor tree Cinnamomum Camphora with anti-inflammatory and analgesic properties.
T2845 Imperatorin Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
T6660 SB705498 SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis.
T2298 ML204 ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
T7189 AMG9810 AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat TRPV1, respectively)...
T7526 JNJ-17203212 JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).
T9245 TRPM4-IN-1 TRPM4-IN-1 is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 μM.
T16688 Pyr6 Pyr6 is a selective TRPC3 inhibitor with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).Pyr6 is an inhibitor of Ca2+ entry...
T15628 JT010 JT010 is an effective agonist of TRPA1 (EC50: 0.65 nM).
T15634 JYL 1421 JYL 1421 is an antagonist of TRPV1 receptor (IC50: 8 nM).
T15758 Linopirdine Linopirdine is a TRPV1 agonist. Linopirdine is an orally active and selective M-type K+ current (IM; Kv7; KCNQ Channels) inhibitor (IC50: 2.4 μM). Linopirdine i...
T8528 AC1903 AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.
T16483 PF-05105679 PF-05105679 has the potential for cold-related pain. PF-05105679 is an orally active and selective TRPM8 antagonist (IC50: 103 nM).
T16532 Pico145 Pico145 is a remarkable inhibitor of TRPC1/4/5 channels. Pico145 inhibits (−)-englerin A-activated TRPC4/TRPC5 channels (IC50s: 0.349 and 1.3 nM in cells) It a...
T16686 Pyr10 Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor. Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal in...
T16763 RN-1747 RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 agonists (EC50: 0.77 μM, 4.0 μM, and 4.1 μM for hTRPV4, mTRPV4, and rT...
T15439 GSK3395879 GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).
T17006 TC-I 2014 TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally active Benzimidazole-containing transient receptor potential melastatin...
T8562 A 425619 A 425619 is a potent TRPV1 antagonist
T8565 N4-benzyl-N2-methylquinazoline-2,4-diamine hydrochloride N4-benzyl-N2-methylquinazoline-2,4-diamine hydrochloride is an inhibitor of TRPC4.
T8607 M-084 hydrochloride M-084 hydrochloride is a blocker of TRPC4/5 channel, with antidepressant and anxiolytic effects.
TN4469 (+)-Lyoniresinol Lyoniresinol has antioxidant effect, it shows robust anti-melanogenic activity, decreases tyrosinase activity and melanin biosynthesis in B16F10 cells by activat...
T13214L TRPV4 agonist-1 free base TRPV4 agonist-1 free base is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).
T21623 AS 1269574 AS 1269574 is a potent, orally available GPR119 agonist. AS1269574 has the potential for the research of type 2 diabetes.
T4680L HC067047 Hydrochloride(883031-03-6 free base) HC-067047 hydrochloride is a potent and selective TRPV4 antagonist. HC-067047 hydrochloride reversibly inhibited currents through the human, rat, and mouse TRPV4...
T15543 IA-Alkyne IA-Alkyne is a TRP channel (TRPC) agonist. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling. It also...
T15434 GSK2798745 GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4). It is used in ...
TQ0001 1,4-Cineole 1,4-Cineole is a natural, oxygenated monoterpene. 1,4-Cineole can activate both human TRPM8 and human TRPA1.
T8440 LASSBio-1135 LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.
T7430 AM-0902 AM-0902 is a potent and specific TRPA1 antagonist (IC50s: 71/131 nM for rTRPA1 and hTRPA1).
TQ0157 EIPA EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
T8307 Hydroxy-​α-​sanshool Hydroxy-​α-​sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 µM).
T8410 ASP7663 ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.
TN1377 Alpha-Spinasterol α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects....
TN1583 Dihydromorin trans-Dihydromorin is an effective hypopigmenting agent in normal skin cells, hypopigmenting agents effective in melanoma system may not be effective on normal m...
T8449 TC-I2000 TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50 of 53 nM.
T8442 M8-B Hydrochloride M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.
T13212 TRPA1 Antagonist 1 TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.
T14067 A-1165442 A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.
T8425 Linoleoyl Ethanolamide Linoleoyl Ethanolamide is an endocannabinoid agent. It acts by binding to TRPV1 increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor i...
T13546 AM12 AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).
T10300 AMG2850 AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).
T11394 GFB-8438 GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).
T12849 SAR7334 SAR7334 is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).
T11172 EIPA hydrochloride EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 ...
T10537 BI-749327 BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).
T7572 RN-1734 RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM,5.9 μM,3.2 μM for hTRPV4,  mTRPV4 and rTRPV4,respectively)
Vanilloid receptor antagonist 1
T9247CAS 871814-52-7
Vanilloid receptor antagonist 1 is a potent vanilloid receptor TRPV1 antagonist.
Hexamethylene amiloride
T4699CAS 1428-95-1
HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 µM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013...
Methyl syringate
T3727CAS 884-35-5
Methyl syringate has a unique inhibitory activity toward aflatoxin production with a different mode of action from that of gallic acid. Methyl syringate from K. ...
GSK1016790A
T6848CAS 942206-85-1
GSK1016790A (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34 nM in choroid plexus epithelial cells.
PF4840154
T4385CAS 1332708-14-1
PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 2...
ML329
T4028CAS 19992-50-8
ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.
SB366791
T6977CAS 472981-92-3
SB-366791 is a new and selective cinnamide TRPV1 antagonist.
beta-Eudesmol
T3865CAS 473-15-4
β-Eudesmol is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a variety of plants, inclu...
2-APB
T4693CAS 524-95-8
2-Aminoethoxydiphenyl borate (2-APB) is a chemical that acts to inhibit both IP3 receptors and TRP channels (although it activates TRPV1, TRPV2, & TRPV3 at highe...
HC067047
T4680CAS 883031-03-6
HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .
AMG517
T6379CAS 659730-32-2
AMG 517 is an effective and specific TRPV1 antagonist, antagonizes proton (IC50: 0.76 nM), capsaicin (IC50: 0.62 nM), and heat activation (IC50: 1.3 nM) of TRPV1...
AMG-333
T5479CAS 1416799-28-4
AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.
GSK2193874
T5640CAS 1336960-13-4
GSK2193874 was identified as a selective, orally active TRPV4 blocker.
TETRAHYDROPIPERINE
T5786CAS 23434-88-0
TETRAHYDROPIPERINE is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.
TRPM8 antagonist 2
T5698CAS 259674-19-6
TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes.
N-Ethyl-p-menthane-3-carboxamide
T5962CAS 39711-79-0
N-Ethyl-p-menthane-3-carboxamide is an agonist of TRPM8( EC50 : 3.7 μM).
A 967079
T7205CAS 1170613-55-4
A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively....
Capsazepine
T7177CAS 138977-28-3
Capsazepine is an antagonist of TRPV1 receptor ( IC50 : 562 nM). Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of ...
BCTC
T7102CAS 393514-24-4
BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 (IC50 of 35 and 6 nM, respectively)
Camphor
T2952CAS 76-22-2
Camphor is a bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infec...
Tryptamine
T0647CAS 61-54-1
Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It ...
WS-12
T7416CAS 68489-09-8
WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM)
Caffeic Acid
T2807CAS 331-39-5
Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activi...
Methyl salicylate
T0399CAS 119-36-8
Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. For acute ...
Methyl salicylate
T0399CAS 119-36-8
Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. For acute ...
RQ00203078
T2007CAS 1254205-52-1
RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist.
SKF-96365 hydrochloride
T2170CAS 130495-35-1
SKF-96365, a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 can induce cyt...
Cardamonin
T2994CAS 19309-14-9
Cardamomin (also known as cardamonin) is a chalconoid that has been isolated from several plants including Alpinia katsumadai and Alpinia conchigera. It is a nov...
Nonivamide
T1321CAS 2444-46-4
Nonivamide is found in herbs and spices. Nonivamide is an alkaloid from Capsicum species Nonivamide is a flavoring ingredient. Nonivamide is an organic compound ...
Zucapsaicin
T1109CAS 25775-90-0
Zucapsaicin is a medication used to treat osteoarthritis of the knee and Others neuropathic pain.Zucapsaicin is a synthetic cis isomer of natural capsaicin that ...
TCS 5861528
T2711CAS 332117-28-9
TCS5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM, respectively.
Probenecid
T0457CAS 57-66-9
Probenecid is a benzoic acid derivative with antihyperuricemic property.
Optovin
T6617CAS 348575-88-2
Optovin is a TRPA1 activator, which is reversibly photoactivated.
HC030031
T6530CAS 349085-38-7
HC-030031 is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2±0.2 and 5.3±0.2 μM, respectively.
ICILIN
T1814CAS 36945-98-9
Icilin(AG 3-5) is a synthetic TRPM8 ion channel super-agonist.
Capsaicin
T1062CAS 404-86-4
Capsaicin is an active component of chili peppers. It selectively binds to TRPV1 which is a heat-activated calcium channel. Capsaicin causes the channel to open ...
D-Camphor
T0882CAS 464-49-3
(+)-Camphor is the oil extracted from the wood of the Camphor tree Cinnamomum Camphora with anti-inflammatory and analgesic properties.
Imperatorin
T2845CAS 482-44-0
Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
SB705498
T6660CAS 501951-42-4
SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis.
ML204
T2298CAS 5465-86-1
ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
AMG9810
T7189CAS 545395-94-6
AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat TRPV1, respectively)...
JNJ-17203212
T7526CAS 821768-06-3
JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).
TRPM4-IN-1
T9245CAS 351424-20-9
TRPM4-IN-1 is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 μM.
Pyr6
T16688CAS 245747-08-4
Pyr6 is a selective TRPC3 inhibitor with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).Pyr6 is an inhibitor of Ca2+ entry...
JT010
T15628CAS 917562-33-5
JT010 is an effective agonist of TRPA1 (EC50: 0.65 nM).
JYL 1421
T15634CAS 401907-26-4
JYL 1421 is an antagonist of TRPV1 receptor (IC50: 8 nM).
Linopirdine
T15758CAS 105431-72-9
Linopirdine is a TRPV1 agonist. Linopirdine is an orally active and selective M-type K+ current (IM; Kv7; KCNQ Channels) inhibitor (IC50: 2.4 μM). Linopirdine i...
AC1903
T8528CAS 831234-13-0
AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.
PF-05105679
T16483CAS 1398583-31-7
PF-05105679 has the potential for cold-related pain. PF-05105679 is an orally active and selective TRPM8 antagonist (IC50: 103 nM).
Pico145
T16532CAS 1628287-16-0
Pico145 is a remarkable inhibitor of TRPC1/4/5 channels. Pico145 inhibits (−)-englerin A-activated TRPC4/TRPC5 channels (IC50s: 0.349 and 1.3 nM in cells) It a...
Pyr10
T16686CAS 1315323-00-2
Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor. Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal in...
RN-1747
T16763CAS 1024448-59-6
RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 agonists (EC50: 0.77 μM, 4.0 μM, and 4.1 μM for hTRPV4, mTRPV4, and rT...
GSK3395879
T15439CAS 2215852-91-6
GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).
TC-I 2014
T17006CAS 1221349-53-6
TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally active Benzimidazole-containing transient receptor potential melastatin...
A 425619
T8562CAS 581809-67-8
A 425619 is a potent TRPV1 antagonist
N4-benzyl-N2-methylquinazoline-2,4-diamine hydrochloride
T8565CAS 1135272-09-1
N4-benzyl-N2-methylquinazoline-2,4-diamine hydrochloride is an inhibitor of TRPC4.
M-084 hydrochloride
T8607CAS 51314-51-3
M-084 hydrochloride is a blocker of TRPC4/5 channel, with antidepressant and anxiolytic effects.
(+)-Lyoniresinol
TN4469CAS 14464-90-5
Lyoniresinol has antioxidant effect, it shows robust anti-melanogenic activity, decreases tyrosinase activity and melanin biosynthesis in B16F10 cells by activat...
TRPV4 agonist-1 free base
T13214LCAS 2314467-59-7
TRPV4 agonist-1 free base is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).
AS 1269574
T21623CAS 330981-72-1
AS 1269574 is a potent, orally available GPR119 agonist. AS1269574 has the potential for the research of type 2 diabetes.
HC067047 Hydrochloride(883031-03-6 free base)
T4680LCAS 1481646-76-7
HC-067047 hydrochloride is a potent and selective TRPV4 antagonist. HC-067047 hydrochloride reversibly inhibited currents through the human, rat, and mouse TRPV4...
IA-Alkyne
T15543CAS 930800-38-7
IA-Alkyne is a TRP channel (TRPC) agonist. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling. It also...
GSK2798745
T15434CAS 1419609-94-1
GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4). It is used in ...
1,4-Cineole
TQ0001CAS 470-67-7
1,4-Cineole is a natural, oxygenated monoterpene. 1,4-Cineole can activate both human TRPM8 and human TRPA1.
LASSBio-1135
T8440CAS 852453-71-5
LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.
AM-0902
T7430CAS 1883711-97-4
AM-0902 is a potent and specific TRPA1 antagonist (IC50s: 71/131 nM for rTRPA1 and hTRPA1).
EIPA
TQ0157CAS 1154-25-2
EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
Hydroxy-​α-​sanshool
T8307CAS 83883-10-7
Hydroxy-​α-​sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 µM).
ASP7663
T8410CAS 1190217-35-6
ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.
alpha-Spinasterol
TN1377CAS 481-18-5
α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects....
Dihydromorin
TN1583CAS 18422-83-8
trans-Dihydromorin is an effective hypopigmenting agent in normal skin cells, hypopigmenting agents effective in melanoma system may not be effective on normal m...
TC-I2000
T8449CAS 1159996-20-9
TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50 of 53 nM.
M8-B Hydrochloride
T8442CAS 883976-12-3
M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.
TRPA1 Antagonist 1
T13212CAS 1984825-08-2
TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.
A-1165442
T14067CAS 1221443-94-2
A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.
Linoleoyl Ethanolamide
T8425CAS 68171-52-8
Linoleoyl Ethanolamide is an endocannabinoid agent. It acts by binding to TRPV1 increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor i...
AM12
T13546CAS 2387510-84-9
AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).
AMG2850
T10300CAS 1470018-52-0
AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).
GFB-8438
T11394CAS 2304549-73-1
GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).
SAR7334
T12849CAS 1333210-07-3
SAR7334 is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).
EIPA hydrochloride
T11172CAS 1345839-28-2
EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 ...
BI-749327
T10537CAS 2361241-23-6
BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).
RN-1734
T7572CAS 946387-07-1
RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM,5.9 μM,3.2 μM for hTRPV4,  mTRPV4 and rTRPV4,respectively)