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Search Results for " tam-receptor "

Targets

26

Compounds

17

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T13074 TAM-IN-2 TAM Receptor
TAM-IN-2 is an inhibitor of TAM.
T7425 RU-301 TAM Receptor
RU-301 is a novel pan-tam inhibitor
T6982 SGI-7079 FLT , c-Met/HGFR , c-RET , TAM Receptor , Src
SGI-7079 is a new selective Axl inhibitor. SGI-7079 can be a dose-dependent manner inhibited growth of tumors. It is also a potential therapeutic target for EGFR inhibitor resistance.
T1968 UNC2250 TAM Receptor
UNC2250 is an effective and specific Mer inhibitor (IC50=1.7 nM).
TQ0041 Ningetinib Tosylate VEGFR , c-Met/HGFR , TAM Receptor
Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.
T2311 LDC1267 TAM Receptor
LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM).
T17205 UNC2541 Others , FLT , TAM Receptor
UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor. It also binds in the MerTK ATP pocket (IC50: 4.4 nM). UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM).
T2005 Dubermatinib TP0903 Apoptosis , TAM Receptor
Dubermatinib (TP0903) is a potent and selective Axl kinase inhibitor.
T8327 ONO-7475 Trk receptor , TAM Receptor
ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase
T9123 DS-1205 TAM Receptor
DS-1205 is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205 also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205 can inhibit cell migration in vitro an...
T6907 NPS-1034 NPS1034,NPS 1034 Apoptosis , c-Met/HGFR , TAM Receptor
NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.
T2629 UNC2881 TAM Receptor
UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively.
TQ0021 Ningetinib CT-053,CT053PTSA VEGFR , c-Met/HGFR , TAM Receptor
Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.
T21302 UNC569 UNC 569 TAM Receptor
UNC569 (UNC 569) is a selective inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body. It is also a selective uric acid re-absorption inhibitor. UNC569 could normalize the amoun...
T4426 CEP-40783 CEP 40783,RXDX-106 c-Met/HGFR , TAM Receptor
CEP-40783 (RXDX-106) is an effective, specific and orally active AXL/c-Met inhibitor (IC50: 7/12 nM). It also inhibits MER and TYRO3 (IC50: 29/19 nM).
T6269 Bemcentinib R428,BGB324 TAM Receptor
Bemcentinib (R428) is a selective inhibitor of Axl (IC50: 14 nM) and has been investigated for the treatment of NSCLC.
T2699 BMS 777607 BMS777607,BMS-777607,BMS 817378 c-Met/HGFR , TAM Receptor
BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met/Axl/Ron/Tyro3 (IC50: 3.9/1.1/1.8/4.3 nM). BMS-777607 has been investigated for the basic science of Malignant Solid Tumour.
T4409 Gilteritinib ASP2215 FLT , TAM Receptor , c-Kit
Gilteritinib (ASP2215) is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively). In preClinicalal studies, gilteritinib showed strong an...
T7379 2-D08 E1/E2/E3 Enzyme , TAM Receptor
2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.
T9052 XL092 CL-092,JUN04542 VEGFR , c-Met/HGFR , TAM Receptor
XL092 (JUN04542) is an Axl Mer cMet KDR inhibitor for the treatment of Axl and Mer receptor tyrosine kinase- dependent disorders.
T2586 Cabozantinib XL184,BMS-907351 Apoptosis , VEGFR , FLT , c-Met/HGFR , c-RET , TAM Receptor , c-Kit
Cabozantinib (BMS-907351) (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50s: 0.035, 1.3, 4.6, 7 and 11.3 nM).
T5164 Cabozantinib hydrochloride XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351 VEGFR , FLT , c-Met/HGFR , TAM Receptor , c-Kit , ROR
Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM).
T16806 RU-302 [2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfanyl]phenyl]-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone TAM Receptor
RU-302 is a pan inhibitor of TAM Receptor blocking the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks the activation of Gas6-inducible AXL and suppresses lung cancer tumor grow...
T6827L Endoxifen hydrochloride
Endoxifen hydrochloride is a key active metabolite of Tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen hydrochloride has the potential for breast ...
T76776 Emactuzumab RO 5509554,RG 7155 c-Fms , TAM Receptor
Emactuzumab(RG 7155) is a monoclonal antibody against colony-stimulating factor-1 receptor targeting tumor-associated macrophages (TAMs) Emactuzumab has antitumor activity and inhibits activation of colony-stimulating fa...
T77085 Mipasetamab
Mipasetamab is an IgG1κ antibody targeting to AXL , a tyrosine kinase receptor and an TAM Receptor . Mipasetamab involves in synthesis of ADCT-601 (Mipasetamab uzoptirine), an AXL-targeted antibody-drug conjugate (ADC) ....

Compounds

TAM-IN-2
T13074
Synonym:
Target: TAM Receptor
RU-301
T7425
Synonym:
Target: TAM Receptor
SGI-7079
T6982
Synonym:
Target: FLT, c-Met/HGFR, c-RET, TAM Receptor, Src
UNC2250
T1968
Synonym:
Target: TAM Receptor
Ningetinib Tosylate
TQ0041
Synonym:
Target: VEGFR, c-Met/HGFR, TAM Receptor
LDC1267
T2311
Synonym:
Target: TAM Receptor
UNC2541
T17205
Synonym:
Target: Others, FLT, TAM Receptor
Dubermatinib
T2005
Synonym: TP0903
Target: Apoptosis, TAM Receptor
ONO-7475
T8327
Synonym:
Target: Trk receptor, TAM Receptor
DS-1205
T9123
Synonym:
Target: TAM Receptor
NPS-1034
T6907
Synonym: NPS1034,NPS 1034
Target: Apoptosis, c-Met/HGFR, TAM Receptor
UNC2881
T2629
Synonym:
Target: TAM Receptor
Ningetinib
TQ0021
Synonym: CT-053,CT053PTSA
Target: VEGFR, c-Met/HGFR, TAM Receptor
UNC569
T21302
Synonym: UNC 569
Target: TAM Receptor
CEP-40783
T4426
Synonym: CEP 40783,RXDX-106
Target: c-Met/HGFR, TAM Receptor
Bemcentinib
T6269
Synonym: R428,BGB324
Target: TAM Receptor
BMS 777607
T2699
Synonym: BMS777607,BMS-777607,BMS 817378
Target: c-Met/HGFR, TAM Receptor
Gilteritinib
T4409
Synonym: ASP2215
Target: FLT, TAM Receptor, c-Kit
2-D08
T7379
Synonym:
Target: E1/E2/E3 Enzyme, TAM Receptor
XL092
T9052
Synonym: CL-092,JUN04542
Target: VEGFR, c-Met/HGFR, TAM Receptor
Cabozantinib
T2586
Synonym: XL184,BMS-907351
Target: Apoptosis, VEGFR, FLT, c-Met/HGFR, c-RET, TAM Receptor, c-Kit
Cabozantinib hydrochloride
T5164
Synonym: XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351
Target: VEGFR, FLT, c-Met/HGFR, TAM Receptor, c-Kit, ROR
RU-302
T16806
Synonym: [2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfanyl]phenyl]-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone
Target: TAM Receptor
Endoxifen hydrochloride
T6827L
Synonym:
Target:
Emactuzumab
T76776
Synonym: RO 5509554,RG 7155
Target: c-Fms, TAM Receptor
Mipasetamab
T77085
Synonym:
Target:

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-01601 AXL Protein, Human, Recombinant (His) Human HEK293
Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multip...
TMPY-04396 C-ABL/ABL1 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy...
TMPK-00901 TYRO3 Protein, Mouse, Recombinant (His) Mouse HEK293
The TAM receptors (Tyro3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew mac...
TMPK-00533 TYRO3 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
The TAM receptors (Tyro3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew mac...
TMPK-00472 AXL Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpre...
TMPK-00407 AXL Protein, Human, Recombinant (His & Avi) Human HEK293
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpre...
TMPK-00408 AXL Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpre...
TMPK-00410 AXL Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated Human HEK293
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpre...
TMPJ-01017 Dtk Protein, Mouse, Recombinant (hFc) Mouse Human Cells
Dtk, also called Tyro3, belongs to the TAM receptor family of receptor protein tyrosine kinases (RPTKs) composed of three receptors Tyro3, Axl, and Mer. These receptors share a characteristic molecular structure of two i...
TMPJ-01018 Dtk Protein, Mouse, Recombinant (mFc) Mouse Human Cells
Dtk, also called Tyro3, belongs to the TAM receptor family of receptor protein tyrosine kinases (RPTKs) composed of three receptors Tyro3, Axl, and Mer. These receptors share a characteristic molecular structure of two i...
TMPJ-00365 GAS6 Protein, Human, Recombinant (Avi & His), Biotinylated Human Human Cells
Human Growth arrest-specific protein 6 (GAS6) is ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signa...
TMPJ-00449 AXL Protein, Human, Recombinant (hFc) Human Human Cells
Axl, also known as Ufo and Ark, is a widely expressed 140 kDa glycoprotein in the TAM receptor tyrosine kinase family. Axl binds the vitamin K-dependent protein Gas6 which triggers tyrosine autophosphorylation of the Axl...
TMPJ-00399 AXL Protein, Mouse, Recombinant (hFc) Mouse Human Cells
Axl, also known as Ufo and Ark, is a widely expressed 140 kDa glycoprotein in the TAM receptor tyrosine kinase family. Axl binds the vitamin K-dependent protein Gas6 which triggers tyrosine autophosphorylation of the Axl...
TMPY-01021 AXL Protein, Mouse, Recombinant (His & hFc) Mouse HEK293
Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multip...
TMPY-06552 AXL Protein, Rat, Recombinant (His) Rat HEK293
Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multip...
TMPY-06478 AXL Protein, Human, Recombinant (mFc) Human HEK293
Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multip...
TMPY-01364 AXL Protein, Mouse, Recombinant (His) Mouse HEK293
Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multip...
AXL Protein, Human, Recombinant (His)
TMPY-01601
Species: Human
Expression System: HEK293
C-ABL/ABL1 Protein, Human, Recombinant (GST)
TMPY-04396
Species: Human
Expression System: Baculovirus-Insect Cells
TYRO3 Protein, Mouse, Recombinant (His)
TMPK-00901
Species: Mouse
Expression System: HEK293
TYRO3 Protein, Cynomolgus, Recombinant (His)
TMPK-00533
Species: Cynomolgus
Expression System: HEK293
AXL Protein, Cynomolgus, Recombinant (His)
TMPK-00472
Species: Cynomolgus
Expression System: HEK293
AXL Protein, Human, Recombinant (His & Avi)
TMPK-00407
Species: Human
Expression System: HEK293
AXL Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00408
Species: Human
Expression System: HEK293
AXL Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated
TMPK-00410
Species: Human
Expression System: HEK293
Dtk Protein, Mouse, Recombinant (hFc)
TMPJ-01017
Species: Mouse
Expression System: Human Cells
Dtk Protein, Mouse, Recombinant (mFc)
TMPJ-01018
Species: Mouse
Expression System: Human Cells
GAS6 Protein, Human, Recombinant (Avi & His), Biotinylated
TMPJ-00365
Species: Human
Expression System: Human Cells
AXL Protein, Human, Recombinant (hFc)
TMPJ-00449
Species: Human
Expression System: Human Cells
AXL Protein, Mouse, Recombinant (hFc)
TMPJ-00399
Species: Mouse
Expression System: Human Cells
AXL Protein, Mouse, Recombinant (His & hFc)
TMPY-01021
Species: Mouse
Expression System: HEK293
AXL Protein, Rat, Recombinant (His)
TMPY-06552
Species: Rat
Expression System: HEK293
AXL Protein, Human, Recombinant (mFc)
TMPY-06478
Species: Human
Expression System: HEK293
AXL Protein, Mouse, Recombinant (His)
TMPY-01364
Species: Mouse
Expression System: HEK293
TargetMol