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Membrane transporter/Ion channel Sodium Channel

Sodium Channel

Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane.
Cat No. product name
T9234 Tocainide hydrochloride Tocainide hydrochloride is a sodium channel blocker. It blocks the sodium channels in the pain-producing foci in the nerve membranes.
T0222 Proparacaine hydrochloride Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. Proparacaine hydrochloride s...
T6955 Propafenone HCl Propafenone HCl is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.
T0511 Tolperisone hydrochloride Tolperisone hydrochloride, a centrally acting muscle relaxant, is used in the therapy of pathologically increased tone of the cross-striated muscle resulted by n...
T1320 Disopyramide A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) wi...
T0843 Ademine Triamterene is a pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.
T0167 Vinpocetine Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
T0802 Procaine hydrochloride Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine ...
T1332 Permethrin Permethrin is a pyrethroid insecticide commonly used in the treatment of LICE INFESTATIONS and SCABIES.
T1389 Dyclonine hydrochloride Dyclonine, an over the counter throat lozenge, is found in Sucretswith local anesthetic effect .
T1046 Mexiletine hydrochloride Mexiletine Hydrochloride is the hydrochloride salt form of mexiletine, a local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine. ...
T0866 Propafenone Propafenone is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmi...
T0939 Phenytoin Phenytoin is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium ef...
T0029 Procaine Procaine is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral ...
T2806 Lappaconitine Lappaconitine, isolated from Aconitum sinomontanum Nakai, was characterized as an analgesic.
T2391 Camostat mesilate Camostat is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.
T0378 Oxybuprocaine hydrochloride Oxybuprocaine hydrochloride, a local anesthetic, is used especially in otolaryngology and ophthalmology.
T3364 Veratramine Veratramine(NSC17821; NSC23880) is a potent signal transduction inhibitor for treating tumors.
T1144L Lidocaine Hydrochloride hydrate Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.
T0364L Dibucaine hydrochloride Dibucaine hydrochloride, a long-acting local amide anestheticsis, is usually used for surface anesthesia.
T0018 Procainamide hydrochloride Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine...
T0266 Quinidine hydrochloride Quinidine is an optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. It prolongs cellular action potential and decr...
T0792 (-)-Sparteine sulfate pentahydrate Sparteine sulfate pentahydrate is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium.
T0008 Phenytoin sodium Phenytoin sodium is an inactive stabilizer for voltage-gated sodium channel .
T0460 Pramoxine hydrochloride Pramocaine hydrochloride, a topical anesthetic, is served as an antipruritic.
T0267 Zonisamide Zonisamide, a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydra...
T6953 Prilocaine Prilocaine is a local anesthetic of the amino amide type, which acts on the sodium channel on the neuronal membrane and limits the spread of seizures.
T1308 Orphenadrine hydrochloride Orphenadrine hydrochloride is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
T0249 Acecainide N-Acetylprocainamide, the N-acetylated metabolite of Procainamide, is a Class III antiarrhythmic agent, while procainamide is a Class Ia antiarrhythmic drug.
T0386L Ropivacaine Ropivacaine is a local anaesthetic drug belonging to the amino amide group.
T0175L Amiloride hydrochloride dihydrate Amiloride hydrochloride is a pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negati...
T3021 Bulleyaconi cine A Bulleyaconitine A, an analgesic and antiinflammatory drug isolated from Aconitum plants, has several potential targets, such as voltage-gated Na+ channels.
T0275 Meticrane Meticrane is a sulphonamide-derivative with thiazide-like diuretic activity.
T6541 Ibutilide Fumarate Ibutilide Fumarate is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominat...
T0024 Primidone Primidone is an anticonvulsant of the pyrimidinedione class.
T2049 GS967 GS967 is a potent, and selective inhibitor of cardiac late sodium current (late INa ).
T0044 Oxethazaine Oxethazaine, a topical anesthetic, is used to prevent acid-induced esophageal pain.
T1386 Phenazopyridine hydrochloride Phenazopyridine Hydrochloride is used orally as a urinary tract analgesic. Side effects of phenazopyridine hydrochloride administration can include nausea, inter...
T1198 Tetracaine hydrochloride Tetracaine hydrochloride (Pontocaine), a potent local anaesthetic, is a channel function allosteric inhibitor. It is primarily used as an antipruritic and topica...
T1073 Dronedarone hydrochloride Dronedarone hydrochloride is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.
T1334 Hydroquinidine Dihydroquinidine is an organic compound, used as an antiarrhythmic agent.
T2238 Cariporide Cariporide (HOE-642), an effective NHE1 inhibitor, has inhibitory effects on the degranulation of human platelets, the formation of platelet-leukocyte-aggregates...
T0946 Mepivacaine hydrochloride Mepivacaine Hydrochloride is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties.
T0349 Riluzole Riluzole is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LA...
T3029 Sparteine sulfate Sparteine sulfate is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium.
T0796 Propitocaine hydrochloride Prilocaine hydrochloride is a local anesthetic of the amino amide type, binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing t...
T0030 Bupivacaine hydrochloride Bupivacaine Hydrochloride is a long-acting, amide-type local anesthetic. Bupivacaine reversibly binds to specific sodium ion channels in the neuronal membrane...
T6782 Benzocaine hydrochloride Benzocaine hydrochloride is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
T0470 Nefopam hydrochloride Nefopam Hydrochloride is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.
T3285 Eslicarbazepine Acetate Eslicarbazepine acetate (ESL) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset...
T6234 Ambroxol hydrochloride Ambroxol hydrochloride is a metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually admin...
T2131 Articaine HCl Articaine hydrochloride is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.
T2192 Indazole Indazole, also called benzpyrazole or isoindazone, is a heterocyclic aromatic organic compound. Indazole derivatives display a broad variety of biological activi...
T1787 Levobupivacaine Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. L...
T6566 Levobupivacaine HCl Levobupivacaine HCl is a reversible neuronal sodium channel inhibitor, which is the pure S(-)-enantiomer of bupivacaine. It was utilized as a long-acting local a...
T0440 Oxcarbazepine Oxcarbazepine is an Anti-epileptic Agent. The physiologic effect of oxcarbazepine is by means of Decreased Central Nervous System Disorganized Electrical Activit...
T0943 Carbamazepine Carbamazepine is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts it...
T1144 Lidocaine hydrochloride Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged...
T0364 Dibucaine Dibucaine, a local anesthetic of the amide type, is now usually used for surface anesthesia.
T13177L Tocainide Tocainide is a blocker of the sodium channel and used for the treatment of tinnitus.
T16887 Sipatrigine Sipatrigine is a glutamate release inhibitor and voltage-dependent sodium channel.
TN2306 Wilfordine Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect.
T13830 Propoxycaine hydrochloride Propoxycaine hydrochloride is an inhibit of voltage-gated sodium channels.
T8444 N-Me-aminopyrimidinone9 N-Me-aminopyrimidinone9 is a sodium channel antagonist
T12608 QX-314 chloride QX-314 chloride is a membrane-impermeable permanently charged blocker of sodium channel.
T10757L Cenobamate Cenobamate, a sodium channel blocker, enhances GABAergic transmission. It has a potential to be a versatile CNS drug.
T15174 DSP-2230 DSP-2230 is a selective blocker of Nav1.7/Nav1.8.
T15207 Eleclazine hydrochloride Eleclazine hydrochloride is a novel inhibitor of late Na+ current (IC50: 0.7 uM).
T15260 Evenamide Evenamide is a sodium channel blocker. Which shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness.
T12951 Sodium Channel inhibitor 2 Sodium Channel inhibitor 2 is a blocker of sodium channel.
T16707 QX-314 bromide QX-314 bromide is a blocker of the membrane-impermeable permanently charged sodium channel.
T19644 Benzonatate Benzonatate is an antagonist of sodium channel protein.
TCA2511 11Beta-hydroxyprogesterone The progesterone derivatives 11 alpha- and 11 beta-hydroxyprogesterone are potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2) in vitro ...
TN1740 Homoeriodictyol Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can in...
TN3042 4-Hydroxycinnamamide 4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
TN3910 Ecdysone Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. A nctional Bombyx Ecdysone receptor binds to EcRE-D a...
TN4276 Isocudraniaxanthone B Isocudraniaxanthone B may have antimalarial activity.
TN4697 Odoroside H Odoroside H has anticancer activities, the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase.
TN5060 Stauntosaponin A Stauntosaponin A and stauntosaponin B show moderate inhibitory activities against Na+/K+-ATPase with IC50 values of 21 and 29 uM, respectively.
TN5141 Thevetin B Thevetin B is a cardiac glycoside. Thevetin A and thevetin B are Na+-, K+-dependent adenosinetriphosphatase (Na+,K+-ATPase) (EC 3.6.1.3) inhibitors.
TN5234 Vindorosine Vindorosine has blood vessel relaxation effect, possible underlying mechanisms involving the inhibition of Ca(2+) entry via L-type Ca(2+) channels in vascular sm...
T7587 Tenapanor Tenapanor is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which plays a prominent role in sodium handling in the gastrointestinal tract and kid...
T8711 PF-05186462 PF-05186462 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.
T6645 Ropivacaine HCl monohydrate Ropivacaine HCl is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.
TP1852L Myomodulin acetate(110570-93-9 free base) Myomodulin acetate is present in two identified aplysia neurons that contain myomodulin A the ARC motor neuron B16 and the abdominal neuron L10.
T6782L Benzocaine xHCl(94-09-7(free base)) Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel(IC50 of 0.8 mM tested with a potential of +30 mV).
TN2239 Strictosamide Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain.
T8299 Dimethyl lithospermate B Dimethyl lithospermate B is a selective Na+ channel agonist.
T2342 CNV1014802 Raxatrigine has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.
T4699 Hexamethylene amiloride HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 µM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013...
T0924 Benzocaine Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
T2024 A803467 A-803467 is a selective NaV1.8 channel blocker.
T0207 Ranolazine dihydrochloride Ranolazine(RS-43285), an antianginal agent, can treat arrhythmia via a novel mechanism of action (inhibition of the late phase of the inward sodium current), and...
T0386 Ropivacaine hydrochloride Ropivacaine hydrochloride is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity.
T2139 Butacaine Butacaine is a local anesthetic.
T2173 Veratridine Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal.
T7056 Dronedarone Dronedarone is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
T7064 Valproic Acid Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various mol...
T4550 Ajmaline Ajmaline is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of Brugada syndrome and the acute treatment of atrial or ventricular tachyc...
T4490 PF01247324 PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker (IC50: 196 nM).
T4539 Nicainoprol Nicainoprol is a fast-sodium-channel blocking drug, which is a potent antiarrhythmic agent.
T5S0890 Oleandrin 1. Oleandrin, the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional lev...
T5324 BI 01383298 BI 01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5).
T7811 Pilsicainide HCl Pilsicainide HCl is a pure sodium channel blocker
T5319 Rimeporide Rimeporide (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.
T5333 Rimeporide hydrochloride Rimeporide (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.
T7066 Fosphenytoin sodium Fosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker
T5850 Benzamil Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane ...
T7182 Metaflumizone Metaflumizone is a sodium channel blocker insecticide.
T7219 Flecainide (acetate) Flecainide (acetate) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart).
T7349 Ralfinamide Ralfinamide is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions.
T7336 ICA-121431 ICA-121431 is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, with little or no activity against human Nav1.5 or Na...
T7547 Ralfinamide mesylate Ralfinamide mesylate is an orally available Na+ channel blocker.
TQ0011 PF-06869206 PF-06869206 is an oral selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1, IC50: 380 nM).
TQ0014 GNE-131 GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).
TQ0157 EIPA EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
T2523 Rufinamide Rufinamide, a triazole derivative, is used as voltage-gated sodium channel blocker for the treatment of seizure disorders.
Tocainide hydrochloride
T9234CAS 71395-14-7
Tocainide hydrochloride is a sodium channel blocker. It blocks the sodium channels in the pain-producing foci in the nerve membranes.
Proparacaine hydrochloride
T0222CAS 5875-06-9
Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. Proparacaine hydrochloride s...
Propafenone HCl
T6955CAS 34183-22-7
Propafenone HCl is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.
Tolperisone hydrochloride
T0511CAS 3644-61-9
Tolperisone hydrochloride, a centrally acting muscle relaxant, is used in the therapy of pathologically increased tone of the cross-striated muscle resulted by n...
Disopyramide
T1320CAS 3737-09-5
A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) wi...
Ademine
T0843CAS 396-01-0
Triamterene is a pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.
Vinpocetine
T0167CAS 42971-09-5
Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
Procaine hydrochloride
T0802CAS 51-05-8
Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine ...
Permethrin
T1332CAS 52645-53-1
Permethrin is a pyrethroid insecticide commonly used in the treatment of LICE INFESTATIONS and SCABIES.
Dyclonine hydrochloride
T1389CAS 536-43-6
Dyclonine, an over the counter throat lozenge, is found in Sucretswith local anesthetic effect .
Mexiletine hydrochloride
T1046CAS 5370-01-4
Mexiletine Hydrochloride is the hydrochloride salt form of mexiletine, a local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine. ...
Propafenone
T0866CAS 54063-53-5
Propafenone is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmi...
Phenytoin
T0939CAS 57-41-0
Phenytoin is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium ef...
Procaine
T0029CAS 59-46-1
Procaine is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral ...
Lappaconitine
T2806CAS 32854-75-4
Lappaconitine, isolated from Aconitum sinomontanum Nakai, was characterized as an analgesic.
Camostat mesilate
T2391CAS 59721-29-8
Camostat is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.
Oxybuprocaine hydrochloride
T0378CAS 5987-82-6
Oxybuprocaine hydrochloride, a local anesthetic, is used especially in otolaryngology and ophthalmology.
Veratramine
T3364CAS 60-70-8
Veratramine(NSC17821; NSC23880) is a potent signal transduction inhibitor for treating tumors.
Lidocaine Hydrochloride hydrate
T1144LCAS 6108-05-0
Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.
Dibucaine hydrochloride
T0364LCAS 61-12-1
Dibucaine hydrochloride, a long-acting local amide anestheticsis, is usually used for surface anesthesia.
Procainamide hydrochloride
T0018CAS 614-39-1
Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine...
Quinidine hydrochloride
T0266CAS 6151-40-2
Quinidine is an optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. It prolongs cellular action potential and decr...
(-)-Sparteine sulfate pentahydrate
T0792CAS 6160-12-9
Sparteine sulfate pentahydrate is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium.
Phenytoin sodium
T0008CAS 630-93-3
Phenytoin sodium is an inactive stabilizer for voltage-gated sodium channel .
Pramoxine hydrochloride
T0460CAS 637-58-1
Pramocaine hydrochloride, a topical anesthetic, is served as an antipruritic.
Zonisamide
T0267CAS 68291-97-4
Zonisamide, a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydra...
Prilocaine
T6953CAS 721-50-6
Prilocaine is a local anesthetic of the amino amide type, which acts on the sodium channel on the neuronal membrane and limits the spread of seizures.
Orphenadrine hydrochloride
T1308CAS 341-69-5
Orphenadrine hydrochloride is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
Acecainide
T0249CAS 32795-44-1
N-Acetylprocainamide, the N-acetylated metabolite of Procainamide, is a Class III antiarrhythmic agent, while procainamide is a Class Ia antiarrhythmic drug.
Ropivacaine
T0386LCAS 84057-95-4
Ropivacaine is a local anaesthetic drug belonging to the amino amide group.
Amiloride hydrochloride dihydrate
T0175LCAS 17440-83-4
Amiloride hydrochloride is a pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negati...
Bulleyaconi cine A
T3021CAS 107668-79-1
Bulleyaconitine A, an analgesic and antiinflammatory drug isolated from Aconitum plants, has several potential targets, such as voltage-gated Na+ channels.
Meticrane
T0275CAS 1084-65-7
Meticrane is a sulphonamide-derivative with thiazide-like diuretic activity.
Ibutilide Fumarate
T6541CAS 122647-32-9
Ibutilide Fumarate is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominat...
Primidone
T0024CAS 125-33-7
Primidone is an anticonvulsant of the pyrimidinedione class.
GS967
T2049CAS 1262618-39-2
GS967 is a potent, and selective inhibitor of cardiac late sodium current (late INa ).
Oxethazaine
T0044CAS 126-27-2
Oxethazaine, a topical anesthetic, is used to prevent acid-induced esophageal pain.
Phenazopyridine hydrochloride
T1386CAS 136-40-3
Phenazopyridine Hydrochloride is used orally as a urinary tract analgesic. Side effects of phenazopyridine hydrochloride administration can include nausea, inter...
Tetracaine hydrochloride
T1198CAS 136-47-0
Tetracaine hydrochloride (Pontocaine), a potent local anaesthetic, is a channel function allosteric inhibitor. It is primarily used as an antipruritic and topica...
Dronedarone hydrochloride
T1073CAS 141625-93-6
Dronedarone hydrochloride is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.
Hydroquinidine
T1334CAS 1435-55-8
Dihydroquinidine is an organic compound, used as an antiarrhythmic agent.
Cariporide
T2238CAS 159138-80-4
Cariporide (HOE-642), an effective NHE1 inhibitor, has inhibitory effects on the degranulation of human platelets, the formation of platelet-leukocyte-aggregates...
Mepivacaine hydrochloride
T0946CAS 1722-62-9
Mepivacaine Hydrochloride is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties.
Riluzole
T0349CAS 1744-22-5
Riluzole is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LA...
Sparteine sulfate
T3029CAS 299-39-8
Sparteine sulfate is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium.
Propitocaine hydrochloride
T0796CAS 1786-81-8
Prilocaine hydrochloride is a local anesthetic of the amino amide type, binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing t...
Bupivacaine hydrochloride
T0030CAS 18010-40-7
Bupivacaine Hydrochloride is a long-acting, amide-type local anesthetic. Bupivacaine reversibly binds to specific sodium ion channels in the neuronal membrane...
Benzocaine hydrochloride
T6782CAS 23239-88-5
Benzocaine hydrochloride is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
Nefopam hydrochloride
T0470CAS 23327-57-3
Nefopam Hydrochloride is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.
Eslicarbazepine Acetate
T3285CAS 236395-14-5
Eslicarbazepine acetate (ESL) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset...
Ambroxol hydrochloride
T6234CAS 23828-92-4
Ambroxol hydrochloride is a metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually admin...
Articaine HCl
T2131CAS 23964-57-0
Articaine hydrochloride is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.
Indazole
T2192CAS 271-44-3
Indazole, also called benzpyrazole or isoindazone, is a heterocyclic aromatic organic compound. Indazole derivatives display a broad variety of biological activi...
Levobupivacaine
T1787CAS 27262-47-1
Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. L...
Levobupivacaine HCl
T6566CAS 27262-48-2
Levobupivacaine HCl is a reversible neuronal sodium channel inhibitor, which is the pure S(-)-enantiomer of bupivacaine. It was utilized as a long-acting local a...
Oxcarbazepine
T0440CAS 28721-07-5
Oxcarbazepine is an Anti-epileptic Agent. The physiologic effect of oxcarbazepine is by means of Decreased Central Nervous System Disorganized Electrical Activit...
Carbamazepine
T0943CAS 298-46-4
Carbamazepine is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts it...
Lidocaine hydrochloride
T1144CAS 73-78-9
Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged...
Dibucaine
T0364CAS 85-79-0
Dibucaine, a local anesthetic of the amide type, is now usually used for surface anesthesia.
Tocainide
T13177LCAS 41708-72-9
Tocainide is a blocker of the sodium channel and used for the treatment of tinnitus.
Sipatrigine
T16887CAS 130800-90-7
Sipatrigine is a glutamate release inhibitor and voltage-dependent sodium channel.
Wilfordine
TN2306CAS 37239-51-3
Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect.
Propoxycaine hydrochloride
T13830CAS 550-83-4
Propoxycaine hydrochloride is an inhibit of voltage-gated sodium channels.
N-Me-aminopyrimidinone9
T8444CAS 1356834-62-2
N-Me-aminopyrimidinone9 is a sodium channel antagonist
QX-314 chloride
T12608CAS 5369-03-9
QX-314 chloride is a membrane-impermeable permanently charged blocker of sodium channel.
Cenobamate
T10757LCAS 913088-80-9
Cenobamate, a sodium channel blocker, enhances GABAergic transmission. It has a potential to be a versatile CNS drug.
DSP-2230
T15174CAS 1233231-30-5
DSP-2230 is a selective blocker of Nav1.7/Nav1.8.
Eleclazine hydrochloride
T15207CAS 1448754-43-5
Eleclazine hydrochloride is a novel inhibitor of late Na+ current (IC50: 0.7 uM).
Evenamide
T15260CAS 1092977-61-1
Evenamide is a sodium channel blocker. Which shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness.
Sodium Channel inhibitor 2
T12951CAS 653573-60-5
Sodium Channel inhibitor 2 is a blocker of sodium channel.
QX-314 bromide
T16707CAS 24003-58-5
QX-314 bromide is a blocker of the membrane-impermeable permanently charged sodium channel.
Benzonatate
T19644CAS 104-31-4
Benzonatate is an antagonist of sodium channel protein.
11Beta-hydroxyprogesterone
TCA2511CAS 600-57-7
The progesterone derivatives 11 alpha- and 11 beta-hydroxyprogesterone are potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2) in vitro ...
Homoeriodictyol
TN1740CAS 446-71-9
Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can in...
4-Hydroxycinnamamide
TN3042CAS 194940-15-3
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
Ecdysone
TN3910CAS 3604-87-3
Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. A nctional Bombyx Ecdysone receptor binds to EcRE-D a...
Isocudraniaxanthone B
TN4276CAS 199851-52-0
Isocudraniaxanthone B may have antimalarial activity.
Odoroside H
TN4697CAS 18810-25-8
Odoroside H has anticancer activities, the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase.
Stauntosaponin A
TN5060CAS 1417887-91-2
Stauntosaponin A and stauntosaponin B show moderate inhibitory activities against Na+/K+-ATPase with IC50 values of 21 and 29 uM, respectively.
Thevetin B
TN5141CAS 27127-79-3
Thevetin B is a cardiac glycoside. Thevetin A and thevetin B are Na+-, K+-dependent adenosinetriphosphatase (Na+,K+-ATPase) (EC 3.6.1.3) inhibitors.
Vindorosine
TN5234CAS 5231-60-7
Vindorosine has blood vessel relaxation effect, possible underlying mechanisms involving the inhibition of Ca(2+) entry via L-type Ca(2+) channels in vascular sm...
Tenapanor
T7587CAS 1234423-95-0
Tenapanor is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which plays a prominent role in sodium handling in the gastrointestinal tract and kid...
PF-05186462
T8711CAS 1235406-03-7
PF-05186462 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.
Ropivacaine HCl monohydrate
T6645CAS 132112-35-7
Ropivacaine HCl is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.
Myomodulin acetate(110570-93-9 free base)
TP1852LCAS TP1852L
Myomodulin acetate is present in two identified aplysia neurons that contain myomodulin A the ARC motor neuron B16 and the abdominal neuron L10.
Benzocaine xHCl(94-09-7(free base))
T6782LCAS T6782L
Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel(IC50 of 0.8 mM tested with a potential of +30 mV).
Strictosamide
TN2239CAS 23141-25-5
Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain.
Dimethyl lithospermate B
T8299CAS 875313-64-7
Dimethyl lithospermate B is a selective Na+ channel agonist.
CNV1014802
T2342CAS 934240-30-9
Raxatrigine has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.
Hexamethylene amiloride
T4699CAS 1428-95-1
HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 µM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013...
Benzocaine
T0924CAS 94-09-7
Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
A803467
T2024CAS 944261-79-4
A-803467 is a selective NaV1.8 channel blocker.
Ranolazine dihydrochloride
T0207CAS 95635-56-6
Ranolazine(RS-43285), an antianginal agent, can treat arrhythmia via a novel mechanism of action (inhibition of the late phase of the inward sodium current), and...
Ropivacaine hydrochloride
T0386CAS 98717-15-8
Ropivacaine hydrochloride is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity.
Butacaine
T2139CAS 149-16-6
Butacaine is a local anesthetic.
Veratridine
T2173CAS 71-62-5
Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal.
Dronedarone
T7056CAS 141626-36-0
Dronedarone is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
Valproic Acid
T7064CAS 99-66-1
Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various mol...
Ajmaline
T4550CAS 4360-12-7
Ajmaline is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of Brugada syndrome and the acute treatment of atrial or ventricular tachyc...
PF01247324
T4490CAS 875051-72-2
PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker (IC50: 196 nM).
Nicainoprol
T4539CAS 76252-06-7
Nicainoprol is a fast-sodium-channel blocking drug, which is a potent antiarrhythmic agent.
Oleandrin
T5S0890CAS 465-16-7
1. Oleandrin, the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional lev...
BI 01383298
T5324CAS 2227549-00-8
BI 01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5).
Pilsicainide HCl
T7811CAS 88069-49-2
Pilsicainide HCl is a pure sodium channel blocker
Rimeporide
T5319CAS 187870-78-6
Rimeporide (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.
Rimeporide hydrochloride
T5333CAS 187870-95-7
Rimeporide (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.
Fosphenytoin sodium
T7066CAS 92134-98-0
Fosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker
Benzamil
T5850CAS 2898-76-2
Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane ...
Metaflumizone
T7182CAS 139968-49-3
Metaflumizone is a sodium channel blocker insecticide.
Flecainide (acetate)
T7219CAS 54143-56-5
Flecainide (acetate) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart).
Ralfinamide
T7349CAS 133865-88-0
Ralfinamide is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions.
ICA-121431
T7336CAS 313254-51-2
ICA-121431 is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, with little or no activity against human Nav1.5 or Na...
Ralfinamide mesylate
T7547CAS 202825-45-4
Ralfinamide mesylate is an orally available Na+ channel blocker.
PF-06869206
TQ0011CAS 2227425-05-8
PF-06869206 is an oral selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1, IC50: 380 nM).
GNE-131
TQ0014CAS 1629063-81-5
GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).
EIPA
TQ0157CAS 1154-25-2
EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
Rufinamide
T2523CAS 106308-44-5
Rufinamide, a triazole derivative, is used as voltage-gated sodium channel blocker for the treatment of seizure disorders.