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Search Results for " sodium-channel "

Targets

211

Compounds

26

Natural Products

15

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T12951 Sodium Channel inhibitor 2 Sodium Channel
Sodium Channel inhibitor 2 is a blocker of sodium channel.
T12948 Sodium Channel inhibitor 1 Others
Sodium Channel inhibitor1 is a novel and selective voltage-gated sodium channel for pain treatment. (IC50 Value of 0.16 uM and 0.41 uM for Na v1.7, V hold-90mV and Na v1.7, V hold-90mV)
T1320 Disopyramide Triombrin,Hypaque sodium,amidotrizoate sodium Potassium Channel , Sodium Channel , AChR
Disopyramide (Triombrin) is a class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the h...
T12608 QX-314 chloride Sodium Channel
QX-314 chloride is a membrane-impermeable permanently charged blocker of sodium channel.
T13177L Tocainide Sodium Channel
Tocainide is a blocker of the sodium channel and used for the treatment of tinnitus.
T4054 Dantrolene sodium hemiheptahydrate Dantrolene sodium hydrate,Dantrolene sodium salt,Dantrium,Sodium dantrolene Calcium Channel , Autophagy
Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1 and decreasing intracellular calcium concentration. Ryanodine receptors mediate the release of calcium from t...
T0008 Phenytoin sodium 5,5-Diphenylhydantoin sodium salt,Diphantoine,Dilantin sodium,Diphenylhydantoin Sodium Virus Protease , Sodium Channel
Phenytoin sodium (Diphantoine) is an inactive stabilizer for voltage-gated sodium channel .
T3956 Sodium ionophore III ETH2120 Sodium Channel
Sodium ionophore III (ETH2120) is a Na+ ionophore suitable for the test of sodium activity in plasma, serum, and blood.
T15260 Evenamide NW-3509 Sodium Channel
Evenamide (NW-3509) is a sodium channel blocker. Which shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness.
T2024 A-803467 A 803467,A803467 Sodium Channel
A-803467 is a selective NaV1.8 channel blocker.
T81134 Sodium Channel inhibitor 4 Sodium Channel
Sodium Channel Inhibitor 4 is a compound that functions as a sodium channel inhibitor [1].
T8711 PF-05186462 PF-05150122 Sodium Channel
PF-05186462 (PF-05150122) is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.
T5850 Benzamil Benzamil (hydrochloride) Na+/Ca2+ Exchanger , Sodium Channel
Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles.
T0440 Oxcarbazepine GP 47680 Apoptosis , Sodium Channel
Oxcarbazepine (GP 47680) is an Anti-epileptic Agent. The physiologic effect of oxcarbazepine is by means of Decreased Central Nervous System Disorganized Electrical Activity.
T12421 PF-04885614 Sodium Channel
PF-04885614 is a potent inhibitor of NaV1.8, has potential for neurological and neurodevelopmental diseases treatment.
T0866 Propafenone Rythmol,Propafenonum Potassium Channel , MRP , Sodium Channel
Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity....
T23070 Nisoxetine hydrochloride Sodium Channel , Monoamine Transporter , Norepinephrine
Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitor
T0077 Dantrolene sodium Lapatinib ditosylate monohydrate,Dantrolene sodium salt Others , Calcium Channel
Dantrolene sodium (Lapatinib ditosylate monohydrate) salt is a skeletal muscle relaxant and can interfere with excitation-contraction coupling in the muscle fiber. It is used for the treatment of spasticity and other neu...
T8581 Flecainide hydrochloride Others
Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias.
TQ0014 GNE-131 Sodium Channel
GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).
T19723 AMTB hydrochloride AMTB TRP/TRPV Channel
AMTB hydrochloride (AMTB HCl) is a novel TRPM8 channel blocker and is effective for pain and urinary diseases. AMTB can act on the bladder afferent pathway to attenuate the bladder micturition reflex and nociceptive refl...
T5324 BI 01383298 Sodium Channel
BI 01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5).
T15174 DSP-2230 Sodium Channel
DSP-2230 is a selective blocker of Nav1.7/Nav1.8.
T4490 PF-01247324 Sodium Channel
PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker (IC50: 196 nM).
T12786 RY785 Potassium Channel
RY785 is a potent and selective inhibitor of voltage-gated potassium channel such as KV2.2 (IC50 = 50 nM). RY785 may be used in pain relief studies.
T16514 PF 04531083 Others , Sodium Channel
PF 04531083 is a selective blocker of the NaV1.8 channel. PF 04531083 can be used for neuropathic and inflammatory pain studies.
TQ0011 PF-06869206 Sodium Channel
PF-06869206 is an oral selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1, IC50: 380 nM).
T37688 Cyfluthrin Reactive Oxygen Species , Sodium Channel
Cyfluthrin binds to voltage-sensitive sodium channel such as Nav 1.8 sodium channel and modify their gating kinetics, thereby disrupting nerve function of pests.
T0030 Bupivacaine hydrochloride Vivacaine,Bupivacaine HCl Sodium Channel
Bupivacaine hydrochloride (Vivacaine) is a long-acting, amide-type local anesthetic. Bupivacaine hydrochloride reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the vol...
T0924 Benzocaine Others , MRP , Sodium Channel
Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
T0275 Meticrane Fontiliz,Arresten Chloride channel , Sodium Channel
Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.
T0386L Ropivacaine LEA-103 HCl Potassium Channel , Sodium Channel
Ropivacaine (LEA-103 HCl) is a local anaesthetic drug belonging to the amino amide group.
T0916 Butamben Butyl 4-aminobenzoate Potassium Channel , Calcium Channel , Sodium Channel
Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.
T19644 Benzonatate Sodium Channel
Benzonatate is an antagonist of sodium channel protein.
T0364 Dibucaine Cinchocaine CaMK , Sodium Channel , AChR
Dibucaine (Cinchocaine), a local anesthetic of the amide type, is now usually used for surface anesthesia.
T9685 DS-1971a Sodium Channel
DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.
T9683 VX-150 Sodium Channel
VX-150 is a highly selective NaV1.8 inhibitor relative to the other sodium channel subtypes (>400-fold).
T7182 Metaflumizone BAS-320I Sodium Channel , Parasite
Metaflumizone (BAS-320I) is a sodium channel blocker insecticide.
T0386 Ropivacaine hydrochloride Ropivacaine monohydrochloride Potassium Channel , Sodium Channel
Ropivacaine hydrochloride (Ropivacaine monohydrochloride) is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity.
T1787 Levobupivacaine Sodium Channel
Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AstraZ...
T12181 NaV1.7 inhibitor-1 Sodium Channel
NaV1.7 inhibitor-1, an efficacious inhibitor of voltage-gated sodium channel (NaV) 1.7 (IC50 of 0.6 nM for hNaV1.7).
T7806 Licarbazepine ​10,11-hydroxy-10,11 Dihydrocarbamezer Others
Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) is the pharmacologically active metabolite of oxcarbazepine, a drug indicated for the treatment of partial seizures and bipolar disorders.
T7547 Ralfinamide mesylate FCE-26742A (mesylate) Sodium Channel
Ralfinamide mesylate (FCE-26742A (mesylate)) is an orally available Na+ channel blocker.
T1260 Cromolyn sodium Disodium Cromoglycate,FPL 670 (Cromolyn) Disodium,FPL-670,Sodium cromoglycate Others , Potassium Channel , GSK-3 , Calcium Channel
Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.
T2049 GS967 GS458967 Sodium Channel
GS967 is a potent, and selective inhibitor of cardiac late sodium current (late INa ).
T23280 Ruthenium Red Ammoniated ruthenium oxychloride Calcium Channel
Ruthenium Red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids ...
T4539 Nicainoprol RU-42924 Sodium Channel
Nicainoprol (RU-42924) is a fast-sodium-channel blocking drug. Nicainoprol is a potent antiarrhythmic agent.
T18975 DIDS sodium salt MDL101114ZA VDAC , ABC
DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1.
T12931 SLC13A5-IN-1 Stearoyl-CoA Desaturase (SCD)
SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5),completely blocks the uptake of 14C-citrate(IC50 : 0.022 μM in HepG2 cells).
T6633 Ranolazine CVT 303,Ranexa,RS 43285-003 Calcium Channel , Sodium Channel
Ranolazine (RS 43285-003) is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina. It affects the sodium-dependent calcium channels during myocardial ischemia in rabbits by altering the...

Compounds

Sodium Channel inhibitor 2
T12951
Synonym:
Target: Sodium Channel
Sodium Channel inhibitor 1
T12948
Synonym:
Target: Others
Disopyramide
T1320
Synonym: Triombrin,Hypaque sodium,amidotrizoate sodium
Target: Potassium Channel, Sodium Channel, AChR
QX-314 chloride
T12608
Synonym:
Target: Sodium Channel
Tocainide
T13177L
Synonym:
Target: Sodium Channel
Dantrolene sodium hemiheptahydrate
T4054
Synonym: Dantrolene sodium hydrate,Dantrolene sodium salt,Dantrium,Sodium dantrolene
Target: Calcium Channel, Autophagy
Phenytoin sodium
T0008
Synonym: 5,5-Diphenylhydantoin sodium salt,Diphantoine,Dilantin sodium,Diphenylhydantoin Sodium
Target: Virus Protease, Sodium Channel
Sodium ionophore III
T3956
Synonym: ETH2120
Target: Sodium Channel
Evenamide
T15260
Synonym: NW-3509
Target: Sodium Channel
A-803467
T2024
Synonym: A 803467,A803467
Target: Sodium Channel
Sodium Channel inhibitor 4
T81134
Synonym:
Target: Sodium Channel
PF-05186462
T8711
Synonym: PF-05150122
Target: Sodium Channel
Benzamil
T5850
Synonym: Benzamil (hydrochloride)
Target: Na+/Ca2+ Exchanger, Sodium Channel
Oxcarbazepine
T0440
Synonym: GP 47680
Target: Apoptosis, Sodium Channel
PF-04885614
T12421
Synonym:
Target: Sodium Channel
Propafenone
T0866
Synonym: Rythmol,Propafenonum
Target: Potassium Channel, MRP, Sodium Channel
Nisoxetine hydrochloride
T23070
Synonym:
Target: Sodium Channel, Monoamine Transporter, Norepinephrine
Dantrolene sodium
T0077
Synonym: Lapatinib ditosylate monohydrate,Dantrolene sodium salt
Target: Others, Calcium Channel
Flecainide hydrochloride
T8581
Synonym:
Target: Others
GNE-131
TQ0014
Synonym:
Target: Sodium Channel
AMTB hydrochloride
T19723
Synonym: AMTB
Target: TRP/TRPV Channel
BI 01383298
T5324
Synonym:
Target: Sodium Channel
DSP-2230
T15174
Synonym:
Target: Sodium Channel
PF-01247324
T4490
Synonym:
Target: Sodium Channel
RY785
T12786
Synonym:
Target: Potassium Channel
PF 04531083
T16514
Synonym:
Target: Others, Sodium Channel
PF-06869206
TQ0011
Synonym:
Target: Sodium Channel
Cyfluthrin
T37688
Synonym:
Target: Reactive Oxygen Species, Sodium Channel
Bupivacaine hydrochloride
T0030
Synonym: Vivacaine,Bupivacaine HCl
Target: Sodium Channel
Benzocaine
T0924
Synonym:
Target: Others, MRP, Sodium Channel
Meticrane
T0275
Synonym: Fontiliz,Arresten
Target: Chloride channel, Sodium Channel
Ropivacaine
T0386L
Synonym: LEA-103 HCl
Target: Potassium Channel, Sodium Channel
Butamben
T0916
Synonym: Butyl 4-aminobenzoate
Target: Potassium Channel, Calcium Channel, Sodium Channel
Benzonatate
T19644
Synonym:
Target: Sodium Channel
Dibucaine
T0364
Synonym: Cinchocaine
Target: CaMK, Sodium Channel, AChR
DS-1971a
T9685
Synonym:
Target: Sodium Channel
VX-150
T9683
Synonym:
Target: Sodium Channel
Metaflumizone
T7182
Synonym: BAS-320I
Target: Sodium Channel, Parasite
Ropivacaine hydrochloride
T0386
Synonym: Ropivacaine monohydrochloride
Target: Potassium Channel, Sodium Channel
Levobupivacaine
T1787
Synonym:
Target: Sodium Channel
NaV1.7 inhibitor-1
T12181
Synonym:
Target: Sodium Channel
Licarbazepine
T7806
Synonym: ​10,11-hydroxy-10,11 Dihydrocarbamezer
Target: Others
Ralfinamide mesylate
T7547
Synonym: FCE-26742A (mesylate)
Target: Sodium Channel
Cromolyn sodium
T1260
Synonym: Disodium Cromoglycate,FPL 670 (Cromolyn) Disodium,FPL-670,Sodium cromoglycate
Target: Others, Potassium Channel, GSK-3, Calcium Channel
GS967
T2049
Synonym: GS458967
Target: Sodium Channel
Ruthenium Red
T23280
Synonym: Ammoniated ruthenium oxychloride
Target: Calcium Channel
Nicainoprol
T4539
Synonym: RU-42924
Target: Sodium Channel
DIDS sodium salt
T18975
Synonym: MDL101114ZA
Target: VDAC, ABC
SLC13A5-IN-1
T12931
Synonym:
Target: Stearoyl-CoA Desaturase (SCD)
Ranolazine
T6633
Synonym: CVT 303,Ranexa,RS 43285-003
Target: Calcium Channel, Sodium Channel
1 2 3 4 5
Cat No. Product Name Synonyms Targets
T4727 Taurolithocholic acid sodium salt Sodium taurolithocholate Others , Calcium Channel
Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, but not to M2 or M3 receptors.
T4S1876 3-Deoxyaconitine Sodium Channel
3- Deoxyaconitine is a derivative of Aconitine (A189875), which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the rele...
T6674 L-Ascorbic acid sodium salt (+)-Sodium L-ascorbate,Vitamin C sodium salt,Sodium ascorbate,L-Ascorbic acid sodium,Sodium L-ascorbate Apoptosis , Others , Calcium Channel , Reactive Oxygen Species , Endogenous Metabolite
L-Ascorbic acid sodium salt (Vitamin C sodium salt) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.
T2946 Tanshinone IIA sulfonate sodium Tanshinone IIA sulfonate,Sodium Tanshinone IIA sulfonate,Tanshinone IIA sodium sulfonate,sodium CaMK , P450 , Calcium Channel
Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator of the human purinergic receptor...
T8125 Quinidine sulfate dihydrate Chinidin Sodium,β-quinine Sodium,Pitayine Sodium,Quinidine sulfate P450
Quinidine sulfate dihydrate (Pitayine Sodium) is a potent and selective cytochrome P450db inhibitor
T3092 Nigericin sodium salt Potassium Channel , NOD-like Receptor (NLR) , Antibacterial , Antibiotic , NOD
Nigericin sodium salt is an antibiotic, an NLRP3 activator, and a cationic ion carrier. Nigericin sodium triggers the activation of the NALP3 inflammasome, which inhibits Golgi function and suppresses the growth of Gram-...
T8299 Dimethyl lithospermate B dmLSB Sodium Channel
Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist.
T3021 Bulleyaconitine A Bulleyaconi cine A Sodium Channel
Bulleyaconitine A (Bulleyaconi cine A), an analgesic and antiinflammatory drug isolated from Aconitum plants, has several potential targets, such as voltage-gated Na+ channels.
T4590 (+)-Kavain Kavain,L-KAWAIN,(R)-KAWAIN Calcium Channel , GABA Receptor , Sodium Channel , Monoamine Transporter
(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.
T4550 Ajmaline Cardiorythmine,Raugalline,Tachmalin,(+)-Ajmaline Sodium Channel
Ajmaline (Cardiorythmine) is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of Brugada syndrome and the acute treatment of atrial or ventricular tachycardia. Ajmaline inhibits cardiac Kv1.5 and...
T7056 Dronedarone SR 33589 P450 , Potassium Channel , Calcium Channel , Sodium Channel , Adrenergic Receptor , AChR , Autophagy
Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
T6856 Halofuginone Tempostatin,empostatin,RU-19110 Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal.
T0167 Vinpocetine RGH-4405,Ethyl apovincaminate IκB/IKK , NF-κB , Sodium Channel , PDE
Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
TN6713 6-Benzoylheteratisine Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth Sodium Channel
6-Benzoylheteratisine (Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth) is a Aconitum alkaloid. It can inhibits voltage-gated Na+ channels in rat brain synaptosomes
T2173 Veratridine Sodium Channel
Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal.
T3402 20(S)-Ginsenoside Rg3 20(S)-Ginsenoside-Rg3,Rg3,20S-Ginsenoside Rg3,Ginsenoside Rg3,S-Ginsenoside Rg3 EGFR , Beta Amyloid , Potassium Channel , NF-κB , COX , Sodium Channel , Endogenous Metabolite
20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhibits the proliferation of human umbilical vein endothelial c...
T3524 Halofuginone hydrobromide Tempostatin,RU-19110 (hydrobromide),Stenorol Others , Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce...
T0792 (-)-Sparteine sulfate pentahydrate (-)-Sparteine Sulfate,Lupinidine sulfate pentahydrate,(-)-Sparteine sulfate salt,sulfate pentahydrate Sodium Channel
(-)-Sparteine sulfate pentahydrate ((-)-Sparteine Sulfate) is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium.
TN1254 3'-Methoxydaidzein Sodium Channel
3'-Methoxydaidzein is a dual isoflavone and Sodium Channel inhibitor. 3'-Methoxydaidzein inhibited NaV1.7, NaV1.8 and NaV1.3 with IC50 of 181 nM, 397 nM and 505 nM, respectively. 3'-Methoxydaidzein was specific for colla...
T7853 (+)-Sparteine Pachycarpine AChR
(+)-Sparteine (Pachycarpine) is a natural product extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent
T3604 Sodium dichloroacetate Sodium Dichloroacetate,DCA,BCA,bichloroacetic acid,Sodium dichloroacetate (DCA) Apoptosis , Dehydrogenase , Reactive Oxygen Species , PDK
Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion chann...
T5065 GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD Monosodium-GMP,cGMP sodium salt,Cyclic GMP PKA
GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD (cGMP sodium salt) , also known as cGMP, is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, inc...
T0266 Quinidine hydrochloride monohydrate Quinidine hydrochloride Potassium Channel , Sodium Channel , Parasite
Quinidine hydrochloride monohydrate is an optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. It prolongs cellular action potential and decreases automaticity. This alkaloid...
TMA2106 (-)-Sparteine P450
Sparteine is a class 1a antiarrhythmic agent, a sodium channel blocker. The deficient debrisoquine hydroxylation of Sparteine is due to the absence of P-450IID1 protein in the livers of poor metabolizers.
T3029 Sparteine sulfate Depasan,Tocosimplex,Actospar Others , Sodium Channel
Sparteine sulfate (Tocosimplex) is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium.
T36068 Brevetoxin B
Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junct...

Natural Products

Taurolithocholic acid sodium salt
T4727
Synonym: Sodium taurolithocholate
Target: Others, Calcium Channel
3-Deoxyaconitine
T4S1876
Synonym:
Target: Sodium Channel
L-Ascorbic acid sodium salt
T6674
Synonym: (+)-Sodium L-ascorbate,Vitamin C sodium salt,Sodium ascorbate,L-Ascorbic acid sodium,Sodium L-ascorbate
Target: Apoptosis, Others, Calcium Channel, Reactive Oxygen Species, Endogenous Metabolite
Tanshinone IIA sulfonate sodium
T2946
Synonym: Tanshinone IIA sulfonate,Sodium Tanshinone IIA sulfonate,Tanshinone IIA sodium sulfonate,sodium
Target: CaMK, P450, Calcium Channel
Quinidine sulfate dihydrate
T8125
Synonym: Chinidin Sodium,β-quinine Sodium,Pitayine Sodium,Quinidine sulfate
Target: P450
Nigericin sodium salt
T3092
Synonym:
Target: Potassium Channel, NOD-like Receptor (NLR), Antibacterial, Antibiotic, NOD
Dimethyl lithospermate B
T8299
Synonym: dmLSB
Target: Sodium Channel
Bulleyaconitine A
T3021
Synonym: Bulleyaconi cine A
Target: Sodium Channel
(+)-Kavain
T4590
Synonym: Kavain,L-KAWAIN,(R)-KAWAIN
Target: Calcium Channel, GABA Receptor, Sodium Channel, Monoamine Transporter
Ajmaline
T4550
Synonym: Cardiorythmine,Raugalline,Tachmalin,(+)-Ajmaline
Target: Sodium Channel
Dronedarone
T7056
Synonym: SR 33589
Target: P450, Potassium Channel, Calcium Channel, Sodium Channel, Adrenergic Receptor, AChR, Autophagy
Halofuginone
T6856
Synonym: Tempostatin,empostatin,RU-19110
Target: Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad
Vinpocetine
T0167
Synonym: RGH-4405,Ethyl apovincaminate
Target: IκB/IKK, NF-κB, Sodium Channel, PDE
6-Benzoylheteratisine
TN6713
Synonym: Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth
Target: Sodium Channel
Veratridine
T2173
Synonym:
Target: Sodium Channel
20(S)-Ginsenoside Rg3
T3402
Synonym: 20(S)-Ginsenoside-Rg3,Rg3,20S-Ginsenoside Rg3,Ginsenoside Rg3,S-Ginsenoside Rg3
Target: EGFR, Beta Amyloid, Potassium Channel, NF-κB, COX, Sodium Channel, Endogenous Metabolite
Halofuginone hydrobromide
T3524
Synonym: Tempostatin,RU-19110 (hydrobromide),Stenorol
Target: Others, Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad
(-)-Sparteine sulfate pentahydrate
T0792
Synonym: (-)-Sparteine Sulfate,Lupinidine sulfate pentahydrate,(-)-Sparteine sulfate salt,sulfate pentahydrate
Target: Sodium Channel
3'-Methoxydaidzein
TN1254
Synonym:
Target: Sodium Channel
(+)-Sparteine
T7853
Synonym: Pachycarpine
Target: AChR
Sodium dichloroacetate
T3604
Synonym: Sodium Dichloroacetate,DCA,BCA,bichloroacetic acid,Sodium dichloroacetate (DCA)
Target: Apoptosis, Dehydrogenase, Reactive Oxygen Species, PDK
GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD
T5065
Synonym: Monosodium-GMP,cGMP sodium salt,Cyclic GMP
Target: PKA
Quinidine hydrochloride monohydrate
T0266
Synonym: Quinidine hydrochloride
Target: Potassium Channel, Sodium Channel, Parasite
(-)-Sparteine
TMA2106
Synonym:
Target: P450
Sparteine sulfate
T3029
Synonym: Depasan,Tocosimplex,Actospar
Target: Others, Sodium Channel
Brevetoxin B
T36068
Synonym:
Target:

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-03697 SCN2B Protein, Human, Recombinant (His) Human HEK293
SCN2B plays a key role in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. Voltage-gated sodium channels (NaV) are composed of one pore-forming alpha-subunit, which...
TMPY-03183 SCN2B Protein, Human, Recombinant (hFc) Human HEK293
SCN2B plays a key role in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. Voltage-gated sodium channels (NaV) are composed of one pore-forming alpha-subunit, which...
TMPY-02722 SCN3B Protein, Human, Recombinant (hFc) Human HEK293
SCN3B (sodium channel, voltage-gated, type III, beta, human IgG1-Fc chimera) belongs to the sodium channel auxiliary subunit SCN3B family. It contains 1 Ig-like C2-type (immunoglobulin-like) domain. Voltage-gated sodium ...
TMPY-02976 SCN3B Protein, Human, Recombinant (His) Human HEK293
SCN3B (sodium channel, voltage-gated, type III, beta, human IgG1-Fc chimera) belongs to the sodium channel auxiliary subunit SCN3B family. It contains 1 Ig-like C2-type (immunoglobulin-like) domain. Voltage-gated sodium ...
TMPH-03274 ATF-4 Protein, Rat, Recombinant (His & Myc) Rat E. coli
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repe...
TMPH-03273 Complement factor I Protein, Rat, Recombinant (His & Myc) Rat Baculovirus
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repe...
TMPH-03278 DHODH Protein, Rat, Recombinant (His) Rat E. coli
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repe...
TMPH-02165 STXBP1 Protein, Human, Recombinant (His) Human HEK293
Excitatory insect beta-toxins induce a spastic paralysis. They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium ch...
TMPH-01905 SMARCA2 Protein, Human, Recombinant (His) Human Yeast
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective chann...
TMPH-03277 DDT Protein, Rat, Recombinant (His & Myc) Rat E. coli
Voltage-gated sodium channels (Nav) gating-modifier. Acts both as alpha- and beta-toxin, since it affects not only activation but also inactivation of Nav channels (Probable). Binds to Nav domain DII and impairs the four...
TMPH-03276 DAO Protein, Rat, Recombinant (His & Myc) Rat E. coli
Voltage-gated sodium channels (Nav) gating-modifier. Acts both as alpha- and beta-toxin, since it affects not only activation but also inactivation of Nav channels (Probable). Binds to Nav domain DII and impairs the four...
TMPY-04997 Prostasin/PRSS8 Protein, Rat, Recombinant (His) Rat HEK293
Prostasin (Prss8), also known as channel activating protease 1 (CAP1), is a trypsinlike serine peptidase, and plays important roles in epithelial physiology. It is originally purified as an active, soluble enzyme from hu...
TMPY-00905 Prostasin/PRSS8 Protein, Human, Recombinant (His) Human HEK293
Prostasin (Prss8), also known as channel activating protease 1 (CAP1), is a trypsinlike serine peptidase, and plays important roles in epithelial physiology. It is originally purified as an active, soluble enzyme from hu...
TMPY-02783 Prostasin/PRSS8 Protein, Mouse, Recombinant (aa 30-289, His) Mouse Baculovirus-Insect Cells
Prostasin (Prss8), also known as channel activating protease 1 (CAP1), is a trypsinlike serine peptidase, and plays important roles in epithelial physiology. It is originally purified as an active, soluble enzyme from hu...
TMPH-00751 YjbL Protein, E. coli, Recombinant (His & KSI) E. coli E. coli
Gating-modifier toxin that potently inhibits inactivation of the mammalian Nav1.1/SCN1A sodium channel (EC(50)=38 nM). Also moderately inhibits inactivation of Nav1.2/SCN2A (EC(50)=236 nM) and Nav1.3/SCN3A (EC(50)=220 nM...
Cat No. Product Name
L7400 Sodium Channel Blocker Library

128 compounds
A unique collection of 128 sodium channel blockers and agonists for high throughput and high content screening;
TargetMol