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Cat No. | Product Name | Synonyms | Targets |
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T12910 | Sigma-1 receptor antagonist 1 | Sigma receptor | |
Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor. Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity and can be used in the treatment of neuropathic pain studie... | |||
T12911 | Sigma-1 receptor antagonist 2 | Sigma receptor | |
Sigma-1 receptor antagonist 2 is a potent and selective antagonist of sigma 1 receptor (σ1 R) (σ1 and σ2 receptor with Kis of 3.88 and 1288 nM , respectively). | |||
T12912 | Sigma-1 receptor antagonist 3 | Sigma receptor , HER | |
Sigma-1 receptor antagonist 3 is a potent and selective antagonist of Sigma-1 (σ1) receptor(Ki : 1.14 nM), has the potential for the neuropathic pain. | |||
T16883 | Sigma-2 receptor antagonist 1 | Others | |
Sigma-2 receptor antagonist 1 is an antagonist of the sigma-2 (σ-2) receptor. | |||
T4596 | 4-IBP | Sigma receptor | |
4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) . | |||
T9244 | σ1 Receptor antagonist-1 | Sigma receptor | |
σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist. | |||
T7488 | BD1063 dhydrochloride | BD1063 | Sigma receptor |
BD1063 dhydrochloride is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM). | |||
T78734 | Sigma-1 receptor antagonist 5 | Sigma receptor | |
Sigma-1 receptor antagonist 5 (compound 12), a 4-pyridylpiperidine derivative, exhibits analgesic properties through its antagonistic action on sigma receptors (Ki=4.5 nM (σ1R), 10 nM (σ2R)) and the histamine H3 receptor... | |||
T5027 | Dimemorfan phosphate | 3,17-dimethylmorphinan | Sigma receptor |
Dimemorfan phosphate (3,17-dimethylmorphinan) is a sigma 1 receptor agonist. Dimemorfan phosphate is used as a potent antitussive. | |||
T1180 | Blonanserin | AD-5423 | Dopamine Receptor , Sigma receptor , 5-HT Receptor , Adrenergic Receptor |
Blonanserin (AD-5423) is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability profile, lacking side effects such as extrapyramidal ... | |||
T15393 | Glycerol phenylbutyrate | HPN-100 | Sigma receptor |
Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02). | |||
T7780 | Blarcamesine | AE-37,AVex-73 | AChR |
Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease. | |||
T15034 | Roluperidone | CYR-101,MIN-101,MT-210 | Sigma receptor , 5-HT Receptor |
Roluperidone (CYR-101) is a novel cyclic amide derivative. It has high equipotent affinities for 5-HT2A and σ2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and σ2). | |||
T1740 | BD-1047 dihydrobromide | BD1047.2HBr | Sigma receptor |
BD-1047 dihydrobromide (BD1047.2HBr) , a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacy in schizophrenia. | |||
T8834 | EST64454 hydrochloride | EST64454 | Sigma receptor |
EST64454 hydrochloride (EST64454) is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management. | |||
T5969 | Ditolylguanidine | DTG,Di-o-tolylguanidine,1,3-Di-o-tolylguanidine | Sigma receptor |
Ditolylguanidine (Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor). | |||
T1885 | Siramesine hydrochloride | Lu 28-179 hydrochloride | Ferroptosis , Sigma receptor , lysosomal autophagy |
Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anticancer activity in vivo. | |||
T3198L | PRE-084 hydrochloride | Sigma receptor | |
PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay). | |||
T4111 | Blarcamesine hydrochloride | Anavex 2-73,AVex-73 hydrochloride,AE-37 hydrochloride | Sigma receptor |
Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM). | |||
T1865 | S1RA | E-52862 | Sigma receptor |
S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating significant selectivity over the sigma-2 receptor (σ2R, Ki > 1000 nM). | |||
T4229 | S1RA hydrochloride | E-52862 hydrochloride | Sigma receptor |
S1RA hydrochloride (E-52862 hydrochloride) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki > 1000 nM). | |||
T20797 | NE-100 hydrochloride | NE100 Hydrochloride,NE 100 HCl,NE 100 Hydrochloride,NE-100 Hydrochloride,NE-100 HCl | Sigma receptor |
NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity. NE100 HCl also suppresses ER stress-induced hippocampal cell death. | |||
T3597 | Cutamesine dihydrochloride | AGY94806 dihydrochloride,SA4503 (dihydrochloride),SA4503 dihydrochloride | Sigma receptor |
Cutamesine dihydrochloride (SA4503 dihydrochloride) is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitr... | |||
T4620 | Siramesine | Lu 28-179 | Sigma receptor |
Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.lysosome-destabilizing agent siram... | |||
T13510 | Sigma-LIGAND-1 | Sigma receptor | |
Sigma-LIGAND-1 is a selective Sigma Receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 has a Ki of 4000 nM at the dopamine D2 receptor. | |||
T62711 | OPC-14523 hydrochloride | ||
OPC-14523 hydrochloride is an orally active sigma and 5-HT1A receptor agonist with antidepressant-like activity. OPC-14523 shows a high affinity for the sigma receptor σ1/2 (IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 ... | |||
T62396 | KB-5492 free base | ||
KB-5492 free base is a potent and selective sigma receptor inhibitor, inhibiting [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 value of 3.15 μM. KB-5492 free base is an anti-ulcer agent. | |||
T79499 | KSK68 | Histamine Receptor | |
KSK68 is a potent dual sigma-1 and histamine H3 receptor antagonist with potential analgesic activity and high affinity for H3 receptors, sigma-1, sigma-2 receptors.KSK68 can be used in the study of pain related diseases... | |||
T79500 | KSK94 | Histamine Receptor | |
KSK94 is a specific H3 receptor antagonist that inhibits H3, sigma-1, and sigma-2 receptors , with Ki values of 7.9, 2958, and 75.2 nM, respectively, and can be used to study injurious pain and neuropathic pain. | |||
T24885 | Tiospirone | BMY 13859-1 | Dopamine Receptor , 5-HT Receptor |
Tiospirone (BMY 13859-1 free base) is a 5-HT2 receptor antagonist and dopamine blocker that inhibits D2, 5-HT1a, 5-HT7, and sigma receptors.Tiospirone is used in the study of neurological disorders such as schizophrenia. | |||
T1186L | Ifenprodil | RC 61-91,RC-61-91,RC61-91,RC 6191 | Adrenergic Receptor , NMDAR |
Ifenprodil (RC61-91) is an inhibitor of the NMDA receptor, specifically of GluN1 (glycine-binding NMDA receptor subunit 1) and GluN2B (glutamate-binding NMDA receptor subunit 2) subunits. Additionally, Ifenprodil inhibit... | |||
T21788 | BD 1008 dihydrobromide | Sigma receptor | |
BD 1008 dihydrobromide is a selective antagonist of the sigma 1 (σ1) receptor (Ki = 2 nM). BD 1008 dihydrobromide have high affinity for sigma1 receptors, moderate affinity for sigma2 receptors. | |||
T39211 | PD 144418 oxalate | Sigma receptor | |
PD 144418 oxalate is a highly potent and selective sigma 1 (σ1) receptor ligand, displaying a Ki value of 0.08 nM for σ1 and 1377 nM for σ2. It exhibits negligible affinity for other receptors, ion channels, and enzymes.... | |||
T22870 | IPAG | Opioid Receptor | |
IPAG is a potent σ-receptor antagonist (pKi=4.3). IPAG can induce cell apoptosis. | |||
T5389 | Volinanserin | M 100907,MDL100907 | 5-HT Receptor |
Volinanserin (MDL100907) (MDL 100907) is a potent and selective antagonist of the serotonin receptor 5-HT2 (Ki: 0.36 nM) and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 adrenergic and sigma recepto... | |||
T4093 | Fabomotizole hydrochloride | Afobazole hydrochloride,CM346 hydrochloride | MAO |
Fabomotizole hydrochloride (CM346 hydrochloride), an anxiolytic drug, produces anxiolytic and neuroprotective effects. The mechanism of Afobazole remains poorly defined, however, with GABAergic, NGF, and BDNF release pro... | |||
T60835 | SKF83959 | Dopamine Receptor | |
SKF83959, a benzazepine analog, is a selective and potent partial agonist of the dopamine D1 receptor with Ki values of 1.18, 7.56, 920, and 399 nM for rat D1, D5, D2, and D3 receptors, respectively.SKF83959 is a potent ... | |||
T22904 | L-745870 trihydrochloride | L-745,870 trihydrochloride | Dopamine Receptor , Sigma receptor , 5-HT Receptor , Adrenergic Receptor |
L-745870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist. | |||
T7352 | Pridopidine | ACR16,ASP2314,FR310826 | Dopamine Receptor |
Pridopidine (FR310826), a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse model. | |||
T11799 | L-745870 hydrochloride | Dopamine Receptor | |
L-745870 hydrochloride has excellent brain penetration. L-745870 hydrochloride is a high-affinity, selective and orally active human dopamine D4 receptor antagonist with a Ki of 0.43 nM, and considerably weaker D2 recept... | |||
T79500L | KSK94 FA | KSK94 FA(2566716-07-0 Free base) | Histamine Receptor |
KSK94 FA is a potent histamine H3 receptor antagonist that inhibits H3 receptors and is used in the study of neuropathic pain and obesity. | |||
T25585 | KSCM-11 | KSCM11 | |
KSCM-11 is a sigma receptor ligand. | |||
T25586 | KSCM-5 | KSCM 5,KSCM5 | |
KSCM-5 is a sigma receptor ligand. | |||
T25584 | KSCM-1 | KSCM 1 | |
KSCM-1 is a selective sigma-1 receptor ligand. | |||
T70809 | BD 1008 Free Base | ||
BD 1008 Free Base is a selective sigma receptor antagonist, with a reported binding affinity of Kᵢ = 2 ± 1 nM for the sigma-1 receptor and 4 times selectivity over the sigma-2 receptor. | |||
T26245 | SW43 | SW-43,SW 43 | |
SW43 is a selective ligand of sigma-2 receptor. | |||
T24334 | L 687384 | L687,384,L 687,384,L-687,384,L-687384,L687384 | |
L 687384 is a high-affinity ligand of sigma receptor. | |||
T71949 | CM304 | ||
CM304 is a highly selective sigma-1 receptor antagonist. | |||
T63048 | Sigma-LIGAND-1 hydrochloride | ||
Sigma-LIGAND-1 hydrochloride is a selective sigma receptor ligand that acts at the DTG (IC50: 16 nM) and PPP (IC50: 19 nM) sites. Sigma-LIGAND-1 hydrochloride is able to act on the dopamine D2 receptor (Ki: 4000 nM). | |||
T1885L | Siramesine Fumarate | LU-28179,LU-28-179,LU 28 179 | |
Siramesine Fumarate, a sigma receptor agonist, is used potentially for the treatment of generalized anxiety disorder. |
Cat No. | Product Name | ||
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L2610 | Neurotransmitter Receptor Compound Library | 1513 compounds | |
A unique collection of 1513 neurotransmitter receptor compounds, can be used for HTS and HCS screening; |