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GPCR/G Protein Sigma receptor

Sigma receptor

The sigma receptors σ1 and σ2 bind to ligands such as 4-PPBP (4-phenyl-1-(4-phenylbutyl) piperidine), SA 4503 (cutamesine), ditolylguanidine, dimethyltryptamine, and siramesine. They are named by pharmacological similarities, and are evolutionarily unrelated.
Cat No. product name
T8834 EST64454 EST64454 is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.
T5027 Dimemorfan phosphate Dimemorfan phosphate is a sigma 1 receptor agonist, used as a potent antitussive.
T3198 PRE-084 hydrochloride PRE-084 hydrochloride is a high affinity, selective σ1 agonist.
T3597 Cutamesine dihydrochloride Cutamesine dihydrochloride is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-i...
T1885 Siramesine hydrochloride Siramesine (Lu 28-179) hydrochloride is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent antic...
T0678 Amitriptyline hydrochloride Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
T1865 S1RA S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).
T4229 S1RA hydrochloride S1RA HCl (E-52862 HCl) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki > 1000 nM).
T4111 Anavex 2-73 Anavex 2-73 is a Sigma-1 Receptor agonist (IC50: 860 nM).
T4596 4-IBP 4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .
T5969 Ditolylguanidine Ditolylguanidine  is an agonist of sigma receptor (σ1/σ2 receptor).
T3198L PRE-084 hydrochloride PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).
T7488 BD1063 BD1063 is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).
T7952 Noscapine Noscapine is a Non-addictive Opioid and Microtubule-Inhibitor in Potential Treatment of Glioblastoma.
T15034 Roluperidone Roluperidone is a novel cyclic amide derivative. It has high equipotent affinities for 5-HT2A and σ2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and σ2).
T15393 Glycerol phenylbutyrate Glycerol phenylbutyrate (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
T12911 Sigma-1 receptor antagonist 2 Sigma-1 receptor antagonist 2 is a potent and selective antagonist of sigma 1 receptor (σ1 R) (σ1 and σ2 receptor with Kis of 3.88 and 1288 nM , respectively)...
T19341 Glycerol phenylbutyrate-D15 Glycerol phenylbutyrate-D15 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
T19342 Glycerol phenylbutyrate-D5 Glycerol phenylbutyrate-D5 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
T16445 PD 144418 PD 144418 displays potential antipsychotic activity. PD 144418 is a high affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki: 0.08 nM and 1377 nM fo...
T1740 BD1047.2HBr BD-1047 hydrobromide, a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacy in schizophrenia.
EST64454
T8834CAS 1950569-11-5
EST64454 is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.
Dimemorfan phosphate
T5027CAS 36304-84-4
Dimemorfan phosphate is a sigma 1 receptor agonist, used as a potent antitussive.
PRE-084 hydrochloride
T3198CAS 138847-85-5
PRE-084 hydrochloride is a high affinity, selective σ1 agonist.
Cutamesine dihydrochloride
T3597CAS 165377-44-6
Cutamesine dihydrochloride is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-i...
Siramesine hydrochloride
T1885CAS 224177-60-0
Siramesine (Lu 28-179) hydrochloride is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent antic...
Amitriptyline hydrochloride
T0678CAS 549-18-8
Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
S1RA
T1865CAS 878141-96-9
S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).
S1RA hydrochloride
T4229CAS 1265917-14-3
S1RA HCl (E-52862 HCl) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki > 1000 nM).
Anavex 2-73
T4111CAS 195615-84-0
Anavex 2-73 is a Sigma-1 Receptor agonist (IC50: 860 nM).
4-IBP
T4596CAS 155798-08-6
4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .
Ditolylguanidine
T5969CAS 97-39-2
Ditolylguanidine  is an agonist of sigma receptor (σ1/σ2 receptor).
PRE-084 hydrochloride
T3198LCAS 75136-54-8
PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).
BD1063
T7488CAS 206996-13-6
BD1063 is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).
Noscapine
T7952CAS 128-62-1
Noscapine is a Non-addictive Opioid and Microtubule-Inhibitor in Potential Treatment of Glioblastoma.
Roluperidone
T15034CAS 359625-79-9
Roluperidone is a novel cyclic amide derivative. It has high equipotent affinities for 5-HT2A and σ2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and σ2).
Glycerol phenylbutyrate
T15393CAS 611168-24-2
Glycerol phenylbutyrate (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
Sigma-1 receptor antagonist 2
T12911CAS 1639220-15-7
Sigma-1 receptor antagonist 2 is a potent and selective antagonist of sigma 1 receptor (σ1 R) (σ1 and σ2 receptor with Kis of 3.88 and 1288 nM , respectively)...
Glycerol phenylbutyrate-D15
T19341CAS T19341
Glycerol phenylbutyrate-D15 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
Glycerol phenylbutyrate-D5
T19342CAS T19342
Glycerol phenylbutyrate-D5 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
PD 144418
T16445CAS 154130-99-1
PD 144418 displays potential antipsychotic activity. PD 144418 is a high affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki: 0.08 nM and 1377 nM fo...
BD1047.2HBr
T1740CAS 138356-21-5
BD-1047 hydrobromide, a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacy in schizophrenia.