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Proteases/Proteasome Serine Protease

Serine Protease

Cat No. product name
T1791 LDK378HOT Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).
T3359 Aprotinin Aprotinin a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, ...
T6564 Leupeptin Hemisulfate Leupeptin hemisulfate is a reversible, competitive serine/cysteine protease inhibitor. It is an orally active, antioxidant and anti-inflammatory agent.
T6986 Sivelestat Sivelestat is a potent and selective inhibitor of neutrophil elastase with IC50 of 44 nM.
T3990 AA26-9 AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase.
T3423 ML281 ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM.
T0175 Amiloride hydrochloride Amiloride hydrochloride is an effective sodium channel blocker of epithelial.
T3442 UK371804 UK-371804 is an effective and specific uPA inhibitor. It was selected as a candidate for further preClinicalal evaluation for the treatment of chronic dermal ulc...
T6370 AEBSF hydrochloride AEBSF hydrochloride is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin.
T0789 PMSF Phenylmethanesulfonyl fluoride (PMSF) is an enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthetase complex.
T2118 SC514 SC-514 is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
T0372 Gabexate mesylate Gabexate mesylate is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a ...
T2392 Nafamostat mesylate Nafamostat mesylate, a synthetic serine protease inhibitor, has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic de...
T3107 Alvelestat Alvelestat is an orally bioavailable, selective and reversible inhibitor of human neutrophil elastase (NE), with potential anti-inflammatory activity.
T1145 Diminazene Aceturate Diminazene is a trypanocidal agent.
T5S0689 Demethylwedelolactone Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect o...
T22451 UK-371804 HCl UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (2700-fol...
T5597 ZT-12-037-01 Zt-12-037-01 is a ATP competitive STK19 inhibitor(IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).
T8362 Benzamidine HCl Benzamidine HCl is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 µM, respectively).
T10254 AE-3763 AE-3763 is a peptide-based human neutrophil elastase inhibitor (IC50: 29 nM).
T15285 FK706 FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine ...
T13568 BCX 1470 BCX 1470 inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively.
T13567 BCX 1470 methanesulfonate BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respecti...
T13257 Upamostat Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.
T13393 ZEN-3411 ZEN-3411 is an inhibitor of BET(IC50s of 0.05, 0.05 and 0.06 μM for BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2), respectively). ZEN-3411 can be used to form PROTACs t...
T13411L ZLN024 hydrochloride (723249-01-2 free base) ZLN024 hydrochloride is an activator of AMPK allosteric.
T13411 ZLN024 ZLN024 is an activator of AMPK allosteric(AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 µM, 0.95 µM, 1.1 µ...
T13412L ZM223 hydrochloride (2031177-48-5 free base) ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.
T16501 PF-3644022 PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα productio...
T17288 ZD8321 ZD8321 is an effective inhibitor of human Neutrophil elastase (Ki: 13±1.7 nM).
T6285 GSK690693 GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
LDK378 HOT
T1791CAS 1032900-25-6
Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).
Aprotinin
T3359CAS 9087-70-1
Aprotinin a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, ...
Leupeptin Hemisulfate
T6564CAS 103476-89-7
Leupeptin hemisulfate is a reversible, competitive serine/cysteine protease inhibitor. It is an orally active, antioxidant and anti-inflammatory agent.
Sivelestat
T6986CAS 127373-66-4
Sivelestat is a potent and selective inhibitor of neutrophil elastase with IC50 of 44 nM.
AA26-9
T3990CAS 1312782-34-5
AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase.
ML281
T3423CAS 1404437-62-2
ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM.
Amiloride hydrochloride
T0175CAS 2016-88-8
Amiloride hydrochloride is an effective sodium channel blocker of epithelial.
UK371804
T3442CAS 256477-09-5
UK-371804 is an effective and specific uPA inhibitor. It was selected as a candidate for further preClinicalal evaluation for the treatment of chronic dermal ulc...
AEBSF hydrochloride
T6370CAS 30827-99-7
AEBSF hydrochloride is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin.
PMSF
T0789CAS 329-98-6
Phenylmethanesulfonyl fluoride (PMSF) is an enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthetase complex.
SC514
T2118CAS 354812-17-2
SC-514 is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
Gabexate mesylate
T0372CAS 56974-61-9
Gabexate mesylate is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a ...
Nafamostat mesylate
T2392CAS 82956-11-4
Nafamostat mesylate, a synthetic serine protease inhibitor, has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic de...
Alvelestat
T3107CAS 848141-11-7
Alvelestat is an orally bioavailable, selective and reversible inhibitor of human neutrophil elastase (NE), with potential anti-inflammatory activity.
Diminazene Aceturate
T1145CAS 908-54-3
Diminazene is a trypanocidal agent.
Demethylwedelolactone
T5S0689CAS 6468-55-9
Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect o...
UK-371804 HCl
T22451CAS 256476-36-5
UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (2700-fol...
ZT-12-037-01
T5597CAS 2328073-61-4
Zt-12-037-01 is a ATP competitive STK19 inhibitor(IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).
Benzamidine HCl
T8362CAS 1670-14-0
Benzamidine HCl is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 µM, respectively).
AE-3763
T10254CAS 291778-77-3
AE-3763 is a peptide-based human neutrophil elastase inhibitor (IC50: 29 nM).
FK706
T15285CAS 144055-55-0
FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine ...
BCX 1470
T13568CAS 217099-43-9
BCX 1470 inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively.
BCX 1470 methanesulfonate
T13567CAS 217099-44-0
BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respecti...
Upamostat
T13257CAS 590368-25-5
Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.
ZEN-3411
T13393CAS 1952264-36-6
ZEN-3411 is an inhibitor of BET(IC50s of 0.05, 0.05 and 0.06 μM for BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2), respectively). ZEN-3411 can be used to form PROTACs t...
ZLN024 hydrochloride (723249-01-2 free base)
T13411LCAS T13411L
ZLN024 hydrochloride is an activator of AMPK allosteric.
ZLN024
T13411CAS 723249-01-2
ZLN024 is an activator of AMPK allosteric(AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 µM, 0.95 µM, 1.1 µ...
ZM223 hydrochloride (2031177-48-5 free base)
T13412LCAS T13412L
ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.
PF-3644022
T16501CAS 1276121-88-0
PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα productio...
ZD8321
T17288CAS 182073-77-4
ZD8321 is an effective inhibitor of human Neutrophil elastase (Ki: 13±1.7 nM).
GSK690693
T6285CAS 937174-76-0
GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.