Search Result

Search Results for " proton-pump "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T17030	Tegoprazan		ATPase , Proton pump
	Tegoprazan is a potassium-competitive acid blocker and is a potent, oral active, and highly selective inhibitor of gastric H+/K+-ATPase. That could control gastric acid secretion and motility (IC50: ranging from 0.29-0.5...		ATPase , Proton pump
T20626	Esomeprazole		Proton pump , Cysteine Protease
	Esomeprazole is the S-isomer of omeprazole, inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Esomeprazole is a proton pump inhibitors (PPI).		Proton pump , Cysteine Protease
T22391	Omeprazole Sodium		P450 , Proton pump , Antibacterial , Autophagy
	Omeprazole Sodium is a proton pump inhibitor(PPI) and suppresses gastric acid secretion. Omeprazole Sodium is a potent neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor). Omeprazole Sodium shows competitive...		P450 , Proton pump , Antibacterial , Autophagy
T11191	EN6		Proton pump , Autophagy
	EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative ...		Proton pump , Autophagy
T16682	Pumaprazole	BY-841	Proton pump
	Pumaprazole (BY-841) is an antagonist of a reversible proton pump.		Proton pump
T10435	Linaprazan	AZD0865	Potassium Channel
	Linaprazan (AZD0865) inhibits gastric H+,K+-ATPase by K+-competitive binding with an IC50 of 1.0 μM.		Potassium Channel
T2188	Thonzonium Bromide		Proton pump , Antibacterial , Autophagy
	Thonzonium bromide is a mono-cationic surfactant that is structurally similar to Farnesol as an antimicrobial agent. It inhibits proton transport in a dose-dependent manner (EC50=69 μM). It inhibits RANKL-induced osteocl...		Proton pump , Antibacterial , Autophagy
T8388	Vonoprazan	TAK-438 (free base)	Proton pump
	Vonoprazan (TAK-438 (free base)) is an orally active potassium-competitive acid blocker.Vonoprazan can be used for the treatment of gastroduodenal ulcer and reflux esophagitis		Proton pump
T1756L	Ilaprazole	IY81149,IY 81149,IY-81149	Proton pump , TOPK
	Ilaprazole (IY-81149) is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Studies also showed that Ilaprazole significantly prevented the developm...		Proton pump , TOPK
T21254	Vonoprazan Fumarate	TAK-438,TAK 438,Vonoprazan Fumurate,TAK438	Proton pump
	Vonoprazan Fumarate (TAK438) , a novel potassium-competitive acid blocker, inhibits gastric acid secretion. Vonoprazan Fumarate (TAK438) inhibited H+,K+-ATPase activity in porcine gastric microsomes with IC50 value of 19...		Proton pump
T1756	Ilaprazole sodium	IY-81149 sodium	Proton pump , TOPK
	Ilaprazole sodium (IY-81149 sodium) , a substituted benzimidazole prodrug, is a selective and irreversible proton pump inhibitor. A weak base, Ilaprazole accumulates in the acidic environment of the secretory canaliculus...		Proton pump , TOPK
T9230	KM 91104		ATPase
	KM 91104 is a cell permeable inhibitor of V-ATPase. KM91104 specifically targets the interaction between V-ATPase subunit A3 and subunit B2.		ATPase
T0502	Zinc pyrithione	OM-1563	Proton pump , Antibacterial , Antifungal
	Zinc pyrithione (OM-1563), an antibacterial and antifungal agent can disrupt membrane transport by blocking the proton pump.		Proton pump , Antibacterial , Antifungal
T1651	Rabeprazole sodium	Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,Rebeprazole sodium,Aciphex Sodium	Apoptosis , Proton pump
	Rabeprazole sodium (Habeprazole Sodium) is a 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. The drug inhibits H(+)-K(+)-exch...		Apoptosis , Proton pump
T6700	Tenatoprazole	TU-199	Proton pump
	Tenatoprazole (TU-199), a prodrug of the proton pump inhibitor (PPI) class, can inhibit proton transport (IC50: 3.2 μM).		Proton pump
T2686L	Esomeprazole Sodium	(S)-Omeprazole sodium	ATPase , Proton pump
	Esomeprazole Sodium ((S)-Omeprazole sodium) is the S-isomer of omeprazole with selective and irreversible proton pump inhibitor activity.Esomeprazole acts as an exosome inhibitor by blocking the exosome release via the i...		ATPase , Proton pump
T1734	Rabeprazole Sulfide	Rabeprazole Related Compound E	Proton pump , Antibacterial
	Rabeprazole Sulfide (Rabeprazole Related Compound E) is an antiulcer drug in the class of proton pump inhibitors.		Proton pump , Antibacterial
T0757	Omeprazole	Losec,Prilosec,H 16868,Antra	Proton pump , Phospholipase , Antibacterial , Autophagy
	Omeprazole (Losec) is a proton pump inhibitor (PPI), Omeprazole(Losec) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).		Proton pump , Phospholipase , Antibacterial , Autophagy
T0674	Lansoprazole	A-65006,AG-1749	Proton pump , Phospholipase , Antibacterial
	Lansoprazole (A-65006) is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is fo...		Proton pump , Phospholipase , Antibacterial
T2686	Esomeprazole Magnesium	(S)-Omeprazole magnesium,NEXIUM,(-)-Omeprazole magnesium	ATPase , Proton pump
	Esomeprazole Magnesium (NEXIUM) is the S-isomer of omeprazole, can reduce gastric acid secretion with selective and irreversible proton pump inhibitor activity.Esomeprazole magnesium acts as an exosome inhibitor by block...		ATPase , Proton pump
T1021	(R)-Lansoprazole	Dexlansoprazole,T 168390,TAK 390,R-(+)-Lansoprazole	Proton pump
	(R)-Lansoprazole (T 168390) is the R-isomer of lansoprazole and a substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity.Lansoprazole (AG 1749) is a potent brain penetrant neutra...		Proton pump
T6928	Pantoprazole	SKF96022,BY1023	Apoptosis , Proton pump , Autophagy
	Pantoprazole (BY1023) is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.		Apoptosis , Proton pump , Autophagy
T8386	Esomeprazole Magnesium trihydrate	(S)-Omeprazole magnesium trihydrate	Proton pump
	Esomeprazole Magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) is a proton pump inhibitor indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history of erosive esophagit...		Proton pump
T0161	Pantoprazole Sodium Hydrate	SKF96022 sodium hydrate,BY1023 (sodium hydrate),SKF96022 (sodium hydrate)	Apoptosis , Potassium Channel , Proton pump , Autophagy
	Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.		Apoptosis , Potassium Channel , Proton pump , Autophagy
T6929	Pantoprazole sodium	Pantecta,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),BY-1023 sodium,Pantoloc	Apoptosis , Others , Proton pump , HIF , Autophagy
	Pantoprazole sodium (Pantecta) is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole sodium is a lipophilic, weak base that crosses the parietal cell membrane and enters...		Apoptosis , Others , Proton pump , HIF , Autophagy
T5449	Bamaquimast	F 10126,L 0042	Proton pump
	Bamaquimast (L 0042) is an inhibitor of proton pump		Proton pump
T28665	Saviprazole	Hoe731,Hoe 731,Hoe-731	Proton pump
	Saviprazole (Hoe-731), a proton pump inhibitor, is used potentially for treatment of gastric ulcer.		Proton pump
T12309	Omeprazole metabolite Omeprazole sulfone	Omeprazole sulphone,Omeprazole sulfone	Others
	Omeprazole metabolite Omeprazole sulfone can inhibit proton pump.		Others
T2687	Omeprazole sulfide	Omeprazole metabolite Omeprazole sulfide,Ufiprazole	Proton pump , Drug Metabolite
	Omeprazole sulfide (Ufiprazole), a metabolite of Omeprazole, functions as a proton pump inhibitor.		Proton pump , Drug Metabolite
T23667	AGN-201904	AGN201904,AGN 201904	ATPase
	AGN-201904 is a proton pump inhibitor, an omeprazole prodrug, which delays aging and may be used for the prevention and treatment of peptic ulcers.		ATPase
T10138	4-Desmethoxy Omeprazole		Drug Metabolite
	4-Desmethoxy Omeprazole is the active metabolite of Omeprazole. Omeprazole is a proton pump inhibitor (PPI). Omeprazole shows competitive inhibition of CYP2C19 activity (Ki: 2 to 6 μM).		Drug Metabolite
T21023	Bedaquiline fumarate	TMC 207,R403323,TMC-207,TMC207,R-403323,R 403323	Antibacterial , Antibiotic
	Bedaquiline fumarate (TMC207), a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections. It blocks the proton pump for ATP synthase of mycobacteria. ...		Antibacterial , Antibiotic
T20714	Levolansoprazole	(S)-Lansoprazole,(-)-Lansoprazole	Proton pump
	Levolansoprazole ((S)-Lansoprazole), a proton pump inhibitor, irreversibly inhibits H+/K+-stimulated ATPase pumps in parietal cells (IC50: 5.2 μM). It also inhibits acid formation in isolated canine parietal cells (IC50:...		Proton pump
T10221	Abeprazan hydrochloride	DWP14012 hydrochloride,Fexuprazan hydrochloride	Proton pump
	Abeprazan hydrochloride (Fexuprazan hydrochloride) is an effective reversible potassium-competitive acid blocker with oral activity, inhibiting H+, K+ -atPase by competitive binding to potassium ions without acid activat...		Proton pump
T28794	SKF-97574 HCl	SKF97574,SKF-97574,B-9937-051,BY 574,SKF 97574,SK&F-97574
	SKF-97574 is proton pump inhibitor.
T11817	Lansoprazole Sulfide D4		Proton pump
	Lansoprazole Sulfide D4 is a deuterium labeled Lansoprazole Sulfide. Lansoprazole Sulfide is an orally active anti-TB (Mycobacterium tuberculosis) agent with IC50 values of 0.59 μM intracellularly and 0.46 μM in broth.La...		Proton pump
T28787	SK&F-95601	SK&F 95601,SKF95601,SKF 95601,SKF-95601
	F-95601 is a proton pump inhibitor.
T70857	Scopadulciol
	Scopadulciol is and enzyme and proton pump inhibitor.
T70825	TY 11345
	TY 11345 is a proton pump inhibitor.
T68303	Esomeprazole strontium
	Esomeprazole strontium is a gastric proton pump inhibitor.
T70135	Nepaprazole sodium dihydrate
	Nepaprazole sodium dihydrate is a proton pump inhibitor potentially for treatment of gastric ulcers.
T29164	WY-47766	WY47766
	WY-47766, a proton pump inhibitor, is used potentially for the treatment of postmenopausal osteoporosis.
T26727	Azeloprazole	E-3710,Z215,E3710,Z 215,E 3710,Z-215
	Azeloprazole, a proton pump inhibitor, is used potentially for the treatment of gastroesophageal reflux disease (GERD).
T39583	Zastaprazan
	Zastaprazan, a proton pump inhibitor (WO2018008929), is utilized in the research of gastrointestinal inflammatory diseases and conditions related to gastric acid.
T11816	Lansoprazole-d4	AG-1749 D4,Lansoprazole D4	Proton pump
	Lansoprazole D4 (AG-1749 D4) is a deuterium labeled Lansoprazole. Lansoprazole is an inhibitor of proton pump which prevents the stomach from producing acid.		Proton pump
T12308	Omeprazole-d3	H 16868 D3	Others
	Omeprazole D3 is deuterium labeled Omeprazole. Omeprazole is a proton pump inhibitor (PPI)		Others
T68250	Omeprazole magnesium
	Omeprazole magnesium, an orally active proton pump inhibitor (PPI), suppresses gastric acid and is utilized for managing symptoms related to acid reflux and frequent heartburn.
T61445	Tenatoprazole sodium
	Tenatoprazole sodium (TU-199 sodium) is a potent proton pump inhibitor that effectively suppresses the activity of hog gastric H+/K+-ATPase, a vital enzymatic pump involved in acid secretion. It achieves this inhibition ...
T81119	S-Pantoprazole sodium trihydrate		Proton pump
	S-Pantoprazole (sodium trihydrate), a variant of Pantoprazole, is pivotal in managing diseases associated with gastric acid secretion disorders, serving as a proton pump inhibitor [1].		Proton pump
T14051	5-Hydroxylansoprazole	AG1908	Proton pump
	5-Hydroxylansoprazole (AG1908) is an active metabolite of Lansoprazole, a gastric proton-pump inhibitor that effectively treats various peptic diseases[1][2]. The metabolism of Lansoprazole occurs through CYP2C19, result...		Proton pump

Compounds

Tegoprazan

T17030

Synonym:

Target: ATPase, Proton pump

Esomeprazole

T20626

Synonym:

Target: Proton pump, Cysteine Protease

Omeprazole Sodium

T22391

Synonym:

Target: P450, Proton pump, Antibacterial, Autophagy

EN6

T11191

Synonym:

Target: Proton pump, Autophagy

Pumaprazole

T16682

Synonym: BY-841

Target: Proton pump

Linaprazan

T10435

Synonym: AZD0865

Target: Potassium Channel

Thonzonium Bromide

T2188

Synonym:

Target: Proton pump, Antibacterial, Autophagy

Vonoprazan

T8388

Synonym: TAK-438 (free base)

Target: Proton pump

Ilaprazole

T1756L

Synonym: IY81149,IY 81149,IY-81149

Target: Proton pump, TOPK

Vonoprazan Fumarate

T21254

Synonym: TAK-438,TAK 438,Vonoprazan Fumurate,TAK438

Target: Proton pump

Ilaprazole sodium

T1756

Synonym: IY-81149 sodium

Target: Proton pump, TOPK

Target: Proton pump, Antibacterial, Antifungal

Rabeprazole sodium

T1651

Synonym: Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,Rebeprazole sodium,Aciphex Sodium

Target: Apoptosis, Proton pump

Tenatoprazole

T6700

Synonym: TU-199

Target: Proton pump

Esomeprazole Sodium

T2686L

Synonym: (S)-Omeprazole sodium

Target: ATPase, Proton pump

Rabeprazole Sulfide

T1734

Synonym: Rabeprazole Related Compound E

Target: Proton pump, Antibacterial

Omeprazole

T0757

Synonym: Losec,Prilosec,H 16868,Antra

Target: Proton pump, Phospholipase, Antibacterial, Autophagy

Lansoprazole

T0674

Synonym: A-65006,AG-1749

Target: Proton pump, Phospholipase, Antibacterial

Esomeprazole Magnesium

T2686

Synonym: (S)-Omeprazole magnesium,NEXIUM,(-)-Omeprazole magnesium

Target: ATPase, Proton pump

(R)-Lansoprazole

T1021

Synonym: Dexlansoprazole,T 168390,TAK 390,R-(+)-Lansoprazole

Target: Proton pump

Pantoprazole

T6928

Synonym: SKF96022,BY1023

Target: Apoptosis, Proton pump, Autophagy

Esomeprazole Magnesium trihydrate

T8386

Synonym: (S)-Omeprazole magnesium trihydrate

Target: Proton pump

Pantoprazole Sodium Hydrate

T0161

Synonym: SKF96022 sodium hydrate,BY1023 (sodium hydrate),SKF96022 (sodium hydrate)

Target: Apoptosis, Potassium Channel, Proton pump, Autophagy

Pantoprazole sodium

T6929

Synonym: Pantecta,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),BY-1023 sodium,Pantoloc

Target: Apoptosis, Others, Proton pump, HIF, Autophagy

Bamaquimast

T5449

Synonym: F 10126,L 0042

Target: Proton pump

Saviprazole

T28665

Synonym: Hoe731,Hoe 731,Hoe-731

Target: Proton pump

Omeprazole metabolite Omeprazole sulfone

T12309

Synonym: Omeprazole sulphone,Omeprazole sulfone

Target: Others

Omeprazole sulfide

T2687

Synonym: Omeprazole metabolite Omeprazole sulfide,Ufiprazole

Target: Proton pump, Drug Metabolite

AGN-201904

T23667

Synonym: AGN201904,AGN 201904

Target: ATPase

4-Desmethoxy Omeprazole

T10138

Synonym:

Target: Drug Metabolite

Bedaquiline fumarate

T21023

Synonym: TMC 207,R403323,TMC-207,TMC207,R-403323,R 403323

Target: Antibacterial, Antibiotic

Levolansoprazole

T20714

Synonym: (S)-Lansoprazole,(-)-Lansoprazole

Target: Proton pump

Abeprazan hydrochloride

T10221

Synonym: DWP14012 hydrochloride,Fexuprazan hydrochloride

Target: Proton pump

SKF-97574 HCl

T28794

Synonym: SKF97574,SKF-97574,B-9937-051,BY 574,SKF 97574,SK&F-97574

Target:

Lansoprazole Sulfide D4

T11817

Synonym:

Target: Proton pump

SK&F-95601

T28787

Synonym: SK&F 95601,SKF95601,SKF 95601,SKF-95601

Esomeprazole strontium

T68303

Synonym:

Target:

Nepaprazole sodium dihydrate

Synonym: E-3710,Z215,E3710,Z 215,E 3710,Z-215

Synonym: AG-1749 D4,Lansoprazole D4

Target: Proton pump

S-Pantoprazole sodium trihydrate

T81119

Synonym:

Target: Proton pump

5-Hydroxylansoprazole

T14051

Synonym: AG1908

Target: Proton pump

Cat No.	Product Name	Synonyms	Targets
TQ0184	Chebulinic acid		ATPase , Proton pump , DNA/RNA Synthesis , Antibacterial , TGF-beta/Smad
	Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
TN1103	Diphyllin		ATPase , Proton pump , Influenza Virus , HIV Protease
	Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling.		ATPase , Proton pump , Influenza Virus , HIV Protease
T6740	Bafilomycin A1		Apoptosis , Proton pump , Antibacterial , Antibiotic , Autophagy
	Bafilomycin A1 belongs to the macrolide class of antibiotics and is a V-ATPase (IC50=0.44 nM) that is specific and reversible. Bafilomycin A1 is an inhibitor of the late phase of autophagy, blocking the fusion of autopha...
T6368	Abscisic Acid	Abscisin II,Dormin,(+)-ABA,Abscisic Acid (Dormin）	Others , Proton pump , Endogenous Metabolite
	Abscisic Acid (Dormin) is a plant hormone, which is involved in many plant developmental processes, modulates ion homeostasis and metabolism, and inhibits germination and seedling growth.		Others , Proton pump , Endogenous Metabolite
T21651	Lansoprazole sodium	Lansoprazole (sodium), AG-1749 sodium	Proton pump , Phospholipase , Antibacterial
	Lansoprazole sodium (Lansoprazole (sodium)) is a proton pump inhibitor (PPI) and a potent inhibitor of gastric acidity which is widely used in the therapy of gastroesophageal reflux and peptic ulcer disease.		Proton pump , Phospholipase , Antibacterial

Natural Products

Chebulinic acid

TQ0184

Synonym:

Target: ATPase, Proton pump, DNA/RNA Synthesis, Antibacterial, TGF-beta/Smad

Diphyllin

TN1103

Synonym:

Target: ATPase, Proton pump, Influenza Virus, HIV Protease

Bafilomycin A1

T6740

Synonym:

Target: Apoptosis, Proton pump, Antibacterial, Antibiotic, Autophagy

Abscisic Acid

T6368

Synonym: Abscisin II,Dormin,(+)-ABA,Abscisic Acid (Dormin）

Target: Others, Proton pump, Endogenous Metabolite

Lansoprazole sodium

T21651

Synonym: Lansoprazole (sodium), AG-1749 sodium

Target: Proton pump, Phospholipase, Antibacterial

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-01892	ATP4A Protein, Human, Recombinant (His & Myc)	Human	E. coli
	The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric ...
TMPH-01893	ATP4B Protein, Human, Recombinant (GST)	Human	E. coli
	The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane...
TMPH-01894	ATP4B Protein, Human, Recombinant	Human	E. coli
	The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane...
TMPH-02310	ATP6V0D1 Protein, Human, Recombinant (GST)	Human	E. coli
	Subunit of the integral membrane V0 complex of the lysosomal proton-transporting V-type ATPase (v-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providin...
TMPH-00785	Bacteriorhodopsin Protein, Halobacterium halobium, Recombinant (His & Myc & SUMO)	Halobacterium halobium	E. coli
	Light-driven proton pump.