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GPCR/G Protein Protease-activated Receptor

Protease-activated Receptor

Protease-activated receptors (PAR) are a subfamily of related G protein-coupled receptors that are activated by cleavage of part of their extracellular domain. They are highly expressed in platelets, and also on endothelial cells, myocytes and neurons.
Cat No. product name
T8917 IUN76750 IUN76750 is a PAR-​2 signaling pathway inhibitor with anti-inflammatory and anticancer effects.
T7513 Protease-Activated Receptor-2, amide Protease-Activated Receptor-2, amide is an agonist of PAR2 (IC50 : 10.4 M)
T1986L Atopaxar Hydrobromide Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Arte...
T7013 Vorapaxar Vorapaxar (SCH 530348) is an effective and orally active thrombin receptor (PAR-1) antagonist (Ki: 8.1 nM).
T3098 Vorapaxar sulfate Vorapaxar sulfate is a potent and orally active thrombin receptor (PAR-1) antagonist.
T4186 AC264613 AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory factor 5 and decreases interleukin-12p40 pr...
T7137 I-191 I-191 is a potent antagonist of protease-activated receptor 2 (PAR2), inhibits multiple signaling functions in human cancer cells.
T7496 Thrombin Receptor Activator for Peptide Thrombin Receptor Activator for Peptide is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of co...
T7380 Protease-Activated Receptor-4 Protease-Activated Receptor-4 is the proteinase-activated receptor-4 (PAR4)  agonist, with Antiplatelet Therapy
T7674 Thrombin Receptor Activator for Peptide Thrombin Receptor Activator for Peptide is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of co...
TQ0012 AZ3451 AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).
T7573 TFLLR-NH2(2TFA) TFLLR-NH2(2TFA) is an agonist of PAR1 (EC50 :1.9 μM).
T8917 IUN76750 IUN76750 is a PAR-​2 signaling pathway inhibitor with anti-inflammatory and anticancer effects.
T7623 PAR-4 Agonist Peptide, amide PAR-4 Agonist Peptide, amide is an agonist of proteinase-activated receptor-4 (PAR-4).
T7625 TRAP-6(2TFA) TRAP-6(2TFA) is an agonist of protease-activated receptor 1 (PAR1).
T7740 Protease-Activated Receptor-4 diTFA(245443-52-1(free base)) Protease-Activated Receptor-4 diTFA,2454 is the proteinase-activated receptor-4 (PAR4)agonist
TP1065 PAR-4 Agonist Peptide, amide TFA PAR-4 Agonist Peptide, amide TFA is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocke...
TP1378 2-Furoyl-LIGRLO-amide TFA(729589-58-6 free base) 2-Furoyl-LIGRLO-amide is a potent and selective protease-activated receptor 2 (PAR2) agonist.
T7573L TFLLR-NH2 2TFA(197794-83-5(free base)) TFLLR-NH2(2TFA) is an agonist of PAR1 (EC50 :1.9 μM).
TP1046L PAR-2 Activating Peptide acetate(171436-38-7 free base) PAR-2 Activating Peptide acetate is an agonist of Protease-Activated Receptor-2 (PAR-2).
TP1046L PAR-2 Activating Peptide acetate(171436-38-7 free base) PAR-2 Activating Peptide acetate is an agonist of Protease-Activated Receptor-2 (PAR-2).
TP1925L TcY-NH2 TFA(327177-34-4 free base) tcY-NH2 TFA is a selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.
TP1904L FSLLRY-NH2 TFA(245329-02-6 free base) FSLLRY-NH2 TFA is a is a protease-activated receptor 2 (PAR2) inhibitor. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in I...
T1893 ML 161 ML 161 is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selectin expressio...
IUN76750
T8917CAS 1690176-75-0
IUN76750 is a PAR-​2 signaling pathway inhibitor with anti-inflammatory and anticancer effects.
Protease-Activated Receptor-2, amide
T7513CAS 190383-13-2
Protease-Activated Receptor-2, amide is an agonist of PAR2 (IC50 : 10.4 M)
Atopaxar Hydrobromide
T1986LCAS 474550-69-1
Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Arte...
Vorapaxar
T7013CAS 618385-01-6
Vorapaxar (SCH 530348) is an effective and orally active thrombin receptor (PAR-1) antagonist (Ki: 8.1 nM).
Vorapaxar sulfate
T3098CAS 705260-08-8
Vorapaxar sulfate is a potent and orally active thrombin receptor (PAR-1) antagonist.
AC264613
T4186CAS 1051487-82-1
AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory factor 5 and decreases interleukin-12p40 pr...
I-191
T7137CAS 1690172-25-8
I-191 is a potent antagonist of protease-activated receptor 2 (PAR2), inhibits multiple signaling functions in human cancer cells.
Thrombin Receptor Activator for Peptide
T7496CAS 141685-53-2
Thrombin Receptor Activator for Peptide is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of co...
Protease-Activated Receptor-4
T7380CAS 245443-52-1
Protease-Activated Receptor-4 is the proteinase-activated receptor-4 (PAR4)  agonist, with Antiplatelet Therapy
Thrombin Receptor Activator for Peptide
T7674CAS T7674
Thrombin Receptor Activator for Peptide is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of co...
AZ3451
TQ0012CAS 2100284-59-9
AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).
TFLLR-NH2(2TFA)
T7573CAS 197794-83-5
TFLLR-NH2(2TFA) is an agonist of PAR1 (EC50 :1.9 μM).
IUN76750
T8917CAS 1690176-75-0
IUN76750 is a PAR-​2 signaling pathway inhibitor with anti-inflammatory and anticancer effects.
PAR-4 Agonist Peptide, amide
T7623CAS 352017-71-1
PAR-4 Agonist Peptide, amide is an agonist of proteinase-activated receptor-4 (PAR-4).
TRAP-6(2TFA)
T7625CAS 141136-83-6
TRAP-6(2TFA) is an agonist of protease-activated receptor 1 (PAR1).
Protease-Activated Receptor-4 diTFA(245443-52-1(free base))
T7740CAS T7740
Protease-Activated Receptor-4 diTFA,2454 is the proteinase-activated receptor-4 (PAR4)agonist
PAR-4 Agonist Peptide, amide TFA
TP1065CAS 1228078-65-6
PAR-4 Agonist Peptide, amide TFA is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocke...
2-Furoyl-LIGRLO-amide TFA(729589-58-6 free base)
TP1378CAS TP1378
2-Furoyl-LIGRLO-amide is a potent and selective protease-activated receptor 2 (PAR2) agonist.
TFLLR-NH2 2TFA(197794-83-5(free base))
T7573LCAS T7573L
TFLLR-NH2(2TFA) is an agonist of PAR1 (EC50 :1.9 μM).
PAR-2 Activating Peptide acetate(171436-38-7 free base)
TP1046LCAS TP1046L
PAR-2 Activating Peptide acetate is an agonist of Protease-Activated Receptor-2 (PAR-2).
PAR-2 Activating Peptide acetate(171436-38-7 free base)
TP1046LCAS TP1046L
PAR-2 Activating Peptide acetate is an agonist of Protease-Activated Receptor-2 (PAR-2).
tcY-NH2 TFA(327177-34-4 free base)
TP1925LCAS TP1925L
tcY-NH2 TFA is a selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.
FSLLRY-NH2 TFA(245329-02-6 free base)
TP1904LCAS TP1904L
FSLLRY-NH2 TFA is a is a protease-activated receptor 2 (PAR2) inhibitor. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in I...
ML 161
T1893CAS 423735-93-7
ML 161 is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selectin expressio...