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Search Results for " prostaglandin-receptor "

Targets

143

Compounds

12

Natural Products

4

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T8883 Pizuglanstat Others , Prostaglandin Receptor
Pizuglanstat is a hematopoietic prostaglandin synthase inhibitor.
T15681 L-161982 Prostaglandin Receptor
L-161982 is a selective antagonist of EP4 receptor. L-161982 could inhibit PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 could alleviate collagen-induced arthritis in mice.
T9153 Picotamide Others
Picotamide has anticoagulant and fibrinolytic properties.
T5505 Terutroban Prostaglandin Receptor
Terutroban, a thromboxane prostaglandin receptor antagonist, affects the progression of atherosclerosis.
T5386 Asapiprant Prostaglandin Receptor
Asapiprant (S-555739) is a potent and selective DP1 receptor antagonist (Ki: 0.44 nM). It exhibited high affinity and selectivity for the DP1 receptor.
T11211 EP4 receptor antagonist 1 Prostaglandin Receptor
EP4 Receptor Antagonist 1 is a highly potent and selective competitive prostanoid EP4 receptor antagonist, effective for cancer immunotherapy. It inhibits both human and mouse EP4 receptors with IC50 values of 6.1 nM and...
T2428 TG6-10-1 5-HT Receptor , Prostaglandin Receptor
TG6-10-1 is an EP2 antagonist.
T5482 TG4-155 Prostaglandin Receptor
TG4-155 is a brain penetrant EP2 antagonist (KB = 2.4 nM) that is over 1000-fold less effective at EP4 (KB = 11.4 µM) and a panel of other receptors and channels
T14148 AH 6809 Prostaglandin Receptor
AH 6809 is an antagonist of EP and DP receptor(with Kis of 1217, 1150, 1597, and 1415 nM for the cloned human EP1, EP2, EP3-III, and DP receptor respectively). AH 6809 has a Ki of 350 nM for mouse EP2 receptor.
TQ0025 E7046 Prostaglandin Receptor
E7046 is a specific, orally bioavailable EP4 antagonist (IC50: 13.5 nM, Ki: 23.14 nM), exhibiting anti-tumor activities.
T6399 AZD1981 GPR , Prostaglandin Receptor
AZD1981 is an effective and specific CRTh2 (DP2) receptor antagonist (IC50: 4 nM), showing >1000-fold selectivity over more than 340 other enzymes and receptors, including DP1. AZD1981 has been used in trials studying th...
T4546 Dinoprost tromethamine salt Dinoprost Tromethamine,Zinoprost,Prostin F2 alpha,PGF2α THAM,Dinolytic,Prostaglandin F2α THAM Apoptosis , Endogenous Metabolite , Prostaglandin Receptor , Autophagy , PROTAC Linker
Dinoprost tromethamine salt (PGF2α THAM) is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.
T16280 Nedocromil FPL 59002 Leukotriene Receptor , Prostaglandin Receptor , Histamine Receptor
Nedocromil (FPL 59002) inhibits the action or formation of multiple mediators. Which including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).
T15712 Laropiprant MK-0524 Prostaglandin Receptor
Laropiprant (MK-0524) is a potent and selective antagonist of prostaglandin D2 (PGD2) receptor (DP) such as and DP/DP1 receptor(Ki = 0.57 nM) and TP Receptor(Ki = 2.95 nM).
T2664 Timapiprant OC000459 GPR , Prostaglandin Receptor
Timapiprant (OC000459) is a potent and selective D prostanoid receptor 2 (DP2) antagonist (IC50: 13 nM).
T4635 Ralinepag APD811 Others , Prostaglandin Receptor
Ralinepag (APD811) is a potent, orally bioavailable agonist of non-prostanoid prostacyclin (IP) receptor, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively.
T28958 TG6-129 TG6 129 Prostaglandin Receptor
TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 µM. TG6-129 reduces the expression of COX-2, IL-1β, IL-6, IL-12, IL-23 and...
T12268 NTP42 Prostaglandin Receptor , PPAR
NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)
T1978 GW627368 GW 627368X Prostaglandin Receptor
GW627368 (GW 627368X)X is a novel, potent and selective antagonist of prostanoid EP4 receptor.
T3306 PF-04418948 PF 04418948,PF04418948 Prostaglandin Receptor
PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a divers...
T3276 Benorilate Benortan,Benoral,Salipran,Benorylate Prostaglandin Receptor
Benorilate (Salipran) is the esterification product of paracetamol and acetylsalicylic acid with anti-inflammatory, analgesic and antipyretic properties.
T2690 Tranilast MK 341,SB 252218 RAAS , Prostaglandin Receptor
Tranilast (SB 252218), an antiallergic drug, suppresses lipid mediator and cytokine release from inflammatory cells, therefore utilized in the treatment of allergic disorders.
T2396 Ramatroban BAY u3405 GPR , Prostaglandin Receptor , PPAR
Ramatroban (BAY u3405) (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. It has been used in trials studying the treatment of Asthma.
T7652 AM211 AM211 free acid Prostaglandin Receptor
AM211 (AM211 free acid) is a potent and orally bioavailable antagonist of prostaglandin D2 (PGD2) receptor type 2 (DP2)
T0002 Ethamsylate Cyclonamine,Etamsylate,Dicynene,Aglumin Prostaglandin Receptor
Ethamsylate (Dicynene) usually is used as a hemostatic drug, which increases capillary endothelial resistance and platelet adhesion, and inhibits biosynthesis and action of prostaglandins.
T9622 MF-766 Prostaglandin Receptor
MF-766 is a highly potent, selective and orally active EP4 antagonist with a Ki of 0.23 nM. It behaves as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay. It...
T15108 DG-041 Prostaglandin Receptor
DG-041 is an antagonist of high-affinity EP3 receptor (IC50s: 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively). DG-041 inhibits PGE2 facilitation of platelet aggregation and has the blood-brain barrier per...
T3174 Taprenepag CP-544326 Prostaglandin Receptor
Taprenepag (CP-544326) (CP-544326) is a potent and selective prostaglandin E2 receptor agonist (EC50 = 2.8 nM). Taprenepag has been used in trials studying the treatment of Ocular Hypertension and Glaucoma, Open-Angle.
T2538 Bimatoprost AGN 192024 Prostaglandin Receptor
Bimatoprost (AGN 192024) is a cloprostenol-derived amide that is used as an antihypertensive agent in the treatment of open-angle glaucoma and ocular hypertension.
TQ0290 ONO-AE3-208 AE 3-208 Prostaglandin Receptor
ONO-AE3-208 (AE 3-208) is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.
T4436 RO1138452 CAY10441 Others , Prostaglandin Receptor
RO1138452 (CAY10441) is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3). It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cycli...
T17232 Vidupiprant AMG 853 Prostaglandin Receptor
Vidupiprant (AMG 853) is an effective dual antagonist of CRTH2 and prostanoid D receptor with IC50s of 8 nM and 35 nM in human plasma. Vidupiprant can be used in studies about the treatment of asthma.
T5171 Treprostinil Sodium UT-15 VEGFR , c-RET , Prostaglandin Receptor
Treprostinil Sodium (UT-15) is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).
T14565 BI-671800 AP-761,Cmpd A GPR , Prostaglandin Receptor
BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2...
T2528 Latanoprost Xalatan,PHXA41 GPR , Prostaglandin Receptor , RAR/RXR 
Latanoprost (Xalatan) is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect.
T0212 Seratrodast AA 2414,ABT-001 COX , Prostaglandin Receptor , PPAR
Seratrodast (ABT-001) (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor antagonist developed as an anti-asthmatic drug and attained ma...
T6236 Ozagrel OKY-046,Domenan Thrombin , Prostaglandin Receptor
Ozagrel (Domenan) is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral isch...
T21976 ONO-8130 Prostaglandin Receptor
ONO-8130 is an orally available antagonist of EP1 receptor.
T5150 Treprostinil LRX-15,Orenitram,Remodulin Prostaglandin Receptor
Treprostinil (Orenitram) is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).
T3216 Selexipag NS-304,ACT-293987,Uptravi Others , Prostaglandin Receptor
Selexipag (ACT-293987)(NS-304) is prostacyclin receptor agonist that causes vasodilation in pulmonary vasculature and is used in the therapy of pulmonary arterial hypertension (PAH).
T1562 Rebamipide Proamipide,OPC12759 Free radical scavengers , COX , Prostaglandin Receptor
Rebamipide (OPC12759) is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis ...
T14975 CJ-42794 CJ-042794 Others
CJ-42794 (CJ-042794) is a selective antagonist of prostaglandin E receptor subtype 4 (EP4). It inhibits [3H]-PGE2 binding to the human EP4 receptor (a mean pKi: 8.5). CJ-42794 is a binding affinity that was at least 200-...
T5841 Travoprost Flu-Ipr,Fluprostenol isopropyl ester,AL6221 Prostaglandin Receptor
Travoprost (Fluprostenol isopropyl ester) is used to treat glaucoma and ocular hypertension,is a potent and selective FP prostaglandin receptor agonist.
TP1929L1 Saralasin acetate(34273-10-4 free base) RAAS
Saralasin acetate is a Non-selective angiotensin II antagonist.
T83779 EP4 Antagonist 14 Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14
EP4 antagonist 14 is a prostaglandin E2 receptor subtype EP4 antagonist, demonstrating an IC50 of 1.1 nM in a HEK293 human receptor reporter assay and blocking β-arrestin recruitment due to PGE2 with an IC50 of 0.9 nM. A...
T6625 Ozagrel hydrochloride Ozagrel HCl,OKY-046 HCl Thrombin , Prostaglandin Receptor
Ozagrel hydrochloride (OKY-046 HCl) is a selective thromboxane A(2) synthetase inhibitor used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia.
T3520 Setipiprant KYTH-105,ACT-129968 GPR , Prostaglandin Receptor
Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in vari...
T26745 BAY 73-1449 BAY-73-1449,BAY73-1449 Others
BAY-73-1449 is an antagonist of prostacyclin receptor.
TQ0292 Grapiprant AAT-007,RQ-00000007,CJ-023423 Prostaglandin Receptor
Grapiprant (AAT-007) is a selective EP4 receptor antagonist. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor (IC50: 35 nM, Ki: 24 nM).
T3965 Fevipiprant QAW039,NVP-QAW039 GPR , Prostaglandin Receptor
Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist.

Compounds

Pizuglanstat
T8883
Synonym:
Target: Others, Prostaglandin Receptor
L-161982
T15681
Synonym:
Target: Prostaglandin Receptor
Picotamide
T9153
Synonym:
Target: Others
Terutroban
T5505
Synonym:
Target: Prostaglandin Receptor
Asapiprant
T5386
Synonym:
Target: Prostaglandin Receptor
EP4 receptor antagonist 1
T11211
Synonym:
Target: Prostaglandin Receptor
TG6-10-1
T2428
Synonym:
Target: 5-HT Receptor, Prostaglandin Receptor
TG4-155
T5482
Synonym:
Target: Prostaglandin Receptor
AH 6809
T14148
Synonym:
Target: Prostaglandin Receptor
E7046
TQ0025
Synonym:
Target: Prostaglandin Receptor
AZD1981
T6399
Synonym:
Target: GPR, Prostaglandin Receptor
Dinoprost tromethamine salt
T4546
Synonym: Dinoprost Tromethamine,Zinoprost,Prostin F2 alpha,PGF2α THAM,Dinolytic,Prostaglandin F2α THAM
Target: Apoptosis, Endogenous Metabolite, Prostaglandin Receptor, Autophagy, PROTAC Linker
Nedocromil
T16280
Synonym: FPL 59002
Target: Leukotriene Receptor, Prostaglandin Receptor, Histamine Receptor
Laropiprant
T15712
Synonym: MK-0524
Target: Prostaglandin Receptor
Timapiprant
T2664
Synonym: OC000459
Target: GPR, Prostaglandin Receptor
Ralinepag
T4635
Synonym: APD811
Target: Others, Prostaglandin Receptor
TG6-129
T28958
Synonym: TG6 129
Target: Prostaglandin Receptor
NTP42
T12268
Synonym:
Target: Prostaglandin Receptor, PPAR
GW627368
T1978
Synonym: GW 627368X
Target: Prostaglandin Receptor
PF-04418948
T3306
Synonym: PF 04418948,PF04418948
Target: Prostaglandin Receptor
Benorilate
T3276
Synonym: Benortan,Benoral,Salipran,Benorylate
Target: Prostaglandin Receptor
Tranilast
T2690
Synonym: MK 341,SB 252218
Target: RAAS, Prostaglandin Receptor
Ramatroban
T2396
Synonym: BAY u3405
Target: GPR, Prostaglandin Receptor, PPAR
AM211
T7652
Synonym: AM211 free acid
Target: Prostaglandin Receptor
Ethamsylate
T0002
Synonym: Cyclonamine,Etamsylate,Dicynene,Aglumin
Target: Prostaglandin Receptor
MF-766
T9622
Synonym:
Target: Prostaglandin Receptor
DG-041
T15108
Synonym:
Target: Prostaglandin Receptor
Taprenepag
T3174
Synonym: CP-544326
Target: Prostaglandin Receptor
Bimatoprost
T2538
Synonym: AGN 192024
Target: Prostaglandin Receptor
ONO-AE3-208
TQ0290
Synonym: AE 3-208
Target: Prostaglandin Receptor
RO1138452
T4436
Synonym: CAY10441
Target: Others, Prostaglandin Receptor
Vidupiprant
T17232
Synonym: AMG 853
Target: Prostaglandin Receptor
Treprostinil Sodium
T5171
Synonym: UT-15
Target: VEGFR, c-RET, Prostaglandin Receptor
BI-671800
T14565
Synonym: AP-761,Cmpd A
Target: GPR, Prostaglandin Receptor
Latanoprost
T2528
Synonym: Xalatan,PHXA41
Target: GPR, Prostaglandin Receptor, RAR/RXR 
Seratrodast
T0212
Synonym: AA 2414,ABT-001
Target: COX, Prostaglandin Receptor, PPAR
Ozagrel
T6236
Synonym: OKY-046,Domenan
Target: Thrombin, Prostaglandin Receptor
ONO-8130
T21976
Synonym:
Target: Prostaglandin Receptor
Treprostinil
T5150
Synonym: LRX-15,Orenitram,Remodulin
Target: Prostaglandin Receptor
Selexipag
T3216
Synonym: NS-304,ACT-293987,Uptravi
Target: Others, Prostaglandin Receptor
Rebamipide
T1562
Synonym: Proamipide,OPC12759
Target: Free radical scavengers, COX, Prostaglandin Receptor
CJ-42794
T14975
Synonym: CJ-042794
Target: Others
Travoprost
T5841
Synonym: Flu-Ipr,Fluprostenol isopropyl ester,AL6221
Target: Prostaglandin Receptor
Saralasin acetate(34273-10-4 free base)
TP1929L1
Synonym:
Target: RAAS
EP4 Antagonist 14
T83779
Synonym: Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14
Target:
Ozagrel hydrochloride
T6625
Synonym: Ozagrel HCl,OKY-046 HCl
Target: Thrombin, Prostaglandin Receptor
Setipiprant
T3520
Synonym: KYTH-105,ACT-129968
Target: GPR, Prostaglandin Receptor
BAY 73-1449
T26745
Synonym: BAY-73-1449,BAY73-1449
Target: Others
Grapiprant
TQ0292
Synonym: AAT-007,RQ-00000007,CJ-023423
Target: Prostaglandin Receptor
Fevipiprant
T3965
Synonym: QAW039,NVP-QAW039
Target: GPR, Prostaglandin Receptor
1 2 3
Cat No. Product Name Synonyms Targets
T5014 Prostaglandin E2 PGE2,Dinoprostone,Prostaglandin E2 (PGE2) Endogenous Metabolite , Prostaglandin Receptor
Prostaglandin E2 (PGE2) is a naturally occurring hormone involved in a variety of physiological processes in the body, including smooth muscle contraction and relaxation, regulation of vasodilatation and constriction, re...
T15133 Dinoprost Prostaglandin F2a,PGF2α Endogenous Metabolite
Dinoprost (Prostaglandin F2a) is a naturally occurring prostaglandin. It is used in medicine to induce labor and as an abortifacient.
T1626 Prostaglandin E1 PGE1,Alprostadil Endogenous Metabolite , Prostaglandin Receptor
Prostaglandin E1 (Alprostadil) is the naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Prostaglandin E1 is a potent vasodilator agent that increases peripheral blood flow, in...
T2S0765 Epibetulinic acid NO Synthase , Prostaglandin Receptor
Epibetulinic acid has anti-inflammatory activity, it exhibits potent inhibitory effects on NO and prostaglandin E(2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin.
T14865 Carboprost tromethamine Prostaglandin Receptor
Carboprost tromethamine, a synthetic 15-methyl analogue of prostaglandin F2α, effectively promotes uterine contractions and significantly reduces bleeding during and post-delivery.
T3868 Agnuside chasteberry oil COX , Prostaglandin Receptor , P-gp
Agnuside (chasteberry oil) inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at conce...
T4S0227 Sinensetin Pedalitin permethyl ether TNF , PGE Synthase
Sinensetin (Pedalitin permethyl ether) is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.
T2791 Pectolinarin Apoptosis , Others , NO Synthase , Prostaglandin Receptor , Interleukin
Pectolinarin is a Cirsium isolate with anti-inflammatory activity.
T3S2007 MRE-269 MRE 269,ACT-333679,MRE269 Prostaglandin Receptor
MRE-269 (ACT-333679) is an orally available and long-acting prostacyclin receptor agonist prodrug. MRE-269(ACT-333679) is used for the treatment of pulmonary arterial hypertension. MRE-269(ACT-333679) is an active metabo...
T3915 Ginsenoside Ro Chikusetsusaponin 5,Polysciasaponin P3,Chikusetsusaponin V Calcium Channel , Reductase , Prostaglandin Receptor
Ginsenoside Ro (Chikusetsusaponin V) can reduce TXA2 production, weakly reduce COX-1 and TXAS activities, and has antiplatelet effects as a Ca2+ antagonist with an IC50 of 155 μM.
T7053 P-Hydroxycinnamic acid p-Coumaric acid,p-Cumaric acid,p-Hydroxy-cinnamic acid,NSC 59260 Thrombin , Endogenous Metabolite , Prostaglandin Receptor
p-Hydroxycinnamic acid (NSC-59260) can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively.
TQ0203 Tafluprost MK2452,AFP-168 Prostaglandin Receptor
Tafluprost, a prostaglandin analog, is the selective agonist of fluoroprostaglandin (FP) receptor PGF2α.

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-03876 PTGFRN Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
EWI-F, also known as PTGFRN, is inversely related to the loss of CD9. Its expression correlates with the metastatic status of hLT. EWI-F inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP rece...
TMPH-00278 Interferon tau-1/IFNT1 Protein, Bovine, Recombinant (E. coli, His) Bovine E. coli
Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-...
TMPH-00279 Interferon tau-1/IFNT1 Protein, Bovine, Recombinant (His) Bovine Yeast
Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-...
TMPH-00308 ISG15 Protein, Bovine, Recombinant (His) Bovine E. coli
Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation i...
TargetMol