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GPCR/G Protein Prostaglandin Receptor

Prostaglandin Receptor

Prostaglandin receptors or prostanoid receptors represent a sub-class of cell surface membrane receptors that are regarded as the primary receptors for one or more of the classical, naturally occurring prostanoids viz., prostaglandin D2, PGE2, PGF2alpha, prostacyclin (PGI2), thromboxane A2 (TXA2), and PGH2. They are named based on the prostanoid to which they preferentially bind and respond, e.g. the receptor responsive to PGI2 at lower concentrations than any other prostanoid is named the Prostacyclin receptor (IP). One exception to this rule is the receptor for thromboxane A2 (TP) which binds and responds to PGH2 and TXA2 equally well.
Cat No. product name
T8993L BGC-20-1531 hydrochloride(1186532-61-5 free base) BGC201531 hydrochloride is a EP4 antagonist for the treatment of acute migraine.
TN1171 1-Dehydro-6-gingerdione 1-Dehydro-6-gingerdione is a 5-HT1A receptor partial agonist.
TQ0025 E7046 E7046 is a specific, orally bioavailable EP4 antagonist (IC50: 13.5 nM, Ki: 23.14 nM), exhibiting anti-tumor activities.
TQ0203 Tafluprost Tafluprost, a prostaglandin analog, is the selective agonist of fluoroprostaglandin (FP) receptor PGF2α.
TQ0290 ONO-AE3-208 ONO-AE3-208 is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.
TQ0292 Grapiprant Grapiprant is a selective EP4 receptor antagonist. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor (IC50: 35 nM, Ki: 24 nM).
T7968 Dazoxiben Dazoxiben is a potent inhibitor of thromboxane (TX) synthase
TN1006 Tirucallol Tirucallol is an antiinflammatory agent isolated from Euphorbia lactea.Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action re...
TN1009 Epimagnolin B Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the s...
TN1019 Beta-mangostin Beta-mangostin has cytotoxic, and anti-inflammatory effects, it exhibits strong antibacterial activity
TN1077 Taraxerol Taraxerol can be used as a lipid biomarker for mangrove input to the SE Atlantic.
TN1109 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7...
TN1134 Euscaphic acid Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 w...
TN1238 3,4-O-Isopropylidene shikimic acid 3,4-Oxo- isopropylidene-shikimic acid has significant anti-inflammatory, anti-thrombosis, antioxidant, analgesic effects, it has protective effects on experiment...
T5841 Travoprost Travoprost is used to treat glaucoma and ocular hypertension,is a potent and selective FP prostaglandin receptor agonist.
TN1257 3-O-Acetyl-alpha-boswellic acid 3-O-Acetyl-alpha-boswellic acid has strong anti-inflammatory activity.
TN1362 Afzelin Afzelin has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protec...
TN1378 Alpha-Viniferin Alpha-viniferin is a prostaglandin H2 synthase inhibitor, which has anti-inflammatory, anti-oxidant, anti-arthritis, and anti-tumor activities.
TN1440 Beta-Hydroxyisovalerylshikonin Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in ...
TN1485 Chicanine Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways.
TN1524 Continentalic acid Continentalic acid from Aralia continentalis has minimum inhibitory concentrations (MICs) of approximately 8-16 µg/mL against S. aureus, including the Methicill...
TN1622 Ermanin Ermanin shows anti-inflammatory activity by suppressing the iNOS and COX-2 expression. Ermanin may have anti-HIV-1activity. Ermanin also has a high deterrent act...
TN1650 Friedelin Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities.
TN1874 Liriodendrin Liriodendrin has anti-inflammatory, antinociceptive, hypoglycemic activities, it plays protective role in sepsis-induced acute lung injury, it regulates lung inf...
TN2115 Pseudohypericin Pseudohypericin has photocytotoxic, and antiretroviral activities, it has potential therapeutic value in diseases such as AIDS.
TN2169 Saikogenin D Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation of...
T5847 Cloprostenol sodium Cloprostenol sodium is a more water solute, crystalline form of cloprostenol than the free acid, is a synthetic analog of prostaglandin F2α.
T5758 Sphondin Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of...
T10046 16,16-Dimethyl prostaglandin E2 16,16-Dimethyl prostaglandin E2 is an orally active vertebrate Hematopoietic stem cells homeostasis critical regulator. It can act through EP2/EP4 and has an int...
T3889 Platycodin D Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat periton...
T3306 PF04418948 PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, ...
T3903 Angoroside C Angoroside C is a Potential anti-inflammatory compound. Inhibitor of prostaglandin E2 release in mouse peritoneal macrophages in vitro. Shows potent antioxidat...
T0795 Rutin Rutin, a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and anticarcinogenic properties.
T2538 Bimatoprost Bimatoprost is a cloprostenol-derived amide that is used as an antihypertensive agent in the treatment of open-angle glaucoma and ocular hypertension.
T0002 Ethamsylate Ethamsylate usually is used as a hemostatic drug, which increases capillary endothelial resistance and platelet adhesion, and inhibits biosynthesis and action of...
T2786 Oxysophocarpine Oxysophocarpine is extracted from Sophra flavescens Ait.
T1978 GW 627368X GW627368X is a novel, potent and selective antagonist of prostanoid EP4 receptor.
T3276 Benorilate Benorylate is the esterification product of paracetamol and acetylsalicylic acid with anti-inflammatory, analgesic and antipyretic properties.
T2868 Evodiamine Evodiamine, an indole alkaloid found in Evodia rutaescarpa, acts as an anti-inflammatory compound.
T0159 Pranoprofen Pranoprofen (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology.
T6485 Embelin Embelin, isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
T1626 Alprostadil Alprostadil is the naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Alprostadil is a potent vasodilator agent that ...
T5774 7-demethylsuberosin 7-demethylsuberosin is a coumarin compound isolated from Angelica gigas Nakai,and has anti-inflammatory activity,and exhibited  inhibitory effects on PGE2 prod...
T3174 Taprenepag Taprenepag (CP-544326) is a potent and selective prostaglandin E2 receptor agonist (EC50 = 2.8 nM). Taprenepag has been used in trials studying the treatment of ...
T7053 P-Hydroxy-cinnamic acid p-Hydroxycinnamic acid can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E...
T3S2007 MRE269 MRE-269 is an orally available and long-acting prostacyclin receptor agonist prodrug. MRE-269 is used for the treatment of pulmonary arterial hypertension. MRE-2...
T4546 Dinoprost Tromethamine Dinoprost(Prostaglandin F2α) tromethamine salt is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.
T4635 Ralinepag Ralinepag is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP re...
T5014 Prostaglandin E2 (PGE2) Prostaglandin E2 is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dila...
T5150 Treprostinil Treprostinil is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).
T5171 Treprostinil Sodium Treprostinil is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).
T4981 Anisotropine Methylbromide Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion.
T5386 Asapiprant Asapiprant (S-555739) is a potent and selective DP1 receptor antagonist (Ki: 0.44 nM). It exhibited high affinity and selectivity for the DP1 receptor.
T5482 TG4-155 TG4-155 is a brain penetrant EP2 antagonist (KB = 2.4 nM) that is over 1000-fold less effective at EP4 (KB = 11.4 µM) and a panel of other receptors and channel...
T12100 MPGES1-IN-3 mPGES1-IN-3 is a potent and selective inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) .
T13488 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound that inhibits stress-induced ulcer. It can maintain the content of phospholipase A2 and pros...
T21976 ONO-8130 ONO-8130 is an orally available antagonist of EP1 receptor.
TN4592 Murrangatin Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the hig...
TN4038 Eupatolide Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradation...
TN4046 Excisanin A ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
TN4062 Flavidin Flavidin shows very good antioxidant capacity. Flavidin can enhance fluorescent imaging, allowing more sensitive and specific cell labeling in tissues, it should...
TN4064 Flavoglaucin Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
TN4162 Goshonoside F5 Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
TN4194 Heliangin Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cel...
TN4303 Isokaempferide Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by red...
TN4420 Latifolin Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latif...
TN4463 Lupeolic acid Lupeolic acid has anti-inflammatory activity.
TN4465 Luvangetin Luvangetin may have anti-inflammatory activity, it can inhibit NO and PGE2 production in LPS-stimulated BV2 cells. Luvangetin shows significant protection agains...
TN4489 Manassantin A Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
TN4635 Neoechinulin A Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block th...
TMA0291 Dehydroglyasperin D Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
TN4675 Nortrachelogenin Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth ...
TN4748 Penduletin Penduletin has anti-inflammatory,anti-tumor cells, and anti-bacterical activities,it inhibits growth of the Gram-negative pathogen neisseria gonorrhoeae. Pendule...
TN4879 Questinol Questinol exhibits significant anti-obesity activity. It shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit th...
TMA1570 Sappanone A Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 ...
TN4959 Schizandriside Schizandriside may have anti-inflammatory effects, it has inhibitory activities against nitric oxide and prostaglandin E(2) production in IFN-γ- and lipopolysac...
TN5011 Shizukaol B Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
TN5017 Sideritoflavone Sideritoflavone has anti-inflammatory effect, it is a selective inhibitor of lipoxygenase activity in vitro.
TN5019 Siegeskaurolic acid Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via...
TN5033 Skullcapflavone I Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and...
TN5248 Voleneol 1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-depende...
T8993 BGC201531 BGC201531 is a EP4 antagonist for the treatment of acute migraine.
TN3839 Desoxo-narchinol A Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
TN3587 Capillarisin Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
T14139 Aganepag Aganepag is a potent Prostanoid EP2 receptor agonist, with an EC50 of 0.19 nM. It shows no activity at EP4 receptor. Aganepag can be used in the research of woun...
T15690 L-902688 L-902688 is an orally active EP4 receptor agonist (Ki: 0.38 nM; EC50: 0.6 nM). L-902688 displays >4,000-fold selective for EP4 over other EP and prostanoid recep...
T14146 AGN 210676 AGN 210676 is a selective agonist of prostaglandin EP2(EC50 : 5 nM).
T14148 AH 6809 AH 6809 is an antagonist of EP and DP receptor(with Kis of 1217, 1150, 1597, and 1415 nM for the cloned human EP1, EP2, EP3-III, and DP receptor respectively). A...
T14500 BAY-1316957 BAY-1316957 is a highly potent and selective EP4 receptor antagonist. With an IC50 of 15.3 nM. Good oral bioavailability[1].
T14865 Carboprost tromethamine Carboprost tromethamine is the synthetic 15-methyl analogue of prostaglandin F2α and it can effectively promote law contraction of the uterus and significantly ...
T15259 Evatanepag Evatanepag is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.CP-533536 demonstrated the ability ...
T15259 Evatanepag Evatanepag is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.CP-533536 demonstrated the ability ...
T11211 EP4 receptor antagonist 1 EP4 receptor antagonist 1 inhibits human and mouse EP4 receptor with IC50s of 6.1 nM and 16.2 nM, respectively. IC50s >10 μM for human EP1, EP2,and EP3 recepto...
T11340 Furprofen Furprofen acts via the inhibition of prostaglandin (PGE) synthesis. Furprofen can be treated orally for the relief of pain. Furprofen is an non-steroidal anti-...
T15642 KAG-308 KAG-308 is an effective selective and orally active agonist of the EP4 receptor (Ki: 2.57 nM and EC50: 17 nM for human EP4 receptor), more selective over EP1, EP...
T15681 L-161982 L-161982 is a selective EP4 receptor antagonist. L-161982 decreases collagen-induced arthritis in mice. L-161982 fully blocks PGE2-induced ERK phosphorylation an...
T15689 L-798106 L-798106 is a highly selective prostanoid EP3 receptor antagonist (Ki=0.3 nM). It also has micromolar activities at EP4, EP1, and EP2 receptors (Ki: 916 nM, >500...
T13466 (+)-Talarozole (+)-Talarozole is a potent retinoic acid metabolism inhibitor .
TN3582 Canniprene Canniprene has anti-inflammatory activity, it can potently inhibit the production of inflammatory eicosanoids via the 5-lipoxygenase pathway (IC50=0.4uM) and als...
T16011 Manumycin A Manumycin A is an antibiotic. Manumycin A induces apoptosis and exerts antitumor activity. Manumycin A inhibits exosome biogenesis and secretion via targeted inh...
T16388 Omidenepag isopropyl Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration. Omidenepag isopropyl is a selective EP2 receptor agonist. Omidenep...
T16389 Omidenepag Omidenepag is a pharmacologically active form of Omidenepag Isopropyl and is a selective, non-prostanoid EP2 receptor agonist (EC50: 1.1 nM). Omidenepag displays...
T16504 PF-4693627 PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM). It is used for the treatment of inflammation caused by oste...
T16988 Taprenepag isopropyl Taprenepag isopropyl is a highly selective agonist of the EP2 receptor.
T17092 Tiaprost Tiaprost is a analog of prostaglandin F2α .
T2S0765 Epibetulinic acid Epibetulinic acid has anti-inflammatory activity, it exhibits potent inhibitory effects on NO and prostaglandin E(2) production in mouse macrophages (RAW 264.7) ...
T3P2855 Chamigrenal β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 ...
T4484 1,7-Dihydroxy-2,3-methylenedioxyxanthone 1,7-Dihydroxy-2,3-methylenedioxyxanthone has antiulcerogenic, anti-oxidation, and antihyperalgesic activities, it can inhibit the carrageenan-induced hyperalgesi...
TMA0536 2-Acetylbenzoic acid 2-Acetylbenzoic acid is more potent than 2-propionyloxybenzoic acid in inhibiting platelet function and platelet prostaglandin (PG) synthesis although the potenc...
TN3144 6,4'-Dihydroxy-7-methoxyflavanone 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. It shows inhibition of osteoclasts differentiation and function...
TN3366 Ailanthoidol Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potentia...
T7652 AM211 AM211 is a potent and orally bioavailable antagonist of prostaglandin D2 (PGD2) receptor type 2 (DP2)
BGC-20-1531 hydrochloride(1186532-61-5 free base)
T8993LCAS 1962928-26-2
BGC201531 hydrochloride is a EP4 antagonist for the treatment of acute migraine.
1-Dehydro-6-gingerdione
TN1171CAS 76060-35-0
1-Dehydro-6-gingerdione is a 5-HT1A receptor partial agonist.
E7046
TQ0025CAS 1369489-71-3
E7046 is a specific, orally bioavailable EP4 antagonist (IC50: 13.5 nM, Ki: 23.14 nM), exhibiting anti-tumor activities.
Tafluprost
TQ0203CAS 209860-87-7
Tafluprost, a prostaglandin analog, is the selective agonist of fluoroprostaglandin (FP) receptor PGF2α.
ONO-AE3-208
TQ0290CAS 402473-54-5
ONO-AE3-208 is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.
Grapiprant
TQ0292CAS 415903-37-6
Grapiprant is a selective EP4 receptor antagonist. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor (IC50: 35 nM, Ki: 24 nM).
Dazoxiben
T7968CAS 74226-22-5
Dazoxiben is a potent inhibitor of thromboxane (TX) synthase
Tirucallol
TN1006CAS 514-46-5
Tirucallol is an antiinflammatory agent isolated from Euphorbia lactea.Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action re...
Epimagnolin B
TN1009CAS 1134188-26-3
Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the s...
Beta-mangostin
TN1019CAS 20931-37-7
Beta-mangostin has cytotoxic, and anti-inflammatory effects, it exhibits strong antibacterial activity
Taraxerol
TN1077CAS 127-22-0
Taraxerol can be used as a lipid biomarker for mangrove input to the SE Atlantic.
3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid
TN1109CAS 168293-14-9
3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7...
Euscaphic acid
TN1134CAS 53155-25-2
Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 w...
3,4-O-Isopropylidene shikimic acid
TN1238CAS 183075-03-8
3,4-Oxo- isopropylidene-shikimic acid has significant anti-inflammatory, anti-thrombosis, antioxidant, analgesic effects, it has protective effects on experiment...
Travoprost
T5841CAS 157283-68-6
Travoprost is used to treat glaucoma and ocular hypertension,is a potent and selective FP prostaglandin receptor agonist.
3-O-Acetyl-alpha-boswellic acid
TN1257CAS 89913-60-0
3-O-Acetyl-alpha-boswellic acid has strong anti-inflammatory activity.
Afzelin
TN1362CAS 482-39-3
Afzelin has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protec...
alpha-Viniferin
TN1378CAS 62218-13-7
Alpha-viniferin is a prostaglandin H2 synthase inhibitor, which has anti-inflammatory, anti-oxidant, anti-arthritis, and anti-tumor activities.
Beta-Hydroxyisovalerylshikonin
TN1440CAS 7415-78-3
Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in ...
Chicanine
TN1485CAS 78919-28-5
Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways.
Continentalic acid
TN1524CAS 19889-23-7
Continentalic acid from Aralia continentalis has minimum inhibitory concentrations (MICs) of approximately 8-16 µg/mL against S. aureus, including the Methicill...
Ermanin
TN1622CAS 20869-95-8
Ermanin shows anti-inflammatory activity by suppressing the iNOS and COX-2 expression. Ermanin may have anti-HIV-1activity. Ermanin also has a high deterrent act...
Friedelin
TN1650CAS 559-74-0
Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities.
Liriodendrin
TN1874CAS 573-44-4
Liriodendrin has anti-inflammatory, antinociceptive, hypoglycemic activities, it plays protective role in sepsis-induced acute lung injury, it regulates lung inf...
Pseudohypericin
TN2115CAS 55954-61-5
Pseudohypericin has photocytotoxic, and antiretroviral activities, it has potential therapeutic value in diseases such as AIDS.
Saikogenin D
TN2169CAS 5573-16-0
Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation of...
Cloprostenol sodium
T5847CAS 55028-72-3
Cloprostenol sodium is a more water solute, crystalline form of cloprostenol than the free acid, is a synthetic analog of prostaglandin F2α.
sphondin
T5758CAS 483-66-9
Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of...
16,16-Dimethyl prostaglandin E2
T10046CAS 39746-25-3
16,16-Dimethyl prostaglandin E2 is an orally active vertebrate Hematopoietic stem cells homeostasis critical regulator. It can act through EP2/EP4 and has an int...
Platycodin D
T3889CAS 58479-68-8
Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat periton...
PF04418948
T3306CAS 1078166-57-0
PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, ...
Angoroside C
T3903CAS 115909-22-3
Angoroside C is a Potential anti-inflammatory compound. Inhibitor of prostaglandin E2 release in mouse peritoneal macrophages in vitro. Shows potent antioxidat...
Rutin
T0795CAS 153-18-4
Rutin, a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and anticarcinogenic properties.
Bimatoprost
T2538CAS 155206-00-1
Bimatoprost is a cloprostenol-derived amide that is used as an antihypertensive agent in the treatment of open-angle glaucoma and ocular hypertension.
Ethamsylate
T0002CAS 2624-44-4
Ethamsylate usually is used as a hemostatic drug, which increases capillary endothelial resistance and platelet adhesion, and inhibits biosynthesis and action of...
Oxysophocarpine
T2786CAS 26904-64-3
Oxysophocarpine is extracted from Sophra flavescens Ait.
GW 627368X
T1978CAS 439288-66-1
GW627368X is a novel, potent and selective antagonist of prostanoid EP4 receptor.
Benorilate
T3276CAS 5003-48-5
Benorylate is the esterification product of paracetamol and acetylsalicylic acid with anti-inflammatory, analgesic and antipyretic properties.
Evodiamine
T2868CAS 518-17-2
Evodiamine, an indole alkaloid found in Evodia rutaescarpa, acts as an anti-inflammatory compound.
Pranoprofen
T0159CAS 52549-17-4
Pranoprofen (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology.
Embelin
T6485CAS 550-24-3
Embelin, isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
Alprostadil
T1626CAS 745-65-3
Alprostadil is the naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Alprostadil is a potent vasodilator agent that ...
7-demethylsuberosin
T5774CAS 21422-04-8
7-demethylsuberosin is a coumarin compound isolated from Angelica gigas Nakai,and has anti-inflammatory activity,and exhibited  inhibitory effects on PGE2 prod...
Taprenepag
T3174CAS 752187-80-7
Taprenepag (CP-544326) is a potent and selective prostaglandin E2 receptor agonist (EC50 = 2.8 nM). Taprenepag has been used in trials studying the treatment of ...
p-Hydroxy-cinnamic acid
T7053CAS 7400-08-0
p-Hydroxycinnamic acid can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E...
MRE269
T3S2007CAS 475085-57-5
MRE-269 is an orally available and long-acting prostacyclin receptor agonist prodrug. MRE-269 is used for the treatment of pulmonary arterial hypertension. MRE-2...
Dinoprost Tromethamine
T4546CAS 38562-01-5
Dinoprost(Prostaglandin F2α) tromethamine salt is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.
Ralinepag
T4635CAS 1187856-49-0
Ralinepag is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP re...
Prostaglandin E2 (PGE2)
T5014CAS 363-24-6
Prostaglandin E2 is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dila...
Treprostinil
T5150CAS 81846-19-7
Treprostinil is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).
Treprostinil Sodium
T5171CAS 289480-64-4
Treprostinil is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).
Anisotropine Methylbromide
T4981CAS 80-50-2
Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion.
Asapiprant
T5386CAS 932372-01-5
Asapiprant (S-555739) is a potent and selective DP1 receptor antagonist (Ki: 0.44 nM). It exhibited high affinity and selectivity for the DP1 receptor.
TG4-155
T5482CAS 1164462-05-8
TG4-155 is a brain penetrant EP2 antagonist (KB = 2.4 nM) that is over 1000-fold less effective at EP4 (KB = 11.4 µM) and a panel of other receptors and channel...
mPGES1-IN-3
T12100CAS 1469976-70-2
mPGES1-IN-3 is a potent and selective inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) .
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide
T13488CAS 137089-36-2
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound that inhibits stress-induced ulcer. It can maintain the content of phospholipase A2 and pros...
ONO-8130
T21976CAS 459841-96-4
ONO-8130 is an orally available antagonist of EP1 receptor.
Murrangatin
TN4592CAS 37126-91-3
Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the hig...
Eupatolide
TN4038CAS 6750-25-0
Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradation...
Excisanin A
TN4046CAS 78536-37-5
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
Flavidin
TN4062CAS 83924-98-5
Flavidin shows very good antioxidant capacity. Flavidin can enhance fluorescent imaging, allowing more sensitive and specific cell labeling in tissues, it should...
Flavoglaucin
TN4064CAS 523-73-9
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
Goshonoside F5
TN4162CAS 90851-28-8
Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
Heliangin
TN4194CAS 13323-48-3
Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cel...
Isokaempferide
TN4303CAS 1592-70-7
Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by red...
Latifolin
TN4420CAS 10154-42-4
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latif...
Lupeolic acid
TN4463CAS 87355-32-6
Lupeolic acid has anti-inflammatory activity.
Luvangetin
TN4465CAS 483-92-1
Luvangetin may have anti-inflammatory activity, it can inhibit NO and PGE2 production in LPS-stimulated BV2 cells. Luvangetin shows significant protection agains...
Manassantin A
TN4489CAS 88497-87-4
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
Neoechinulin A
TN4635CAS 51551-29-2
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block th...
Dehydroglyasperin D
TMA0291CAS 517885-72-2
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
Nortrachelogenin
TN4675CAS 34444-37-6
Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth ...
Penduletin
TN4748CAS 569-80-2
Penduletin has anti-inflammatory,anti-tumor cells, and anti-bacterical activities,it inhibits growth of the Gram-negative pathogen neisseria gonorrhoeae. Pendule...
Questinol
TN4879CAS 35688-09-6
Questinol exhibits significant anti-obesity activity. It shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit th...
Sappanone A
TMA1570CAS 102067-84-5
Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 ...
Schizandriside
TN4959CAS 71222-06-5
Schizandriside may have anti-inflammatory effects, it has inhibitory activities against nitric oxide and prostaglandin E(2) production in IFN-γ- and lipopolysac...
Shizukaol B
TN5011CAS 142279-40-1
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
Sideritoflavone
TN5017CAS 70360-12-2
Sideritoflavone has anti-inflammatory effect, it is a selective inhibitor of lipoxygenase activity in vitro.
Siegeskaurolic acid
TN5019CAS 52645-97-3
Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via...
Skullcapflavone I
TN5033CAS 41060-16-6
Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and...
Voleneol
TN5248CAS 70389-88-7
1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-depende...
BGC201531
T8993CAS 1186532-61-5
BGC201531 is a EP4 antagonist for the treatment of acute migraine.
Desoxo-narchinol A
TN3839CAS 53859-06-6
Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
Capillarisin
TN3587CAS 56365-38-9
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
Aganepag
T14139CAS 910562-18-4
Aganepag is a potent Prostanoid EP2 receptor agonist, with an EC50 of 0.19 nM. It shows no activity at EP4 receptor. Aganepag can be used in the research of woun...
L-902688
T15690CAS 634193-54-7
L-902688 is an orally active EP4 receptor agonist (Ki: 0.38 nM; EC50: 0.6 nM). L-902688 displays >4,000-fold selective for EP4 over other EP and prostanoid recep...
AGN 210676
T14146CAS 910562-15-1
AGN 210676 is a selective agonist of prostaglandin EP2(EC50 : 5 nM).
AH 6809
T14148CAS 33458-93-4
AH 6809 is an antagonist of EP and DP receptor(with Kis of 1217, 1150, 1597, and 1415 nM for the cloned human EP1, EP2, EP3-III, and DP receptor respectively). A...
BAY-1316957
T14500CAS 1613264-40-6
BAY-1316957 is a highly potent and selective EP4 receptor antagonist. With an IC50 of 15.3 nM. Good oral bioavailability[1].
Carboprost tromethamine
T14865CAS 58551-69-2
Carboprost tromethamine is the synthetic 15-methyl analogue of prostaglandin F2α and it can effectively promote law contraction of the uterus and significantly ...
Evatanepag
T15259CAS 223488-57-1
Evatanepag is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.CP-533536 demonstrated the ability ...
Evatanepag
T15259CAS 223488-57-1
Evatanepag is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.CP-533536 demonstrated the ability ...
EP4 receptor antagonist 1
T11211CAS 2287259-07-6
EP4 receptor antagonist 1 inhibits human and mouse EP4 receptor with IC50s of 6.1 nM and 16.2 nM, respectively. IC50s >10 μM for human EP1, EP2,and EP3 recepto...
Furprofen
T11340CAS 66318-17-0
Furprofen acts via the inhibition of prostaglandin (PGE) synthesis. Furprofen can be treated orally for the relief of pain. Furprofen is an non-steroidal anti-...
KAG-308
T15642CAS 1215192-68-9
KAG-308 is an effective selective and orally active agonist of the EP4 receptor (Ki: 2.57 nM and EC50: 17 nM for human EP4 receptor), more selective over EP1, EP...
L-161982
T15681CAS 147776-06-5
L-161982 is a selective EP4 receptor antagonist. L-161982 decreases collagen-induced arthritis in mice. L-161982 fully blocks PGE2-induced ERK phosphorylation an...
L-798106
T15689CAS 244101-02-8
L-798106 is a highly selective prostanoid EP3 receptor antagonist (Ki=0.3 nM). It also has micromolar activities at EP4, EP1, and EP2 receptors (Ki: 916 nM, >500...
(+)-Talarozole
T13466CAS 201410-66-4
(+)-Talarozole is a potent retinoic acid metabolism inhibitor .
Canniprene
TN3582CAS 70677-47-3
Canniprene has anti-inflammatory activity, it can potently inhibit the production of inflammatory eicosanoids via the 5-lipoxygenase pathway (IC50=0.4uM) and als...
Manumycin A
T16011CAS 52665-74-4
Manumycin A is an antibiotic. Manumycin A induces apoptosis and exerts antitumor activity. Manumycin A inhibits exosome biogenesis and secretion via targeted inh...
Omidenepag isopropyl
T16388CAS 1187451-19-9
Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration. Omidenepag isopropyl is a selective EP2 receptor agonist. Omidenep...
Omidenepag
T16389CAS 1187451-41-7
Omidenepag is a pharmacologically active form of Omidenepag Isopropyl and is a selective, non-prostanoid EP2 receptor agonist (EC50: 1.1 nM). Omidenepag displays...
PF-4693627
T16504CAS 1312815-93-2
PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM). It is used for the treatment of inflammation caused by oste...
Taprenepag isopropyl
T16988CAS 1005549-94-9
Taprenepag isopropyl is a highly selective agonist of the EP2 receptor.
Tiaprost
T17092CAS 71116-82-0
Tiaprost is a analog of prostaglandin F2α .
Epibetulinic acid
T2S0765CAS 38736-77-5
Epibetulinic acid has anti-inflammatory activity, it exhibits potent inhibitory effects on NO and prostaglandin E(2) production in mouse macrophages (RAW 264.7) ...
Chamigrenal
T3P2855CAS 19912-84-6
β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 ...
1,7-Dihydroxy-2,3-methylenedioxyxanthone
T4484CAS 183210-63-1
1,7-Dihydroxy-2,3-methylenedioxyxanthone has antiulcerogenic, anti-oxidation, and antihyperalgesic activities, it can inhibit the carrageenan-induced hyperalgesi...
2-Acetylbenzoic acid
TMA0536CAS 577-56-0
2-Acetylbenzoic acid is more potent than 2-propionyloxybenzoic acid in inhibiting platelet function and platelet prostaglandin (PG) synthesis although the potenc...
6,4'-Dihydroxy-7-methoxyflavanone
TN3144CAS 189689-32-5
6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. It shows inhibition of osteoclasts differentiation and function...
Ailanthoidol
TN3366CAS 156398-61-7
Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potentia...
AM211
T7652CAS 1175526-27-8
AM211 is a potent and orally bioavailable antagonist of prostaglandin D2 (PGD2) receptor type 2 (DP2)