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Search Results for " progesterone receptor "

Targets

58

Compounds

8

Natural Products

8

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T3036 Dydrogesterone Progesterone Receptor
Dydrogesterone is a potent progestogen which can be used in progesterone deficiency studies.
T13703 Gestonorone Capronate Prostaglandin Receptor
Gestonorone Capronate  is a progesterone used to treat benign prostatic hyperplasia and endometrial cancer.
T28362 PF-02413873 PF02413873 Progesterone Receptor
PF-02413873 is a competitive antagonist of nonsteroidal progesterone receptor with a Ki of 2.6 nM. PF-02413873 can be used in studies about the treatment of gynecological conditions such as endometriosis.
T7537 Norgestimate Progesterone Receptor
Norgestimate is an acetylated progestinused in combination with ethinyl estradiol as an oral contraceptive.
T1514 Norethindrone Norethisterone Estrogen/progestogen Receptor , Progesterone Receptor
Norethindrone (Norethisterone) is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties...
T8395 Nomegestrol acetate Others , Progesterone Receptor
Nomegestrol acetate is a widely used progestin-like drug,which is characterized as a full agonist at the progesterone receptor
T1596 Chlormadinone acetate Gestafortin Progesterone Receptor , Androgen Receptor
Chlormadinone acetate (Gestafortin) is an orally active synthetic progestational hormone used often in combinations as an oral contraceptive.
T1541 Drospirenone ZK 3059,Dihydrospirorenone Glucocorticoid Receptor , Estrogen/progestogen Receptor , Progesterone Receptor , Androgen Receptor , COX
Drospirenone (ZK 3059) is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
T0996 Ethynodiol diacetate Ethynodiol acetate,8080 CB Estrogen/progestogen Receptor , Progesterone Receptor
Ethynodiol diacetate (Ethynodiol acetate) is a synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.
T6819 Desogestrel Org-2969,Desogen,Desogestrelum,Cerazette Estrogen/progestogen Receptor , Progesterone Receptor
Desogestrel (Cerazette) is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
T6713 Ulipristal Estrogen/progestogen Receptor , Progesterone Receptor
Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.
T5317 Cridanimod CMA,XBIO-101,10-carboxymethyl-9-acridanone Progesterone Receptor , STING , IFNAR
Cridanimod (10-carboxymethyl-9-acridanone, CMA) is a potent STING agonist that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route.
T2577 Dienogest STS 557 Apoptosis , Estrogen/progestogen Receptor , Progesterone Receptor , Autophagy
Dienogest (STS 557) is an orally-active, semisynthetic, fourth generation, nonethinylated progestogen with antiproliferative, antiandrogenic, anti-inflammatory and antiangiogenic activities that is used in hormone therap...
T1490 Gestodene SHB 331,WL 70 Estrogen/progestogen Receptor , Progesterone Receptor
Gestodene (WL 70) is a progestogen hormonal contraceptive.
T5174 Nestoron ST-1435,Segesterone Acetate,Nestorone,Elcometrine Estrogen/progestogen Receptor , Progesterone Receptor
Nestoron (Segesterone Acetate), a synthetic progestin, is a high-affinity agonist of the progesterone receptor (EC50: 10.3 nM).
T0870 Altrenogest R2267,RU2267,Allyltrenbolone,A35957 Estrogen/progestogen Receptor , Progesterone Receptor
Altrenogest (Allyltrenbolone)(A35957; RU2267), a progestogen, has structural relation with veterinary steroid trenbolone.
T14975 CJ-42794 CJ-042794 Others
CJ-42794 (CJ-042794) is a selective antagonist of prostaglandin E receptor subtype 4 (EP4). It inhibits [3H]-PGE2 binding to the human EP4 receptor (a mean pKi: 8.5). CJ-42794 is a binding affinity that was at least 200-...
T2527 Ulipristal acetate Ulipristal,CDB-2914 Estrogen/progestogen Receptor , Progesterone Receptor , Autophagy
Ulipristal acetate (CDB-2914) is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity. Ulipristal binds to the progesterone receptor (PR), thereb...
T2567 Etonogestrel 3-Oxodesogestrel,3-keto-Desogestrel,Nexplanon,Implanon Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Progesterone Receptor , Endogenous Metabolite
Etonogestrel (Implanon) is a steroidal progestin used as hormonal contraceptives.
T1102 Mifepristone C-1073,RU486,RU 38486 Glucocorticoid Receptor , Estrogen/progestogen Receptor , Progesterone Receptor , NO Synthase , Autophagy
Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
T2231 Estradiol dipropionate 17-Beta-Estradiol-3,17-Dipropionate Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Progesterone Receptor
Estradiol dipropionate (17-Beta-Estradiol-3,17-Dipropionate) is a synthetic ester, specifically the 3, 17-dipropanoyl ester, of the natural estrogen, estradiol.
T20720 Norethisterone enanthate NSC 9564,Norethindrone enanthate,LG-202,LG202,NSC9564,LG 202,NSC-9564 Estrogen/progestogen Receptor
Norethisterone enanthate (NSC-9564) is a long-acting parenteral progestogen with antigonadotropic effects.
T60056 Benzonitrile, 4-[[5-cyclopropyl-3-methyl-1-[(methylsulfonyl)methyl]-1H-pyrazol-4-yl]oxy]-2,6-dimethyl- Progesterone Receptor
Benzonitrile, 4-[[5-cyclopropyl-3-methyl-1-[(methylsulfonyl)methyl]-1H-pyrazol-4-yl]oxy]-2,6-dimethyl- is a progesterone receptor antagonist with antiprogestin effects.
T35054 Vilaprisan BAY 1002670,BAY10-02670,BAY-1002670,BAY1002670,BAY-10-02670,BAY 10-02670 Progesterone Receptor
Vilaprisan (BAY 1002670) is a novel orally available and selective progesterone receptor modulator (SPRM) with antiproliferative activity against uterine fibroids (UF) and can be used for the study of uterine fibroids.
TP1862L [Sar9] Substance P acetate(77128-75-7 free base) Neurokinin receptor
[Sar9]-Substance P acetate is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.
T21395 Finerenone BAY948862,BAY-948862,BAY94-8862,BAY 94-8862,BAY-94-8862,BAY 948862 Glucocorticoid Receptor
Finerenone (BAY-948862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM for the treatment of chronic heart failure. Finerenone (BAY-948862...
T16502 PF-3882845 Others
PF-3882845 also binds to the progesterone receptor (the binding IC50: 310 nM). PF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC50=2.7 nM) antagonist for ...
T17291 ZK 216348 (+)-ZK 216348 Others
ZK 216348 also binds to Progesterone and mineralocorticoid receptors (IC50s: 20.4 nM and 79.9 nM, respectively). ZK 216348 is a nonsteroidal selective glucocorticoid receptor agonist (IC50: 20.3 nM). ZK 216348 has an an...
T28995 Tosagestin Org 30659,Org30659,Org-30659
Tosagestin is a progesterone receptor agonist.
T28263 Org-31710 Org 31710,Org31710
Org-31710 is a progesterone receptor antagonist potentially for contraception.
T31082 CP-8668 UNII-5371O2R79D,CP 8668
CP-8668 is an orally active nonsteroidal progesterone receptor modulator with tetrahydrobenzoindolone skeleton.
T29224 ZK112993 ZK-112993,ZK 112993
ZK112993 is an antagonist of human progesterone receptor.
T14332 Asoprisnil J867 Others
Asoprisnil is a selective modulator of progesterone receptor.
T28264 Org-33628
Org-33628, a progesterone receptor antagonist, is used potentially for female contraception.
T34798 Telapristone metabolite of telapristone acetate (CDB-4124)
Telapristone, is the active metabolite of telapristone acetate (also known as CDB-4124). Telapristone is a selective progesterone receptor modulator (SPRM) being studied for the treatment of certain progesterone-sensitiv...
T27108 Cymipristone ZXH951,ZXH 951,ZXH-951
Cymipristone, a progesterone receptor antagonist, is used potentially for termination of intrauterine pregnancy.
T27662 JNJ-1250132 JNJ 1250132,JNJ1250132
JNJ-1250132 is a steroidal progesterone receptor modulator that inhibits binding of the receptor to DNA in vitro.
T25304 Demegestone R-2453,Lutionex,R 2453,RU 2453,R2453
Demegestone is a progestin, or a synthetic progestogen, and hence is a progesterone receptor agonist, the biological target of progestogens like progesterone. It has no androgenic activity. Previously used to treat lutea...
T28237 Onapristone IVV-1001,ZK 98299,IVV 1001,ZK98299,ZK-98299,IVV1001
Onapristone, a progesterone receptor antagonist, is used potentially for the treatment of breast cancer, advanced prostate cancer, and inducer of vaginal bleeding.
T16985 Tanaproget NSP-989 Others
Tanaproget is a novel nonsteroidal progesterone receptor agonist which can bind to the PR from various species with a higher relative affinity than reference steroidal progestins (IC50: 0.1 nM),
T37319 5β-Dihydroprogesterone
5β-Dihydroprogesterone (5β-DHP) is a progesterone receptor agonist and metabolite of progesterone .1,2It is formed from progesterone by 5β-reductase.25β-DHP inhibits spontaneous contractions in isolated rat uterus when u...
T16396 OP-3633 Others
OP-3633 is an effective and selective steroidal glucocorticoid receptor (GR) antagonist (IC50: 29 nM). OP-3633 shows low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism. It also has an inhibition...
T19697 Norgestomet SC21009,Norprogesterone, Syncro-Mate B,SC-21009,SC 21009
Norgestomet is a steroidal progestin of the 19-norprogesterone group used in veterinary medicine to control estrus and ovulation in cattle. In addition to the progesterone receptor, norgestomet possesses a weak (micromol...
T68473 WAY-255348
WAY-255348 is a potent nonsteroidal progesterone receptor (PR) antagonist. WAY-255348 inhibits the activity of progesterone. WAY-255348 achieves antagonist activity by binding to and subsequently preventing progesterone-...
T69895 Lonaprisan
Lonaprisan is an orally bioavailable pentafluoroethyl derivative of a mifepristone-related steroid with antiprogestagenic activity. Lonaprisan is a pure, highly receptor-selective progesterone receptor (PR) antagonist; b...
T69717 Dimethandrolone
Dimethandrolone (DMA), also known by its developmental code name CDB-1321, is an experimental androgen/anabolic steroid (AAS) and progestogen medication which is under investigation for potential clinical use. Dimethandr...
T28280 Oxendolone Roxenone,Prostetin
Oxendolone is a steroidal progestin and antiandrogen. Oxendolone binds to the progesterone receptor (Ki = 20 nM) and androgen receptor (AR) (Ki = 320 nM) and acts as a weak but clinically relevant inhibitor of 5α-reducta...
T26669 Asoprisnil ecamate J956,J-956,J 956
Asoprisnil ecamate is a selective progesterone receptor modulator. Asoprisnil inhibits proliferation and induces apoptosis in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cell...
T19684 Pregnanolone SKF 6455,Kabi-2213,Kabi 2213,Eltanolone,Kabi2213,SKF6455
Pregnanolone is a cell membrane modulator potentially for the treatment of pain. Pregnanolone is an endogenous neurosteroid that is biosynthesized from progesterone. It is a positive allosteric modulator of the GABAA rec...
T38448 (Rac)-Finerenone (Rac)-Finerenone,(Rac)-BAY 94-8862
Rac-Finerenone, also known as (Rac)-BAY 94-8862, is the racemate derivative of Finerenone, a selective third-generation nonsteroidal mineralocorticoid receptor antagonist (MR) that is taken orally. With an IC50 value of ...

Compounds

Dydrogesterone
T3036
Synonym:
Target: Progesterone Receptor
Gestonorone Capronate
T13703
Synonym:
Target: Prostaglandin Receptor
PF-02413873
T28362
Synonym: PF02413873
Target: Progesterone Receptor
Norgestimate
T7537
Synonym:
Target: Progesterone Receptor
Norethindrone
T1514
Synonym: Norethisterone
Target: Estrogen/progestogen Receptor, Progesterone Receptor
Nomegestrol acetate
T8395
Synonym:
Target: Others, Progesterone Receptor
Chlormadinone acetate
T1596
Synonym: Gestafortin
Target: Progesterone Receptor, Androgen Receptor
Drospirenone
T1541
Synonym: ZK 3059,Dihydrospirorenone
Target: Glucocorticoid Receptor, Estrogen/progestogen Receptor, Progesterone Receptor, Androgen Receptor, COX
Ethynodiol diacetate
T0996
Synonym: Ethynodiol acetate,8080 CB
Target: Estrogen/progestogen Receptor, Progesterone Receptor
Desogestrel
T6819
Synonym: Org-2969,Desogen,Desogestrelum,Cerazette
Target: Estrogen/progestogen Receptor, Progesterone Receptor
Ulipristal
T6713
Synonym:
Target: Estrogen/progestogen Receptor, Progesterone Receptor
Cridanimod
T5317
Synonym: CMA,XBIO-101,10-carboxymethyl-9-acridanone
Target: Progesterone Receptor, STING, IFNAR
Dienogest
T2577
Synonym: STS 557
Target: Apoptosis, Estrogen/progestogen Receptor, Progesterone Receptor, Autophagy
Gestodene
T1490
Synonym: SHB 331,WL 70
Target: Estrogen/progestogen Receptor, Progesterone Receptor
Nestoron
T5174
Synonym: ST-1435,Segesterone Acetate,Nestorone,Elcometrine
Target: Estrogen/progestogen Receptor, Progesterone Receptor
Altrenogest
T0870
Synonym: R2267,RU2267,Allyltrenbolone,A35957
Target: Estrogen/progestogen Receptor, Progesterone Receptor
CJ-42794
T14975
Synonym: CJ-042794
Target: Others
Ulipristal acetate
T2527
Synonym: Ulipristal,CDB-2914
Target: Estrogen/progestogen Receptor, Progesterone Receptor, Autophagy
Etonogestrel
T2567
Synonym: 3-Oxodesogestrel,3-keto-Desogestrel,Nexplanon,Implanon
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Progesterone Receptor, Endogenous Metabolite
Mifepristone
T1102
Synonym: C-1073,RU486,RU 38486
Target: Glucocorticoid Receptor, Estrogen/progestogen Receptor, Progesterone Receptor, NO Synthase, Autophagy
Estradiol dipropionate
T2231
Synonym: 17-Beta-Estradiol-3,17-Dipropionate
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Progesterone Receptor
Norethisterone enanthate
T20720
Synonym: NSC 9564,Norethindrone enanthate,LG-202,LG202,NSC9564,LG 202,NSC-9564
Target: Estrogen/progestogen Receptor
Benzonitrile, 4-[[5-cyclopropyl-3-methyl-1-[(methylsulfonyl)methyl]-1H-pyrazol-4-yl]oxy]-2,6-dimethyl-
T60056
Synonym:
Target: Progesterone Receptor
Vilaprisan
T35054
Synonym: BAY 1002670,BAY10-02670,BAY-1002670,BAY1002670,BAY-10-02670,BAY 10-02670
Target: Progesterone Receptor
[Sar9] Substance P acetate(77128-75-7 free base)
TP1862L
Synonym:
Target: Neurokinin receptor
Finerenone
T21395
Synonym: BAY948862,BAY-948862,BAY94-8862,BAY 94-8862,BAY-94-8862,BAY 948862
Target: Glucocorticoid Receptor
PF-3882845
T16502
Synonym:
Target: Others
ZK 216348
T17291
Synonym: (+)-ZK 216348
Target: Others
Tosagestin
T28995
Synonym: Org 30659,Org30659,Org-30659
Target:
Org-31710
T28263
Synonym: Org 31710,Org31710
Target:
CP-8668
T31082
Synonym: UNII-5371O2R79D,CP 8668
Target:
ZK112993
T29224
Synonym: ZK-112993,ZK 112993
Target:
Asoprisnil
T14332
Synonym: J867
Target: Others
Org-33628
T28264
Synonym:
Target:
Telapristone
T34798
Synonym: metabolite of telapristone acetate (CDB-4124)
Target:
Cymipristone
T27108
Synonym: ZXH951,ZXH 951,ZXH-951
Target:
JNJ-1250132
T27662
Synonym: JNJ 1250132,JNJ1250132
Target:
Demegestone
T25304
Synonym: R-2453,Lutionex,R 2453,RU 2453,R2453
Target:
Onapristone
T28237
Synonym: IVV-1001,ZK 98299,IVV 1001,ZK98299,ZK-98299,IVV1001
Target:
Tanaproget
T16985
Synonym: NSP-989
Target: Others
5β-Dihydroprogesterone
T37319
Synonym:
Target:
OP-3633
T16396
Synonym:
Target: Others
Norgestomet
T19697
Synonym: SC21009,Norprogesterone, Syncro-Mate B,SC-21009,SC 21009
Target:
WAY-255348
T68473
Synonym:
Target:
Lonaprisan
T69895
Synonym:
Target:
Dimethandrolone
T69717
Synonym:
Target:
Oxendolone
T28280
Synonym: Roxenone,Prostetin
Target:
Asoprisnil ecamate
T26669
Synonym: J956,J-956,J 956
Target:
Pregnanolone
T19684
Synonym: SKF 6455,Kabi-2213,Kabi 2213,Eltanolone,Kabi2213,SKF6455
Target:
(Rac)-Finerenone
T38448
Synonym: (Rac)-Finerenone,(Rac)-BAY 94-8862
Target:
1 2
Cat No. Product Name Synonyms Targets
T0478 Progesterone Pregn-4-ene-3,20-dione Estrogen/progestogen Receptor , Progesterone Receptor , Opioid Receptor , Endogenous Metabolite
Progesterone (Pregn-4-ene-3,20-dione) is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is require...
T1263 Levonorgestrel D-Norgestrel Others , Estrogen/progestogen Receptor , Progesterone Receptor
Levonorgestrel (D-Norgestrel) is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization.
T5040 Medroxyprogesterone Estrogen/progestogen Receptor , Progesterone Receptor
Medroxyprogesterone is used in the treatment of renal carcinoma. It is a synthetic progestational hormone used in veterinary practice as an estrus regulator.
T1261 Medroxyprogesterone Acetate Medroxyprogesterone 17-acetate,Provera,Metigestrona,NSC-26386,Farlutin,Medroxyprogesterone (acetate) Glucocorticoid Receptor , Estrogen/progestogen Receptor , Progesterone Receptor , Androgen Receptor , Endogenous Metabolite
Medroxyprogesterone Acetate (Farlutin) is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been...
T1429 17α-Hydroxyprogesterone Hydroxyprogesterone,17-OHP,17-Hydroxyprogesterone Estrogen/progestogen Receptor , Progesterone Receptor , Endogenous Metabolite
17α-Hydroxyprogesterone (17-OHP) is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester of pregnancy. Hydroxyprogesterone binds to th...
T1284 Megestrol acetate SC10363,BDH1298 Glucocorticoid Receptor , Estrogen/progestogen Receptor , Progesterone Receptor , HIV Protease , Autophagy
Megestrol acetate (BDH1298) is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. It is given by mouth in the palliative treatment ...
T7974 Lynestrenol Progesterone Receptor
Lynestrenol is a synthetic progestational hormone, is the progesterone receptor agonist
T7931 16a,17a-Epoxy-4-Pregnen-3,20-Dione Others
16a,17a-Epoxy-4-Pregnen-3,20-Dione is a synthetic progestin, a metabolite of the luteinizing hormone hormone, which acts by binding to the luteinizing hormone receptor. It has been used to study the effects of progestero...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPK-00591 RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (aa 70-316, His) Mouse HEK293
Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK ...
TMPK-00717 RANKL/TNFSF11/CD254 Protein, Human, Recombinant (His & Flag) Human HEK293
Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK ...
TMPK-00716 RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244) Human HEK293
Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK ...
TMPH-01614 LDHC Protein, Human, Recombinant (His & SUMO) Human E. coli
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentia...
TMPY-01383 PRMT6 Protein, Human, Recombinant (His & Flag) Human HEK293
Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly ex...
TMPH-00782 OMP P5 Protein, Haemophilus influenzae, Recombinant (His & Myc & SUMO) Haemophilus influenzae E. coli
A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the...
TMPY-02138 Uteroglobin Protein, Human, Recombinant (His) Human HEK293
Uteroglobin (UG), also known as Secretoglobin 1A member 1 (SCGB1A1), Blastokinin, Clara cell secretor protein (CCSP) or Clara cell-specific 10-kDa protein (CC10), is the founding member of the secretoglobin family of sma...
TMPY-02328 Uteroglobin Protein, Mouse, Recombinant (His) Mouse HEK293
Uteroglobin (UG), also known as Secretoglobin 1A member 1 (SCGB1A1), Blastokinin, Clara cell secretor protein (CCSP) or Clara cell-specific 10-kDa protein (CC10), is the founding member of the secretoglobin family of sma...
Cat No. Product Name
L2191 Anti-Breast Cancer Compound Library

1965 compounds
A unique collection of 1965 compounds with anti-breast cancer therapeutic activity or targeting breast cancer’s major signaling pathways, can be used for anti-breast cancer drug discovery and mechanism study;
TargetMol