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Membrane transporter/Ion channel Potassium Channel

Potassium Channel

Potassium Channels. K+ channels are membrane proteins that allow rapid and selective flow of K+ ions across the cell membrane, and thus generate electrical signals in cells. Voltage-gated K+ channels (Kv channels), present in all animal cells, open and close upon changes in the transmembrane potential.
Cat No. product name
T4294 NS11021 NS11021, a novel opener of large-conductance Ca(2+)-activated K(+) channels
T1449 Hydrochlorothiazide Hydrochlorothiazide is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis.
T1278 Astemizole Astemizole is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors...
T0075 Nicorandil Nicorandil(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It undertakes this through two methods. First...
T1054 Tolbutamide Tolbutamide is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.
T0266 Quinidine hydrochloride Quinidine is an optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. It prolongs cellular action potential and dec...
T6631 Quinine HCl Dihydrate Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.
T0342 Carvedilol phosphate Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intr...
T3959 ICA069673 ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).
T0447 Carvedilol Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intr...
T0866 Propafenone Propafenone is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythm...
T1206 Amsacrine Amsacrine (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells. Amsacrine also expresses topoisomerase inhibitor activity, specific...
T1266 Terfenadine Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistami...
T0791 Reserpine Reserpine is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resu...
T0847 Chenodeoxycholic acid Chenodiol is a bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorb...
T0451 Minoxidil Minoxidil is an orally administered vasodilator with hair growth stimulatory and antihypertensive effects.
T1320 Disopyramide A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) w...
T0038 Doxapram hydrochloride monohydrate Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.
T1204 Bendroflumethiazide A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, ede...
T1752 NS6180 NS6180 is a potent and selective KCa3.1 channel inhibitor(IC50= 9 nM). It prevents T-cell activation and inflammation.
T4030 ML213 ML213 is a selective activator of Kv7.2 (KCNQ2) and Kv7.4 (KCNQ4) channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively.
T5S0890 Oleandrin 1. Oleandrin, the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional le...
T3S0081 Oxypeucedanin 1. Oxypeucedanin has novel anticancer effect, mediated via induction of G2-M cell cycle arrest and apoptosis in human prostate carcinoma DU145 cells. 2. Oxypeuc...
TMS2171 (±)-Naringenin (±)-Naringenin is a natural product. It displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.
T7056 Dronedarone Dronedarone is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
T4316 ML365 ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3).
T4224 ML335 ML335 is a selective activator of both TREK-1 and TREK-2.
T0386 Ropivacaine hydrochloride Ropivacaine hydrochloride is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity.
T6504 Flupirtine maleate Flupirtine maleate, a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal po...
T0816 Acetohexamide Acetohexamide is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. It inhibits sulfonylurea receptor 1 (SUR1) linked to the inwa...
T0483 Sotalol hydrochloride Sotalol Hydrochloride is the hydrochloride salt form of sotalol, an ethanolamine derivative with Class III antiarrhythmic and antihypertensive properties.
T1650 Chlorzoxazone Chlorzoxazone is a Muscle Relaxant. The physiologic effect of chlorzoxazone is by means of Centrally-mediated Muscle Relaxation.
T0916 Butyl 4-aminobenzoate Butamben is a long-duration local anesthetic used for the treatment of chronic pain.
T0127 Glimepiride Glimepiride is a long-acting, third-generation sulfonylurea with hypoglycemic activity.
T1453 Phenformin hydrochloride Phenformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
T1291 Cisapride Cisapride is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal p...
T0126 Diazoxide Diazoxide is a benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it l...
T1138 Taurocholic acid sodium salt hydrate Taurocholic acid sodium salt hydrate is the product of conjugation of taurine with cholic acid. The sodium salt, the main ingredient of the bile of carnivorous ...
T4612 NS309 NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for S...
T0700 Ursodeoxycholic acid Ursodeoxycholic acid can be used to dissolve gallstones and reduce cholesterol absorption.
T3303 ML277 ML277 was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).
T3557 GAL021 GAL-021 an intravenous BKCa-channel blocker.
T1088 Repaglinide Repaglinide is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been...
T0690 Quinine Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria. Quinine is also used for idiopathic muscle cra...
T2712 Nifekalant hydrochloride Nifekalant hydrochloride is a pure potassium channel blocker and class III antiarrhythmic.
T0365 Thioridazine hydrochloride Thioridazine, an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity.
T3581 KS176 KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter, showing no inhibitory activity against P-gp or M...
T1334 Hydroquinidine Dihydroquinidine is an organic compound, used as an antiarrhythmic agent.
T6592 ML133 HCl ML133 HCl is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for...
T3876 Loureirin B Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppres...
T3876 Loureirin B Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppres...
T1333 Tolazamide Tolazamide is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.
T6476 Dofetilide Dofetilide is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid compon...
T1674 Nateglinide Nateglinide is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 dia...
T1634 Glyburide Glyburide is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T1073 Dronedarone hydrochloride Dronedarone hydrochloride is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.
T0974 Novobiocin Sodium Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces nive...
T0371 Gliquidone Gliquidone is a potent, second-generation sulfonylurea with antihyperglycemic activity. Like other second-generation compounds, gliquidone exerts greater bindin...
T1146 Nifedipine Nifedipine is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and v...
T0150 Hydroxyhexamide Hydroxyhexamide is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agent.
T0150 Hydroxyhexamide Hydroxyhexamide is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agent.
T3528 Senicapoc Senicapoc is a potent inhibitor of the Gardos channel and ameliorates RBC dehydration in the SAD mouse. Senicapoc blocked Ca2+-induced rubidium flux from human ...
T3332 Isosteviol Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolys...
T1498 Indapamide Indapamide is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.
T0344 Miconazole Miconazole is an imidazole antifungal agent that is used topically and by intravenous infusion.
T1527 Gliclazide Gliclazide, an oral antihyperglycemic agent, belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating beta-cells of the pancreas to ...
T0954 Anestan Halothane is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be ade...
T1530 Mitiglinide calcium dihydrate Mitiglinide calcium dihydrate is a drug for the treatment of type 2 diabetes. Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive...
T2546 Pimozide Pimozide is a diphenylbutylpiperidine derivative and a dopamine antagonist with the antipsychotic property. Pimozide selectively inhibits type 2 dopaminergic re...
T1496 Amiodarone hydrochloride Amiodarone hydrochloride is an antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting PO...
T1050 Prazosin hydrochloride Prazosin Hydrochloride reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not complet...
T0161 Pantoprazole Sodium Hydrate Pantoprazole is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease...
T1260 Sodium cromoglycate Cromolyn sodium is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.
T3102 NS 1619 NS1619 have cardio-protective effects after ischemia-reperfusion injury.
T4664 ML297 ML297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively). ML297 exhibits ...
T5183 AUT1 AUT1 (AUT-1) is a novel specific modulator of Kv3 channels (EC50: 4.7 and 4.9 uM for Kv3.1b and Kv3.2a).
T26324 VU0071063 VU0071063 is a Kir6.2/SUR1 activator.
T17262 XE 991 dihydrochloride XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker. XE 991 dihydrochloride potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, an...
TN3379 Allocryptopine Allocryptopine has certain effects on anti-injury for hepatocyte, ameliorating liver function, and prohibiting hepatic fibrosis; it increases mRNA levels of cyt...
TN3319 9-Hydroxycanthin-6-one 9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as...
TN3042 4-Hydroxycinnamamide 4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
TN2918 3-Acetoxy-8(17),13E-labdadien-15-oic acid ent-3-Acetoxy-labda-8(17),13-dien-15-oic acid have vasorelaxant and hypotensive actions, the mechanisms underlying the cardiovascular actions of the labdane inv...
T3S0870 Paederosidic acid methyl ester Paederosidic acid methyl ester has antinociception, is possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels.
T2S1635 3-Isomangostin 3-Isomangostin is a potent human aldose reductase inhibitor with an IC50 of 3.48 uM; it is also an acetylcholinesterase selective inhibitor. 3-Isomangostin has ...
T17243 VU0463271 VU0463271 is an effective antagonist of KCC2 (IC50: 61 nM).
TN3636 Chlorahololide C Chlorahololide C is a potent and selective potassium channel blocker, it exerts potent and selective inhibition on the delayed rectifier (I(K)) K(+) current wit...
T13320L VU591 1222810-74-3
T16347 NS3623 NS3623 is an activator of human ether-a-go-go-related gene potassium channels. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels. NS3623 ac...
T16285 Neosolaniol Neosolaniol evokes a robust anorectic response. Neosolaniol is a type A trichothecene mycotoxin from Fusarium sp.
T16124 MMP13-IN-3 MMP13-IN-3 is >1000 selective over other MMPs. MMP13-IN-3 is an effective, selective, and orally active MMP-13 inhibitor (IC50=1 nM) for the potential treatment...
T16110 ML418 ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker (IC50 = 310 nM), and also potently inhibits Kir6.2/SUR1.
T11753 Keto Ziprasidone Ziprasidone, an antipsychotic agent, is a combined 5-HT (serotonin) and dopamine receptor antagonist. Keto Ziprasidone is an impurity of Ziprasidone.
T13316 VU0134992 hydrochloride VU0134992 hydrochloride is the first subtype-preferring, orally active and selective blocker of Kir4.1 potassium channel pore(IC50 : 0.97 µM).
TN3460 Asebogenin Asebogenin has anti-bacterial activity, it shows inhibitory activity against S. aureus and methicillin-resistant S. aureus (IC50 of 10 and 4.5 micrograms/ml, re...
TN3831 Denudatin B Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin, it inhibits th...
T15545 ICA-27243 ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 μM). ICA-27...
T22745 DPO-1 DPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels
T9070 ASP-2905 ASP-2905 is a potent and selective inhibitor of potassium channel Kv12.2 encoded by the Kcnh3/BEC1 gene. It can cross the blood-brain barrier and has antipsych...
T8977 Kv2-IN-A1 Kv2-IN-A1 is an inhibitor of Kv2.1 and Kv2.2.
TP1858L Phe-Met-Arg-Phe, amide acetate(64190-70-1 freebase) Phe-Met-Arg-Phe, amide acetate dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons. This peptide appears to localize wit...
TP1852L Myomodulin acetate(110570-93-9 free base) Myomodulin acetate is present in two identified aplysia neurons that contain myomodulin A the ARC motor neuron B16 and the abdominal neuron L10.
T21487 Retigabine dihydrochloride Retigabine dihydrochloride is an anticonvulsant used as an adjunctive treatment for partial epilepsies in treatment-experienced adult patients. The mechanism o...
T8700 TKIM TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1.
TN5141 Thevetin B Thevetin B is a cardiac glycoside. Thevetin A and thevetin B are Na+-, K+-dependent adenosinetriphosphatase (Na+,K+-ATPase) (EC 3.6.1.3) inhibitors.
TN3910 Ecdysone Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. A nctional Bombyx Ecdysone receptor binds to EcRE-D ...
TN5060 Stauntosaponin A Stauntosaponin A and stauntosaponin B show moderate inhibitory activities against Na+/K+-ATPase with IC50 values of 21 and 29 uM, respectively.
TN4697 Odoroside H Odoroside H has anticancer activities, the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase.
TN4638 Neolinine Neolinine(at 10uM) shows significant hERG K+ channel inhibition activity.
TMA0763 Methyl 3,4,5-trimethoxycinnamate Methyl 3,4,5-trimethoxycinnamate may protect the heart from arrhythmias via its inhibitory effect on calcium channel.
TMA0805 Lupanine Lupanine has a weak sedative effect on the central nervous system, interaction with specific drugs used for treatment of the CNS and for analgesic activity. Lup...
TN4322 Isopulegol Isopulegol presents depressant- and anxiolytic-like effects, it also has anticonvulsant and bioprotective effects against PTZ-induced convulsions are possibly r...
TN4303 Isokaempferide Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by re...
T15758 Linopirdine Linopirdine is a TRPV1 agonist. Linopirdine is an orally active and selective M-type K+ current (IM; Kv7; KCNQ Channels) inhibitor (IC50: 2.4 μM). Linopirdine ...
T13320 VU591 hydrochloride VU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50:0.24 μM). Thought to block the intracellular pore ...
T5180 SKA31 SKA 31 is an activator of KCa3.1 and KCa2 channels (EC50s: 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively).
T7612 ICA 110381 ICA 110381 is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy
T7775 A2764 dihydrochloride A2764 dihydrochloride is a highly selective inhibitor of TRESK.
TQ0307 Vernakalant Vernakalant (RSD-1235) is a mixed ion channel blocker.
TQ0179 PAP-1 PAP-1 is a selective, and orally active Kv1.3 blocker (EC50: 2 nM).
TQ0150 Levcromakalim Levcromakalim is an activator of the ATP-sensitive K+ channel.
TQ0139 VU 0240551 VU 0240551 is a neuronal K-Cl cotransporter KCC2 inhibitor (IC50: 560 nM for K+ uptake assay in KCC2-overexpressing cells).
T7653 JNJ 303 JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).
T7512 BMS-191011 BMS-191011 is an activator of large-conductance calcium-activated potassium (BKCa) channels ,effective in stroke models
T8182 Guan-fu base A Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.
T7505 Azimilide Dihydrochloride Azimilide Dihydrochloride, a novel class III antiarrhythmic agent, blocks both the slowly activating (IKs) and rapidly activating (IKr) components of the delaye...
T7198 E-4031 E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)
T7195 GSK369796 Dihydrochloride GSK369796 Dihydrochloride,is an anti-malaria drug candidate. is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization...
T6978 Almitrine dimesylate Almitrine dimesylate inhibits selectively the Ca2+-dependent K+ channel and that in rat chemoreceptor cells,used in the treatment of hypoxemic chronic lung dise...
T5444 CLP-290 CLP290 is an activator of the neuron-specific K+-Cl− cotransporter KCC2 and displays potential for the treatment of a wide range of neurological and psychiatr...
T5585 AM-92016 hydrochloride AM-92016 is a specific blocker of rectifier potassium current. AM-92016 delays rectifier potassium channel and repolarizes the membrane thereby restricting the ...
T5336 Zacopride hydrochloride Zacopride is a highly potent 5-HT3 receptor antagonist (Kd = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). It also is a selective IK1 channel agonist.
T8040 Cholesterol myristate Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the nicotinic ac...
T7899 VU0810464 VU0810464 is a non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator.
T14984 CLP257 CLP257 is a selective activator of K+-Cl− cotransporter KCC2 (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alle...
T12478 Pinacidil monohydrate Pinacidil monohydrate is a potassium channel activator, antihypertensive drug.
T14982 Clofilium tosylate Clofilium tosylate is a potassium channel blocker. It induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspas...
T15555 IK1 inhibitor PA-6 IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1 (KIR2.x ion-channel-carried inward rectifier current)(IC50 of 12-15 nM for human and mouse ...
T14666 BL-1249 BL-1249 is a nonsteroidal anti-inflammatory drug (NSAID) and a potassium channel activator. BL-1249 exhibits more selective for the bladder (EC50 of 1.26 μM) t...
T14189 Almokalant Almokalant is a class III antiarrhythmic drug, acts as a potassium channel blocker. And it inhibits a specific component (Ikr) of the time-dependent delayed rec...
T14040 4-Hydroxytolbutamide 4-Hydroxytolbutamide(Hydroxytolbutamide), a metabolite of Tolbutamide, which is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium ch...
T10979 DCPIB DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μ...
T12504 (+)-KCC2 blocker 1 (+)-KCC2 blocker 1 is a selective blocker of K+-Cl- cotransporter KCC2(IC50 of 0.4 μM).
T8446 QO-40 QO-40 is a KCNQ2/3 potassium channels activator.
T8361 Tetraethylammonium bromide Tetraethylammonium bromide can selectively block potassium channels.
T8372 VU 0134992 VU0134992 is an Kir4.1 blocker with an IC50 value of 0.97 µM
TN2306 Wilfordine Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect.
TN2239 Strictosamide Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain.
TN1874 Liriodendrin Liriodendrin has anti-inflammatory, antinociceptive, hypoglycemic activities, it plays protective role in sepsis-induced acute lung injury, it regulates lung in...
TN1757 Hypophyllanthin Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.
TN1588 Dihydroisotanshinone I Dihydroisotanshinone I has protective action against menadione-induced hepatotoxicity, attributed to its antioxidant properties including the free radical scave...
TN1367 Alismol Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for...
T3574 Sematilide HCl Sematilide (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in...
NS11021
T4294CAS 956014-19-0
NS11021, a novel opener of large-conductance Ca(2+)-activated K(+) channels
Hydrochlorothiazide
T1449CAS 58-93-5
Hydrochlorothiazide is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis.
Astemizole
T1278CAS 68844-77-9
Astemizole is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors...
Nicorandil
T0075CAS 65141-46-0
Nicorandil(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It undertakes this through two methods. First...
Tolbutamide
T1054CAS 64-77-7
Tolbutamide is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.
Quinidine hydrochloride
T0266CAS 6151-40-2
Quinidine is an optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. It prolongs cellular action potential and dec...
Quinine HCl Dihydrate
T6631CAS 6119-47-7
Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.
Carvedilol phosphate
T0342CAS 610309-89-2
Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intr...
ICA069673
T3959CAS 582323-16-8
ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).
Carvedilol
T0447CAS 72956-09-3
Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intr...
Propafenone
T0866CAS 54063-53-5
Propafenone is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythm...
Amsacrine
T1206CAS 51264-14-3
Amsacrine (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells. Amsacrine also expresses topoisomerase inhibitor activity, specific...
Terfenadine
T1266CAS 50679-08-8
Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistami...
Reserpine
T0791CAS 50-55-5
Reserpine is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resu...
Chenodeoxycholic acid
T0847CAS 474-25-9
Chenodiol is a bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorb...
Minoxidil
T0451CAS 38304-91-5
Minoxidil is an orally administered vasodilator with hair growth stimulatory and antihypertensive effects.
Disopyramide
T1320CAS 3737-09-5
A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) w...
Doxapram hydrochloride monohydrate
T0038CAS 7081-53-0
Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.
Bendroflumethiazide
T1204CAS 73-48-3
A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, ede...
NS6180
T1752CAS 353262-04-1
NS6180 is a potent and selective KCa3.1 channel inhibitor(IC50= 9 nM). It prevents T-cell activation and inflammation.
ML213
T4030CAS 489402-47-3
ML213 is a selective activator of Kv7.2 (KCNQ2) and Kv7.4 (KCNQ4) channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively.
Oleandrin
T5S0890CAS 465-16-7
1. Oleandrin, the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional le...
Oxypeucedanin
T3S0081CAS 737-52-0
1. Oxypeucedanin has novel anticancer effect, mediated via induction of G2-M cell cycle arrest and apoptosis in human prostate carcinoma DU145 cells. 2. Oxypeuc...
(±)-Naringenin
TMS2171CAS 67604-48-2
(±)-Naringenin is a natural product. It displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.
Dronedarone
T7056CAS 141626-36-0
Dronedarone is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
ML365
T4316CAS 947914-18-3
ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3).
ML335
T4224CAS 825658-06-8
ML335 is a selective activator of both TREK-1 and TREK-2.
Ropivacaine hydrochloride
T0386CAS 98717-15-8
Ropivacaine hydrochloride is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity.
Flupirtine maleate
T6504CAS 75507-68-5
Flupirtine maleate, a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal po...
Acetohexamide
T0816CAS 968-81-0
Acetohexamide is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. It inhibits sulfonylurea receptor 1 (SUR1) linked to the inwa...
Sotalol hydrochloride
T0483CAS 959-24-0
Sotalol Hydrochloride is the hydrochloride salt form of sotalol, an ethanolamine derivative with Class III antiarrhythmic and antihypertensive properties.
Chlorzoxazone
T1650CAS 95-25-0
Chlorzoxazone is a Muscle Relaxant. The physiologic effect of chlorzoxazone is by means of Centrally-mediated Muscle Relaxation.
Butyl 4-aminobenzoate
T0916CAS 94-25-7
Butamben is a long-duration local anesthetic used for the treatment of chronic pain.
Glimepiride
T0127CAS 93479-97-1
Glimepiride is a long-acting, third-generation sulfonylurea with hypoglycemic activity.
Phenformin hydrochloride
T1453CAS 834-28-6
Phenformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
Cisapride
T1291CAS 81098-60-4
Cisapride is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal p...
Diazoxide
T0126CAS 364-98-7
Diazoxide is a benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it l...
Taurocholic acid sodium salt hydrate
T1138CAS 345909-26-4
Taurocholic acid sodium salt hydrate is the product of conjugation of taurine with cholic acid. The sodium salt, the main ingredient of the bile of carnivorous ...
NS309
T4612CAS 18711-16-5
NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for S...
Ursodeoxycholic acid
T0700CAS 128-13-2
Ursodeoxycholic acid can be used to dissolve gallstones and reduce cholesterol absorption.
ML277
T3303CAS 1401242-74-7
ML277 was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).
GAL021
T3557CAS 1380341-99-0
GAL-021 an intravenous BKCa-channel blocker.
Repaglinide
T1088CAS 135062-02-1
Repaglinide is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been...
Quinine
T0690CAS 130-95-0
Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria. Quinine is also used for idiopathic muscle cra...
Nifekalant hydrochloride
T2712CAS 130656-51-8
Nifekalant hydrochloride is a pure potassium channel blocker and class III antiarrhythmic.
Thioridazine hydrochloride
T0365CAS 130-61-0
Thioridazine, an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity.
KS176
T3581CAS 1253452-78-6
KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter, showing no inhibitory activity against P-gp or M...
Hydroquinidine
T1334CAS 1435-55-8
Dihydroquinidine is an organic compound, used as an antiarrhythmic agent.
ML133 HCl
T6592CAS 1222781-70-5
ML133 HCl is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for...
Loureirin B
T3876CAS 119425-90-0
Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppres...
Loureirin B
T3876CAS 119425-90-0
Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppres...
Tolazamide
T1333CAS 1156-19-0
Tolazamide is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.
Dofetilide
T6476CAS 115256-11-6
Dofetilide is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid compon...
Nateglinide
T1674CAS 105816-04-4
Nateglinide is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 dia...
Glyburide
T1634CAS 10238-21-8
Glyburide is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
Dronedarone hydrochloride
T1073CAS 141625-93-6
Dronedarone hydrochloride is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.
Novobiocin Sodium
T0974CAS 1476-53-5
Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces nive...
Gliquidone
T0371CAS 33342-05-1
Gliquidone is a potent, second-generation sulfonylurea with antihyperglycemic activity. Like other second-generation compounds, gliquidone exerts greater bindin...
Nifedipine
T1146CAS 21829-25-4
Nifedipine is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and v...
Hydroxyhexamide
T0150CAS 3168-01-2
Hydroxyhexamide is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agent.
Hydroxyhexamide
T0150CAS 3168-01-2
Hydroxyhexamide is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agent.
Senicapoc
T3528CAS 289656-45-7
Senicapoc is a potent inhibitor of the Gardos channel and ameliorates RBC dehydration in the SAD mouse. Senicapoc blocked Ca2+-induced rubidium flux from human ...
Isosteviol
T3332CAS 27975-19-5
Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolys...
Indapamide
T1498CAS 26807-65-8
Indapamide is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.
Miconazole
T0344CAS 22916-47-8
Miconazole is an imidazole antifungal agent that is used topically and by intravenous infusion.
Gliclazide
T1527CAS 21187-98-4
Gliclazide, an oral antihyperglycemic agent, belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating beta-cells of the pancreas to ...
Anestan
T0954CAS 151-67-7
Halothane is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be ade...
Mitiglinide calcium dihydrate
T1530CAS 207844-01-7
Mitiglinide calcium dihydrate is a drug for the treatment of type 2 diabetes. Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive...
Pimozide
T2546CAS 2062-78-4
Pimozide is a diphenylbutylpiperidine derivative and a dopamine antagonist with the antipsychotic property. Pimozide selectively inhibits type 2 dopaminergic re...
Amiodarone hydrochloride
T1496CAS 19774-82-4
Amiodarone hydrochloride is an antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting PO...
Prazosin hydrochloride
T1050CAS 19237-84-4
Prazosin Hydrochloride reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not complet...
Pantoprazole Sodium Hydrate
T0161CAS 164579-32-2
Pantoprazole is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease...
Sodium cromoglycate
T1260CAS 15826-37-6
Cromolyn sodium is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.
NS 1619
T3102CAS 153587-01-0
NS1619 have cardio-protective effects after ischemia-reperfusion injury.
ML297
T4664CAS 1443246-62-5
ML297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively). ML297 exhibits ...
AUT1
T5183CAS 1311136-84-1
AUT1 (AUT-1) is a novel specific modulator of Kv3 channels (EC50: 4.7 and 4.9 uM for Kv3.1b and Kv3.2a).
VU0071063
T26324CAS 333415-38-6
VU0071063 is a Kir6.2/SUR1 activator.
XE 991 dihydrochloride
T17262CAS 122955-13-9
XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker. XE 991 dihydrochloride potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, an...
Allocryptopine
TN3379CAS 24240-04-8
Allocryptopine has certain effects on anti-injury for hepatocyte, ameliorating liver function, and prohibiting hepatic fibrosis; it increases mRNA levels of cyt...
9-Hydroxycanthin-6-one
TN3319CAS 138544-91-9
9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as...
4-Hydroxycinnamamide
TN3042CAS 194940-15-3
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
3-Acetoxy-8(17),13E-labdadien-15-oic acid
TN2918CAS 63399-37-1
ent-3-Acetoxy-labda-8(17),13-dien-15-oic acid have vasorelaxant and hypotensive actions, the mechanisms underlying the cardiovascular actions of the labdane inv...
Paederosidic acid methyl ester
T3S0870CAS 122413-01-8
Paederosidic acid methyl ester has antinociception, is possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels.
3-Isomangostin
T2S1635CAS 19275-46-8
3-Isomangostin is a potent human aldose reductase inhibitor with an IC50 of 3.48 uM; it is also an acetylcholinesterase selective inhibitor. 3-Isomangostin has ...
VU0463271
T17243CAS 1391737-01-1
VU0463271 is an effective antagonist of KCC2 (IC50: 61 nM).
Chlorahololide C
TN3636CAS 1007859-25-7
Chlorahololide C is a potent and selective potassium channel blocker, it exerts potent and selective inhibition on the delayed rectifier (I(K)) K(+) current wit...
VU591
T13320LCAS 1222810-74-3
1222810-74-3
NS3623
T16347CAS 343630-41-1
NS3623 is an activator of human ether-a-go-go-related gene potassium channels. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels. NS3623 ac...
Neosolaniol
T16285CAS 36519-25-2
Neosolaniol evokes a robust anorectic response. Neosolaniol is a type A trichothecene mycotoxin from Fusarium sp.
MMP13-IN-3
T16124CAS 1222173-37-6
MMP13-IN-3 is >1000 selective over other MMPs. MMP13-IN-3 is an effective, selective, and orally active MMP-13 inhibitor (IC50=1 nM) for the potential treatment...
ML418
T16110CAS 1928763-08-9
ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker (IC50 = 310 nM), and also potently inhibits Kir6.2/SUR1.
Keto Ziprasidone
T11753CAS 884305-07-1
Ziprasidone, an antipsychotic agent, is a combined 5-HT (serotonin) and dopamine receptor antagonist. Keto Ziprasidone is an impurity of Ziprasidone.
VU0134992 hydrochloride
T13316CAS 1052515-91-9
VU0134992 hydrochloride is the first subtype-preferring, orally active and selective blocker of Kir4.1 potassium channel pore(IC50 : 0.97 µM).
Asebogenin
TN3460CAS 520-42-3
Asebogenin has anti-bacterial activity, it shows inhibitory activity against S. aureus and methicillin-resistant S. aureus (IC50 of 10 and 4.5 micrograms/ml, re...
Denudatin B
TN3831CAS 87402-88-8
Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin, it inhibits th...
ICA-27243
T15545CAS 325457-89-4
ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 μM). ICA-27...
DPO-1
T22745CAS 43077-30-1
DPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels
ASP-2905
T9070CAS 792184-90-8
ASP-2905 is a potent and selective inhibitor of potassium channel Kv12.2 encoded by the Kcnh3/BEC1 gene. It can cross the blood-brain barrier and has antipsych...
Kv2-IN-A1
T8977CAS 689297-68-5
Kv2-IN-A1 is an inhibitor of Kv2.1 and Kv2.2.
Phe-Met-Arg-Phe, amide acetate(64190-70-1 freebase)
TP1858LCAS TP1858L
Phe-Met-Arg-Phe, amide acetate dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons. This peptide appears to localize wit...
Myomodulin acetate(110570-93-9 free base)
TP1852LCAS TP1852L
Myomodulin acetate is present in two identified aplysia neurons that contain myomodulin A the ARC motor neuron B16 and the abdominal neuron L10.
Retigabine dihydrochloride
T21487CAS 150812-13-8
Retigabine dihydrochloride is an anticonvulsant used as an adjunctive treatment for partial epilepsies in treatment-experienced adult patients. The mechanism o...
TKIM
T8700CAS 326921-25-9
TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1.
Thevetin B
TN5141CAS 27127-79-3
Thevetin B is a cardiac glycoside. Thevetin A and thevetin B are Na+-, K+-dependent adenosinetriphosphatase (Na+,K+-ATPase) (EC 3.6.1.3) inhibitors.
Ecdysone
TN3910CAS 3604-87-3
Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. A nctional Bombyx Ecdysone receptor binds to EcRE-D ...
Stauntosaponin A
TN5060CAS 1417887-91-2
Stauntosaponin A and stauntosaponin B show moderate inhibitory activities against Na+/K+-ATPase with IC50 values of 21 and 29 uM, respectively.
Odoroside H
TN4697CAS 18810-25-8
Odoroside H has anticancer activities, the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase.
Neolinine
TN4638CAS 112515-37-4
Neolinine(at 10uM) shows significant hERG K+ channel inhibition activity.
Methyl 3,4,5-trimethoxycinnamate
TMA0763CAS 7560-49-8
Methyl 3,4,5-trimethoxycinnamate may protect the heart from arrhythmias via its inhibitory effect on calcium channel.
Lupanine
TMA0805CAS 550-90-3
Lupanine has a weak sedative effect on the central nervous system, interaction with specific drugs used for treatment of the CNS and for analgesic activity. Lup...
Isopulegol
TN4322CAS 7786-67-6
Isopulegol presents depressant- and anxiolytic-like effects, it also has anticonvulsant and bioprotective effects against PTZ-induced convulsions are possibly r...
Isokaempferide
TN4303CAS 1592-70-7
Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by re...
Linopirdine
T15758CAS 105431-72-9
Linopirdine is a TRPV1 agonist. Linopirdine is an orally active and selective M-type K+ current (IM; Kv7; KCNQ Channels) inhibitor (IC50: 2.4 μM). Linopirdine ...
VU591 hydrochloride
T13320CAS 1315380-70-1
VU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50:0.24 μM). Thought to block the intracellular pore ...
SKA31
T5180CAS 40172-65-4
SKA 31 is an activator of KCa3.1 and KCa2 channels (EC50s: 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively).
ICA 110381
T7612CAS 325457-99-6
ICA 110381 is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy
A2764 dihydrochloride
T7775CAS 861038-72-4
A2764 dihydrochloride is a highly selective inhibitor of TRESK.
Vernakalant
TQ0307CAS 794466-70-9
Vernakalant (RSD-1235) is a mixed ion channel blocker.
PAP-1
TQ0179CAS 870653-45-5
PAP-1 is a selective, and orally active Kv1.3 blocker (EC50: 2 nM).
Levcromakalim
TQ0150CAS 94535-50-9
Levcromakalim is an activator of the ATP-sensitive K+ channel.
VU 0240551
TQ0139CAS 893990-34-6
VU 0240551 is a neuronal K-Cl cotransporter KCC2 inhibitor (IC50: 560 nM for K+ uptake assay in KCC2-overexpressing cells).
JNJ 303
T7653CAS 878489-28-2
JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).
BMS-191011
T7512CAS 202821-81-6
BMS-191011 is an activator of large-conductance calcium-activated potassium (BKCa) channels ,effective in stroke models
Guan-fu base A
T8182CAS 1394-48-5
Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.
Azimilide Dihydrochloride
T7505CAS 149888-94-8
Azimilide Dihydrochloride, a novel class III antiarrhythmic agent, blocks both the slowly activating (IKs) and rapidly activating (IKr) components of the delaye...
E-4031
T7198CAS 113559-13-0
E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)
GSK369796 Dihydrochloride
T7195CAS 1010411-21-8
GSK369796 Dihydrochloride,is an anti-malaria drug candidate. is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization...
Almitrine dimesylate
T6978CAS 29608-49-9
Almitrine dimesylate inhibits selectively the Ca2+-dependent K+ channel and that in rat chemoreceptor cells,used in the treatment of hypoxemic chronic lung dise...
CLP-290
T5444CAS 1181083-81-7
CLP290 is an activator of the neuron-specific K+-Cl− cotransporter KCC2 and displays potential for the treatment of a wide range of neurological and psychiatr...
AM-92016 hydrochloride
T5585CAS 133229-11-5
AM-92016 is a specific blocker of rectifier potassium current. AM-92016 delays rectifier potassium channel and repolarizes the membrane thereby restricting the ...
Zacopride hydrochloride
T5336CAS 101303-98-4
Zacopride is a highly potent 5-HT3 receptor antagonist (Kd = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). It also is a selective IK1 channel agonist.
Cholesterol myristate
T8040CAS 1989-52-2
Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the nicotinic ac...
VU0810464
T7899CAS 2126040-21-7
VU0810464 is a non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator.
CLP257
T14984CAS 1181081-71-9
CLP257 is a selective activator of K+-Cl− cotransporter KCC2 (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alle...
Pinacidil monohydrate
T12478CAS 85371-64-8
Pinacidil monohydrate is a potassium channel activator, antihypertensive drug.
Clofilium tosylate
T14982CAS 92953-10-1
Clofilium tosylate is a potassium channel blocker. It induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspas...
IK1 inhibitor PA-6
T15555CAS 500715-03-7
IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1 (KIR2.x ion-channel-carried inward rectifier current)(IC50 of 12-15 nM for human and mouse ...
BL-1249
T14666CAS 18200-13-0
BL-1249 is a nonsteroidal anti-inflammatory drug (NSAID) and a potassium channel activator. BL-1249 exhibits more selective for the bladder (EC50 of 1.26 μM) t...
Almokalant
T14189CAS 123955-10-2
Almokalant is a class III antiarrhythmic drug, acts as a potassium channel blocker. And it inhibits a specific component (Ikr) of the time-dependent delayed rec...
4-Hydroxytolbutamide
T14040CAS 5719-85-7
4-Hydroxytolbutamide(Hydroxytolbutamide), a metabolite of Tolbutamide, which is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium ch...
DCPIB
T10979CAS 82749-70-0
DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μ...
(+)-KCC2 blocker 1
T12504CAS 1228439-71-1
(+)-KCC2 blocker 1 is a selective blocker of K+-Cl- cotransporter KCC2(IC50 of 0.4 μM).
QO-40
T8446CAS 1259536-70-3
QO-40 is a KCNQ2/3 potassium channels activator.
Tetraethylammonium bromide
T8361CAS 71-91-0
Tetraethylammonium bromide can selectively block potassium channels.
VU 0134992
T8372CAS 755002-90-5
VU0134992 is an Kir4.1 blocker with an IC50 value of 0.97 µM
Wilfordine
TN2306CAS 37239-51-3
Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect.
Strictosamide
TN2239CAS 23141-25-5
Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain.
Liriodendrin
TN1874CAS 573-44-4
Liriodendrin has anti-inflammatory, antinociceptive, hypoglycemic activities, it plays protective role in sepsis-induced acute lung injury, it regulates lung in...
Hypophyllanthin
TN1757CAS 33676-00-5
Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.
Dihydroisotanshinone I
TN1588CAS 20958-18-3
Dihydroisotanshinone I has protective action against menadione-induced hepatotoxicity, attributed to its antioxidant properties including the free radical scave...
Alismol
TN1367CAS 87827-55-2
Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for...
Sematilide HCl
T3574CAS 101526-62-9
Sematilide (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in...