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Search Results for " ptp1b "

Targets

49

Compounds

38

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T7356 PTP1B-IN-1 PTP1B inhibitor Phosphatase
PTP1B-IN-1 (PTP1B inhibitor) is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B) (IC50 : 1.6 mM)
T12577 PTP1B-IN-3 Phosphatase
PTP1B-IN-3 is a selective and potent PTP1B inhibitor with anticancer activity that inhibits PTP1B and TCPTP.PTP1B-IN-3 is used in the study of diabetes.
T67893 PTP1B-IN-22 Phosphatase
PTP1B-IN-22 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that inhibits glucose uptake in skeletal muscle L6 myotubes.
T4256 PTP1B-IN-2 Phosphatase
PTP1B-IN-2 is an effective protein tyrosine phosphatase 1B (PTP1B) inhibitor(IC50=50 nM).
T12579 RAMB4 PTP1B-IN-9 Proteasome
RAMB4 (PTP1B-IN-9) is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity.
T40745 PTP1B-IN-13 PTP1B-IN-13
PTP1B-IN-13, a potent and selective inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B), effectively targets the allosteric site, exhibiting an IC50 value of 1.59 μM.
T24073 PTP1B-IN-4 NUN 17724,PTP1B-inhibitor-2,PTP1B IN 2,PTP1B-IN-2,PTP1B-inhibitor-4,FRJ,PTP1B inhibitor 4,NUN17724,PTP1B inhibitor 2,PTP1BIN2,NUN-17724 Phosphatase
PTP1B-IN-4 (NUN-17724) is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.
T40835 PTP1B-IN-14 PTP1B-IN-14
PTP1B-IN-14 is a selective inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B) that targets the allosteric site, exhibiting an inhibitory concentration (IC50) value of 0.72 μM.
T12578 (E,E)-RAMB4 PTP1B-IN-8 Phosphatase
PTP1B-IN-8 is a potent and selective inhibitor of protein tyrosine phosphatase-1B (PTP1B).
T63435 PTP1B-IN-16
PTP1B-IN-16 is a promising and selective benzimidazole derivative and an inhibitor of protein tyrosine phosphatase 1B (PTP1B) (Ki: 12.6 μM).PTP1B-IN-16 can be used to study type 2 diabetes.
T63023 PTP1B-IN-19
PTP1B-IN-19 (Compound 43) is a promising selective benzimidazole derivative as a protein tyrosine phosphatase 1B (PTP1B) inhibitor (Ki: 23.3 μM).PTP1B-IN-17 can be used to study type 2 diabetes.
T63022 PTP1B-IN-18
PTP1B-IN-18 is an orally active, fully mixed protein tyrosine phosphatase 1B (PTP1B) inhibitor (Ki: 35.2 μM).PTP1B-IN-18 can be used to study type 2 diabetes.
T63021 PTP1B-IN-17
PTP1B-IN-17 (Compound 45) is a selective benzimidazole derivative with potential as a protein tyrosine phosphatase 1B (PTP1B) inhibitor (Ki: 30.2 μM).PTP1B-IN-17 can be used in the study of type 2 diabetes.
T63739 PTP1B-IN-15
PTP1B-IN-15 is a potent and selective protein tyrosine phosphatase 1B (PTP1B) inhibitor that has shown research potential in type II diabetes and obesity.
T61851 PTP1B-IN-3 diammonium
PTP1B-IN-3 diammonium is a highly effective and orally bioavailable inhibitor of the protein tyrosine phosphatase 1B (PTP1B) enzyme, with an IC50 value of 120 nM for both PTP1B and TCPTP. This compound exhibits potent an...
T78702 PTP1B/AKR1B1-IN-1 Phosphatase
PTP1B/AKR1B1-IN-1 is a dual inhibitor targeting protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AKR1B1), exhibiting inhibitory potency with IC50s of 0.06 μM for PTP1B and 4.3 μM for AKR1B1. Additionally, it...
T78703 PTP1B/AKR1B1-IN-2 Phosphatase
PTP1B/AKR1B1-IN-2 (Compound 7f) is a potent inhibitor targeting both PTP1B and AKR1B1 with IC50 values of 3.2 and 2.1 μM, respectively, and K i values of 4.0 and 0.9 μM. This compound acts as an insulin mimetic and enhan...
T4340 SPI-112 Phosphatase
SPI-112, the SPI-112 methyl ester analog, can inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competitive inhibitor kinetics to Shp2.
T23133 Pentamidine Phosphatase , Antibacterial , Antibiotic , Parasite , Antifungal
Pentamidine is an antifungal and antiprotozoal agent, interacting directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication.
T9921 Infliximab TNF
Infliximab is a humanized antibody against tumor necrosis factor α TNF-α) that is used in the treatment of Crohn's disease and rheumatoid arthritis.
T7704 KY-226 Phosphatase
KY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM,)
T28410 PHPS1 PHPS-1,PHPS 1 Phosphatase
PHPS1 is an inhibitor of Shp2. PHPS1 efficiently inhibits activation of Erk1/2 by the leukemia-associated Shp2 mutant, Shp2-E76K, and blocks the anchorage-independent growth of a variety of human tumor cell lines.
T1654 Pentamidine isethionate Pentamidine isethionate salt,Pentamidine diisethionate Phosphatase , Antibacterial , Antibiotic , Parasite , Antifungal
Pentamidine isethionate (Pentamidine diisethionate) is a synthetic amidine derivative, Pentamidine Isethionate is an antiprotozoal and antifungal agent.
T23132 Pentamidine dihydrochloride MP-601205 dihydrochloride Phosphatase , Antibacterial , Antibiotic , Parasite , Antifungal
Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi...
T22276 Bis(maltolato)oxovanadium(IV) BMOV,Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium,Bis(maltolato)oxovanadium (IV) Phosphatase , Others
Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases)inhibitor with insulin-mimicking effects and anti-diabetic properties. BMOV is a potent i...
T7381 TCS 401 Phosphatase
TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B; Ki = 0.29 µM)
T7084 2-Bromo-4'-hydroxyacetophenone SHP-1 Inhibitor II,PTP Inhibitor I,α-Bromo-4-hydroxyacetophenone,4-Hydroxyphenacyl bromide Phosphatase
2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SH...
T9938 RA371 EX-A4742 Others
RA371 (EX-A4742) is a derivative of PTP1B-IN-8, an inhibitor of PTP1B.
T4627 SPI--112Me Others
SPI--112Me, a prodrug of SPI-112, preferentially inhibits the PTPase activity of Shp2 over Shp1 and PTP1B by more than 20-fold in cell-free assays.
T22137 PTP Inhibitor IV Others
PTP Inhibitor IV is an effective protein tyrosine phosphatase (PTP) inhibitor, which can selectively inhibit DUSP14 phosphatase activity (IC50.5.21μm). PTP Inhibitor IV inhibited SHP-2, PTP1B, PTp-ε, PTP Meg-2, PTP-σ, PT...
T13013 Sodium stibogluconate Stibogluconate trisodium nonahydrate Phosphatase
Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent protein tyrosine phosphatase inhibitor.
T16724 Razuprotafib AKB-9778 Phosphatase , Others
Razuprotafib (AKB-9778) is a protein tyrosine phosphatase ß (HPTPß) inhibitor (IC50: 50 nM). Razuprotafib is effective for the activation of Tie-2 and is protective against acute kidney injury.
T15166 DPM-1001 Phosphatase
DPM-1001 is an orally bioavailable and non-competitive protein-tyrosine phosphatase (PTP1B) inhibitor (IC50: 100 nM) with the anti-diabetic property.
T11730 JTT 551 Others
JTT 551 can be used in the research of type 2 diabetes mellitus. JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosp...
T15243 Ertiprotafib PTP 112 Phosphatase , PPAR
Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ).
T39167 GS-493
GS-493, a highly specific protein tyrosine phosphatase SHP2 (PTPN11) inhibitor, exhibits remarkable potency with an IC50 of 71 nM. It displays 29- and 45-fold greater affinity towards SHP2 compared to its related counter...
T25953 PHPS1 Sodium PHPS1 Na,PHPS1 Sodium salt
PHPS1 sodium is a potent and selective inhibitor of Shp2, with Kis of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively [1].
T35877 MurA-IN-1
MurA-IN-1 (compound 1a), a PTPRR inhibitor, exhibits IC50 values of 0.09 μM for PTPRR, 0.23 μM for PTP1B, 0.75 μM for PTPN7, and 0.8 μM for PTPN5, respectively, targeting a family of human MAPK-specific protein tyrosine ...
T69633 TCS-401
TCS-401 is an insulin receptor sensitizing agent; Selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B).
T72216 DPM-1001 trihydrochloride
DPM-1001 trihydrochloride, an analog of the specific protein-tyrosine phosphatase (PTP1B) inhibitor MSI-1436, is a potent, specific, non-competitive, orally active inhibitor of PTP1B with an IC50 of 100 nM, exhibiting an...
T79845 Anticancer agent 144 Phosphatase
Compound 144 (also known as Anticancer Agent 144) is a potent inhibitor of both PTPN2 and PTP1B, exhibiting IC50 values of less than 2.5 nM, making it suitable for cancer research applications [1].
T41018 CPT-157633
CPT-157633 is a difluoro-phosphonomethyl phenylalanine derivative that acts as a potent inhibitor of the enzyme PTP1B. It effectively prevents the development of glucose intolerance induced by binge drinking.
TP1613 [pTyr5] EGFR (988-993) [pTyr5] EGFR 988-993
[pTyr5] EGFR (988-993) is a compound obtained from the auto-phosphorylation site, Tyr992, located within the sequence of the epidermal growth factor receptor (EGFR 988-993). This compound is frequently found bound with t...
T79844 Anticancer agent 143 Phosphatase
Anticancer Agent 143 (Compound 369), a potent dual inhibitor targeting PTPN2 and PTP1B, exhibits IC50 values below 2.5 nM. It is employed in cancer research [1].
T76019 [pTyr5] EGFR (988-993) (TFA)
[pTyr5] EGFR (988-993) TFA, originating from the Tyr992 autophosphorylation site of the epidermal growth factor receptor (EGFR 988-993), frequently forms a complex with catalytically inactive protein-tyrosine phosphate 1...
T79479 MptpB-IN-2 Antibiotic
MptpB-IN-2 (compound 20), a selective inhibitor for mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB), exhibits half maximal inhibitory concentrations (IC50) of 0.64 μM for MptpB, 4.06 μM for MptpA, and 4...
T71811 Lobaric acid
Lobaric acid is a depsidone metabolite that has been isolated from Stereocaulon lichen species with antioxidant, antiproliferative, antiviral, and enzyme inhibitory activites. It scavenges superoxide radicals in a cell-f...
T39677 MY33-3 MY33-3
MY33-3 is a powerful and specific inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, demonstrating an IC50 value of approximately 0.1 μM. Moreover, MY33-3 exhibits inhibitory activity against PTP-1B with an IC...
T10594 BpV(phen) PTEN
bpV(phen) is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor (IC50s: 343 nM, 920 nM, and 38 nM for PTP-β, PTP-1B, and PTEN).

Compounds

PTP1B-IN-1
T7356
Synonym: PTP1B inhibitor
Target: Phosphatase
PTP1B-IN-3
T12577
Synonym:
Target: Phosphatase
PTP1B-IN-22
T67893
Synonym:
Target: Phosphatase
PTP1B-IN-2
T4256
Synonym:
Target: Phosphatase
RAMB4
T12579
Synonym: PTP1B-IN-9
Target: Proteasome
PTP1B-IN-13
T40745
Synonym: PTP1B-IN-13
Target:
PTP1B-IN-4
T24073
Synonym: NUN 17724,PTP1B-inhibitor-2,PTP1B IN 2,PTP1B-IN-2,PTP1B-inhibitor-4,FRJ,PTP1B inhibitor 4,NUN17724,PTP1B inhibitor 2,PTP1BIN2,NUN-17724
Target: Phosphatase
PTP1B-IN-14
T40835
Synonym: PTP1B-IN-14
Target:
(E,E)-RAMB4
T12578
Synonym: PTP1B-IN-8
Target: Phosphatase
PTP1B-IN-16
T63435
Synonym:
Target:
PTP1B-IN-19
T63023
Synonym:
Target:
PTP1B-IN-18
T63022
Synonym:
Target:
PTP1B-IN-17
T63021
Synonym:
Target:
PTP1B-IN-15
T63739
Synonym:
Target:
PTP1B-IN-3 diammonium
T61851
Synonym:
Target:
PTP1B/AKR1B1-IN-1
T78702
Synonym:
Target: Phosphatase
PTP1B/AKR1B1-IN-2
T78703
Synonym:
Target: Phosphatase
SPI-112
T4340
Synonym:
Target: Phosphatase
Pentamidine
T23133
Synonym:
Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal
Infliximab
T9921
Synonym:
Target: TNF
KY-226
T7704
Synonym:
Target: Phosphatase
PHPS1
T28410
Synonym: PHPS-1,PHPS 1
Target: Phosphatase
Pentamidine isethionate
T1654
Synonym: Pentamidine isethionate salt,Pentamidine diisethionate
Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal
Pentamidine dihydrochloride
T23132
Synonym: MP-601205 dihydrochloride
Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal
Bis(maltolato)oxovanadium(IV)
T22276
Synonym: BMOV,Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium,Bis(maltolato)oxovanadium (IV)
Target: Phosphatase, Others
TCS 401
T7381
Synonym:
Target: Phosphatase
2-Bromo-4'-hydroxyacetophenone
T7084
Synonym: SHP-1 Inhibitor II,PTP Inhibitor I,α-Bromo-4-hydroxyacetophenone,4-Hydroxyphenacyl bromide
Target: Phosphatase
RA371
T9938
Synonym: EX-A4742
Target: Others
SPI--112Me
T4627
Synonym:
Target: Others
PTP Inhibitor IV
T22137
Synonym:
Target: Others
Sodium stibogluconate
T13013
Synonym: Stibogluconate trisodium nonahydrate
Target: Phosphatase
Razuprotafib
T16724
Synonym: AKB-9778
Target: Phosphatase, Others
DPM-1001
T15166
Synonym:
Target: Phosphatase
JTT 551
T11730
Synonym:
Target: Others
Ertiprotafib
T15243
Synonym: PTP 112
Target: Phosphatase, PPAR
GS-493
T39167
Synonym:
Target:
PHPS1 Sodium
T25953
Synonym: PHPS1 Na,PHPS1 Sodium salt
Target:
MurA-IN-1
T35877
Synonym:
Target:
TCS-401
T69633
Synonym:
Target:
DPM-1001 trihydrochloride
T72216
Synonym:
Target:
Anticancer agent 144
T79845
Synonym:
Target: Phosphatase
CPT-157633
T41018
Synonym:
Target:
[pTyr5] EGFR (988-993)
TP1613
Synonym: [pTyr5] EGFR 988-993
Target:
Anticancer agent 143
T79844
Synonym:
Target: Phosphatase
[pTyr5] EGFR (988-993) (TFA)
T76019
Synonym:
Target:
MptpB-IN-2
T79479
Synonym:
Target: Antibiotic
Lobaric acid
T71811
Synonym:
Target:
MY33-3
T39677
Synonym: MY33-3
Target:
bpV(phen)
T10594
Synonym:
Target: PTEN
Cat No. Product Name Synonyms Targets
T73072 PTP1B-IN-20
PTP1B-IN-20 is a selective PTP1B (protein tyrosine phosphatase 1B) inhibitor, exhibiting an IC50 of 1.05 μM, and demonstrates selectivity over TCPTP (T-cell protein tyrosine phosphatase), which has an IC50 of 78.0 μM. Th...
T73073 PTP1B-IN-21
PTP1B-IN-21 is a compound that functions as a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B; IC50=1.56 μM), demonstrating a marked preference over the structurally similar T-cell protein tyrosine phosphat...
T5708 LUPENONE Phosphatase , Parasite
Lupenone is a natural product isolated from Rhizoma Musae and has good anti-diabetic activity,and has anti-inflammatory activity.lupenone were potent PTP1B inhibitors with IC50 values of 15.11±1.23μM.
TCS1372 Atraric acid Phosphatase , Androgen Receptor
Atraric acid derivatives as a new chemical lead structure for novel therapeutic compounds as AR antagonists, that can be used for prophylaxis or treatment of prostatic diseases. It inhibits PTP1B activity in a dose-depen...
TN1990 Norathyriol 芒果 Akt , DNA/RNA Synthesis , AMPK , PPAR
Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
TN1470 Cassiaside B2 Phosphatase , MAO , 5-HT Receptor
Cassiaside B2 is an inhibitor of protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A).Cassiaside B2 is an agonist of the 5-HT2C receptor with anti-allergic activity.Cassiaside B2 is one of the a...
TN1956 Mulberrofuran G Phosphatase , HBV , Glucosidase
Mulberrofuran G is a small molecule compound from Morus alba L. It has anti-hepatitis B virus activity and protects against ischemic injury-induced cell death.Mulberrofuran G is a dual inhibitor of PTP1B and α-glucosidas...
TN2111 Prunin Naringenin 7-0-glucoside Phosphatase , Anti-infection , Virus Protease
Prunin (Naringenin 7-0-glucoside) possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-resistant HepG2 cells; it also can...
TN1691 Glabrol P450 , NF-κB , NO Synthase , Acyltransferase
Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15uM.
T3851 Vicenin 2 Vicenin -2 RAAS
Vicenin 2 is an angiotensin-converting enzyme (ACE) inhibitor (IC50=43.83 μM) from the aerial parts of Desmodium styracifolium. Vicenin 2 is an inhibitor of α-glucosidase, PTP1B, and RLAR. Vicenin 2 has hepatoprotective,...
T3S1612 Kuwanon G Moracenin B,Kuwanone G Phosphatase , Antibacterial , Bombesin Receptor , AChR , AChE , Glucosidase
1. Kuwanon G (Moracenin B) as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for Type II diabetes mellitus. 2. Kuwanon G has a...
T7028 Licochalcone C LICOCHALCONEC Phosphatase , Antioxidant , Glucosidase
Licochalcone C (LICOCHALCONEC) has potent antioxidant properties and inhibition of bacterial growth and cellular respiration. It has cardioprotection effect, via antioxidant, anti-inflammatory, and anti-apoptotic activit...
TN1053 Aloe-emodin-8-O-β-D-glucopyranoside Aloe-emodin-8-O-beta-D-glucopyranoside Phosphatase
Aloe-emodin-8-O-β-D-glucopyranoside (Aloe-emodin-8-O-beta-D-glucopyranoside) shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro.
TN1859 Licoflavone A Phosphatase
Licoflavone A is a natural product isolated from the roots of Glycyrrhiza uralensis.
T13740 Isotanshinone IIA Others
Isotanshinone IIA, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 0f 11.4 μM. is an abietane-type diterpene metabolite.
TN1775 Isocryptotanshinone ERK , JNK , STAT
Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negative regulator of insulin signaling, and selective inhibition of ...
TN3505 Beta-Peltoboykinolic acid Phosphatase
Beta-Peltoboykinolic acid has in vitro protein tyrosine phosphatase 1B (PTP1B) inhibitory, it inhibits PTP1B with IC50 values of 5.2+/-0.5 microM. It also has cytotoxic activity.
T38587 Chrysophanol triglucoside
Chrysophanol triglucoside, an anthraquinone derivative obtained from Cassia obtusifolia, demonstrates inhibitory activity against protein tyrosine phosphatases 1B (PTP1B) and α-glucosidase, with half-maximal inhibitory c...
TN5400 Aerugidiol
Aerugidiol inhibits protein tyrosine phosphatase 1B (PTP1B).
T75603 Cis-Ferulic acid 4-O-β-D-glucopyranoside
Cis-Ferulic acid 4-O-β-D-glucopyranoside (compound 7), a phenolic glycoside derived from Nitraria sibirica, demonstrates antioxidant properties and a potent inhibitory effect on Phosphatase PTP1B [1].
TN2887 3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid Phosphatase
(24E)-3,4-Seco-cucurbita-4,24-diene-3,26,29-trioic acid can inhibit the activity of protein tyrosine phosphatase 1B (PTP1B), with IC 50 values of 0.4uM.
TN2913 3-Acetoxy-11-ursen-28,13-olide Phosphatase
3β-Acetoxy-urs-11-en-28,13-olide exhibits significant protein tyrosine phosphatase 1B (PTP1B) inhibitory activity, it is a mixed-type PTP1B inhibitor. It exhibits weak-moderate antiproliferative activity against the A278...
TN3335 Abyssinone V Phosphatase
Abyssinone V is a natural compound isolated from the stem bark of Erythrina melanacantha and an inhibitor of protein tyrosine phosphatase-1B (PTP1B).
TN2288 Uralenol Others , Estrogen/progestogen Receptor , Tyrosinase
Uralenol significantly shows the inhibitory activities against the PTP1B enzyme; it also shows inhibitory activities on mushroom tyrosinase using l-tyrosine as substrate( IC50 =49.5 μM). Uralenol shows potent anti-prolif...
T75495 Rubrofusarin 6-O-β-D-glucopyranoside
Rubrofusarin 6-O-β-D-glucopyranoside, a glycosidic derivative of Rubrofusarin, functions as an inhibitor of protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 87.36 μM. It is utilized in research investigating...
TN3525 Boehmenan ERK , Phosphatase , EGFR , PARP , MEK , Wnt/beta-catenin , Akt , Caspase , STAT , p53
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in a competitive manner. Boehmenan exhibits the potent cytotox...
TN1832 Kanzonol C Others , NF-κB , Tyrosinase
Kanzonol C has antimicrobial activity, it also shows potent PTP1B inhibitory activity (IC50 value of 0.31-0.97uM). Kanzonol C has chemopreventive activity,it shows the inhibition of matrix metalloproteinase (MMP)-2 secre...
TN4839 Psidial A Others
Psidial A shows activity to enzyme PTP1B; it also reduces tumor growth and stimulate uterus proliferation.
TN4551 Methyl orsellinate Phosphatase , cAMP , Antifection
Methyl orsellinate is a phytotoxic compound, it exhibits antifungal activity, it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus and Echinochloa crus-galli, interact with bovine-brain cal...
T80008 Stevisaliosides D Phosphatase
Stevisaliosides D (Compound 5), extracted from the roots of Stevia serrata, exhibits inhibition of PTP1B with an IC50 of 31.8 μM and has applications in antidiabetic research [1].
TN4279 Isoderrone Tyrosinase
Isoderrone shows inhibitory effects on α-glucosidase in vitro; it is a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with IC50 value of 22.7 ± 1.7 uM, suggests that it may be a new drug for treatment of type 2 diabe...
T79985 Cryptosporioptide A Phosphatase
Cryptosporioptide A (Compound 3), a protein tyrosine phosphatase inhibitor, originates from the insect-parasitic fungus Cordyceps gracilioides. This compound effectively inhibits several enzymes including PTP1B, SHP2, CD...
T3930 Taraxerol acetate Taraxeryl acetate Phosphatase , HSV
Taraxeryl acetate shows the significant antiviral activity against herpes simplex virus (type II). It has less effect on cell cycle arrest and apoptosis of AGS cells than taraxerol. A. roxburghiana has antidiabetic activ...
T80007 Stevisalioside A Phosphatase
Stevisalioside A (Compound 2), isolated from the roots of Stevia serrata, is an orally active antidiabetic agent that inhibits Protein Tyrosine Phosphatase 1B (PTP1B) with an IC50 value of 526.8 μM. It effectively lowers...
TN4064 Flavoglaucin Phosphatase , IL Receptor , TNF , NOS , NF-κB , COX , Nrf2 , Prostaglandin Receptor , Autophagy
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannabinoid receptors. Flavoglaucin appears to be an antitumor pr...
TN2928 Pygenic acid A 3-Epicorosolic acid
3-Epicorosolic acid has a potent inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induction, it has potential anti-inflammatory activities as well as cancer chemopreventive activity.3-Epicorosolic acid show...
T38069 Aquastatin A
Aquastatin A is a fungal metabolite originally isolated fromF. aquaeductuumthat has diverse biological activities.1It is active againstS. aureus(MIC = 32 μg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC...
T3827 Rhein-8-glucoside calcium Rhein-8-O-β-D-glucopyranoside,Rhein-8-glucoside calcium salt Phosphatase , Antibacterial
Rhein-8-O-beta-D-glucopyranoside(Rhein-8-glucoside calcium (Rhein-8-glucoside calcium salt) salt) shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro.

Natural Products

PTP1B-IN-20
T73072
Synonym:
Target:
PTP1B-IN-21
T73073
Synonym:
Target:
LUPENONE
T5708
Synonym:
Target: Phosphatase, Parasite
Atraric acid
TCS1372
Synonym:
Target: Phosphatase, Androgen Receptor
Norathyriol
TN1990
Synonym: 芒果
Target: Akt, DNA/RNA Synthesis, AMPK, PPAR
Cassiaside B2
TN1470
Synonym:
Target: Phosphatase, MAO, 5-HT Receptor
Mulberrofuran G
TN1956
Synonym:
Target: Phosphatase, HBV, Glucosidase
Prunin
TN2111
Synonym: Naringenin 7-0-glucoside
Target: Phosphatase, Anti-infection, Virus Protease
Glabrol
TN1691
Synonym:
Target: P450, NF-κB, NO Synthase, Acyltransferase
Vicenin 2
T3851
Synonym: Vicenin -2
Target: RAAS
kuwanon G
T3S1612
Synonym: Moracenin B,Kuwanone G
Target: Phosphatase, Antibacterial, Bombesin Receptor, AChR, AChE, Glucosidase
Licochalcone C
T7028
Synonym: LICOCHALCONEC
Target: Phosphatase, Antioxidant, Glucosidase
Aloe-emodin-8-O-β-D-glucopyranoside
TN1053
Synonym: Aloe-emodin-8-O-beta-D-glucopyranoside
Target: Phosphatase
Licoflavone A
TN1859
Synonym:
Target: Phosphatase
Isotanshinone IIA
T13740
Synonym:
Target: Others
Isocryptotanshinone
TN1775
Synonym:
Target: ERK, JNK, STAT
Beta-Peltoboykinolic acid
TN3505
Synonym:
Target: Phosphatase
Chrysophanol triglucoside
T38587
Synonym:
Target:
Aerugidiol
TN5400
Synonym:
Target:
cis-Ferulic acid 4-O-β-D-glucopyranoside
T75603
Synonym:
Target:
3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid
TN2887
Synonym:
Target: Phosphatase
3-Acetoxy-11-ursen-28,13-olide
TN2913
Synonym:
Target: Phosphatase
Abyssinone V
TN3335
Synonym:
Target: Phosphatase
Uralenol
TN2288
Synonym:
Target: Others, Estrogen/progestogen Receptor, Tyrosinase
Rubrofusarin 6-O-β-D-glucopyranoside
T75495
Synonym:
Target:
Boehmenan
TN3525
Synonym:
Target: ERK, Phosphatase, EGFR, PARP, MEK, Wnt/beta-catenin, Akt, Caspase, STAT, p53
Kanzonol C
TN1832
Synonym:
Target: Others, NF-κB, Tyrosinase
Psidial A
TN4839
Synonym:
Target: Others
Methyl orsellinate
TN4551
Synonym:
Target: Phosphatase, cAMP, Antifection
Stevisaliosides D
T80008
Synonym:
Target: Phosphatase
Isoderrone
TN4279
Synonym:
Target: Tyrosinase
Cryptosporioptide A
T79985
Synonym:
Target: Phosphatase
Taraxerol acetate
T3930
Synonym: Taraxeryl acetate
Target: Phosphatase, HSV
Stevisalioside A
T80007
Synonym:
Target: Phosphatase
Flavoglaucin
TN4064
Synonym:
Target: Phosphatase, IL Receptor, TNF, NOS, NF-κB, COX, Nrf2, Prostaglandin Receptor, Autophagy
Pygenic acid A
TN2928
Synonym: 3-Epicorosolic acid
Target:
Aquastatin A
T38069
Synonym:
Target:
Rhein-8-glucoside calcium
T3827
Synonym: Rhein-8-O-β-D-glucopyranoside,Rhein-8-glucoside calcium salt
Target: Phosphatase, Antibacterial

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-04125 PTP1B Protein, Human, Recombinant (His) Human E. coli
PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly c...
TargetMol