pge-synthase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2681	HPGDS-IN-1		PGE Synthase
	hPGDS-IN-1 is a hPGDS inhibitor.		PGE Synthase
T1866	AT-56		Others , PGE Synthase
	AT56, a specific inhibitor of prostaglandin D2 synthase enzymatic activity, blunted adipogenic aldosterone effects.		Others , PGE Synthase
T5843L	(S)-Flurbiprofen	esflurbiprofen	COX , PGE Synthase
	Esflurbiprofen is an inhibitor of COX-1 and COX-2.		COX , PGE Synthase
T7948	HPGDS inhibitor 2	GSK-2894631A	PGE Synthase
	HPGDS inhibitor 2 (GSK-2894631A) is a potent, selective hematopoietic prostaglandin D synthase (h-pgds) inhibitor, IC50 = 9.9 nm.		PGE Synthase
T0159	Pranoprofen	Pyranoprofen	Apoptosis , COX , PGE Synthase , Prostaglandin Receptor
	Pranoprofen (Pyranoprofen) (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology.		Apoptosis , COX , PGE Synthase , Prostaglandin Receptor
T10098	PGS-IN-1	KME-4	Lipoxygenase , Prostaglandin Receptor
	PGS-IN-1 (KME-4) is a potent inhibitor of prostaglandin synthetase (PGS, IC50: 0.28 μM) and 5-lipoxygenase (IC50: 1.05 μM).		Lipoxygenase , Prostaglandin Receptor
T1804	HPGDS inhibitor 1	HPGDS-inhibitor-1	PGE Synthase
	HPGDS inhibitor 1 is a novel and selective inhibitor for Hematopoietic Prostaglandin D Synthase (HPGDS) with an IC50 Value of 0.7 nM.		PGE Synthase
T0726	Benzydamine hydrochloride	Benzydamine HCl,AF864	COX , PGE Synthase , Antibacterial
	Benzydamine hydrochloride (AF864), a locally-acting nonsteroidal anti-inflammatory drug, has local anaesthetic and analgesic properties.		COX , PGE Synthase , Antibacterial
T0264	Zomepirac sodium salt	Zomepirac Sodium,McN-2783-21-98	PGE Synthase , PDE
	Zomepirac sodium salt (McN-2783-21-98) is a prostaglandin synthetase inhibitor.		PGE Synthase , PDE
T6687	Suprofen	Maldocil,Suprol,TN-762,Profenal	COX , PGE Synthase
	Suprofen (Suprol) is an IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.		COX , PGE Synthase
T23861	CAY10526	CAY-10526,BTH,CAY 10526	Prostaglandin Receptor
	CAY10526 (BTH) is a selective mPGES-1 inhibitor that acts as an inhibitor of the NF-κB signaling pathway.		Prostaglandin Receptor
T0424	Bismuth Subsalicylate	Bismuth subsalicylat,Bismuth(III) salicylate basic,Bismuth oxysalicylate	COX , PGE Synthase
	Bismuth Subsalicylate (Bismuth subsalicylat) is the active ingredient in the popular medication Pepto-Bismol that is used to treat nausea, heartburn, indigestion, upset stomach, diarrhea, and other temporary discomforts ...		COX , PGE Synthase
T12352L	Oxidopamine hydrobromide	6-Hydroxydopamine hydrobromide,6-OHDA hydrobromide	Mitophagy , Dopamine Receptor , Autophagy
	Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.		Mitophagy , Dopamine Receptor , Autophagy
T12352	Oxidopamine hydrochloride	6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride	Mitophagy , Dopamine Receptor , Autophagy
	Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.		Mitophagy , Dopamine Receptor , Autophagy
T15757	Limaprost	17α,20-dimethyl-δ2-PGE1,OP1206,ONO1206	PGE Synthase
	Limaprost (17α,20-dimethyl-δ2-PGE1) is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency.It is a potent and orally active vasodilator. Limaprost increases blood...		PGE Synthase
T68334	AF3442
	AF3442 is a potent and selective mPGES-1 inhibitor (microsomal prostaglandin (PG) E synthase-1). AF3442 caused a concentration-dependent inhibition of PGE(2) in human recombinant mPGES-1 with an IC(50) of 0.06microM. AF3...
T36045	1a,1b-dihomo Prostaglandin E2	1a,1b-dihomo Prostaglandin E2
	1a,1b-dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid . 1a,1b-dihomo PGE2 has also b...

Compounds

hPGDS-IN-1

T2681

Synonym:

Target: PGE Synthase

AT-56

T1866

Synonym:

Target: Others, PGE Synthase

(S)-Flurbiprofen

T5843L

Synonym: esflurbiprofen

Target: COX, PGE Synthase

HPGDS inhibitor 2

T7948

Synonym: GSK-2894631A

Target: PGE Synthase

Pranoprofen

T0159

Synonym: Pyranoprofen

Target: Apoptosis, COX, PGE Synthase, Prostaglandin Receptor

PGS-IN-1

T10098

Synonym: KME-4

Target: Lipoxygenase, Prostaglandin Receptor

HPGDS inhibitor 1

T1804

Synonym: HPGDS-inhibitor-1

Target: PGE Synthase

Benzydamine hydrochloride

T0726

Synonym: Benzydamine HCl,AF864

Target: COX, PGE Synthase, Antibacterial

Zomepirac sodium salt

T0264

Synonym: Zomepirac Sodium,McN-2783-21-98

Target: PGE Synthase, PDE

Suprofen

T6687

Synonym: Maldocil,Suprol,TN-762,Profenal

Target: COX, PGE Synthase

CAY10526

T23861

Synonym: CAY-10526,BTH,CAY 10526

Target: Prostaglandin Receptor

Bismuth Subsalicylate

T0424

Synonym: Bismuth subsalicylat,Bismuth(III) salicylate basic,Bismuth oxysalicylate

Target: COX, PGE Synthase

Oxidopamine hydrobromide

T12352L

Synonym: 6-Hydroxydopamine hydrobromide,6-OHDA hydrobromide

Target: Mitophagy, Dopamine Receptor, Autophagy

Oxidopamine hydrochloride

T12352

Synonym: 6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride

Target: Mitophagy, Dopamine Receptor, Autophagy

Limaprost

T15757

Synonym: 17α,20-dimethyl-δ2-PGE1,OP1206,ONO1206

Target: PGE Synthase

1a,1b-dihomo Prostaglandin E2

T36045

Synonym: 1a,1b-dihomo Prostaglandin E2

Target:

Cat No.	Product Name	Synonyms	Targets
T2S2335	Dehydroevodiamine	DHED	Others , NF-κB , COX , PGE Synthase , NO Synthase
	Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood fl...		Others , NF-κB , COX , PGE Synthase , NO Synthase
T4S0227	Sinensetin	Pedalitin permethyl ether	TNF , PGE Synthase
	Sinensetin (Pedalitin permethyl ether) is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.		TNF , PGE Synthase
T5727	CAFESTOL		ERK , NF-κB , COX , PGE Synthase
	CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production...		ERK , NF-κB , COX , PGE Synthase
T5681	ETHYL CAFFEATE	ETHYL 3,4-DIHYDROXYCINNAMATE	NF-κB , COX , PGE Synthase , NO Synthase
	Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro. Furthermore, Ethyl Caffeate intensely blocked the transcriptional expression in interferon-γ-related s...		NF-κB , COX , PGE Synthase , NO Synthase