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Neuroscience P2 Receptor

P2 Receptor

Nucleotides if get released into the extracellular environment can lead to cell death or some other harmful cellular consequences. To avoid them it is required that they should be neutralized. Therefore P2 receptors come to work. Almost every cell type expresses P2 receptors. Purinergic signalling also has a pathophysiological role in several immune cells including calcium mobilization, actin polymerization, chemotaxis, the release of mediators, cell maturation, cytotoxicity, and cell death etc.Depending on the nature of the receptor they are found to be of two types:P2Y receptors and P2X receptors,P is for purinergic, P2 refers to ATP receptors, as opposed to P1 adenosine adenosine receptors. P2X receptors are ATP activated channels that allow the passage of ions across cell membranes. P2Y receptors are ATP activated G protein-coupled receptors (GPCRs) that initiate an intracellular chain of reactions.
Cat No. product name
T4298 JNJ-47965567 JNJ-47965567 is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for human and rat P2X...
T6172 MRS 2578 MRS2578, an effective P2Y6 receptor antagonist with IC50 of 37 nM, shows insignificant inhibition at P2Y1, P2Y2, P2Y4, and P2Y11 receptors.
T4699 Hexamethylene amiloride HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 µM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013...
T4132 BPTU Allosteric antagonist of P2Y1 (EC50 = 0.06-0.3 μM). Non-nucleotide ligand. Binds receptor outside of the helical bundle. Blocks inhibition of spontaneous contra...
T3578 Pyridoxal phosphate Pyridoxal Phosphate is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic t...
T3536 AZD1283 AZD1283 is an effective P2Y12 receptor antagonist (EC50: 3.0 ug/kg/min, binding IC50: 11 nM). AZD1283 dose-dependently induced increases in blood flow and inhibi...
T2673 A-438079 hydrochloride A-438079 hydrochloride is a potent and selective P2X7 receptor antagonist with pIC50 of 6.9.
T2087 AF 353 AF-353, an effective and orally bioavailable antagonist of the P2X3/P2X2/3 receptor, inhibits human and rat P2X3 (pIC50= 8.0).
T3690 A 740003 A 740003 is an effective and specific P2X7 receptor antagonist (IC50: 18/40 nM, for rat/human). It can reduce nociception in animal models of persistent neuropa...
T1131 Ivermectin Ivermectin is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.
T5099 Gefapixant Gefapixant is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors.
T0362 Ticlopidine hydrochloride Ticlopidine hydrochloride is an effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
T6952 Prasugrel Hydrochloride Prasugrel hydrochloride is a piperazine derivative and pletelet aggregation inhibitor that is used to prevent thrombosis in patients with acute coronary syndrome...
T6526 GW791343 3HCl GW791343 HCl is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7.
T0179 Ticagrelor Ticagrelor, produced by AstraZeneca, is an inhibitor of platelet aggregation. Unlike clopidogrel, ticagrelor is not a prodrug required metabolic activation. The ...
T0230 Prasugrel Prasugrel is a piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNSTABLE ANG...
T0182L2 (±) Clopidogrel hydrogen sulfate Clopidogrel, an antiplatelet agent pharmacologically and structurally analogous to ticlopidine, is used to inhibit blood clots in various conditions such as cere...
T0182L (S)-(+)-Clopidogrel hydrogen sulfate (S)-(+)-Clopidogrel hydrogensulfate, a selective, high-affinity P2Y12 receptor antagonist, suppressess fibrinogen binding to platelets and platelet adhesion and ...
T0182 (S)-Clopidogrel Clopidogrel, a P2Y12 receptor antagonist, decreases platelet aggregation.
T3345 Hederasaponin B Hederasaponin B has antiviral activity, via inhibiting the viral VP2 protein expression and blocking viral capsid protein synthesis.
T4706 UDP disodium salt UDP is a specific agonist of the P2Y6 receptors (EC50 = 13 nM for human P2Y6), stimulating the production of inflammatory mediators, phagocytosis, and vasoconstr...
T8946 Indophagolin Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and...
T10560 P2X3 antagonist 34 P2X3 antagonist 34 is a selective and orally active antagonist of P2X3 homotrimeric receptor (IC50s: 25 nM, 92 nM, and 126 nM for the human, rat, and guine...
T8333 Aurintricarboxylic acid Aurintricarboxylic acid is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing ...
T21059 Ticagrelor metabolite M5 Ticagrelor metabolite M5 is a metabolite of Ticagrelor, the first reversible oral antagonist of P2Y12 receptor. Compared to Clopidogrel, Ticagrelor has faster an...
TP2226 BzATP triethylammonium salt BzATP triethylammonium salt is a P2X7 receptor agonist.
T8582 Piperazine, 1-[(5-methyl-3-isoxazolyl)methyl]- (9CI) Piperazine, 1-[(5-methyl-3-isoxazolyl)methyl]- (9CI) is a P2Y12 inhibitor.
T16672 PSB-1114 tetrasodium PSB-1114 tetrasodium shows >50-fold selectivity versus the P2Y4 (EC50: 9.3 μM) and P2Y6 (EC50: 7.0 μM) receptors. PSB-1114 tetrasodium is an effective, enzymat...
T16572 Prasugrel (Maleic acid) Prasugrel Maleic acid is an orally active and potent P2Y12 receptor antagonist and inhibits ADP-induced platelet aggregation. Prasugrel Maleic acid is a thienopy...
T16399 Opiranserin Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is...
T5513 RO3 RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor
T10466 BAY-1797 BAY-1797 is an orally active and selective P2X4 antagonist (IC50: 211 nM against human P2X4) with anti-nociceptive and anti-inflammatory effects. BAY-1797 displa...
T7423 Diquafosol tetrasodium Diquafosol Tetrasodium is a P2Y2 receptor agonist that stimulates the secretion of mucins from ocular tissues Diquafosol tetrasodium improves tear film stability...
T11177 Elinogrel Elinogrel can be given orally and intravenously and has a strong anti-platelet effect.Elinogrel is an effective, direct acting, competitive, reversible platelet ...
T14920 CE-224535 CE-224535 is an antagonist of P2X7 receptor.
T14844 BX430 BX430 is used for chronic pain and cardiovascular disease and it is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with...
T14076 A 839977 A 839977 is a P2X7 selective antagonist and the antihyperalgesic effects of P2X7 receptor blockade are mediated by blocking the release of IL-1beta[1]. It blocks...
T10207 A 438079 A 438079 is a potent, and selective antagonist of P2X7 receptor (pIC50: 6.9).
T12568 PSB-12062 PSB-12062 is a potent and selective antagonist of P2X4(IC50 of 1.38 μM for human P2X4).
T7805 GW791343 (HCl) GW791343 is a P2X7 allosteric modulator.
TQ0002 A-317491 A-317491 is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors.
T3639 A804598 A-804598 is a competitive and selective P2X7 receptor antagonist (IC50: 10 nM, rat; 9 nM, mouse; 11 nM, human).
JNJ-47965567
T4298CAS 1428327-31-4
JNJ-47965567 is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for human and rat P2X...
MRS 2578
T6172CAS 711019-86-2
MRS2578, an effective P2Y6 receptor antagonist with IC50 of 37 nM, shows insignificant inhibition at P2Y1, P2Y2, P2Y4, and P2Y11 receptors.
Hexamethylene amiloride
T4699CAS 1428-95-1
HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 µM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013...
BPTU
T4132CAS 870544-59-5
Allosteric antagonist of P2Y1 (EC50 = 0.06-0.3 μM). Non-nucleotide ligand. Binds receptor outside of the helical bundle. Blocks inhibition of spontaneous contra...
Pyridoxal phosphate
T3578CAS 54-47-7
Pyridoxal Phosphate is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic t...
AZD1283
T3536CAS 919351-41-0
AZD1283 is an effective P2Y12 receptor antagonist (EC50: 3.0 ug/kg/min, binding IC50: 11 nM). AZD1283 dose-dependently induced increases in blood flow and inhibi...
A-438079 hydrochloride
T2673CAS 899431-18-6
A-438079 hydrochloride is a potent and selective P2X7 receptor antagonist with pIC50 of 6.9.
AF 353
T2087CAS 865305-30-2
AF-353, an effective and orally bioavailable antagonist of the P2X3/P2X2/3 receptor, inhibits human and rat P2X3 (pIC50= 8.0).
A 740003
T3690CAS 861393-28-4
A 740003 is an effective and specific P2X7 receptor antagonist (IC50: 18/40 nM, for rat/human). It can reduce nociception in animal models of persistent neuropa...
Ivermectin
T1131CAS 70288-86-7
Ivermectin is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.
Gefapixant
T5099CAS 1015787-98-0
Gefapixant is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors.
Ticlopidine hydrochloride
T0362CAS 53885-35-1
Ticlopidine hydrochloride is an effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
Prasugrel Hydrochloride
T6952CAS 389574-19-0
Prasugrel hydrochloride is a piperazine derivative and pletelet aggregation inhibitor that is used to prevent thrombosis in patients with acute coronary syndrome...
GW791343 3HCl
T6526CAS 309712-55-8
GW791343 HCl is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7.
Ticagrelor
T0179CAS 274693-27-5
Ticagrelor, produced by AstraZeneca, is an inhibitor of platelet aggregation. Unlike clopidogrel, ticagrelor is not a prodrug required metabolic activation. The ...
Prasugrel
T0230CAS 150322-43-3
Prasugrel is a piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNSTABLE ANG...
(±) Clopidogrel hydrogen sulfate
T0182L2CAS 135046-48-9
Clopidogrel, an antiplatelet agent pharmacologically and structurally analogous to ticlopidine, is used to inhibit blood clots in various conditions such as cere...
(S)-(+)-Clopidogrel hydrogen sulfate
T0182LCAS 120202-66-6
(S)-(+)-Clopidogrel hydrogensulfate, a selective, high-affinity P2Y12 receptor antagonist, suppressess fibrinogen binding to platelets and platelet adhesion and ...
(S)-Clopidogrel
T0182CAS 113665-84-2
Clopidogrel, a P2Y12 receptor antagonist, decreases platelet aggregation.
Hederasaponin B
T3345CAS 36284-77-2
Hederasaponin B has antiviral activity, via inhibiting the viral VP2 protein expression and blocking viral capsid protein synthesis.
UDP disodium salt
T4706CAS 27821-45-0
UDP is a specific agonist of the P2Y6 receptors (EC50 = 13 nM for human P2Y6), stimulating the production of inflammatory mediators, phagocytosis, and vasoconstr...
Indophagolin
T8946CAS 1207660-00-1
Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and...
P2X3 antagonist 34
T10560CAS T10560
P2X3 antagonist 34 is a selective and orally active antagonist of P2X3 homotrimeric receptor (IC50s: 25 nM, 92 nM, and 126 nM for the human, rat, and guine...
Aurintricarboxylic acid
T8333CAS 4431-00-9
Aurintricarboxylic acid is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing ...
Ticagrelor metabolite M5
T21059CAS 1251765-07-7
Ticagrelor metabolite M5 is a metabolite of Ticagrelor, the first reversible oral antagonist of P2Y12 receptor. Compared to Clopidogrel, Ticagrelor has faster an...
BzATP triethylammonium salt
TP2226CAS 112898-15-4
BzATP triethylammonium salt is a P2X7 receptor agonist.
Piperazine, 1-[(5-methyl-3-isoxazolyl)methyl]- (9CI)
T8582CAS 173850-51-6
Piperazine, 1-[(5-methyl-3-isoxazolyl)methyl]- (9CI) is a P2Y12 inhibitor.
PSB-1114 tetrasodium
T16672CAS 1657025-60-9
PSB-1114 tetrasodium shows >50-fold selectivity versus the P2Y4 (EC50: 9.3 μM) and P2Y6 (EC50: 7.0 μM) receptors. PSB-1114 tetrasodium is an effective, enzymat...
Prasugrel (Maleic acid)
T16572CAS 389574-20-3
Prasugrel Maleic acid is an orally active and potent P2Y12 receptor antagonist and inhibits ADP-induced platelet aggregation. Prasugrel Maleic acid is a thienopy...
Opiranserin
T16399CAS 1441000-45-8
Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is...
RO3
T5513CAS 1026582-88-6
RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor
BAY-1797
T10466CAS 2055602-83-8
BAY-1797 is an orally active and selective P2X4 antagonist (IC50: 211 nM against human P2X4) with anti-nociceptive and anti-inflammatory effects. BAY-1797 displa...
Diquafosol tetrasodium
T7423CAS 211427-08-6
Diquafosol Tetrasodium is a P2Y2 receptor agonist that stimulates the secretion of mucins from ocular tissues Diquafosol tetrasodium improves tear film stability...
Elinogrel
T11177CAS 936500-94-6
Elinogrel can be given orally and intravenously and has a strong anti-platelet effect.Elinogrel is an effective, direct acting, competitive, reversible platelet ...
CE-224535
T14920CAS 724424-43-5
CE-224535 is an antagonist of P2X7 receptor.
BX430
T14844CAS 688309-70-8
BX430 is used for chronic pain and cardiovascular disease and it is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with...
A 839977
T14076CAS 870061-27-1
A 839977 is a P2X7 selective antagonist and the antihyperalgesic effects of P2X7 receptor blockade are mediated by blocking the release of IL-1beta[1]. It blocks...
A 438079
T10207CAS 899507-36-9
A 438079 is a potent, and selective antagonist of P2X7 receptor (pIC50: 6.9).
PSB-12062
T12568CAS 55476-47-6
PSB-12062 is a potent and selective antagonist of P2X4(IC50 of 1.38 μM for human P2X4).
GW791343 (HCl)
T7805CAS 1019779-04-4
GW791343 is a P2X7 allosteric modulator.
A-317491
TQ0002CAS 475205-49-3
A-317491 is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors.
A804598
T3639CAS 1125758-85-1
A-804598 is a competitive and selective P2X7 receptor antagonist (IC50: 10 nM, rat; 9 nM, mouse; 11 nM, human).