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Opioid Receptor

T0102 Naloxone hydrochloride Naloxone hydrochloride is a specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.
T0137 Mirtazapine Mirtazapine is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevat...
T0201 Meptazinol hydrochloride Meptazinol Hcl, a unique centrally opioid analgesic, is used as a narcotic antagonist with analgesic properties.
T0209 Loperamide hydrochloride Loperamide Hydrochloride is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity.
T0262 Dextromethorphan HBr monohydrate Methyl analog of DEXTRORPHAN that shows high-affinity binding to some areas of the brain, including the medullary cough center. This compound is an NMDA recepto...
T0478 Progesterone Progesterone is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY ...
T0783 Mianserin hydrochloride Mianserin hydrochloride is a tetracyclic compound with antidepressant effects. it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin ...
T0918 Trimebutine Trimebutine is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu-opioid agonist eff...
T0929 Docusate sodium Docusate is an orally available, over-the-counter laxative and stool softener used to treat or prevent constipation. Docusate has not been linked to serum enzym...
T0963 Naltrexone hydrochloride Naltrexone is a synthetic opioid antagonist used in the prevention of relapse of opiate addiction and alcoholism.
T0981 Noscapine hydrochloride Noscapine Hydrochloride is the orally available hydrochloride salt of the opioid agonist noscapine, a phthalide isoquinoline alkaloid derived from the opium pop...
T1242 Alvimopan Alvimopan is a synthetic trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a se...
T1407 L-Menthol L-Menthol is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic prope...
T2388 Nalfurafine hydrochloride Nalfurafine(TRK-820) is an opioid κ-selective agonist; has been approved in Japan for treatment of itch in patients with chronic kidney disease.
T2870 (+)-Matrine Matrine, an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.
T3417 Amentoflavone Amentoflavone, as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in ...
T6175 ADL5859 HCl ADL5859 HCl is a selective δ-opioid receptor agonist ( Ki: 0.8 nM), selectivity against opioid receptor κ, μ, and little inhibition for the hERG channel.
T6221 Nalmefene hydrochloride Nalmefene antagonizes the effects of opioids by competing for the opioid receptors in the CNS.
T4351 DAMGO DAMGO is an opioid receptor agonist with the ability to affect the locomotive activity in rodents. Possible analgesic agent due to μ-opiod receptor interaction...
T4407 SR17018 SR17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC50 of 97 nM.
T4411 DAMGO TFA (78123-71-4(Free base)) Potent, selective agonist of Mu-opioid receptor. Antinociceptive. Stimulates calcium-activated adenylyl cyclases related cAMP production. Expresses chemokines a...
T4386 PZM21 PZM21 is an effective and selective μ opioid receptor agonist (EC50: 1.8 nM).
T4478 CID 16020046 CID16020046 is a selective GPR55 antagonist, inhibiting GPR55 constitutive activity with IC50 of 0.15 μM in yeast.
T4691 Asimadoline hydrochloride Asimadoline HCl is a κ-opioid receptor agonist potentially for the treatment of pruritus. Asimadoline has also been shown to be used in the treatment of irrita...
T5158 N-Desmethylclozapine N-Desmethylclozapine is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist ...
T5167 Cebranopadol Cebranopadol is an analgesic NOP and opioid receptor agonist with Kis of 0.9 nM, 0.7 nM, 2.6 nM, 18 nM for human NOP, μ-opioid (MOP), κ-opioid (KOP) and δ-op...
TWS0414 Cannabidiol Cannabidiol is GPR55 and weak CB1 antagonist (IC50s: 0.445 and 3.35 μM), CB2 receptor inverse agonist and inhibitor of anandamide uptake (IC50: 27.5 μM). It a...
T7218 Endomorphin 2 Endomorphins-2 (EM-2) could decrease both the frequency and amplitude of the sEPSC of the motoneurons in lamina IX, which was reversed by the MOR antagonist CTO...
T7211 Tyr-Gly-Gly-Phe-Met-OH Tyr-Gly-Gly-Phe-Met-OH, is a naturally occurring, endogenous opioid peptide that inhibits tumor growth via binding to the opioid receptor.
T7173 [Leu5]-Enkephalin [Leu5]-Enkephalin is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and -opioid receptors (Kis = 4.0 and 3.4 nM, respectively)
T7306 Valorphin Valorphin has opioid analgesic activity, binds to rat mu-opioid receptor, with an IC50 of 14 nM.
T7404 Dermorphin Dermorphin is agonist of μ-opioid receptor (MOR) agonist.
TQ0082 Aticaprant Aticaprant (CERC-501) is a potent and centrally-penetrant antagonist of the kappa-opioid receptor (Ki: 0.807 nM).
TQ0091 LY2795050 LY2795050 is a novel specific κ-Opioid Receptor antagonist (IC50: 0.72 nM).
TQ0267 Endomorphin-1 Endomorphin 1 is a high affinity and selective agonist of the μ-opioid receptor and displays reasonable affinities for kappa3 binding sites (Ki: 20~30 nM).
T7567 Adrenorphin(3TFA) Adrenorphin(3TFA) is an agonist of μ-opioid receptor(Ki :12 nM).
T7576 β-Casomorphin, bovine(2TFA) β-Casomorphin, bovine(2TFA) is an opioid peptide isolated from casein peptone
T7613 β-Casomorphin, human(TFA) β-Casomorphin, human(TFA) is an opioid receptor agonist.
T7637 Deltorphin I(TFA) Deltorphin I(TFA) is an agonist of δ-opioid receptor.
T7639 Deltorphin 2(TFA) Deltorphin 2(TFA) is an agonist of δ opioid receptor(IC50:0.41 nM)
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