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Search Result

Search Results for " opioid-receptor "

Targets

Opioid Receptor

275

Compounds

9

Natural Products

2

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T12314 Opioid receptor modulator 1 Opioid Receptor
Opioid receptor modulator 1 is a modulator of opioid receptor.
T9459 GR103545 Others
GR103545 is a selective agonist of the κ-opioid receptor, which is a radiotracer that can be used as in vivo imaging.
TP1832 Gluten Exorphin C Opioid Receptor
Gluten exorphin C is an opioid peptide derived from wheat gluten. Its IC50 values are 40 μM and 13.5 μM for μ opioid and δ opioid activities in the GPI and MVD assays, respectively.Gluten Exorphin C, isolated from the pe...
T8991 BMS986187 Opioid Receptor
BMS986187 is a novel Potent and Selective Positive Allosteric Modulators of the delta-Opioid Receptor.
T13414 ZT 52656A hydrochloride Opioid Receptor
ZT 52656A is a selective agonist of kappa opioid, and used for the prevention or alleviation of pain in the eye.
T4351 DAMGO Dagol,DAGO,RX-783006 Opioid Receptor
DAMGO (DAGO) is an opioid receptor agonist with the ability to affect the locomotive activity in rodents. Possible analgesic agent due to μ-opiod receptor interaction.
T4386 PZM21 Opioid Receptor
PZM21 is an effective and selective μ opioid receptor agonist (EC50: 1.8 nM).
T4407 SR17018 Opioid Receptor
SR17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC50 of 97 nM.
T8992 BMS986188 Opioid Receptor
BMS986188 is a novel Potent and Selective Positive Allosteric Modulator of the delta-Opioid Receptor.
T0918 Trimebutine Mebutin Opioid Receptor
Trimebutine (Mebutin) is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu-opioid agonist effects. It is marketed for the treatment of irritabl...
T62673 Mu opioid receptor antagonist 5
Mu opioid receptor antagonist 5 (compound NAP) is a selective mu opioid receptor (MOR) antagonist that crosses the blood-brain barrier (EC50: 1.14 nM, Ki: 0.37 nM). Mu opioid receptor antagonist 5 can be used to study op...
T62766 Mu opioid receptor antagonist 2
Mu opioid receptor antagonist 2 (compound 25) is a potent and selective mu opioid receptor (MOR) antagonist that permeates the blood-brain barrier (Ki: 0.37 nM, EC50: 0.44 nM). Mu opioid receptor antagonist 2 can be used...
T62768 Mu opioid receptor antagonist 4
Mu opioid receptor antagonist 4 (compound 31) is a potent and selective mu opioid receptor (MOR) antagonist that permeates the blood-brain barrier (Ki: 0.38 nM, EC50: 0.38 nM). Mu opioid receptor antagonist 2 can be used...
T7748 Dermorphin TFA Others , Opioid Receptor
Dermorphin TFA is a new class of opioids-like peptides
T61901 σ1 Receptor/μ Opioid receptor modulator 1
σ 1 Receptor/ μ Opioid receiver modulator 1 (Compound 44) is an effective σ 1 receptor antagonist (Ki=1.86 nM) and μ Opioid receptor agonists (Ki=2.1 nM). Opioid receptor modulator 1 shows potent analgesic activity, and ...
T7218 Endomorphin 2 Opioid Receptor
Endomorphins-2 (EM-2) could decrease both the frequency and amplitude of the sEPSC of the motoneurons in lamina IX, which was reversed by the MOR antagonist CTOP. EM-2-IR fibers originated from primary afferent fibers f...
T79430 μ opioid receptor agonist 3 Opioid Receptor
Compound 20, identified as μ opioid receptor agonist 3, is a potent µOR agonist that exhibits an EC50 value of 0.87 nM. It holds promise for research into pain management and neuropsychiatric disorders [1].
T62767 Mu opioid receptor antagonist 3
Mu opioid receptor antagonist 3 (compound 26) is a potent and selective mu opioid receptor (MOR) antagonist that penetrates the blood-brain barrier (Ki: 0.24 nM, EC50: 0.54 nM). Mu opioid receptor antagonist 2 can be use...
T62025 μ opioid receptor agonist 2
μ opioid receptor agonist 2 （Compound H-3）is a MOR receptor agonist. μ opioid receptor agonist 2 can be used for the research of pain and pain related diseases.
T4691 Asimadoline hydrochloride EMD-61753 hydrochloride Opioid Receptor
Asimadoline hydrochloride (EMD-61753 hydrochloride) is a κ-opioid receptor agonist potentially for the treatment of pruritus. Asimadoline hydrochloride has also been shown to be used in the treatment of irritable bowel s...
T79431 Mu opioid receptor antagonist 7 Opioid Receptor
Compound 24, also known as Mu opioid receptor antagonist 7, is a potent, centrally-acting µ-opioid receptor (µOR) antagonist with an inhibitory concentration (IC50) of 29 ± 3.0 nM. It is valuable for pain and opioid use ...
T62268 μ opioid receptor agonist 1
μ opioid receptor agonist 1 (Compound H-1a) is an optically pure oxyheterocyclic substituted pyrroloxypyrazole derivative and an MOR receptor agonist that can be used in the study of pain and pain-related disorders.
TP1071 Nociceptin Orphanin FQ Opioid Receptor
Nociceptin (Orphanin FQ) is a 17-amino-acid polypeptide that is structurally related to the opioid peptide dynorphin A.
T1242 Alvimopan Opioid Receptor
Alvimopan (LY 246736) is a synthetic trans-3, 4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competitive antagonist at mu-opioid...
TQ0091 LY2795050 Opioid Receptor
LY2795050 is a novel specific κ-Opioid Receptor antagonist (IC50: 0.72 nM).
T9833 Opiranserin hydrochloride P2X Receptor , GlyT , 5-HT Receptor
Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. It shows antagonistic activity on rP2X3 (IC50...
T2071 MCOPPB triHydrochloride MCOPPB trihydrochlride,MCOPPB 3HCl Opioid Receptor
MCOPPB triHydrochloride (MCOPPB 3HCl) is a nociceptin receptor agonist.
TQ0267 Endomorphin 1 Endomorphin-1 Opioid Receptor
Endomorphin 1 is a high affinity and selective agonist of the μ-opioid receptor and displays reasonable affinities for kappa3 binding sites (Ki: 20~30 nM).
T1197 Trimebutine maleate Debridat,Polibutin Calcium Channel , Opioid Receptor
Trimebutine maleate (Polibutin) is a weak mu-opioid agonist and has antimuscarinic effects. Trimebutine is an agonist of peripheral mu, delta, and kappa opiate receptors served as a spasmolytic drug for therapy of both c...
T6414 Bisacodyl Fenilaxan,Dulcolax,Brocalax Others
Bisacodyl (Fenilaxan) is a diphenylmethane stimulant laxative used for the treatment of constipation and for bowel evacuation.
T5167 Cebranopadol GRT6005 Opioid Receptor
Cebranopadol (GRT6005) is an analgesic NOP and opioid receptor agonist with Kis of 0.9 nM, 0.7 nM, 2.6 nM, 18 nM for human NOP, μ-opioid (MOP), κ-opioid (KOP) and δ-opioid (DOP) receptor, respectively.
TP1905 BW-180C DADLE Opioid Receptor
BW-180C (DADLE) is a prototypical δ-opioid receptor agonist that also displays activity at the μ-opioid receptor. Displays antinociceptive activity in vivo.
T3996 Dapiprazole Hydrochloride Glamidolo Hydrochloride,Reversil Hydrochloride Adrenergic Receptor
Dapiprazole Hydrochloride (Glamidolo Hydrochloride) is an alpha-1-adrenergic antagonist that acts by blocking alpha-adrenergic receptors in the smooth muscle of blood vessels (arteries, arterioles and veins), gastrointes...
T26869 BMS-986122 BMS 986122 Opioid Receptor
BMS-986122 (BMS 986122) is a positive allosteric modulator of μ-opioid receptors that increases β-arrestin recruitment stimulated by endomorphin 1 in U2OS-OPRM1 human osteosarcoma cells expressing μ-opioid receptors (EC5...
T15799 LY2940094 LY-2940094 Opioid Receptor
LY2940094 (LY-2940094) decreases ethanol self-administration in animal models. LY2940094 is an effective, selective, and orally available nociceptin receptor antagonist with high affinity (Ki=0.105 nM) and antagonist pot...
T5158 N-Desmethylclozapine Desmethylclozapine,Normethylclozapine,Norclozapine Virus Protease , Dopamine Receptor , 5-HT Receptor , Opioid Receptor , AChR , Drug Metabolite
N-Desmethylclozapine (Desmethylclozapine) is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist at δ-opioid receptors.
TP1367 [D-Ala2]leucine-enkephalin Opioid Receptor
[D-Ala2]-Leucine enkephalin is a delta opioid agonist used to study the signaling pathway of delta opioid receptors.
T14551 Bevenopran CB-5945,ADL-5945 Opioid Receptor
Bevenopran (CB-5945) is a peripheral antagonist of μ-opioid receptor and can be used in studies about the treatment of opioid-induced bowel dysfunction.
TQ0082 Aticaprant LY-2456302,CERC-501 Opioid Receptor
Aticaprant (LY-2456302) (CERC-501) is a potent and centrally-penetrant antagonist of the kappa-opioid receptor (Ki: 0.807 nM).
T7637 Deltorphin I Deltorphin 1,Deltorphin I(TFA),Deltorphin C Opioid Receptor
Deltorphin I is an agonist of δ-opioid receptor.
T6175 ADL-5859 ADL5859 Hydrochloride,ADL5859 HCl Opioid Receptor
ADL-5859 (ADL5859 Hydrochloride) is a selective δ-opioid receptor agonist ( Ki: 0.8 nM), selectivity against opioid receptor κ, μ, and little inhibition for the hERG channel.
T7639 Deltorphin 2 Deltorphin 2(TFA),[D-Ala2]-Deltorphin II Opioid Receptor
Deltorphin 2 ([D-Ala2]-Deltorphin II) is an agonist of δ opioid receptor with an IC50 of 1 nM.
T14835 BTRX-335140 CYM-53093 Opioid Receptor
BTRX-335140 (CYM-53093) is a potent and selective, orally active κ opioid receptor (KOR) antagonist, has antagonist activity for κOR, μOR and δOR with IC50 values of 0.8 nM, 110 nM, and 6500 nM, respectively. BTRX-335140...
TP2036L DPDPE TFA (88373-73-3 free base) DPDPE TFA Opioid Receptor
DPDPE TFA is selective δ-opioid receptor agonist peptide. Inhibits electrically stimulated contraction of mouse vas deferens in vitro (EC50 = 5.2 nM), and is antinociceptive in vivo.
T7173 [Leu5]-Enkephalin Leucine enkephalin,Leucyl-enkephalin,Leu-enkephalin Opioid Receptor , Endogenous Metabolite
[Leu5]-Enkephalin (Leu-enkephalin) is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM, respectively)
T7211 Tyr-Gly-Gly-Phe-Met-OH Methionine enkephalin,Met-Enkephalin Opioid Receptor
Tyr-Gly-Gly-Phe-Met-OH (Met-Enkephalin), is a naturally occurring, endogenous opioid peptide that inhibits tumor growth via binding to the opioid receptor.
T21422 Methylnaltrexone bromide Relistor,MOA-728,MOA 728,Methylnaltrexone,MOA728 Opioid Receptor
Methylnaltrexone bromide (MOA-728) is one of the newer agents of peripherally-acting μ-opioid antagonists. Methylnaltrexone bromide acts to reverse some of the side effects of opioid drugs such as constipation without af...
T4478 CID 16020046 C390-0219 Cannabinoid Receptor
CID 16020046 (C390-0219) is a selective GPR55 antagonist, inhibiting GPR55 constitutive activity with IC50 of 0.15 μM in yeast.
TP2036 DPDPE Opioid Receptor
DPDPE is selective δ-opioid receptor agonist peptide. Inhibits electrically stimulated contraction of mouse vas deferens in vitro (EC50 = 5.2 nM), and is antinociceptive in vivo.
T4633 Asimadoline EMD-61753 Opioid Receptor
Asimadoline (EMD-61753) is a proprietary small molecule therapeutic, originally discovered by Merck KGaA of Darmstadt, Germany. Asimadoline was originally developed to treat peripheral pain such as arthritis. Asimadoline...

Compounds

Opioid receptor modulator 1
T12314
Synonym:
Target: Opioid Receptor
GR103545
T9459
Synonym:
Target: Others
Gluten Exorphin C
TP1832
Synonym:
Target: Opioid Receptor
BMS986187
T8991
Synonym:
Target: Opioid Receptor
ZT 52656A hydrochloride
T13414
Synonym:
Target: Opioid Receptor
DAMGO
T4351
Synonym: Dagol,DAGO,RX-783006
Target: Opioid Receptor
PZM21
T4386
Synonym:
Target: Opioid Receptor
SR17018
T4407
Synonym:
Target: Opioid Receptor
BMS986188
T8992
Synonym:
Target: Opioid Receptor
Trimebutine
T0918
Synonym: Mebutin
Target: Opioid Receptor
Mu opioid receptor antagonist 5
T62673
Synonym:
Target:
Mu opioid receptor antagonist 2
T62766
Synonym:
Target:
Mu opioid receptor antagonist 4
T62768
Synonym:
Target:
Dermorphin TFA
T7748
Synonym:
Target: Others, Opioid Receptor
σ1 Receptor/μ Opioid receptor modulator 1
T61901
Synonym:
Target:
Endomorphin 2
T7218
Synonym:
Target: Opioid Receptor
μ opioid receptor agonist 3
T79430
Synonym:
Target: Opioid Receptor
Mu opioid receptor antagonist 3
T62767
Synonym:
Target:
μ opioid receptor agonist 2
T62025
Synonym:
Target:
Asimadoline hydrochloride
T4691
Synonym: EMD-61753 hydrochloride
Target: Opioid Receptor
Mu opioid receptor antagonist 7
T79431
Synonym:
Target: Opioid Receptor
μ opioid receptor agonist 1
T62268
Synonym:
Target:
Nociceptin
TP1071
Synonym: Orphanin FQ
Target: Opioid Receptor
Alvimopan
T1242
Synonym:
Target: Opioid Receptor
LY2795050
TQ0091
Synonym:
Target: Opioid Receptor
Opiranserin hydrochloride
T9833
Synonym:
Target: P2X Receptor, GlyT, 5-HT Receptor
MCOPPB triHydrochloride
T2071
Synonym: MCOPPB trihydrochlride,MCOPPB 3HCl
Target: Opioid Receptor
Endomorphin 1
TQ0267
Synonym: Endomorphin-1
Target: Opioid Receptor
Trimebutine maleate
T1197
Synonym: Debridat,Polibutin
Target: Calcium Channel, Opioid Receptor
Bisacodyl
T6414
Synonym: Fenilaxan,Dulcolax,Brocalax
Target: Others
Cebranopadol
T5167
Synonym: GRT6005
Target: Opioid Receptor
BW-180C
TP1905
Synonym: DADLE
Target: Opioid Receptor
Dapiprazole Hydrochloride
T3996
Synonym: Glamidolo Hydrochloride,Reversil Hydrochloride
Target: Adrenergic Receptor
BMS-986122
T26869
Synonym: BMS 986122
Target: Opioid Receptor
LY2940094
T15799
Synonym: LY-2940094
Target: Opioid Receptor
N-Desmethylclozapine
T5158
Synonym: Desmethylclozapine,Normethylclozapine,Norclozapine
Target: Virus Protease, Dopamine Receptor, 5-HT Receptor, Opioid Receptor, AChR, Drug Metabolite
[D-Ala2]leucine-enkephalin
TP1367
Synonym:
Target: Opioid Receptor
Bevenopran
T14551
Synonym: CB-5945,ADL-5945
Target: Opioid Receptor
Aticaprant
TQ0082
Synonym: LY-2456302,CERC-501
Target: Opioid Receptor
Deltorphin I
T7637
Synonym: Deltorphin 1,Deltorphin I(TFA),Deltorphin C
Target: Opioid Receptor
ADL-5859
T6175
Synonym: ADL5859 Hydrochloride,ADL5859 HCl
Target: Opioid Receptor
Deltorphin 2
T7639
Synonym: Deltorphin 2(TFA),[D-Ala2]-Deltorphin II
Target: Opioid Receptor
BTRX-335140
T14835
Synonym: CYM-53093
Target: Opioid Receptor
DPDPE TFA (88373-73-3 free base)
TP2036L
Synonym: DPDPE TFA
Target: Opioid Receptor
[Leu5]-Enkephalin
T7173
Synonym: Leucine enkephalin,Leucyl-enkephalin,Leu-enkephalin
Target: Opioid Receptor, Endogenous Metabolite
Tyr-Gly-Gly-Phe-Met-OH
T7211
Synonym: Methionine enkephalin,Met-Enkephalin
Target: Opioid Receptor
Methylnaltrexone bromide
T21422
Synonym: Relistor,MOA-728,MOA 728,Methylnaltrexone,MOA728
Target: Opioid Receptor
CID 16020046
T4478
Synonym: C390-0219
Target: Cannabinoid Receptor
DPDPE
TP2036
Synonym:
Target: Opioid Receptor
Asimadoline
T4633
Synonym: EMD-61753
Target: Opioid Receptor
1 2 3 4 5 6
Cat No. Product Name Synonyms Targets
T5S0581 Sec-O-Glucosylhamaudol Hamaudol 3-glucoside Others , Opioid Receptor
Sec-O-Glucosylhamaudol (Hamaudol 3-glucoside) has anti-inflammatory effect through regulation of p38 Mitogen-Activated Protein Kinase in Lipopolysaccharide-stimulated RAW264.7 cell line. Intrathecal Sec-O-Glucosylhamaudo...
T2726 Sinomenine Cucoline,Kukoline Apoptosis , Others , NF-κB , Opioid Receptor , Autophagy
Sinomenine (Kukoline) is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.
T5S2360 Corydaline Corydalin,(+)-Corydaline P450 , Virus Protease , Opioid Receptor , AChE
1. Corydaline (Corydalin), an isoquinoline alkaloid, is one of the major active constituents in a new prokinetic botanical agent. 2. Corydaline promotes gastric emptying and small intestinal transit and facilitates gastr...
T2921 Sinomenine hydrochloride Sabianine A hydrochloride,Cucoline hydrochloride,Kukoline hydrochloride Apoptosis , NF-κB , Opioid Receptor , Autophagy
Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.
T2870 Matrine Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.
T2S2362 Dehydrocorydaline nitrate BCL , Others , PARP , p38 MAPK , Caspase , Parasite , Autophagy
1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially a...
T13433 β-Endorphin, human Others
β-Endorphin, human, a prominent endogenous peptide, existing in the hypophysis cerebri and hypothalamus,and is an agonist of opioid receptor.
TN4613 (-)-N-methylcoclaurine N-Methylcoclaurine Others
N-Methylcoclaurine shows binding affinities for the ĸ opioid receptor with the equilibrium dissociation constant (Ki) value of 0.9 ± 0.1 uM. N-methylcoclaurine also shows promising butyrylcholinesterase inhibition a...
T83913 Mitraciliatine
Mitraciliatine, an alkaloid discovered in M. speciosa (Kratom in Thai), acts as a partial agonist for the μ-opioid receptor (MOR) and an agonist for the κ-opioid receptor (KOR), demonstrating selectivity for these recept...

Natural Products

Sec-O-Glucosylhamaudol
T5S0581
Synonym: Hamaudol 3-glucoside
Target: Others, Opioid Receptor
Sinomenine
T2726
Synonym: Cucoline,Kukoline
Target: Apoptosis, Others, NF-κB, Opioid Receptor, Autophagy
Corydaline
T5S2360
Synonym: Corydalin,(+)-Corydaline
Target: P450, Virus Protease, Opioid Receptor, AChE
Sinomenine hydrochloride
T2921
Synonym: Sabianine A hydrochloride,Cucoline hydrochloride,Kukoline hydrochloride
Target: Apoptosis, NF-κB, Opioid Receptor, Autophagy
Matrine
T2870
Synonym: Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine
Target: Mitophagy, Ferroptosis, Opioid Receptor, Autophagy
Dehydrocorydaline nitrate
T2S2362
Synonym:
Target: BCL, Others, PARP, p38 MAPK, Caspase, Parasite, Autophagy
β-Endorphin, human
T13433
Synonym:
Target: Others
(-)-N-methylcoclaurine
TN4613
Synonym: N-Methylcoclaurine
Target: Others
Mitraciliatine
T83913
Synonym:
Target:

Recombinant Proteins

Species：
Androctonus mauritanicus (1)
Human (1)
Expression System：
Baculovirus (1)
Human Cells (1)
Tag：
C-6His (1)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (1)
Cat No. Product Name Species Expression System
TMPJ-00737 PDYN Protein, Human, Recombinant (His) Human Human Cells
Proenkephalin-B(PDYN), belongs to the opioid neuropeptide precursor family. The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. Leu-enkephalins, which is a ...
TMPH-00055 Alpha-toxin Amm8  Protein, Androctonus mauritanicus, Recombinant (His & Myc) Androctonus mauritanicus Baculovirus
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The toxin principally slows the inactivation proc...
Cat No. Product Name
L2610 Neurotransmitter Receptor Compound Library

1513 compounds
A unique collection of 1513 neurotransmitter receptor compounds, can be used for HTS and HCS screening；

Libraries

Neurotransmitter Receptor Compound Library
L2610
Compounds: 1513
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