Cart
GPCR/G Protein OX Receptor

OX Receptor

The orexin receptor (also referred to as the hypocretin receptor) is a G-protein-coupled receptor that binds the neuropeptide orexin. There are two variants, OX1 and OX2, each encoded by a different gene. Both orexin receptors exhibit a similar pharmacology - the 2 orexin peptides, orexin-A and orexin-B, bind to both receptors and, in each case, agonist binding results in an increase in intracellular calcium levels. However, orexin-B shows a 10-fold selectivity for orexin receptor type 2, whilst orexin-A is equipotent at both receptors.
Cat No. product name
T5498 SB-649868 SB-649868 is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).
T6155 Almorexant HCl Almorexant HCl (ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1...
T1913 MK3697 MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).
T3177 Orexin 2 Receptor Agonist Orexin 2 Receptor Agonist is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.
T6658 SB408124 SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity ove...
T6140 SB334867 SB-334867 is a selective orexin-1 (OX1) receptor antagonist.
T2613 Almorexant Almorexant is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respec...
T3347 PF3274167 PF-3274167 is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist.
T2710 TCS 1102 TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).
T5503 IPSU IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.
T4965 TCS-OX2-29 TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.
TQ0237 Lemborexant Lemborexant is a reversible and orally active dual antagonist of the orexin OX1 and OX2 receptors (IC50s: 6.1 nM and 2.6 nM).
T11186 EMPA EMPA is a selective, high-affinity and reversible antagonist of orexin OX2 receptor(human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respecti...
T16328 Nitroaspirin Nitroaspirin is a nitric oxide donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin induces signifi...
T5500 DORA-22 DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory
T12877L Seltorexant Seltorexant crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 rece...
TP1045L Orexin B, rat, mouse Acetate(202801-92-1 free base) Orexin B, rat, mouse Acetate is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
T3722 MK1064 MK-1064 is a selective orexin 2 receptor antagonist (2-SORA).
SB-649868
T5498CAS 380899-24-1
SB-649868 is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).
Almorexant HCl
T6155CAS 913358-93-7
Almorexant HCl (ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1...
MK3697
T1913CAS 1224846-01-8
MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).
Orexin 2 Receptor Agonist
T3177CAS 1796565-52-0
Orexin 2 Receptor Agonist is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.
SB408124
T6658CAS 288150-92-5
SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity ove...
SB334867
T6140CAS 792173-99-0
SB-334867 is a selective orexin-1 (OX1) receptor antagonist.
Almorexant
T2613CAS 871224-64-5
Almorexant is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respec...
PF3274167
T3347CAS 900510-03-4
PF-3274167 is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist.
TCS 1102
T2710CAS 916141-36-1
TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).
IPSU
T5503CAS 1373765-19-5
IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.
TCS-OX2-29
T4965CAS 372523-75-6
TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.
Lemborexant
TQ0237CAS 1369764-02-2
Lemborexant is a reversible and orally active dual antagonist of the orexin OX1 and OX2 receptors (IC50s: 6.1 nM and 2.6 nM).
EMPA
T11186CAS 680590-49-2
EMPA is a selective, high-affinity and reversible antagonist of orexin OX2 receptor(human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respecti...
Nitroaspirin
T16328CAS 175033-36-0
Nitroaspirin is a nitric oxide donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin induces signifi...
DORA-22
T5500CAS 1088991-95-0
DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory
Seltorexant
T12877LCAS 1293281-49-8
Seltorexant crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 rece...
Orexin B, rat, mouse Acetate(202801-92-1 free base)
TP1045LCAS TP1045L
Orexin B, rat, mouse Acetate is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
MK1064
T3722CAS 1207253-08-4
MK-1064 is a selective orexin 2 receptor antagonist (2-SORA).