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Nrf2

Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NRF2 is a basic leucine zipper (bZIP) protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress.
Cat. No. Product name CAS No. Purity Chemical Structure
T11251 Ezetimibe ketone 191330-56-0 98%
Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor.Ezetimibe ketone ...
TMA1570 Sappanone A 102067-84-5 98%
Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 ...
TN6711 Toralactone 41743-74-2 98%
Toralactone is a natural product isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism
TN1670 Ganodermanondiol 107900-76-5 98%
Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated anti...
T16352 NSC23925 858474-14-3 98%
NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).
TN1548 6"-O-Malonyldaidzin 124590-31-4 98%
Daidzin 6''-O-malonate may have anticancer activity.
TN3726 Cudraflavone B 19275-49-1 98%
Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mo...
TN3806 Dehydroglyasperin C 199331-35-6 98%
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
TN1151 Procyanidol B4 29106-51-2 98%
Procyanidin B4 reveals significant antioxidant activity
T60487 DDO-7263 2254004-96-9 98%
DDO-7263 is a potent Nrf2-ARE activator. DDO-7263 induces Nrf2 translocation into the nucleus. DDO-7263 inhibits activation of NLRP3 inflammasome. DDO-7263 upreg...
TN1989 Niga-ichigoside F1 95262-48-9 98%
Niga-ichigoside F1(NI) has anti-inflammatory, gastroprotective ,antinociceptive, and cytotoxic effects.
TN1058 Pelargonidin chloride 134-04-3 98%
Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels t...
TN4064 Flavoglaucin 523-73-9 98%
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
T15474 Hesperin 4430-35-7 98%
Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi). It has been shown to be an activator of Nrf2.
TN5278 Zederone 7727-79-9 98%
Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads t...
T2A2486 3',​4',​5',​5,​7-​Pentamethoxyflavone 53350-26-8 98%
3',4',5',5,7-Pentamethoxyflavone has anti-inflammatory and cancer chemopreventive activities. 3',4',5',5,7-Pentamethoxyflavone could be used as an effective adju...
TQ0199 Ginsenoside Rh3 105558-26-7 98%
Ginsenoside Rh3 is a natural product extracted from Panax ginseng C. A. Mey. Ginsenoside Rh3 treatment in human retinal cells induces Nrf2 activation.
TN4420 Latifolin 10154-42-4 98%
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latifol...
TMA0237 Carlinoside 59952-97-5 98%
Carlinoside could be a worthy choice to intervene hyperbilirubinemia due to liver dysfunction. Carlinoside upregulates Nrf2 gene expression, increases its nuclea...
T8281 (R)-Sulforaphane 142825-10-3 98%
(R)-Sulforaphane is a potent inducer of the Keap1/Nrf2/ARE pathway.
Ezetimibe ketone
T11251
Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor.Ezetimibe ketone ...
Sappanone A
TMA1570
Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 ...
toralactone
TN6711
Toralactone is a natural product isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism
Ganodermanondiol
TN1670
Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated anti...
NSC23925
T16352
NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).
6"-O-Malonyldaidzin
TN1548
Daidzin 6''-O-malonate may have anticancer activity.
Cudraflavone B
TN3726
Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mo...
Dehydroglyasperin C
TN3806
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
Procyanidol B4
TN1151
Procyanidin B4 reveals significant antioxidant activity
DDO-7263
T60487
DDO-7263 is a potent Nrf2-ARE activator. DDO-7263 induces Nrf2 translocation into the nucleus. DDO-7263 inhibits activation of NLRP3 inflammasome. DDO-7263 upreg...
Niga-ichigoside F1
TN1989
Niga-ichigoside F1(NI) has anti-inflammatory, gastroprotective ,antinociceptive, and cytotoxic effects.
Pelargonidin chloride
TN1058
Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels t...
Flavoglaucin
TN4064
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
Hesperin
T15474
Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi). It has been shown to be an activator of Nrf2.
Zederone
TN5278
Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads t...
3',​4',​5',​5,​7-​Pentamethoxyflavone
T2A2486
3',4',5',5,7-Pentamethoxyflavone has anti-inflammatory and cancer chemopreventive activities. 3',4',5',5,7-Pentamethoxyflavone could be used as an effective adju...
Ginsenoside Rh3
TQ0199
Ginsenoside Rh3 is a natural product extracted from Panax ginseng C. A. Mey. Ginsenoside Rh3 treatment in human retinal cells induces Nrf2 activation.
Latifolin
TN4420
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latifol...
Carlinoside
TMA0237
Carlinoside could be a worthy choice to intervene hyperbilirubinemia due to liver dysfunction. Carlinoside upregulates Nrf2 gene expression, increases its nuclea...
(R)-Sulforaphane
T8281
(R)-Sulforaphane is a potent inducer of the Keap1/Nrf2/ARE pathway.
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