Search Result

Search Results for " neutrophils "

Targets

Compounds

Natural Products

251

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T39437	Cevidoplenib dimesylate		Syk
	Cevidoplenib dimesylate is an inhibitor of spleen tyrosine kinase (Syk), possessing anti-inflammatory and immunomodulating properties.		Syk
T21815	ONO-RS-082		Others
	ONO-RS-082 is a Ca2+-independent phospholipase A2 inhibitor.		Others
TQ0105	CAY10650		Phospholipase
	CAY10650 is an effective inhibitor of cytosolic phospholipase A2α (cPLA2α, IC50: 12 nM).		Phospholipase
T17250	W-54011		ROS , Complement System
	W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki: 2.2 nM). W-54011 inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and g...		ROS , Complement System
T8930	CID44216842	KUC103479N-02	CDK , Ras
	CID44216842 (KUC103479N-02) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively. The EC50s for Cdc42 WT...		CDK , Ras
T8531	M-3M3FBS		Apoptosis , Phospholipase
	m-3M3FBS is a phospholipase C (PLC) activator.		Apoptosis , Phospholipase
T1076	Dexamethasone	MK 125,Prednisolone F,NSC 34521,Hexadecadrol	Glucocorticoid Receptor , Mitophagy , IL Receptor , SARS-CoV , Antibacterial , Antibiotic , Autophagy , Complement System
	Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory and immunosuppressive activity and induces autophagy. Dexamethasone inhibits LPS-induced...
T40446	AG-09/1		Others
	AG-09/1 is a selective and potent formyl peptide receptor 1 (FPR1) agonist that activates chemotaxis in human neutrophils.		Others
T72322	R 59-022 hydrochloride	DKGI-I hydrochloride,Diacylglycerol kinase inhibitor I hydrochloride,DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride	5-HT Receptor , PKC
	R 59-022 hydrochloride (DKGI-I hydrochloride) is a 5-HT Receptor antagonist that activates protein kinase C (PKC).R 59-022 hydrochloride is a DGK inhibitor (IC50:2.8 µM) that inhibits the phosphorylation of OAG to OAPA.R...		5-HT Receptor , PKC
TP1672L	N-Formyl-Met-Ala-Ser TFA(17351-32-5 free base)		Others
	N-Formyl-Met-Ala-Ser TFA is a peptide, binds to formyl peptide receptors on neutrophils.N-Formyl-Met-Ala-Ser Peptide (fMet-Ala-Ser) binds to formyl peptide receptors on neutrophils. N-Formylmethionine-containing peptides...		Others
T1639	Amlexanox	CHX3673,Amoxanox,AA673	IL Receptor , FGFR , Others , IκB/IKK
	Amlexanox (AA673) is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils, and mononuclear cells. Amlexan...		IL Receptor , FGFR , Others , IκB/IKK
T77638	BIRM 271		Phospholipase , LTR
	BIRM 271 is a novel arachidonic acid release inhibitor that blocks leukotriene B4 and platelet-activating factor biosynthesis in human neutrophils. BIRM 271 and BIRM 270 are enantiomers that inhibit the production of leu...		Phospholipase , LTR
T9878	Croconazole		Lipoxygenase , LTR
	Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic agent. The IC50s for the synthesis of leukotriene B4 (LTB4) and 5-hydroxyeicosatetraeno...		Lipoxygenase , LTR
T0468	Lidocaine	Lignocaine,Alphacaine,Xylocaine	Apoptosis , ERK , NF-κB , MEK , Sodium Channel , Histamine Receptor
	Lidocaine (Alphacaine) is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellular adhesion molecule-1 (ICAM-1), pro-inflammat...
TP1168	N-Formyl-Met-Leu-Phe-Lys	fMLFK	Others
	N-Formyl-Met-Leu-Phe-Lys (fMLFK) (fMLFK) is a peptide, acts as a potent and selective agonist of FPR1, with EC50s of 3.5 nM, 6.7 μM and 0.88 μM for FPR1, FPR2 and FPR2-D2817.32G, respectively.Chemotactic peptide (fMLFK) ...		Others
T14138	AG-825	Tyrphostin AG-825	Apoptosis , EGFR
	AG-825（Tyrphostin C15） is a selective and competitive ErbB2 inhibitor that inhibits tyrosine phosphorylation with an IC50 value of 0.35 μM.AG-825 (Tyrphostin C15) inhibits HER2 and shows anticancer activity in a mouse xe...		Apoptosis , EGFR
T38287	C3a Receptor Agonist	C3a receptor agonist 1,Complement 3a Receptor Agonist	Complement System
	C3a Receptor Agonist (C3a receptor agonist 1) binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway. Activation of C3aR prevents neutrophils from being mobilized in a model of intestin...		Complement System
T22526	BML-111	5(S),6(R)-7-trihydroxymethyl Heptanoate	Others
	inhibits leukotriene B4 (LTB4)-induced polymorphonuclear neutrophils (PMN) chemotaxis		Others
T37278	2-chloro Stearic Acid
	2-chloro Stearic acid is a bioactive fatty acid that accumulates in primary human monocytes and neutrophils as well as murine neutrophils stimulated with phorbol 12-myristate 13-acetate . It induces DNA release from prim...
T30916	CI 922	CI-922,UNII-5VC7KY707F,CI922
	CI 922 is an anaphylaxis mediator release inhibitor. It inhibits the activation of human neutrophils.
T37303	5-OxoETE	5-KETE,5-OxoETE
	5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils by a specific dehydrogenase.[1] It stimulates cytosolic calcium levels in neutrophils with an EC50 value of 2 nM.[2] 5-OxoETE...
T41134	Defensin HNP-2 human
	Defensin HNP-2 is a naturally occurring antibiotic and monocyte chemotactic peptide synthesized by human neutrophils.
T26699	AZ10397767	AZ 10397767,AZ-10397767
	AZ10397767 is a potent CXCR2 antagonist (IC50 = 1 nM). AZ10397767 significantly reduced the numbers of infiltrating neutrophils into both in vitro and in vivo tumor models.
T35968	Nitrosobenzene
	Nitrosobenzene is a spin trap that has been used in the study of oxidative DNA damage and nitroso-compound-induced respiratory burst in neutrophils.
T36043	17(R)-Protectin D1	17(R)-Protectin D1
	17(R)-Protectin D1 is an aspirin-triggered epimer of the specialized pro-resolving mediator protectin D1 .1It decreases leukotriene B4-induced transendothelial migration of human polymorphonuclear (PMN) neutrophils when ...
T26523	Abroquinone A
	Abroquinone A, a natural isoflavanquinone, has been shown to block cytosolic phospholipase A(2) and 5-lipoxygenase activation in neutrophils, it may have pharmaceutical potential as an antiallergic agent.
T10454	Bactenecin	Bactenecin, bovine	Antibacterial
	Bactenecin is a cyclic antimicrobial peptide isolated from bovine neutrophils with potent activity against Bacterial and Fungal species.		Antibacterial
T81316	Rabbit neutrophil peptide 3b
	Rabbit Neutrophil Peptide 3b is an antimicrobial peptide isolated from rabbit peritoneal neutrophils [1].
T37967	12(S)-HEPE
	12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S),20-diHEPE, whereas stimulated neutrophils produce 5(S),12(S)-HEPE via the 5-lipo...
TP1672	N-Formyl-Met-Ala-Ser
	N-Formyl-Met-Ala-Ser is a peptide, binds to formyl peptide receptors on neutrophils.N-Formyl-Met-Ala-Ser Peptide (fMet-Ala-Ser) binds to formyl peptide receptors on neutrophils. N-Formylmethionine-containing peptides inc...
T36221	2-chloro Palmitic Acid
	2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic aci...
T75748	Indolicidin TFA
	Indolicidin TFA, a powerful antimicrobial peptide isolated from the cytoplasmic granules of bovine neutrophils [1], exhibits significant potency.
T37617	Leukotriene B3
	LTB3 is the LTA hydrolase metabolite of LTA3 in the leukotriene biosynthetic pathway. LTB3 and LTB4 are equipotent in their pro-inflammatory effects. However, LTB3 is five times less potent than LTB4 in eliciting chemota...
TP1919	Ac2-12
	Annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Reduces neutrophil adhesion and emigration, and promotes detachment of neutrophils from activated mesenteric endothelium in mice in vivo.
T38087	20-hydroxy Leukotriene B4	20-hydroxy Leukotriene B4
	20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing deg...
T37618	Leukotriene B4 dimethyl amide	Leukotriene B4 dimethyl amide
	LTB4 dimethyl amide is a moderate inhibitor of LTB4-induced degranulation of human neutrophils (Ki = 130 nM) and lysozyme release from rat PMNL. LTB4 dimethyl amide appears to be an antagonist of the LTB4 receptor on gui...
T37166	RCTR1
	Resolvin conjugate in tissue regeneration 1 (RCTR1) is a specialized pro-resolving mediator (SPM) biosynthesized from docosahexaenoic acid by isolated human macrophages and apoptotic polymorphonuclear (PMN) neutrophils.1...
T38043	Resolvin E4
	Resolvin E4 (RvE4) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acid by 15-lipoxygenase (15-LO)via15(S)-HpEPE and 15S-hydroxy, 5S-HpEPE inte...
T35773	Gliotoxin-13C13	Gliotoxin-13C13
	Gliotoxin-13C13is intended for use as an internal standard for the quantification of gliotoxin by GC- or LC-MS. Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains ofAspergillusand other fungi with...
T36604	(±)5-HETE
	(±)5-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. It contains equal amounts of 5(S)-HETE and 5(R)-HETE. (±)5-HETE induces the aggregation of isolated neutrop...
TP1864	[Glu1]-Fibrinopeptide B
	[Glu1]-Fibrinopeptide B, a derivative of fibrinopeptide B amino acid residues 1-14, originates from human fibrinopeptide B (hFpB). hFpB is a proteolytic cleavage product of the fibrinogen B beta-chain, specifically gener...
T80323	Bovine neutrophil beta-defensin 12	BNBD-12
	Bovine neutrophil beta-defensin 12, an antimicrobial peptide originating from bovine neutrophils, exhibits antibacterial properties against Escherichia coli and Staphylococcus aureus [1].
T38157	Ricinelaidic Acid
	Ricinelaidic acid is a 12-hydroxy fatty acid and an antagonist of leukotriene B4 (LTB4) receptors (Ki = 2 μM in porcine neutrophil membranes). It inhibits chemotaxis and calcium flux induced by LTB4 in isolated human neu...
T81279	RhB-PBP10 TFA
	RhB-PBP10 TFA, a Rhodamine B-labeled PBP10 TFA (FPR2 antagonist), selectively inhibits granule mobilization and oxygen radical secretion in FPRL1-induced neutrophils [1].
T35507	12-HETE
	(±)12-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The biological activity of (±)12-HETE is similar to that of its constituent enantiomers . It aggregates ne...
T38354	Lactosylsphingosine (d18:1)	Lactosylsphingosine (d18:1)
	Lactosylsphingosine is a bioactive sphingolipid and a form of lactosylceramide that is lacking the fatty acyl group. Lyso-lactosylceramide (1-50 μM) reduces viability of human neutrophils in a concentration-dependent man...
T38042	Resolvin D4	Resolvin D4,RvD4
	Resolvin D4 (RvD4) is a specialized pro-resolving mediator derived from docosahexaenoic acid . [1] It has been detected in human milk, in the dorsal pouch of mice before and after infection with S. aureus, and in untreat...
TP1948	PBP10	PBP 10
	Selective formyl peptide receptor 2 (FPR2) antagonist; cell permeable. Selectively inhibits FPR2-mediated NADPH oxidase activity but has no effect on FPR1 signaling in neutrophils. Displays PIP2 binding activity in vitro...
T37156	8(S),15(S)-DiHETE
	8(S),15(S)-DiHETE is formed when 15(S)-HETE is subjected to further oxidation by 15-LO. It causes eosinophil chemotaxis with an ED50 value of 1.5 μM but is not chemotactic for neutrophils. 8(S),15(S)-DiHETE antagonizes t...
T61356	CXCR2 antagonist 3
	CXCR2 antagonist 3 (compound 11h) is a highly effective antagonist of CXC chemokine receptor 2 (CXCR2). It displays potent activity in inhibiting neutrophil infiltration into the air pouch, with double-digit nanomolar po...

Compounds

Cevidoplenib dimesylate

Target: Phospholipase

W-54011

T17250

Synonym:

Target: ROS, Complement System

CID44216842

T8930

Synonym: KUC103479N-02

Target: Apoptosis, Phospholipase

Dexamethasone

T1076

Synonym: MK 125,Prednisolone F,NSC 34521,Hexadecadrol

Target: Glucocorticoid Receptor, Mitophagy, IL Receptor, SARS-CoV, Antibacterial, Antibiotic, Autophagy, Complement System

R 59-022 hydrochloride

T72322

Synonym: DKGI-I hydrochloride,Diacylglycerol kinase inhibitor I hydrochloride,DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride

Target: 5-HT Receptor, PKC

N-Formyl-Met-Ala-Ser TFA(17351-32-5 free base)

Synonym: CHX3673,Amoxanox,AA673

Target: IL Receptor, FGFR, Others, IκB/IKK

BIRM 271

T77638

Synonym:

Target: Phospholipase, LTR

Croconazole

T9878

Synonym:

Target: Lipoxygenase, LTR

Lidocaine

T0468

Synonym: Lignocaine,Alphacaine,Xylocaine

Target: Apoptosis, ERK, NF-κB, MEK, Sodium Channel, Histamine Receptor

N-Formyl-Met-Leu-Phe-Lys

Synonym: Tyrphostin AG-825

Target: Apoptosis, EGFR

C3a Receptor Agonist

T38287

Synonym: C3a receptor agonist 1,Complement 3a Receptor Agonist

Target: Complement System

BML-111

T22526

Synonym: 5(S),6(R)-7-trihydroxymethyl Heptanoate

Target: Others

2-chloro Stearic Acid

Synonym: CI-922,UNII-5VC7KY707F,CI922

Target:

5-OxoETE

T37303

Synonym: 5-KETE,5-OxoETE

Synonym: AZ 10397767,AZ-10397767

Synonym: 17(R)-Protectin D1

Synonym: Bactenecin, bovine

Target: Antibacterial

Rabbit neutrophil peptide 3b

2-chloro Palmitic Acid

20-hydroxy Leukotriene B4

T38087

Synonym: 20-hydroxy Leukotriene B4

Target:

Leukotriene B4 dimethyl amide

T37618

Synonym: Leukotriene B4 dimethyl amide

Synonym: Gliotoxin-13C13

[Glu1]-Fibrinopeptide B

TP1864

Synonym:

Target:

Bovine neutrophil beta-defensin 12

Lactosylsphingosine (d18:1)

T38354

Synonym: Lactosylsphingosine (d18:1)

Target:

Resolvin D4

T38042

Synonym: Resolvin D4,RvD4

Cat No.	Product Name	Synonyms	Targets
T8288	14-Deoxyandrographolide		Apoptosis , Others
	14-Deoxyandrographolide is a bioactive compound of Andrographis paniculata with hepatoprotective efficacy. It desensitizes hepatocytes to TNF-α-mediated apoptosis through the release of TNFRSF1A release.		Apoptosis , Others
TN1933	Mitraphylline		IL Receptor , TNF , NF-κB
	Mitraphylline has antiproliferative effects on human glioma and neuroblastoma cell lines. It also has anti-inflammatory activity, it inhibits lipopolysaccharide-mediated activation of primary human neutrophils.		IL Receptor , TNF , NF-κB
T5S1897	Linderalactone		Apoptosis , Others , JAK
	1. Linderalactone showed significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB, values of IC5 is 8.48 μg/mL.		Apoptosis , Others , JAK
TN6647	4-O-Cinnamoylquinic acid		Prostaglandin Receptor
	4-O-Cinnamoylquinic acid is a small molecule compound extracted from the dried fruits of Casearia grewiifolia, which has an inhibitory effect on prostaglandins and inhibits the production of superoxide anions in human ne...		Prostaglandin Receptor
TN2286	Tsugaric acid A		NO Synthase
	Tsugaric acid A can significantly inhibit superoxide anion formation in fMLP/CB-stimulated rat neutrophils, it is also able to protect human keratinocytes against damage induced by ultraviolet B (UV B) light, indicates t...		NO Synthase
TN7224	2,2'-Dihydroxy chalcone		Antibacterial , Autophagy
	2,2'-Dihydroxy chalcone is a potent inhibitor of β-glucuronidase (IC50=1.6±0.2 μM) and lysozyme (IC50=1.4±0.2 μM) release from rat neutrophils stimulated with fMLP/CB.2,2'-Dihydroxy chalcone has inhibitory activity again...		Antibacterial , Autophagy
TN3469	Aucuparin	2,6-dimethoxy-4-phenylphenol	NADPH-oxidase
	Aucuparin (2,6-dimethoxy-4-phenylphenol) is a plant antibiotic with anti-inflammatory activity. Aucuparin inhibited pulmonary fibrosis in mouse models induced by bleomycin (BLM). ABTS and FRAP showed clear scavenging act...		NADPH-oxidase
T5280	3-Chloro-L-Tyrosine	3-Chlorotyrosine,Chlorotyrosine	Others , Endogenous Metabolite
	3-Chloro-L-Tyrosine (Chlorotyrosine), a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low-density lipoprotein isolated from human atherosclerotic intima. In particular, myeloperoxidase h...		Others , Endogenous Metabolite
T40615	N,N'-Dimethylthiourea	DMTU	Antioxidant
	N,N'-Dimethylthiourea (DMTU) (DMTU), isolated from Allii Sativi Bulbus, is an orally active scavenger of hydroxyl radical ( OH) and blocks OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects a...		Antioxidant
TN1448	(-)-Bornyl acetate	L-(-)-Bornyl acetate,Bornyl acetate	p38 MAPK , NF-κB , JNK , Antifungal
	(-)-Bornyl acetate (L-(-)-Bornyl acetate) is a less active enantiomer of (+)-Bornyl acetate. (-)-Bornyl acetate isolates from hyssop oil and possesses antifungal activity. (-)-Bornyl acetate shows highly active whitening...		p38 MAPK , NF-κB , JNK , Antifungal
T38097	Antibiotic PF 1052
	Antibiotic PF 1052 is a fungal metabolite originally isolated from Phoma.1,2 It is active against S. aureus, S. parvulus, and C. perfringens (MICs = 3.13, 0.78, and 0.39 μg/ml, respectively), among others.1 It inhibits n...
TN4317	Isopedicin		NADPH-oxidase , cAMP , p38 MAPK , PKA , JNK , PDE
	Isopedicin has anti-inflammatory functions, it inhibits the O(2)()(-) production in human neutrophils* by an elevation of cellular cAMP and activation of PKA through its inhibition of cAMP-specific PDE.		NADPH-oxidase , cAMP , p38 MAPK , PKA , JNK , PDE
TN2973	3'-O-Methylmurraol
	3'-O-Methylmurraol may have potential anti-inflammatory activity, it exhibits inhibition (IC50 ≤ 7.31 ug/mL) of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/...
TN4388	Kielcorin		Antifection
	Kielcorin shows antibacterial activity against strain EMRSA-16. It also shows in vitro anti-inflammatory (respiratory burst) inhibiting activities using isolated human neutrophils (IC (50) = 965.21 ± 65.80 uM). trans-Kie...		Antifection
TN5227	(+/-)-Vestitol		NOS , CXCR , Antifection
	Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential to be applied in the pharmaceutical and food industries. Vest...		NOS , CXCR , Antifection
T79951	Piperkadsin A		Reactive Oxygen Species
	Piperkadsin A effectively inhibits reactive oxygen species (ROS) production, specifically targeting PMA-induced ROS in human polymorphonuclear neutrophils, exhibiting an inhibition concentration (IC50) of 4.3 μM [1].		Reactive Oxygen Species
TN2767	2'-Hydroxygenistein		Antifection
	2'-Hydroxygenistein has antifungal activity, dimerization of it causes a remarkable increase of antifungal activity. It shows significant concentration-dependent inhibitory effects on the release of beta-glucuronidase an...		Antifection
TN3744	Cyclomorusin		NOS , AChR
	Cyclomorusin exhibits competitive inhibition toward monophenolase activity of mushroom tyrosinase, the IC50 value of 0.092 microM. It evokes the stimulation of superoxide anion generation in fMLP-stimulated rat neutrophi...		NOS , AChR
TN2408	Evofolin B		Cannabinoid Receptor
	Evofolin B is a natural compound isolated from the stem bark of Zanthoxylum ailanthoides. Evofolin B has an inhibitory effect on the superoxide anion produced by human neutrophils in response to formyl-L-methionine-L-leu...		Cannabinoid Receptor
T38262	Sphingosine (d14:1)
	Sphingosine (d14:1) is a bioactive sphingolipid that has been found in B. mori (silkworm), P. clarkii (crayfish), and A. aurita (jellyfish) extracts. It increases the germination rate of N. rileyi, an entomopathogenic fu...
T36051	Lipoxin A4	LXA4
	Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of (±)15-HETE or 15-HpETE with human leukocytes.[1] LXA4 is equipotent to leukotriene B4 in inducing superoxide g...
TN5164	Trans-Hinokiresinol		IL Receptor , TNF , NOS , LTR
	Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction. Hinokiresinol (trans-hinokiresinol) and nyaso...		IL Receptor , TNF , NOS , LTR
T75967	Bactenecin TFA
	Bactenecin TFA (Bactenecin, bovine TFA), a potent 12-aa looped antimicrobial peptide derived from bovine neutrophils, effectively inhibits bacterial and yeast growth and eradicates Trichophyton rubrum fungus. It enhances...
T37291	Lyso-Globotriaosylceramide (d18:1)	Lyso-Globotriaosylceramide (d18:1)
	Lyso-globotriaosylceramide is a form of globotriaosylceramide that is lacking the fatty acyl group. It binds to Shiga toxin 1 (Stx1) in the presence of cholesterol and phosphatidylcholine but does not bind Stx2. It also ...
TN2766	2'-Hydroxydaidzein		Cannabinoid Receptor , Antioxidant
	2'-Hydroxydaidzein is an isoflavonoid phytonutrient found in plant species, when a natural compound. 2'-Hydroxydaidzein has antioxidant activity, driven mainly by o-hydrogen bond dissociation enthalpy (BDE) and hydrogen ...		Cannabinoid Receptor , Antioxidant

Natural Products

14-Deoxyandrographolide

T8288

Synonym:

Target: Apoptosis, Others

Mitraphylline

TN1933

Synonym:

Target: IL Receptor, TNF, NF-κB

Linderalactone

T5S1897

Synonym:

Target: Apoptosis, Others, JAK

4-O-Cinnamoylquinic acid

TN6647

Synonym:

Target: Prostaglandin Receptor

2,2'-Dihydroxy chalcone

TN7224

Synonym:

Target: Antibacterial, Autophagy

Aucuparin

TN3469

Synonym: 2,6-dimethoxy-4-phenylphenol

Target: NADPH-oxidase

3-Chloro-L-Tyrosine

T5280

Synonym: 3-Chlorotyrosine,Chlorotyrosine

Target: Others, Endogenous Metabolite

N,N'-Dimethylthiourea

Synonym: L-(-)-Bornyl acetate,Bornyl acetate

Target: p38 MAPK, NF-κB, JNK, Antifungal

Target: NADPH-oxidase, cAMP, p38 MAPK, PKA, JNK, PDE

Target: NOS, CXCR, Antifection

Piperkadsin A

T79951

Synonym:

Target: Reactive Oxygen Species

Target: Cannabinoid Receptor

Target: IL Receptor, TNF, NOS, LTR

Lyso-Globotriaosylceramide (d18:1)

T37291

Synonym: Lyso-Globotriaosylceramide (d18:1)

Target: Cannabinoid Receptor, Antioxidant

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-00970	CD31/PECAM-1 Protein, Human, Recombinant (His)	Human	HEK293
	The Cluster of Differentiation 31 (CD31) adhesion molecule, also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1), is the only known member of the CAM family on platelets. CD31 protein is a 130-kDa transm...
TMPY-00754	IL-8/CXCL8 Protein, Human, Recombinant (aa 23-99)	Human	HEK293
	Interleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proang...
TMPY-00472	IL-8/CXCL8 Protein, Human, Recombinant (aa 28-99)	Human	E. coli
	Interleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proang...
TMPY-04726	IL-8/CXCL8 Protein, Human, Recombinant (His)	Human	Yeast
	Interleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proang...
TMPJ-00211	CD47 Protein, Human, Recombinant (His)	Human	Human Cells
	CD47(Integrin-Associated Protein,IAP) is a 40 ‑ 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 binds to SIRP family members on macrophages, neutrophils, an...
TMPY-03050	CXCL5 Protein, Human, Recombinant	Human	E. coli
	CXCL5 is a small cytokine belonging to the CXC chemokine family. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. CXCL5 is produced following stimulation of cells with the ...
TMPY-06076	LILRA2/CD85h/ILT1 Protein, Human, Recombinant (hFc)	Human	HEK293
	LILRA2 (Leukocyte Immunoglobulin Like Receptor A2, also known as LIR7 and ILT1) is a Protein Coding gene. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentatio...
TMPY-00888	MMP-9 Protein, Human, Recombinant (His)	Human	HEK293
	Matrix metalloproteinases (MMPs) are neutral proteinases that are involved in the breakdown and remodeling of the extracellular matrix (ECM) under a variety of physiological and pathological conditions, such as morphogen...
TMPY-01248	MMP-9 Protein, Human, Recombinant	Human	HEK293
	Matrix metalloproteinases (MMPs) are neutral proteinases that are involved in the breakdown and remodeling of the extracellular matrix (ECM) under a variety of physiological and pathological conditions, such as morphogen...
TMPY-01919	MMP-9 Protein, Mouse, Recombinant	Mouse	HEK293
	Matrix metalloproteinases (MMPs) are neutral proteinases that are involved in the breakdown and remodeling of the extracellular matrix (ECM) under a variety of physiological and pathological conditions, such as morphogen...
TMPY-02709	P-Selectin Protein, Human, Recombinant (His)	Human	HEK293
	P selectin (SELP) is a 140kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. SELP mediates rapid rolling of leukocyte rolling over vascular surfaces during the in...
TMPY-00672	Azurocidin/CAP37 Protein, Human, Recombinant (His)	Human	HEK293
	Azurocidin (AZU1), also known as heparin-binding protein (HBP) or cationic antimicrobial protein 37 (CAP37), is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. The Azurophil...
TMPY-01850	CEACAM3 Protein, Human, Recombinant (His)	Human	HEK293
	CeACAM3 (CD66d), a member of carcinoembryonic antigen family, is a granulocyte-specific receptor involved in the opsonin-independent recognition of several bacterial pathogens. There are four members in this family: CD66...
TMPY-04902	Complement C5a Protein, Mouse, Recombinant	Mouse	E. coli
	C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway...
TMPY-05057	Complement C5 Protein, Human, Recombinant (His & FLAG)	Human	HEK293
	C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway...
TMPY-00653	Complement C5 Protein, Human, Recombinant (Complement C5a)	Human	E. coli
	C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway...
TMPY-06844	CD93/C1qR1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protei...
TMPY-06027	CD93/C1qR1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protei...
TMPY-00695	I-309 Protein, Human, Recombinant (hFc)	Human	HEK293
	CCL1 or chemokine (C-C motif) ligand 1, also known as I-309 or TCA-3, is a member of the chemokine (C-C motif) ligand family. The C-C chemokines have two cysteines nearby the amino terminus. There have been at least 27 d...
TMPY-02268	CD93/C1qR1 Protein, Human, Recombinant (His)	Human	HEK293
	CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protei...
TMPY-01371	IL-17RA Protein, Human, Recombinant (His)	Human	HEK293
	Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor that binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secret...
TMPJ-00137	APRIL/TNFSF13 Protein, Human, Recombinant (Flag & His)	Human	Human Cells
	APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to relea...
TMPY-01774	TREM-1 Protein, Human, Recombinant (His)	Human	HEK293
	TREM1 (triggering receptor expressed on myeloid cells) is a type I transmembrane protein with a single Ig-like domain, and is selectively expressed on blood neutrophils and a subset of monocytes. As a member of the growi...
TMPY-03481	IL-1R2 Protein, Human, Recombinant	Human	HEK293
	Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interl...
TMPY-03079	IL-1R2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interl...
TMPY-00716	CD89 Protein, Human, Recombinant (His)	Human	HEK293
	FCAR, also called FcαRI or CD89, is a type I transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This recep...
TMPY-01366	IL-1R2 Protein, Human, Recombinant (His)	Human	HEK293
	Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interl...
TMPY-01750	HVEM Protein, Human, Recombinant (His)	Human	HEK293
	Herpesvirus entry mediator (HVEM), also referred to as TNFRSF14, TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a member of type I transmembrane protein belonging to the TNF-receptor sup...
TMPY-00988	Lipocalin-2/LCN2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a 25 kDa protein belonging to the lipocalin superfamily. It was initially found in activated neutrophils, however, many other cells,...
TMPY-00873	Lipocalin-2/LCN2 Protein, Human, Recombinant (His)	Human	HEK293
	Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a 25 kDa protein belonging to the lipocalin superfamily. It was initially found in activated neutrophils, however, many other cells,...
TMPY-04114	GM-CSF/CSF2 Protein, Mouse, Recombinant	Mouse	HEK293
	Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestatio...
TMPY-03662	GM-CSF/CSF2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestatio...
TMPY-03858	GM-CSF/CSF2 Protein, Human, Recombinant	Human	HEK293
	Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestatio...
TMPY-00750	GM-CSF/CSF2 Protein, Human, Recombinant (hFc)	Human	HEK293
	Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestatio...
TMPY-03713	GM-CSF/CSF2 Protein, Rat, Recombinant (His)	Rat	HEK293
	Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestatio...
TMPJ-00925	Grancalcin Protein, Human, Recombinant	Human	E. coli
	Grancalcin (GCA) is a cytoplasmic granule membrane protein that contains 4 EF-hand domains. GCA is calcium-binding protein and particularly abundant in human neutrophils. GCA is highly expressed in bone marrow, and it ca...
TMPH-00794	Dps Protein, Helicobacter pylori, Recombinant (His & SUMO)	Helicobacter pylori	E. coli
	Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical produ...
TMPH-03577	Staphopain B Protein, S. aureus, Recombinant (GST)	Staphylococcus aureus	E. coli
	Cysteine protease that plays an important role in the inhibition of host innate immune response. Degrades host elastin, fibrogen, fibronectin and kininogen. Blocks phagocytosis of opsonised S. aureus by neutrophils and m...
TMPH-02972	VDB Protein, Mouse, Recombinant (E. coli, His)	Mouse	E. coli
	Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
TMPH-02973	VDB Protein, Mouse, Recombinant (His)	Mouse	Yeast
	Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
TMPJ-01240	CD99L2 Protein, Human, Recombinant (His)	Human	Human Cells
	CD99 Antigen-Like Protein 2 (CD99L2) belongs to the CD99 family. CD99L2 is a single-pass type I membrane protein and expressed in many tissues, with low expression in thymus. CD99L2 plays a role in a late step of leukocy...
TMPJ-01239	CD99L2 Protein, Human, Recombinant (hFc)	Human	Human Cells
	CD99 Antigen-Like Protein 2 (CD99L2) belongs to the CD99 family. CD99L2 is a single-pass type I membrane protein and expressed in many tissues, with low expression in thymus. CD99L2 plays a role in a late step of leukocy...
TMPJ-00926	GCA Protein, Human, Recombinant (GST)	Human	E. coli
	Grancalcin (GCA) is a member of the penta EF hand subfamily which includes sorcin, calpain and ALG2. Grancalcin is highly expressed bone marrow and also can detected in neutrophils and macrophages. Grancalcin interacts w...
TMPJ-00419	CD16b Protein, Human, Recombinant (hFc & His)	Human	Human Cells
	Low affinity immunoglobulin gamma Fc region receptor III-B, also known as Fc-gamma RIII-beta, FcR-10, IgG Fc receptor III-1, FCG3, FCGR3, CD16b and FCGR3B. FCGR3B is a GPI-anchor membrane protein and contains two Ig-like...
TMPH-03121	CXCL4 Protein, Pig, Recombinant (His & Myc)	Sus scrofa (Pig)	E. coli
	Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophil...
TMPK-00005	CD24 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated	Human	HEK293
	CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential fo...
TMPK-00003	CD24 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential fo...
TMPK-00002	CD24 Protein, Human, Recombinant (His & Avi)	Human	HEK293
	CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential fo...
TMPK-00001	CD24 Protein-VLP, Human, Recombinant	Human	HEK293
	CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential fo...
TMPY-00707	CD31/PECAM-1 Protein, Human, Recombinant	Human	HEK293
	The Cluster of Differentiation 31 (CD31) adhesion molecule, also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1), is the only known member of the CAM family on platelets. CD31 protein is a 130-kDa transm...
------------------------ More ------------------------