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Neuroscience Neurokinin receptor

Neurokinin receptor

Neurokinin 1 (NK1) antagonists (-pitants) are a novel class of medications that possesses unique antidepressant, anxiolytic, and antiemetic properties. NK-1 antagonists boost the efficacy of 5-HT3 antagonists to prevent nausea and vomiting. The discovery of neurokinin 1 (NK1) receptor antagonists was a turning point in the prevention of nausea and vomiting associated with cancer chemotherapy.
Cat No. product name
T10688 Casopitant mesylate Casopitant mesylate (GW679769B) is a selective, brain permeable, and orally active antagonist of neurokinin 1 (NK1) receptor. It is a second in the class of ant...
T10892 CS-003 Free base CS-003 free base (CS-003) is a triple tachykinin receptor antagonist with high affinity for human (neurokinin) NK1, NK2 and NK3 receptors, with Ki values of 2.3...
T13329 Vofopitant Vofopitant is a potent antagonist of the tachykinin NK1 receptor (pKis: 10.6, 9.5, and 9.8 for the human, rat, and ferret NK1 receptor, respectively).
T13329L Vofopitant dihydrochloride Vofopitant dihydrochloride is a selective and orally available antagonist of tachykinin neurokinin 1(NK1) receptor (pKi: 9.5 and 10.6 in rat and human membranes...
T16406 Orvepitant maleate Orvepitant maleate is an effective, selective, and well-tolerated neurokinin-1 receptor (NK-1) antagonist (pKi: 10.2 for human neurokinin-1 receptor). Orvepitan...
T1743 Aprepitant Aprepitant is a Substance P/Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome P450 3A4 Inh...
T1790 Fosaprepitant dimeglumine Fosaprepitant Dimeglumine is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Up...
T19518 Physalaemin Physalaemin is a non-mammalian tachykinin.
T3716 Rolapitant Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor)...
T3724 Rolapitant hydrochloride Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor)...
T6905 Netupitant Netupitant is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM).
T7209 Maropitant Maropitant is a selective neurokinin (NK1) receptor antagonist.
T7549 Talnetant Talnetant is a selective, competitive, brain-penetrant NK3 receptor antagonist with the ability to modulate mesolimbic and mesocortical dopaminergic neurotransm...
T7633 Senktide Senktide is an agonist of tachykinin NK3 receptor.
T7828 Bhsar-sp Bhsar-sp is an agonist of NK1 receptor.
T8235 L-732138 L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM)
T8789 N-Acetyl-L-tryptophan N-Acetyl-L-tryptophan is an inhibitor of neurokinin 1 receptor (NK1-receptor, NK1R).
TP1008 Neurokinin A Neurokinin A (NKA), formerly known as Substance K, is a neurologically active peptide translated from the pre-protachykinin gene.
TP1008 Neurokinin A Neurokinin A (NKA), formerly known as Substance K, is a neurologically active peptide translated from the pre-protachykinin gene.
TP1086 Men 10376 TFA(135306-85-3,free) Men 10376 TFA is an effective and selective tachykinin nk-2 receptor antagonist with a K I value of 4.4 M for the nk-2 receptor in the small intestine of rats.
TP1087 Substance P Substance P (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.
TP1369L [Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base) [Sar9,Met(O2)11]-Substance P acetate is a tachykinin NK1 receptor selective agonist. [Sar9,Met(O2)11]-Substance P acetate is a selective tachykinin NK1 receptor...
TP1385 Neurokinin A(4-10) TFA(97559-35-8 free base) Neurokinin A (4-10) TFA is a tachykinin NK2 receptor agonist[1].
TP1572 GR-73632 Potent and selective tachykinin NK1 receptor agonist (EC50 = 2 nM in guinea pig vas deferens).
TP1772L Hemokinin 1 (mouse) acetate(208041-90-1 free base) Hemokinin 1 (mouse) acetate is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 rece...
TP1883 [Lys5,MeLeu9,Nle10]-NKA(4-10) Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).
Casopitant mesylate
T10688CAS 414910-30-8
Casopitant mesylate (GW679769B) is a selective, brain permeable, and orally active antagonist of neurokinin 1 (NK1) receptor. It is a second in the class of ant...
CS-003 Free base
T10892CAS 191672-52-3
CS-003 free base (CS-003) is a triple tachykinin receptor antagonist with high affinity for human (neurokinin) NK1, NK2 and NK3 receptors, with Ki values of 2.3...
Vofopitant
T13329CAS 168266-90-8
Vofopitant is a potent antagonist of the tachykinin NK1 receptor (pKis: 10.6, 9.5, and 9.8 for the human, rat, and ferret NK1 receptor, respectively).
Vofopitant dihydrochloride
T13329LCAS 168266-51-1
Vofopitant dihydrochloride is a selective and orally available antagonist of tachykinin neurokinin 1(NK1) receptor (pKi: 9.5 and 10.6 in rat and human membranes...
Orvepitant maleate
T16406CAS 579475-24-4
Orvepitant maleate is an effective, selective, and well-tolerated neurokinin-1 receptor (NK-1) antagonist (pKi: 10.2 for human neurokinin-1 receptor). Orvepitan...
Aprepitant
T1743CAS 170729-80-3
Aprepitant is a Substance P/Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome P450 3A4 Inh...
Fosaprepitant dimeglumine
T1790CAS 265121-04-8
Fosaprepitant Dimeglumine is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Up...
Physalaemin
T19518CAS 2507-24-6
Physalaemin is a non-mammalian tachykinin.
Rolapitant
T3716CAS 552292-08-7
Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor)...
Rolapitant hydrochloride
T3724CAS 914462-92-3
Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor)...
Netupitant
T6905CAS 290297-26-6
Netupitant is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM).
Maropitant
T7209CAS 147116-67-4
Maropitant is a selective neurokinin (NK1) receptor antagonist.
Talnetant
T7549CAS 174636-32-9
Talnetant is a selective, competitive, brain-penetrant NK3 receptor antagonist with the ability to modulate mesolimbic and mesocortical dopaminergic neurotransm...
Senktide
T7633CAS 106128-89-6
Senktide is an agonist of tachykinin NK3 receptor.
Bhsar-sp
T7828CAS 110880-55-2
Bhsar-sp is an agonist of NK1 receptor.
L-732138
T8235CAS 148451-96-1
L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM)
N-Acetyl-L-tryptophan
T8789CAS 1218-34-4
N-Acetyl-L-tryptophan is an inhibitor of neurokinin 1 receptor (NK1-receptor, NK1R).
Neurokinin A
TP1008CAS 86933-74-6
Neurokinin A (NKA), formerly known as Substance K, is a neurologically active peptide translated from the pre-protachykinin gene.
Neurokinin A
TP1008CAS 86933-74-6
Neurokinin A (NKA), formerly known as Substance K, is a neurologically active peptide translated from the pre-protachykinin gene.
Men 10376 TFA(135306-85-3,free)
TP1086CAS TP1086
Men 10376 TFA is an effective and selective tachykinin nk-2 receptor antagonist with a K I value of 4.4 M for the nk-2 receptor in the small intestine of rats.
Substance P
TP1087CAS 33507-63-0
Substance P (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.
[Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base)
TP1369LCAS TP1369L
[Sar9,Met(O2)11]-Substance P acetate is a tachykinin NK1 receptor selective agonist. [Sar9,Met(O2)11]-Substance P acetate is a selective tachykinin NK1 receptor...
Neurokinin A(4-10) TFA(97559-35-8 free base)
TP1385CAS TP1385
Neurokinin A (4-10) TFA is a tachykinin NK2 receptor agonist[1].
GR-73632
TP1572CAS 133156-06-6
Potent and selective tachykinin NK1 receptor agonist (EC50 = 2 nM in guinea pig vas deferens).
Hemokinin 1 (mouse) acetate(208041-90-1 free base)
TP1772LCAS TP1772L
Hemokinin 1 (mouse) acetate is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 rece...
[Lys5,MeLeu9,Nle10]-NKA(4-10)
TP1883CAS 137565-28-7
Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).