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Cat No. | Product Name | Synonyms | Targets |
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TP1008 | Neurokinin A | α-Neurokinin,Substance K,Neuromedin L | Neurokinin receptor |
Neurokinin A (NKA), formerly known as Substance K, is a neurologically active peptide translated from the pre-protachykinin gene. | |||
TP1087 | Substance P | Neurokinin P | Endogenous Metabolite , Neurokinin receptor |
Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family. | |||
T7633 | Senktide | Neurokinin receptor | |
Senktide is an agonist of tachykinin NK3 receptor. | |||
T23316 | SB 218795 | Neurokinin receptor | |
SB 218795 is an effective and selective antagonist of NK3 with a Ki 13 nM for hNK3 which is about 90-fold and 7000-fold selectivity over hNK2 and hNK1. | |||
T16849 | SB-222200 | Neurokinin receptor | |
SB-222200 is a selective, reversible, and competitive antagonist of the human NK-3 receptor(Ki=4.4 nM). | |||
TP1086 | Men 10376 TFA(135306-85-3,free) | Men 10376 TFA,Neurokinin-2 receptor antagonist TFA | Neurokinin receptor |
Men 10376 TFA(135306-85-3,free) (Neurokinin-2 receptor antagonist TFA) is an effective and selective tachykinin nk-2 receptor antagonist with a K I value of 4.4 M for the nk-2 receptor in the small intestine of rats. | |||
T7209 | Maropitant | Neurokinin receptor | |
Maropitant is a selective neurokinin (NK1) receptor antagonist. | |||
TP1572 | GR-73632 | Neurokinin receptor | |
Potent and selective tachykinin NK1 receptor agonist (EC50 = 2 nM in guinea pig vas deferens). | |||
T38144 | Elinzanetant | Neurokinin receptor | |
Elinzanetant is a dual antagonist of neurokinin (NK) receptors 1 and 3 and modulates reproductive hormone secretion. | |||
T15278 | Fezolinetant | ESN-364 | Neurokinin receptor |
Fezolinetant (ESN-364) is an antagonist of the neurokinin 3 receptor (NK3R). It is used for the treatment of menopausal hot flushes. | |||
T7549 | Talnetant | SB 223412 | Neurokinin receptor |
Talnetant (SB 223412) is a selective, competitive, brain-penetrant NK3 receptor antagonist with the ability to modulate mesolimbic and mesocortical dopaminergic neurotransmission | |||
T76429 | Neurokinin Receptor (393-407), rat | ||
Neurokinin Receptor (393-407), rat (SPR393–407), a fragment of the rat neurokinin 1 receptor (NK1R), undergoes rapid endocytosis and subsequent recycling to the plasma membrane upon substance P (SP) binding. This compoun... | |||
T8235 | L-732138 | Neurokinin receptor | |
L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM) | |||
TP1883 | [Lys5,MeLeu9,Nle10]-NKA(4-10) | Neurokinin receptor | |
Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively). | |||
T17156 | Tradipitant | VLY-686,LY686017 | Neurokinin receptor |
Tradipitant (VLY-686) is an antagonist of neurokinin-1. | |||
T7554 | Substance P (7-11) | Substance P 7-11(TFA) | Others , Neurokinin receptor |
Substance P (7-11) (Substance P 7-11(TFA)) is a C-terminal fragment of Substance P . | |||
T16038 | Men 10376 | Neurokinin-2 receptor antagonist | CDK |
Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor. | |||
T6905 | Netupitant | Ro 67-31898/000,CID 6451149 | Neurokinin receptor |
Netupitant (CID 6451149) is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM). | |||
T3716 | Rolapitant | SCH619734 | Neurokinin receptor |
Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. ... | |||
T7559 | Neurokinin A(4-10) | Neurokinin A(4-10)(TFA) | Neurokinin receptor |
Neurokinin A(4-10)(TFA) is an agonist of tachykinin NK2 receptor . | |||
T1743 | Aprepitant | MK-869,MK-0869,L-754030,Aprepitant` | HIV Protease , Antibacterial , Antibiotic , Neurokinin receptor |
Aprepitant (Aprepitant`) is a Substance P/Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inducer, and C... | |||
T13306L | Vapreotide acetate | RC-160 acetate,BMY-41606 acetate | Neurokinin receptor |
Vapreotide acetate (BMY-41606 acetate) is an antagonist of the neurokinin-1 (NK1) receptor (IC50: 330 nM). | |||
T1790 | Fosaprepitant dimeglumine | L785298,MK-0517,Fosaprepitant dimeglumine salt | Neurokinin receptor |
Fosaprepitant dimeglumine (MK-0517) is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Upon intravenous administration and rapid conversion... | |||
T3034 | Eprazinone dihydrochloride | Resplen,Mucitux,Eftapan,NSC 317935,Eprazinone 2HCl | Others , Neurokinin receptor |
Eprazinone dihydrochloride (NSC 317935) is a mucolytic with antitussive and mucolytic effect. | |||
T7828 | [Sar9,Met(O2)11]-Substance P | Bhsar-sp,NA | Neurokinin receptor |
[Sar9,Met(O2)11]-Substance P (NA) is an agonist of NK1 receptor. | |||
T7396 | Substance P(1-7) | Substance P 1-7 | Others , Neurokinin receptor |
Substance P(1-7) (Substance P 1-7) is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effects | |||
T7631 | Eledoisin Related Peptide | Eledoisin RP,Eledoisin-Related Peptide,Eledoisin Related Peptide(2TFA) | Neurokinin receptor |
Eledoisin Related Peptide (Eledoisin RP) is a tachykinin receptor ligand. | |||
T29157 | WIN 51,708 | WIN51,708,WIN-51,708 | |
WIN 51,708 is an antagonist of neurokinin-1 receptor. | |||
TP1363L | Neurokinin B acetate(86933-75-7 free base) | Neurokinin K | Neurokinin receptor |
Neurokinin B acetate(86933-75-7 free base) is the acetate form of Neurokinin B, which belongs to the tachykinin family. Neurokinin binds to neurokinin receptor 1 (NK1R), nk2r and NK3R, and mediates its biological effects... | |||
TP1385 | Neurokinin A(4-10) TFA(97559-35-8 free base) | Neurokinin A(4-10) TFA | Neurokinin receptor |
Neurokinin A(4-10) TFA(97559-35-8 free base) is a tachykinin NK2 receptor agonist[1]. | |||
T68068 | Ezlopitant | CJ 11974,CJ-11974,CJ11974 | Neurokinin receptor |
Ezlopitant (CJ-11974) is a small molecule neurokinin-1-receptor (NK1) antagonist used to treat nausea, vomiting and pain. | |||
T69140 | Burapitant | SSR 240600 | Neurokinin receptor |
Burapitant (SSR 240600) is a novel non-peptide tachykinin neurokinin 1 (NK) receptor antagonist with anti-coke oven and antidepressant activity. | |||
T68068L | (R)-CJ 11974 | Neurokinin receptor | |
(R)-CJ 11974 is a novel non-peptide neurokinin NK1 substance P receptor antagonist with potential analgesic activity that can be used to study chemotherapy-induced vomiting. | |||
TP1851L | Scyliorhinin II acetate | Neurokinin receptor | |
Scyliorhinin II acetate is a selective agonist of the neurokinin-3 (NK3) receptor (Ki = 2.5 nM) in rat cerebral cortex. | |||
T19518L | Physalaemin acetate | Neurokinin receptor | |
Physalaemin acetate is a non-mammalian tachykinin with high affinity when binding selectively to neurokinin-1 (NK1) receptor. | |||
T25616 | Lanepitant 2HCl | LY303870 dihydrochloride,LY 303870 dihydrochloride,LY-303870 dihydrochloride,Lanepitant dihydrochloride | Neurokinin receptor |
Lanepitant 2HCl is a non-peptide neurokinin-1 receptor antagonist with analgesic and anti-inflammatory activity.Lanepitant 2HCl inhibits the binding of Substance P to the neurokinin-1 receptor, inhibits neurogenic inflam... | |||
T16114 | Pavinetant | AZD4901,MLE-4901,AZD2624 | MEK |
Pavinetant is a small molecule orally active and selective neurokinin-3 (NK3) receptor antagonist for the treatment of hot flashes and polycystic ovarian syndrome (PCOS), which is a potential compound for the treatment o... | |||
T3724 | Rolapitant hydrochloride | Rolapitant HCl | Neurokinin receptor |
Rolapitant (SCH619734) hydrochloride is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a K i of 0.66 nM. Rolapitant hydrochloride (Rolapitant HCl) does not interact with CY... | |||
T9417L | Gamma-preprotachykinin amide (72-92) acetate | gamma-preprotachykinin amide (72-92) acetate (114882-65-4 Free base) | Others |
gamma-preprotachykinin amide (72-92) acetate is a 21 amino acid peptide belonging to the tachykinin (TK) family and including neurokinin A (NKA) in its C-terminal sequence. gamma-preprotachykinin amide (72-92) acetate po... | |||
T68556 | GW679769 | ||
GW679769 is a neurokinin-1 receptor antagonist. | |||
T20148 | L 659,877 | L 659877,L-659,877,L-659877,L659,877,L659877 | |
L 659,877 is an antagonist of the Tachykinin and neurokinin-2 receptor. | |||
T70587 | CJ-12255 | ||
CJ-12255 is a Neurokinin-1 Receptor Antagonist. | |||
T76427 | (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B | ||
(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B functions as a competitive antagonist to the Neurokinin B receptor, exhibiting a pA2 value of 5.5. Notably, it does not affect Substance P or Neurokinin A [1]. | |||
T29210 | ZD6021 | ZD-6021,ZD 6021 | |
ZD6021 is an antagonist of neurokinin 1 receptor. | |||
T69295 | DNK 333 | ||
DNK 333 is a dual neurokinin NK1/NK2 receptor antagonist. | |||
T26169 | S 16474 | S16474,S-16474 | |
S 16474 is an antagonist of Neurokinin-1 Receptor. | |||
T16406 | Orvepitant maleate | GW823296 maleate | Neurokinin receptor |
Orvepitant maleate is an effective, selective, and well-tolerated neurokinin-1 receptor (NK-1) antagonist (pKi: 10.2 for human neurokinin-1 receptor). Orvepitant maleate has the potential for depressive disorder and chro... | |||
T27175 | Dilopetine Citrate | E-6006 Citrate,E-6039,E6039,E 6039 | |
Dilopetine Citrate, a tachykinin receptor modulator and a neurokinin receptor modulator, is used potentially for the treatment of depression. | |||
T24357 | L 741671 | L741671,L 741,671,L741,671,L-741,671,L-741671 | |
L 741671 is an antagonist of the neurokinin-1 receptor. | |||
T34799 | Telmapitant | ||
Telmapitant is an antagonist of the neurokinin NK1 receptor. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8789 | N-Acetyl-L-tryptophan | N-acetyltryptophan | Endogenous Metabolite , Neurokinin receptor |
N-Acetyl-L-tryptophan (N-acetyltryptophan) is an inhibitor of neurokinin 1 receptor (NK1-receptor, NK1R). |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01379 | TAC3 Protein, Human, Recombinant (His) | Human | E. coli |
Tachykinin 3 (TAC3) is a secreted protein that belongs to the Tachykinin family. Tachykinins are active peptides that excite neurons and evoke behavioral responses; they are potent vasodilators and secretagogues, and con... |