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Search Results for " no synthase "

Targets

47

Compounds

38

Natural Products

3

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T7474 7-Nitroindazole NOS
7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro for neuronal nitric oxide synthase showing a 10-fold selectivity for neuronal NOS.
T10107 3-Bromo-7-nitroindazole NOS
3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or iNOS. It affects the intercellular messenger NO synthesis throughout the brain and body.
T1322 Bendazol Dibazol,Dibazole Dopamine Receptor , NO Synthase
Bendazol (Dibazol) is always used as the drug for hypertension and cerebral Angiospasm.
T22724 Dimaprit dihydrochloride NOS , NO Synthase , Histamine Receptor
Dimaprit dihydrochloride is a selective histamine H2 receptor agonist. Dimaprit dihydrochloride also inhibits nNOS with an IC50 of 49 μM. It can stimulate gastric acid secretion.
T1479 Isosorbide dinitrate Isordil,Nitrosorbide,Sorbide nitrate,Sorbidnitrate Others , NO Synthase
Isosorbide dinitrate (Isordil) is a vasodilator used in the treatment of angina pectoris.
T15697 L-NMMA acetate Tilarginine acetate,Methylarginine acetate NOS
L-NMMA acetate (Tilarginine acetate) is an inhibitor of nitric oxide synthase of all NOS isoforms (i.e. NOS1, NOS2, and NOS3). The Ki values are 0.18, 0.4, and 6 µM for nNOS, eNOS, and iNOS, respectively.
T21700 NOS-IN-1  2-Imino-4-methylpiperidine (acetate) NOS
NOS-IN-1 (2-Imino-4-methylpiperidine acetate) is a potent and orally active inhibitor of NO synthase (NOS) isoforms. NOS-IN-1 exhibits IC50s of 0.1 μM, 0.2 μM, and 1.1μM for human iNOS (hiNOS), hnNOS and heNOS, respectiv...
T19853 Dimethoxycurcumin Veratrylcurcuminoid Others
Dimethoxycurcumin (Veratrylcurcuminoid) is an analog of curcumin with more metabolical stability. Dimethoxycurcumin induces epigenetic changes in leukemia cells and the expression of promoter methylated genes.
T21507 7-Ethoxyresorufin Resorufin ethyl ether P450 , NO Synthase
7-Ethoxyresorufin (Resorufin ethyl ether) (7-ER) is a fluorometric substrate for and competitive inhibitor of cytochrome P450, especially CYP1A1.
T3491 1400W dihydrochloride 1400W 2HCl,N-(3-(Aminomethyl)benzyl)acetamidine NOS , NO Synthase
1400W dihydrochloride (N-(3-(Aminomethyl)benzyl)acetamidine) is a highly effective and specific inhibitor of inducible NOS2 (iNOS).
T2334 Avanafil TA1790 PDE
Avanafil (TA1790) is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as therapy of erectile dysfunction.
T7461 2,4-Diamino-6-hydroxypyrimidine DAHP Reactive Oxygen Species , NO Synthase
2,4-Diamino-6-hydroxypyrimidine (DAHP) (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis
T12808 S-Nitroso-N-acetyl-DL-penicillamine SNAP NO Synthase
S-Nitroso-N-acetyl-DL-penicillamine (SNAP) acts as a stable inhibitor of platelet aggregation, is a nitric oxide donor and .
T19916 TRIM 1-(2-Trifluoromethylphenyl)imidazole NOS
TRIM (1-(2-Trifluoromethylphenyl)imidazole) is an inhibitor of nNOS.
T7206L 2-Iminobiotin hydrobromide Guanidinobiotin NOS , NO Synthase
2-Iminobiotin hydrobromide (Guanidinobiotin) is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of 21.8 and 37.5 μM for mouse i...
T3198L PRE-084 hydrochloride Sigma receptor
PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).
T1102 Mifepristone C-1073,RU486,RU 38486 Glucocorticoid Receptor , Estrogen/progestogen Receptor , Progesterone Receptor , NO Synthase , Autophagy
Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
T22419 S-Methylisothiourea sulfate (S)-Methylisothiourea sulfate NOS , NO Synthase , HSV
S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic shock[1].
T6888 Methylene Blue methylthioninium chloride,CI-52015,Tetramethylthionine chloride,Basic Blue 9 Guanylate cyclase , Microtubule Associated , NO Synthase , Parasite , Monoamine Oxidase
Methylene Blue (Tetramethylthionine chloride) (IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
T0006 Methylene Blue trihydrate Methylthionine chloride,Basic blue 9,Methylene Blue Guanylate cyclase , Microtubule Associated , NO Synthase , Parasite , Monoamine Oxidase
Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene Blue trihydrate...
T3211 Midostaurin N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251 Others , PKC
PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platel...
T0358 Aminoguanidine hydrochloride Imino semicarbazide,Pimagedine hydrochloride,CP-12009-18 tartrate,Hydrazinecarboximidamide,Guanyl hydrazine,Pimagedine NOS , NO Synthase
Aminoguanidine hydrochloride (Hydrazinecarboximidamide) is a diamine oxidase and NO synthase inhibitor, used in the treatment of diabetic nephropathy.
T9537 N'-Nitro-D-arginine N'-Nitro-D-arginine,H-D-Arg(NO2)-OH,(R)-2-Amino-5-(3-nitroguanidino)pentanoic acid Others
N'-Nitro-D-arginine (N'-Nitro-D-arginine) is a Building Block.
T7206 2-Iminobiotin 2-IMINOBIOTIN HYDROBROMIDE,Guanidinobiotin NOS , NO Synthase
2-Iminobiotin (Guanidinobiotin) is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of 21.8 and 37.5 μM for mouse iNOS and rat n...
T6570 L-NAME hydrochloride L-NAME HCl,N(G)-Nitro-L-arginine methyl ester,NG-Nitroarginine methyl ester hydrochloride NOS , NO Synthase
L-NAME hydrochloride (L-NAME HCl), a cell-permeable NO synthase inhibitor, displays Ki values of 4.4 μM, 15 nM, and 39 nM, for iNOS (mouse) , nNOS (bovine) , and eNOS (human), respectively.
T30219 AVE-9488 AVE 9488,AVE9488
AVE-9488 is a novel enhancer of endothelial NO synthase (eNOS).
T21546 NG,NG-dimethyl-L-Arginine dihydrochloride NO Synthase
NG,NG-dimethyl-L-Arginine dihydrochloride is an endogenous nitric oxide synthase inhibitor. Nitric oxide (NO) that is synthesised from L-arginine contributes to the regulation of blood pressure and to host defence[1].
T4567 Sulfaphenazole Plisulfan,Raziosulfa,Depocid,Depotsulfonamide P450 , Antibacterial
Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1...
T16344 NS-2028 Others , Guanylate cyclase
NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity). It is commonly used in the research of nitric oxide signaling pathways. NS-2028...
T21967 MEG hemisulfate Mercaptoethylguanidine hemisulfate NOS
MEG hemisulfate (Mercaptoethylguanidine hemisulfate) is a potent and selective inhibitor of the inducible NO synthase (iNOS), with EC50s of 11.5, 110, and 60 μM for iNOS, ecNOS, and bNOS respectively in tissue homogenate...
T11805 L-NIL Others
L-NIL is a potent and selective inhibitor of inducible NO synthase with IC50s of 92 and 3.3 μM for rat brain constitutive NO synthase and mouse inducible NO synthase, respectively.
TP2164 TP508 TFA (121341-81-9 free base) TP508 TFA Others
TP508 TFA is a nonproteolytic thrombin peptide. TP508 TFA activates endothelial NO synthase (eNOS) and stimulates the production of NO in human endothelial cells. It activates endothelial cells and stem cells to revascul...
T75725 Camstatin TFA
Camstatin TFA, a functionally active 25-residue fragment of PEP-19's IQ motif, binds calmodulin and inhibits neuronal nitric oxide (NO) synthase [1] .
T60403 COX-2/NO-IN-1
COX-2/NO-IN-1 is an orally active nitric oxide synthase (iNOS) and NO ( IC 50 of 3.52 μM) inhibitor as well as suppresses the expression of COX-2. COX-2/NO-IN-1 has anti-inflammatory effects and reduces pathological dama...
T75763 TP508 TFA
TP508 TFA is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 TFA activates endothelial NO synthase (eNOS) and stimulates production of ...
T15503 HQL-79 Others
HQL-79 is a selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor. It inhibits the synthesis of PGD2 and acts as an anti-allergic agent (Kd: 0.8 μM and IC50: 6 μM). It also shows no ...
T36512 PTIO NO Synthase
PTIO is a specific scavenger of NO. PTIO reacts with nitric oxide to form nitric dioxide and corresponding imino nitroxides. PTIO can be used to examine nitric oxide synthase inhibitory activity.
T62987 INOs-IN-1
iNOs-IN-1 (YPW) is a potent inhibitor of inducible nitric oxide synthase (iNOS) with anti-inflammatory effects. iNOs-IN-1 significantly inhibits IL-6 and iNOS expression in a dose-dependent manner in murine macrophages, ...
T62849 INOS-IN-2
iNOS-IN-2 (Compound 53) is a potent inducible nitric oxide synthase (iNOS) protein down-regulator. iNOS-IN-2 effectively inhibits NO production (IC50: 6.4 μM). iNOS-IN-2 can be used in studies of chronic inflammation.
T61250 HPGDS inhibitor 3
HPGDS inhibitor 3 is a powerful oral compound that selectively inhibits the hematopoietic prostaglandin D synthase (H-PGDS). With an IC50 value of 9.4 nM and EC50 of 42 nM, it demonstrates high potency in peripherally re...
T36719 D-NAME (hydrochloride)
N(G)-Nitro-D-arginine methyl ester (D-NAME) is the less active enantiomer of the nitric oxide (NO) synthase inhibitor N(G)-nitro-L-arginine methyl ester . D-NAME was initially thought to be inactive and was often used as...
TP2195 Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell Others
Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell (Ac-Pro-Tyr-Asn-Ser-Ser-Pro-Arg-Pro-Glu-Gln-His-Lys-Ser-Tyr-Lys-Cys) is a peptide that inhibits the function of NOSs as a result it blocks the pro...
T78855 Anticancer agent 157 NO Synthase
Anticancer Agent 157 (compound 15) is a nitric oxide (NO) inhibitor with IC50 values of 0.62 μg/mL, exhibiting both anti-inflammatory and anticancer effects. It interacts with inducible NO synthase (iNOS) and caspase 8, ...
T14021 20-HETE 20-hydroxy Arachidonic Acid Others
20-HETE (20-hydroxy Arachidonic Acid) is a CYP450 metabolite and a potent vasoconstrictor and it is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles. 20-HETE increases NADPH ...
T36610 (E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine
(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities. It stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM). CSTMP r...
T75339 Methylene blue hydrate
Methylene blue (Basic Blue 9) hydrate is a guanylyl cyclase (sGC) , monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. M...
T36974 D-threo-PPMP hydrochloride
D-threo-PPMP is a glucosylceramide (GlyCer) synthetase inhibitor.1,2It is the active enanantiomer and enzymatic inhibitory component of the racemic DL-threo-PPMP . In MDCK kidney epithelial cells, D-threo-PPMP induces a ...

Compounds

7-Nitroindazole
T7474
Synonym:
Target: NOS
3-Bromo-7-nitroindazole
T10107
Synonym:
Target: NOS
Bendazol
T1322
Synonym: Dibazol,Dibazole
Target: Dopamine Receptor, NO Synthase
Dimaprit dihydrochloride
T22724
Synonym:
Target: NOS, NO Synthase, Histamine Receptor
Isosorbide dinitrate
T1479
Synonym: Isordil,Nitrosorbide,Sorbide nitrate,Sorbidnitrate
Target: Others, NO Synthase
L-NMMA acetate
T15697
Synonym: Tilarginine acetate,Methylarginine acetate
Target: NOS
NOS-IN-1 
T21700
Synonym: 2-Imino-4-methylpiperidine (acetate)
Target: NOS
Dimethoxycurcumin
T19853
Synonym: Veratrylcurcuminoid
Target: Others
7-Ethoxyresorufin
T21507
Synonym: Resorufin ethyl ether
Target: P450, NO Synthase
1400W dihydrochloride
T3491
Synonym: 1400W 2HCl,N-(3-(Aminomethyl)benzyl)acetamidine
Target: NOS, NO Synthase
Avanafil
T2334
Synonym: TA1790
Target: PDE
2,4-Diamino-6-hydroxypyrimidine
T7461
Synonym: DAHP
Target: Reactive Oxygen Species, NO Synthase
S-Nitroso-N-acetyl-DL-penicillamine
T12808
Synonym: SNAP
Target: NO Synthase
TRIM
T19916
Synonym: 1-(2-Trifluoromethylphenyl)imidazole
Target: NOS
2-Iminobiotin hydrobromide
T7206L
Synonym: Guanidinobiotin
Target: NOS, NO Synthase
PRE-084 hydrochloride
T3198L
Synonym:
Target: Sigma receptor
Mifepristone
T1102
Synonym: C-1073,RU486,RU 38486
Target: Glucocorticoid Receptor, Estrogen/progestogen Receptor, Progesterone Receptor, NO Synthase, Autophagy
S-Methylisothiourea sulfate
T22419
Synonym: (S)-Methylisothiourea sulfate
Target: NOS, NO Synthase, HSV
Methylene Blue
T6888
Synonym: methylthioninium chloride,CI-52015,Tetramethylthionine chloride,Basic Blue 9
Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase
Methylene Blue trihydrate
T0006
Synonym: Methylthionine chloride,Basic blue 9,Methylene Blue
Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase
Midostaurin
T3211
Synonym: N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251
Target: Others, PKC
Aminoguanidine hydrochloride
T0358
Synonym: Imino semicarbazide,Pimagedine hydrochloride,CP-12009-18 tartrate,Hydrazinecarboximidamide,Guanyl hydrazine,Pimagedine
Target: NOS, NO Synthase
N'-Nitro-D-arginine
T9537
Synonym: N'-Nitro-D-arginine,H-D-Arg(NO2)-OH,(R)-2-Amino-5-(3-nitroguanidino)pentanoic acid
Target: Others
2-Iminobiotin
T7206
Synonym: 2-IMINOBIOTIN HYDROBROMIDE,Guanidinobiotin
Target: NOS, NO Synthase
L-NAME hydrochloride
T6570
Synonym: L-NAME HCl,N(G)-Nitro-L-arginine methyl ester,NG-Nitroarginine methyl ester hydrochloride
Target: NOS, NO Synthase
AVE-9488
T30219
Synonym: AVE 9488,AVE9488
Target:
NG,NG-dimethyl-L-Arginine dihydrochloride
T21546
Synonym:
Target: NO Synthase
Sulfaphenazole
T4567
Synonym: Plisulfan,Raziosulfa,Depocid,Depotsulfonamide
Target: P450, Antibacterial
NS-2028
T16344
Synonym:
Target: Others, Guanylate cyclase
MEG hemisulfate
T21967
Synonym: Mercaptoethylguanidine hemisulfate
Target: NOS
L-NIL
T11805
Synonym:
Target: Others
TP508 TFA (121341-81-9 free base)
TP2164
Synonym: TP508 TFA
Target: Others
Camstatin TFA
T75725
Synonym:
Target:
COX-2/NO-IN-1
T60403
Synonym:
Target:
TP508 TFA
T75763
Synonym:
Target:
HQL-79
T15503
Synonym:
Target: Others
PTIO
T36512
Synonym:
Target: NO Synthase
iNOs-IN-1
T62987
Synonym:
Target:
iNOS-IN-2
T62849
Synonym:
Target:
HPGDS inhibitor 3
T61250
Synonym:
Target:
D-NAME (hydrochloride)
T36719
Synonym:
Target:
Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell
TP2195
Synonym:
Target: Others
Anticancer agent 157
T78855
Synonym:
Target: NO Synthase
20-HETE
T14021
Synonym: 20-hydroxy Arachidonic Acid
Target: Others
(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine
T36610
Synonym:
Target:
Methylene blue hydrate
T75339
Synonym:
Target:
D-threo-PPMP hydrochloride
T36974
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T6S2023 Harpagoside Others , COX , NO Synthase
1. Harpagoside has anti-inflammatory activity. 2. Harpagoside at 3 mM concentration, shows moderate inhibition of seed germination. 3. Harpagoside can inhibit lipopolysaccharide-induced mRNA levels and protein expression...
TQ0301 Kuwanon A NO Synthase
Kuwanon A inhibits nitric oxide production (IC50: 10.5 μM). Kuwanon A is a flavone derivative isolated from Morus alba L.
T6S1665 Irisflorentin Others , NO Synthase
1. Irisflorentin blocks apoptosis pathways, by exerting its effects by promoting rpn-3 expression to enhance the activity of proteasomes and down-regulating egl-1 expression. 2. Irisflorentin has anti-inflammatory mechan...
T2S0765 Epibetulinic acid NO Synthase , Prostaglandin Receptor
Epibetulinic acid has anti-inflammatory activity, it exhibits potent inhibitory effects on NO and prostaglandin E(2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin.
T7682 Asymmetric dimethylarginine Endogenous Metabolite , NO Synthase , NOD
Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS)
T3847 Asperuloside Asperulosid Others , NO Synthase
Asperuloside (Asperulosid) has anti-inflammatory activity.
T2S2335 Dehydroevodiamine DHED Others , NF-κB , COX , PGE Synthase , NO Synthase
Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood fl...
T5838 L-Canavanine sulfate NO Synthase , NOD
L-Canavanine sulfate is a selective inducible NO synthase inhibitor.
T5681 ETHYL CAFFEATE ETHYL 3,4-DIHYDROXYCINNAMATE NF-κB , COX , PGE Synthase , NO Synthase
Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro. Furthermore, Ethyl Caffeate intensely blocked the transcriptional expression in interferon-γ-related s...
T5S0285 Cistanoside A Others
1. Cistanoside A possesses protective activities on CCl4 induced hepatotoxicity in mice, which is involved with increasing free radicals clearing activities, alleviating lipid-overoxidation damage, and improving respirat...
T7597 6-Biopterin L-Biopterin Endogenous Metabolite , NO Synthase , NOD
6-Biopterin (L-Biopterin) is a natural product,is a NO synthase cofactor.
T2791 Pectolinarin Apoptosis , Others , NO Synthase , Prostaglandin Receptor , Interleukin
Pectolinarin is a Cirsium isolate with anti-inflammatory activity.
T4808 Agmatine sulfate Agmatine sulfate salt Endogenous Metabolite , NO Synthase , Imidazoline Receptor
Agmatine sulfate (Agmatine sulfate salt) is a bioactive metabolite of the arginine amino acid. It exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide sy...
T2980 Chondroitin sulfate Chonsurid,Chondroitin polysulfate MMP , Others , Endogenous Metabolite , NO Synthase
Chondroitin sulfate (Chonsurid) is extracted from shark bone;Store the product in sealed, cool and dry condition
TN2139 Regaloside B NOS , COX , NO Synthase
Regaloside B can inhibit the expression of iNOS and COX-2. Regaloside B is a phenylpropanoid isolated from Lilium longiflorum.It has anti-inflammatory activity.
T1310 2-Thiouracil Thiouracil,Deracil Thyroid hormone receptor(THR) , NO Synthase
2-Thiouracil (Deracil) is a thiolated uracil derivative that is a known anti-hyperthyroid agent.
T3S0364 L-Arginine L-Arg,(S)-(+)-Arginine IL Receptor , Endogenous Metabolite , NO Synthase
1. L-Arginine (L-Arg) exhibits anti-atherosclerotic effect. 2. L-Arginine and soy enriched diet are effective in prevention of osteoporosis associated with diabetes mellitus. 3. Exogenous L-Arginine could enhance neonate...
TN1373 α-Humulene Alpha-caryophyllene TNF , NOS , COX
α-Humulene (Alpha-caryophyllene) is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatory effects, probably by interfering with TNFalpha production an...
T7030 Anemarsaponin B p38 MAPK , NF-κB , MEK , COX , NO Synthase
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity, possibly via the p38 MAP kinase pathway. Anemarsaponin B c...
T7786 Tryptanthrin DNA gyrase
Tryptanthrin is a natural DNA gyrase inhibitor.
T5684 Ethyl 3,4-dihydroxybenzoate Apoptosis , Others , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , NO Synthase , Autophagy
Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
T3918 Ginsenoside Rb3 Gypenoside IV NF-κB , COX , NO Synthase
Ginsenoside Rb3 (Gypenoside IV) is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity. It also inhibits the induction of COX-2 and iNOS mRNA.
T3805 Prim-O-glucosylcimifugin Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside TNF , COX , JAK , NO Synthase
Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) can inhibit the proliferation of SMC(smooth muscle cell) stimulated by TNF-alpha, increase the proportion of G0/G1 phase.
T3779 Crocin II Crocin 2,Crocetin gentiobiosylglucosyl ester,Tricrocin,Crocin B Caspase , COX , NO Synthase
Crocin II (Crocetin gentiobiosylglucosyl ester) has anti-inflammatory and anti-apoptotic effects against gastric ischemia-reperfusion injury in rats, the effect of crocin is mainly mediated by reducing the protein expres...
T3811 Ginsenoside C-K Ginsenoside compound K,Ginsenoside K P450 , cell cycle arrest , COX , NO Synthase
Ginsenoside C-K (Ginsenoside K) is a bacterial metabolite of G-Rb1 exhibiting anti-inflammatory effects by reducing iNOS and COX-2.
T5S0754 Isoquercetin 3-Glucosylquercetin,Hirsutrin,Isoquercitrin,Quercetin 3-o-glucopyranoside NF-κB , Wnt/beta-catenin , NO Synthase
1. Isoquercetin (3-Glucosylquercetin) is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercetin may be as a potential therapeutic agent against neurodegeneration in ...
T3S0401 Piceatannol 3'-O-glucoside Piceatannol 3-glycoside,Quzhaqigan Arginase , NO Synthase
Piceatannol 3'-O-glucoside (Piceatannol 3-glycoside) increases pulmonary blood oxygen tension and decreases pulmonary interstitial edema, so it can protect lung injury.
T2758 Madecassic acid 6-Deoxy-L-Galactose,L-Fucose,Brahmic acid,L-fucopyranose Others , TNF , COX , NO Synthase , Interleukin
Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica.
T0670 L-Arginine hydrochloride (S)-(+)-Arginine hydrochloride,L-Arginine HCl (L-Arg),L-arginine monohydrochloride Amino Acids and Derivatives , Endogenous Metabolite , NO Synthase
L-Arginine hydrochloride is a nitrogen donor for synthesis of nitric oxide.
TN1102 Physalin L Others , NO Synthase
Physalin L is a natural product,it shows a distinct fluorescence spot under UV 365 nm with good separation.
TN1109 3-O-Acetyl-16α-hydroxydehydrotrametenolic acid 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid NOS , NO Synthase , Prostaglandin Receptor
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid (3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid) shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7 cells.
T38248 2-Ethylpyrazine Endogenous Metabolite , NO Synthase
2-Ethylpyrazine is present in roasted coffee beans and is a volatile compound .2-Ethylpyrazine induces vasodilation through the activity of endothelium-derived relaxing factors.2-Ethylpyrazine activates NO synthesis thro...
T7344 SDMA NG,NG'-Dimethyl-L-arginine,Symmetric dimethylarginine Endogenous Metabolite
SDMA (Symmetric dimethylarginine) is the most potent endogenous inhibitor of nitric oxide synthase (NOS), with higher levels in patients with end-stage renal disease (ESRD).
T3794 Pentagalloylglucose Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose Influenza Virus
1, 2, 3, 4, 6-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) and gallic acid from Pistacia lentiscus have antimutagenic and antioxidant activities. 2. 1, 2, 3, 4, 6-Penta-O-galloyl-beta-D-glucose (PGG) possesses poten...
T75616 Inflexuside A
Inflexuside A, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO production ( NO Synthase ) in RAW264.7 macrophages [...
T75615 Inflexuside B
Inflexuside B, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO Synthase in RAW264.7 macrophages [1] .
TN3318 9-Hydroxy-alpha-lapachone Antifection
9-Hydroxy-alpha-lapachone can highly inhibit the growth of H. pylori, it exhibits potent inhibitory activity against H. pylori Cystathionine gamma-synthase, with IC(50) values of 4.64 microM. It may have anti-inflammator...
TN2534 1-Hydroxy-2,3,5-trimethoxyxanthone IκB/IKK , Calcium Channel , NOS , 5-HT Receptor , COX
1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type vo...

Natural Products

Harpagoside
T6S2023
Synonym:
Target: Others, COX, NO Synthase
Kuwanon A
TQ0301
Synonym:
Target: NO Synthase
Irisflorentin
T6S1665
Synonym:
Target: Others, NO Synthase
Epibetulinic acid
T2S0765
Synonym:
Target: NO Synthase, Prostaglandin Receptor
Asymmetric dimethylarginine
T7682
Synonym:
Target: Endogenous Metabolite, NO Synthase, NOD
Asperuloside
T3847
Synonym: Asperulosid
Target: Others, NO Synthase
Dehydroevodiamine
T2S2335
Synonym: DHED
Target: Others, NF-κB, COX, PGE Synthase, NO Synthase
L-Canavanine sulfate
T5838
Synonym:
Target: NO Synthase, NOD
ETHYL CAFFEATE
T5681
Synonym: ETHYL 3,4-DIHYDROXYCINNAMATE
Target: NF-κB, COX, PGE Synthase, NO Synthase
Cistanoside A
T5S0285
Synonym:
Target: Others
6-Biopterin
T7597
Synonym: L-Biopterin
Target: Endogenous Metabolite, NO Synthase, NOD
Pectolinarin
T2791
Synonym:
Target: Apoptosis, Others, NO Synthase, Prostaglandin Receptor, Interleukin
Agmatine sulfate
T4808
Synonym: Agmatine sulfate salt
Target: Endogenous Metabolite, NO Synthase, Imidazoline Receptor
Chondroitin sulfate
T2980
Synonym: Chonsurid,Chondroitin polysulfate
Target: MMP, Others, Endogenous Metabolite, NO Synthase
Regaloside B
TN2139
Synonym:
Target: NOS, COX, NO Synthase
2-Thiouracil
T1310
Synonym: Thiouracil,Deracil
Target: Thyroid hormone receptor(THR), NO Synthase
L-Arginine
T3S0364
Synonym: L-Arg,(S)-(+)-Arginine
Target: IL Receptor, Endogenous Metabolite, NO Synthase
α-Humulene
TN1373
Synonym: Alpha-caryophyllene
Target: TNF, NOS, COX
anemarsaponin B
T7030
Synonym:
Target: p38 MAPK, NF-κB, MEK, COX, NO Synthase
Tryptanthrin
T7786
Synonym:
Target: DNA gyrase
Ethyl 3,4-dihydroxybenzoate
T5684
Synonym:
Target: Apoptosis, Others, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, NO Synthase, Autophagy
Ginsenoside Rb3
T3918
Synonym: Gypenoside IV
Target: NF-κB, COX, NO Synthase
Prim-O-glucosylcimifugin
T3805
Synonym: Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside
Target: TNF, COX, JAK, NO Synthase
Crocin II
T3779
Synonym: Crocin 2,Crocetin gentiobiosylglucosyl ester,Tricrocin,Crocin B
Target: Caspase, COX, NO Synthase
Ginsenoside C-K
T3811
Synonym: Ginsenoside compound K,Ginsenoside K
Target: P450, cell cycle arrest, COX, NO Synthase
Isoquercetin
T5S0754
Synonym: 3-Glucosylquercetin,Hirsutrin,Isoquercitrin,Quercetin 3-o-glucopyranoside
Target: NF-κB, Wnt/beta-catenin, NO Synthase
Piceatannol 3'-O-glucoside
T3S0401
Synonym: Piceatannol 3-glycoside,Quzhaqigan
Target: Arginase, NO Synthase
Madecassic acid
T2758
Synonym: 6-Deoxy-L-Galactose,L-Fucose,Brahmic acid,L-fucopyranose
Target: Others, TNF, COX, NO Synthase, Interleukin
L-Arginine hydrochloride
T0670
Synonym: (S)-(+)-Arginine hydrochloride,L-Arginine HCl (L-Arg),L-arginine monohydrochloride
Target: Amino Acids and Derivatives, Endogenous Metabolite, NO Synthase
Physalin L
TN1102
Synonym:
Target: Others, NO Synthase
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid
TN1109
Synonym: 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid
Target: NOS, NO Synthase, Prostaglandin Receptor
2-Ethylpyrazine
T38248
Synonym:
Target: Endogenous Metabolite, NO Synthase
SDMA
T7344
Synonym: NG,NG'-Dimethyl-L-arginine,Symmetric dimethylarginine
Target: Endogenous Metabolite
Pentagalloylglucose
T3794
Synonym: Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose
Target: Influenza Virus
Inflexuside A
T75616
Synonym:
Target:
Inflexuside B
T75615
Synonym:
Target:
9-Hydroxy-alpha-lapachone
TN3318
Synonym:
Target: Antifection
1-Hydroxy-2,3,5-trimethoxyxanthone
TN2534
Synonym:
Target: IκB/IKK, Calcium Channel, NOS, 5-HT Receptor, COX

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-03172 Argininosuccinate lyase Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
The recycling of citrulline by argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL) is crucial to maintain arginine availability and nitric oxide (NO) production. Nitric oxide (NO) plays an established r...
TMPY-03452 PTS Protein, Human, Recombinant (His) Human E. coli
PTS(6-pyruvoyltetrahydropterin synthase) belongs to the PTPS family. It catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesi...
TMPJ-01058 ARG2 Protein, Human, Recombinant (His) Human E. coli
Arginase-2 (ARG2) is a member of the arginase family. Arginase is a manganese-containing enzyme which catalyzes the hydrolysis of arginine to ornithine and urea. ARG2 is highly expressed in kidney and prostate, not found...
TargetMol