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Cytoskeletal Signaling Microtubule Associated

Microtubule Associated

Microtubule-associated proteins (MAPs) are proteins that interact with the microtubules of the cellular cytoskeleton. MAPs bind to the tubulin subunits that make up microtubules to regulate their stability. A large variety of MAPs have been identified in many different cell types, and they have been found to carry out a wide range of functions. These include both stabilizing and destabilizing microtubules, guiding microtubules towards specific cellular locations, cross-linking microtubules and mediating the interactions of microtubules with other proteins in the cell.
Cat No. product name
T1270 Vincristine sulfateHOT Vincristine binds irreversibly to microtubules (Ki: 85 nM) and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spi...
T1034 DocetaxelHOT Docetaxel is a microtubule inhibitor that inhibits microtubule disassembly (IC50: 0.2 μM).
T0968 PaclitaxelHOT Paclitaxel is a cyclodecane isolated from the bark of the Pacific yew tree. It stabilizes microtubules in their polymerized form leading to cell death.
T0320 ColchicineHOT Colchicine is a tubulin inhibitor (IC50: 3 nM) and blocks polymerization of microtubules by binding to tubulin.
T21351 Maytansine Maytansine, an ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata, inhibits the assembly of microtubules by binding to tubulin at...
T0714 Oxfendazole Oxfendazole, a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.
T2802 Nocodazole Nocodazole is a synthetic inhibitor of microtubule polymerization, also inhibits Abl (IC50: 0.21 μM), Abl(E255K, IC50: 0.53 μM) and Abl(T315I, IC50: 0.64 μM) ...
T1155 Mebendazole Mebendazole is a hedgehog inhibitor, used as an antihelminthic.
T2220 2-Methoxyestradiol 2-Methoxyestradiol is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing en...
T1820 CK636 CK-636, an Arp2/3 complex inhibitor, can inhibit actin polymerization induced by the human (IC50: 4 μM), fission yeast (IC50: 24 μM) and bovine (IC50: 32 μM) ...
T6897 Monomethyl auristatin E Monomethyl auristatin E (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug c...
T1121 Podophyllotoxin Podophyllotoxin is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, ...
T1152 Albendazole Albendazole is used as a drug indicated for the treatment of a variety of worm infestations.
T6372 Albendazole Oxide Albendazole Sulfoxide (Albendazole EP Impurity B) is a metabolite of Albendazole, an anthelmintic.
T2502 INH1 INH1 is a cell-permeable Hec1 inhibitor that specifically disrupts the Hec1/Nek2 interaction.
T6888 Methylene Blue Methylene Blue(IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
T2937 4'-Demethylepipodophyllotoxin 4'-Demethylepipodophyllotoxin is a potent inhibitor of microtubule assembly.
T1910 Ansamitocin P-3 Ansamitocin P-3 is an antibody-drug conjugate cytotoxin with antitumor activity.
T0838 Triclabendazole Triclabendazole has been used in trials studying Parasitic Disease.
T2511 Plinabulin Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and bind...
T0190 Vinorelbine Vinorelbine is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor c...
T2217 Cephalomannine Cephalomannine is a taxol derivative obtained from Taxus yunnanensis with antitumor activity.
T0009 Flubendazole Flubendazole is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.
T2773 Vindoline Vindoline is an indole alkaloid that exhibits antimitotic activity by inhibiting microtubule assembly.
T6864 Ixabepilone Ixabepilone is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arres...
T1992 Mertansine Mertansine refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through react...
T0651 N-Phenylbenzylamine A series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization
T6212 Combretastatin A4 Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM).
T6722 Vinflunine Tartrate Vinflunine Tartrat is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity.
T2060 LR510444 ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter ...
T7003 TRx0237 mesylate TRx 0237 (LMTX) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
T6213 Vinorelbine Tartrate Vinorelbine Tartrate, a semi-synthetic vinca alkaloid, interacts with tubulin resulting in mitosis inhibition.
T1382 Griseofulvin Griseofulvin is an antifungal agent used in the treatment of TINEA infections.
T6691 TAI1 TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.
T1992 Mertansine Mertansine refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through react...
T1753 D64131 D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM.
T1758 ABT751 ABT-751 has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer.
T0186 Docetaxel trihydrate Docetaxel is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the the...
T0938 Thiabendazole Thiabendazole is a benzimidazole derivative with anthelminthic property.
T6490 Epothilone A Epothilone A is a microtubule-stabilizing agent with EC0.01 of 2 μM.
T6075 Epothilone B Epothilone B is a compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabili...
T6209 CW069 CW069( IC50=75 μM), an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.
T6272 Fosbretabulin Disodium Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium, a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-t...
T2543 Cabazitaxel Cabazitaxel is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of docet...
T0006 Methylene Blue trihydrate Methylene blue is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue...
T6721 Vinblastine Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to treat certain kinds of cancer.
T17229 Verubulin Verubulin is a microtubule-disrupting agent with potent and broad-spectrum in vitro and in vivo cytotoxic activities.
T10826 CK-666 CK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex. It binds to the Arp2/3 complex, stabilizes the inactive state of the complex, block...
T19573 T807 T807 a novel tau positron emission tomography (PET) tracer.
T10460 Batabulin Batabulin is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization....
T13224 Tubulin inhibitor 6 Tubulin inhibitor 6 is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines.
T13225 Tubulin inhibitor 7 Tubulin inhibitor 7 is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines (tubulin polymerization (IC50: 0.52 μM), K562 cell growth (I...
T13226 Tubulin inhibitor 8 Tubulin inhibitor 8 is an inhibitor of tubulin and multiple cancer cell lines (tubulin polymerization with an IC50 of 0.73 μM, K562 cell growth with an IC50 of ...
T13227 Tubulin inhibitor 1 Tubulin inhibitor 1 is an inhibitor of tubulin, inhibits tubulin polymerization, with potent anti-tumor activity, induces cellular apoptosis causes and cellular ...
T13228 Tubulysin D Tubulysin D is a tetrapeptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and displays potent antitumor activity.
T13298 Verubulin hydrochloride Verubulin hydrochloride is an agent of blood brain barrier permeable microtubule-disrupting, with potent and broad-spectrum cytotoxic activities,with potent anti...
T15576 Indibulin Indibulin is a synthetic small molecule with antimitotic and potential antineoplastic activities.Indibulin  an orally applicable inhibitor of tubulin assembly, ...
T12823 S516 S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 μM), has marked antitumor activity.
T16016 Maytansinol Maytansinol inhibits microtubule assembly and causes microtubule disassembly in vitro.
T16031 McMMAF McMMAF is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor.It is a MMAF derivative having a Maleimidocaproyl linker (MC link...
T16031 McMMAF McMMAF is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor.It is a MMAF derivative having a Maleimidocaproyl linker (MC link...
T16386 Ombrabulin hydrochloride Ombrabulin hydrochloride is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of ...
T16387 Ombrabulin Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial ce...
T16543 Pironetin Pironetin binds to α-tubulin and is an effective inhibitor of microtubule polymerization. It also has cell cycle arrest and antitumor activity. Pironetin is an ...
T11917 Lys-SMCC-DM1 DM1 is a tubulin inhibitor. Lys-SMCC-DM1 is the active metabolite of DM1.
T16997 Tasidotin hydrochloride Tasidotin hydrochloride is a peptide analog of the antimitotic depsipeptide dolastatin 15. Tasidotin hydrochloride is an inhibitor of microtubule assembly and mi...
T17228 VERU-111 VERU-111 is an effective and orally bioavailable α and β tubulin inhibitor (average IC50: 5.2 nM) against panels of melanoma and prostate cancer cell lines. VE...
T13901 SS28 SS28 inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase.
T12805 S-methyl DM1 S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin(Kd of 0.93 μM) and inhibts microtubule polymerization.
T2090 Lexibulin Lexibulin(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and lea...
TQ0112 Tubulysin A Tubulysin A is a natural product from myxobacterial. It has many function in vitro assays, including anti-microtubule, anti-mitotic, an apoptosis inducer, antica...
T4077 PE859 PE859 is a potent inhibitor of both tau and Aβ aggregation.
T4232 VCMMAE VcMMAE is a drug-linker conjugate for ADC with potent antitumor activity.
T4029 BTB1 BTB-1 is a novel small molecule inhibitor of the mitotic motor protein Kif18A.
T4451 Estramustine phosphate sodium Estramustine phosphate sodium is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.
T4677 MMAD MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs).
T5170 KHS101 hydrochloride KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype.
T5699 SSE15206 SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindl...
T6071 Parbendazole Parbendazole is a potent inhibitor of microtubule assembly(EC50 : 8.79 nM).Parbendazole is a carbamate ester-amine. It finds applications in control or treatme...
TQ0141 Taltobulin Taltobulin (HTI-286) is a potent tubulin inhibitor.
T15012 Crolibulin Crolibulin is an inhibitor of small molecule tubulin polymerization.
TQ0202 Epothilone D Epothilone D (KOS 862) is an effective microtubule stabilizer.
TN1087 Deoxypodophyllotoxin Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammat...
T8216 T-1101 tosylate T-1101 tosylate is an inhibitor of Hec1/Nek2, with antitumor activity.
T12052 Mivobulin Mivobulin is an inhibitor of tubulin .
T13807 OSIP-486823 OSIP-486823 is a microtubule-interfering agent with distinct biological effects on both protein kinase G (PKG) and microtubules.
T14349 Auristatin F Auristatin F is a potent cytotoxin. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA), can be used in antibody-drug conjugates (AD...
T14350 Soblidotin Soblidotin (Auristatin PE) is an inhibitor of tubulin polymerization. It also is a novel synthetic Dolastatin 10 derivative.
T14694 BNC105 BNC105 is a tubulin polymerization inhibitor. It has potent antiproliferative and tumor vascular disrupting properties.
T10428 AZ82 AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor (Ki: 43 nM; IC50: 300 nM for KIFC1).
T6180 INH6 INH6, an effective Hec1 inhibitor, selectively disrupts the Hec1/Nek2 interaction and induces chromosome mis-alignment.
Vincristine sulfate HOT
T1270CAS 2068-78-2
Vincristine binds irreversibly to microtubules (Ki: 85 nM) and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spi...
Docetaxel HOT
T1034CAS 114977-28-5
Docetaxel is a microtubule inhibitor that inhibits microtubule disassembly (IC50: 0.2 μM).
Paclitaxel HOT
T0968CAS 33069-62-4
Paclitaxel is a cyclodecane isolated from the bark of the Pacific yew tree. It stabilizes microtubules in their polymerized form leading to cell death.
Colchicine HOT
T0320CAS 64-86-8
Colchicine is a tubulin inhibitor (IC50: 3 nM) and blocks polymerization of microtubules by binding to tubulin.
Maytansine
T21351CAS 35846-53-8
Maytansine, an ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata, inhibits the assembly of microtubules by binding to tubulin at...
Oxfendazole
T0714CAS 53716-50-0
Oxfendazole, a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.
Nocodazole
T2802CAS 31430-18-9
Nocodazole is a synthetic inhibitor of microtubule polymerization, also inhibits Abl (IC50: 0.21 μM), Abl(E255K, IC50: 0.53 μM) and Abl(T315I, IC50: 0.64 μM) ...
Mebendazole
T1155CAS 31431-39-7
Mebendazole is a hedgehog inhibitor, used as an antihelminthic.
2-Methoxyestradiol
T2220CAS 362-07-2
2-Methoxyestradiol is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing en...
CK636
T1820CAS 442632-72-6
CK-636, an Arp2/3 complex inhibitor, can inhibit actin polymerization induced by the human (IC50: 4 μM), fission yeast (IC50: 24 μM) and bovine (IC50: 32 μM) ...
Monomethyl auristatin E
T6897CAS 474645-27-7
Monomethyl auristatin E (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug c...
Podophyllotoxin
T1121CAS 518-28-5
Podophyllotoxin is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, ...
Albendazole
T1152CAS 54965-21-8
Albendazole is used as a drug indicated for the treatment of a variety of worm infestations.
Albendazole Oxide
T6372CAS 54029-12-8
Albendazole Sulfoxide (Albendazole EP Impurity B) is a metabolite of Albendazole, an anthelmintic.
INH1
T2502CAS 313553-47-8
INH1 is a cell-permeable Hec1 inhibitor that specifically disrupts the Hec1/Nek2 interaction.
Methylene Blue
T6888CAS 61-73-4
Methylene Blue(IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
4'-Demethylepipodophyllotoxin
T2937CAS 6559-91-7
4'-Demethylepipodophyllotoxin is a potent inhibitor of microtubule assembly.
Ansamitocin P-3
T1910CAS 66547-09-9
Ansamitocin P-3 is an antibody-drug conjugate cytotoxin with antitumor activity.
Triclabendazole
T0838CAS 68786-66-3
Triclabendazole has been used in trials studying Parasitic Disease.
Plinabulin
T2511CAS 714272-27-2
Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and bind...
Vinorelbine
T0190CAS 71486-22-1
Vinorelbine is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor c...
Cephalomannine
T2217CAS 71610-00-9
Cephalomannine is a taxol derivative obtained from Taxus yunnanensis with antitumor activity.
Flubendazole
T0009CAS 31430-15-6
Flubendazole is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.
Vindoline
T2773CAS 2182-14-1
Vindoline is an indole alkaloid that exhibits antimitotic activity by inhibiting microtubule assembly.
Ixabepilone
T6864CAS 219989-84-1
Ixabepilone is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arres...
Mertansine
T1992CAS 139504-50-0
Mertansine refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through react...
N-Phenylbenzylamine
T0651CAS 103-32-2
A series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization
Combretastatin A4
T6212CAS 117048-59-6
Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM).
Vinflunine Tartrate
T6722CAS 1201898-17-0
Vinflunine Tartrat is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity.
LR510444
T2060CAS 1233948-35-0
ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter ...
TRx0237 mesylate
T7003CAS 1236208-20-0
TRx 0237 (LMTX) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
Vinorelbine Tartrate
T6213CAS 125317-39-7
Vinorelbine Tartrate, a semi-synthetic vinca alkaloid, interacts with tubulin resulting in mitosis inhibition.
Griseofulvin
T1382CAS 126-07-8
Griseofulvin is an antifungal agent used in the treatment of TINEA infections.
TAI1
T6691CAS 1334921-03-7
TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.
Mertansine
T1992CAS 139504-50-0
Mertansine refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through react...
D64131
T1753CAS 74588-78-6
D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM.
ABT751
T1758CAS 141430-65-1
ABT-751 has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer.
Docetaxel trihydrate
T0186CAS 148408-66-6
Docetaxel is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the the...
Thiabendazole
T0938CAS 148-79-8
Thiabendazole is a benzimidazole derivative with anthelminthic property.
Epothilone A
T6490CAS 152044-53-6
Epothilone A is a microtubule-stabilizing agent with EC0.01 of 2 μM.
Epothilone B
T6075CAS 152044-54-7
Epothilone B is a compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabili...
CW069
T6209CAS 1594094-64-0
CW069( IC50=75 μM), an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.
Fosbretabulin Disodium
T6272CAS 168555-66-6
Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium, a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-t...
Cabazitaxel
T2543CAS 183133-96-2
Cabazitaxel is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of docet...
Methylene Blue trihydrate
T0006CAS 7220-79-3
Methylene blue is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue...
Vinblastine
T6721CAS 865-21-4
Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to treat certain kinds of cancer.
Verubulin
T17229CAS 827031-83-4
Verubulin is a microtubule-disrupting agent with potent and broad-spectrum in vitro and in vivo cytotoxic activities.
CK-666
T10826CAS 442633-00-3
CK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex. It binds to the Arp2/3 complex, stabilizes the inactive state of the complex, block...
T807
T19573CAS 1415379-56-4
T807 a novel tau positron emission tomography (PET) tracer.
Batabulin
T10460CAS 195533-53-0
Batabulin is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization....
Tubulin inhibitor 6
T13224CAS 105925-39-1
Tubulin inhibitor 6 is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines.
Tubulin inhibitor 7
T13225CAS 1309925-41-4
Tubulin inhibitor 7 is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines (tubulin polymerization (IC50: 0.52 μM), K562 cell growth (I...
Tubulin inhibitor 8
T13226CAS 1309925-39-0
Tubulin inhibitor 8 is an inhibitor of tubulin and multiple cancer cell lines (tubulin polymerization with an IC50 of 0.73 μM, K562 cell growth with an IC50 of ...
Tubulin inhibitor 1
T13227CAS 2237054-53-2
Tubulin inhibitor 1 is an inhibitor of tubulin, inhibits tubulin polymerization, with potent anti-tumor activity, induces cellular apoptosis causes and cellular ...
Tubulysin D
T13228CAS 309935-57-7
Tubulysin D is a tetrapeptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and displays potent antitumor activity.
Verubulin hydrochloride
T13298CAS 917369-31-4
Verubulin hydrochloride is an agent of blood brain barrier permeable microtubule-disrupting, with potent and broad-spectrum cytotoxic activities,with potent anti...
Indibulin
T15576CAS 204205-90-3
Indibulin is a synthetic small molecule with antimitotic and potential antineoplastic activities.Indibulin  an orally applicable inhibitor of tubulin assembly, ...
S516
T12823CAS 1016543-77-3
S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 μM), has marked antitumor activity.
Maytansinol
T16016CAS 57103-68-1
Maytansinol inhibits microtubule assembly and causes microtubule disassembly in vitro.
McMMAF
T16031CAS 863971-19-1
McMMAF is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor.It is a MMAF derivative having a Maleimidocaproyl linker (MC link...
McMMAF
T16031CAS 863971-19-1
McMMAF is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor.It is a MMAF derivative having a Maleimidocaproyl linker (MC link...
Ombrabulin hydrochloride
T16386CAS 253426-24-3
Ombrabulin hydrochloride is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of ...
Ombrabulin
T16387CAS 181816-48-8
Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial ce...
Pironetin
T16543CAS 151519-02-7
Pironetin binds to α-tubulin and is an effective inhibitor of microtubule polymerization. It also has cell cycle arrest and antitumor activity. Pironetin is an ...
Lys-SMCC-DM1
T11917CAS 1281816-04-3
DM1 is a tubulin inhibitor. Lys-SMCC-DM1 is the active metabolite of DM1.
Tasidotin hydrochloride
T16997CAS 623174-20-9
Tasidotin hydrochloride is a peptide analog of the antimitotic depsipeptide dolastatin 15. Tasidotin hydrochloride is an inhibitor of microtubule assembly and mi...
VERU-111
T17228CAS 1332881-26-1
VERU-111 is an effective and orally bioavailable α and β tubulin inhibitor (average IC50: 5.2 nM) against panels of melanoma and prostate cancer cell lines. VE...
SS28
T13901CAS 141172-08-9
SS28 inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase.
S-methyl DM1
T12805CAS 912569-84-7
S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin(Kd of 0.93 μM) and inhibts microtubule polymerization.
Lexibulin
T2090CAS 917111-44-5
Lexibulin(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and lea...
Tubulysin A
TQ0112CAS 205304-86-5
Tubulysin A is a natural product from myxobacterial. It has many function in vitro assays, including anti-microtubule, anti-mitotic, an apoptosis inducer, antica...
PE859
T4077CAS 1402727-29-0
PE859 is a potent inhibitor of both tau and Aβ aggregation.
VCMMAE
T4232CAS 646502-53-6
VcMMAE is a drug-linker conjugate for ADC with potent antitumor activity.
BTB1
T4029CAS 86030-08-2
BTB-1 is a novel small molecule inhibitor of the mitotic motor protein Kif18A.
Estramustine phosphate sodium
T4451CAS 52205-73-9
Estramustine phosphate sodium is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.
MMAD
T4677CAS 203849-91-6
MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs).
KHS101 hydrochloride
T5170CAS 1784282-12-7
KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype.
SSE15206
T5699CAS 1370046-40-4
SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindl...
Parbendazole
T6071CAS 14255-87-9
Parbendazole is a potent inhibitor of microtubule assembly(EC50 : 8.79 nM).Parbendazole is a carbamate ester-amine. It finds applications in control or treatme...
Taltobulin
TQ0141CAS 228266-40-8
Taltobulin (HTI-286) is a potent tubulin inhibitor.
Crolibulin
T15012CAS 1000852-17-4
Crolibulin is an inhibitor of small molecule tubulin polymerization.
Epothilone D
TQ0202CAS 189453-10-9
Epothilone D (KOS 862) is an effective microtubule stabilizer.
Deoxypodophyllotoxin
TN1087CAS 19186-35-7
Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammat...
T-1101 tosylate
T8216CAS 2250404-95-4
T-1101 tosylate is an inhibitor of Hec1/Nek2, with antitumor activity.
Mivobulin
T12052CAS 122332-18-7
Mivobulin is an inhibitor of tubulin .
OSIP-486823
T13807CAS 200803-37-8
OSIP-486823 is a microtubule-interfering agent with distinct biological effects on both protein kinase G (PKG) and microtubules.
Auristatin F
T14349CAS 163768-50-1
Auristatin F is a potent cytotoxin. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA), can be used in antibody-drug conjugates (AD...
Soblidotin
T14350CAS 149606-27-9
Soblidotin (Auristatin PE) is an inhibitor of tubulin polymerization. It also is a novel synthetic Dolastatin 10 derivative.
BNC105
T14694CAS 945771-74-4
BNC105 is a tubulin polymerization inhibitor. It has potent antiproliferative and tumor vascular disrupting properties.
AZ82
T10428CAS 1449578-65-7
AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor (Ki: 43 nM; IC50: 300 nM for KIFC1).
INH6
T6180CAS 1001753-24-7
INH6, an effective Hec1 inhibitor, selectively disrupts the Hec1/Nek2 interaction and induces chromosome mis-alignment.