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Microtubule Associated

T0009 Flubendazole Flubendazole is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.
T0186 Docetaxel trihydrate Docetaxel is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the th...
T0190 Vinorelbine Vinorelbine is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor ...
T0320 Colchicine Colchicine is a tubulin inhibitor (IC50: 3 nM) and blocks polymerization of microtubules by binding to tubulin.
T0651 N-Phenylbenzylamine A series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization
T0714 Oxfendazole Oxfendazole, a broad spectrum benzimidazole anthelmintic,protects livestock against roundworm, strongyles and pinworms.
T0838 Triclabendazole Triclabendazole has been used in trials studying Parasitic Disease.
T0938 Thiabendazole Thiabendazole is a benzimidazole derivative with anthelminthic property.
T0968 Paclitaxel Paclitaxel is a cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to ce...
T1034 Docetaxel Docetaxel is a microtubule inhibitor that inhibits microtubule disassembly (IC50: 0.2 μM).
T1121 Podophyllotoxin Podophyllotoxin is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally,...
T1152 Albendazole Albendazole is used as a drug indicated for the treatment of a variety of worm infestations.
T1155 Mebendazole Mebendazole is a hedgehog inhibitor, used as an antihelminthic.
T1270 Vincristine sulfate Vincristine binds irreversibly to microtubules (Ki: 85 nM) and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic sp...
T1382 Griseofulvin Griseofulvin is an antifungal agent used in the treatment of TINEA infections.
T1753 D64131 D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM.
T1758 ABT-751 ABT-751 has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer.
T1820 CK-636 CK-636, an Arp2/3 complex inhibitor, can inhibit actin polymerization induced by the human (IC50: 4 μM), fission yeast (IC50: 24 μM) and bovine (IC50: 32 μM)...
T1910 Ansamitocin P-3 Ansamitocin P-3 is an antibody-drug conjugate cytotoxin with antitumor activity.
T2060 LR-510444 ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter...
T2090 Lexibulin Lexibulin(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and le...
T2220 2-Methoxyestradiol 2-Methoxyestradiol is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing e...
T2502 INH1 INH1 is a cell-permeable Hec1 inhibitor that specifically disrupts the Hec1/Nek2 interaction.
T2511 Plinabulin Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and bin...
T2543 Cabazitaxel Cabazitaxel is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of doce...
T2802 Nocodazole Nocodazole is a synthetic inhibitor of microtubule polymerization, also inhibits Abl (IC50: 0.21 μM), Abl(E255K, IC50: 0.53 μM) and Abl(T315I, IC50: 0.64 μM)...
T3652 KRIBB11 KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.
T4029 BTB-1 BTB-1 is a novel small molecule inhibitor of the mitotic motor protein Kif18A.
T4077 PE859 PE859 is a potent inhibitor of both tau and Aβ aggregation.
T4125 HSF1A HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.
T4232 VCMMAE VcMMAE is a drug-linker conjugate for ADC with potent antitumor activity.
T6075 Epothilone B Epothilone B is a compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabil...
T6180 INH6 INH6, an effective Hec1 inhibitor, selectively disrupts the Hec1/Nek2 interaction and induces chromosome mis-alignment.
T6209 CW069 CW069( IC50=75 μM), an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.
T6212 Combretastatin A4 Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM).
T6213 Vinorelbine Tartrate Vinorelbine Tartrate, a semi-synthetic vinca alkaloid, interacts with tubulin resulting in mitosis inhibition.
T6272 Fosbretabulin Disodium Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium, a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-...
T6372 Albendazole Oxide Albendazole is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations.
T6490 Epothilone A Epothilone A is a microtubule-stabilizing agent with EC0.01 of 2 μM.
T6721 Vinblastine Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to treat certain kinds of cancer.
T6864 Ixabepilone Ixabepilone is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arre...
T6888 Methylene Blue Methylene Blue(IC50 of 1.9μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
T6897 Monomethyl auristatin E Monomethyl auristatin E (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug ...
T4677 MMAD MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs).
T5170 KHS101 hydrochloride KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype.
T5699 SSE15206 SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spind...
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