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Search Results for " melanocortin receptor "

Targets

73

Compounds

8

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T8485 THIQ Melanocortin Receptor
THIQ is a selective melanocortin-4 receptor (MC4R) agonist (hMC4R and rMC4R with IC50 of 1.2 nM and 0.6 nM , respectively).
TP1898 HS024 HS 024 Melanocortin Receptor
HS024 is a highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-...
TP1889 MCL0020 MCL 0020 Melanocortin Receptor
MCL0020 is a potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no e...
T7589 Afamelanotide acetate afamelanotide Melanocortin Receptor
Afamelanotide acetate is a synthetic α-melanocyte stimulating hormone analogue and first-in-class melanocortin-1 receptor agonist, used to for Erythropoietic Protoporphyria.
T5464 JNJ-10229570 JNJ10229570,UNII-N9IX402L35,JNJ 10229570 Melanocortin Receptor
JNJ-10229570 (UNII-N9IX402L35) is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids.
T7608 Bremelanotide Acetate bremelanotide,PT-141 Acetate Melanocortin Receptor
Bremelanotide Acetate (PT-141 Acetate) is an agonist of melanocortin receptor (MCR) .
TP1097 Melanotan I [Nle4,D-Phe7]-α-MSH,Afamelanotide,MT-I Others
Melanotan I (Afamelanotide) has the amino acid sequence of Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val and a molecular weight of 1647.4 Dalton.
T7813 α-MSH MSH, amide,CZEN-002,α-Melanocyte-Stimulating Hormone (MSH), amide Melanocortin Receptor , Adenylyl cyclase
α-MSH (MSH, amide) is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.
T7769 Nonapeptide-1 Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-,Melanostatine™ 5 Others
Nonapeptide-1 (Melanostatine™ 5) can inhibit the synthesis of melanin, which makes it of interest for treating certain skin conditions.
T7627 Adrenocorticotropic Hormone (ACTH) (4-10), human Adrenocorticotropic Hormone (ACTH) (4-10),ACTH (4-10), human,Acth (4-10) Melanocortin Receptor
Adrenocorticotropic Hormone (ACTH) (4-10) is an agonist of potent melanocortin(MC4R) receptor .
T8231 Adrenocorticotropic Hormone (ACTH) (1-39), human ACTH (1-39), human Others
Adrenocorticotropic Hormone (ACTH) (1-39), human (ACTH (1-39), human) is an agonist of melanocortin receptor.
T7627L Adrenocorticotropic Hormone (ACTH) (4-10) TFA Adrenocorticotropic Hormone (ACTH) (4-10) TFA(4037-01-8(free base)),Acth (4-10) Melanocortin Receptor
Adrenocorticotropic Hormone (ACTH) (4-10) TFA (Acth (4-10)) is an agonist of potent melanocortin(MC4R) receptor .
T69526 PF-07258669
PF-07258669, a melanocortin-4 receptor (MC4) antagonist, is utilized in researching cachexia, anorexia, or anorexia nervosa.
TP1011L ACTH (1-17) acetate Melanocortin Receptor
ACTH (1-17) acetate is a potent agonist at the human melanocortin 1 (MC1) receptor with high affinity(Ki = 0.21 nM).
TP1324 Melanotan (MT)-II Melanocortin Receptor
Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH).
TP1004L Beta-MSH (1-22) (human) acetate Beta-MSH (1-22) (human) acetate (17908-57-5 Free base) Melanocortin Receptor
Beta-MSH (1-22) (human) acetate (Beta-MSH (1-22) (human) acetate (17908-57-5 Free base)) , is an endogenous melanocortin-4 receptor (MC4-R) agonist.
TP1893L1 [D-Trp8]-γ-MSH acetate(321351-81-9 free base) Melanocortin Receptor
Selective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively). Displays anti-inflammatory efficacy.
T12882L Setmelanotide Acetate(920014-72-8 free base) RM-493 Acetate,IRC-022493 Acetate,BIM-22493 Acetate Melanocortin Receptor
Setmelanotide Acetate(920014-72-8 free base) (RM-493 Acetate) is a selective agonist of melanocortin 4 receptor (MC4R)(human and rat MC4R with EC50s of 0.27 nM and 0.28 nM, respectively).
TP1952L PG 106 acetate PG 106 acetate(944111-22-2 Free base) Melanocortin Receptor
PG 106 acetate is an effective and selective antagonist of the human melanocortin 3 (hMC3) receptor with an IC50 of 210 nM. PG 106 acetate has no activity with the hMC5 receptor and hMC4 receptors with an EC50 of 9900 nM...
TP2212L A-MSH, amide Acetate(581-05-5 free base) Melanocortin Receptor
a-MSH, amide Acetate as an endogenous neuropeptide. It is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelano...
TP2015L HS 014 acetate(207678-81-7 free base) Melanocortin Receptor
HS 014 acetate is a potent and selective melanocortin MC4 receptor antagonist (Ki values are 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake in rats and no...
T25310 Dersimelagon MT-7117 Melanocortin Receptor
Dersimelagon (MT-7117) is an orally active, selective agonist for the melanocortin 1 receptor (MC1R), demonstrating EC50 values of 8.16 nM (h), 3.91 nM (cm), 1.14 nM (m), and 0.251 nM (r) across species such as human, cy...
T22989 ML 00253764 hydrochloride Others
melanocortin MC4 receptor antagonist
T24495 MPCI
MPCI is a selective melanocortin-4 receptor antagonist.
T28635 RY764 RY 764,RY-764
RY764 is a potent and selective agonist of melanocortin subtype-4 receptor.
T33419 MK-0493 HCl MK 0493,MK-0493,MK0493
MK-0493 is a novel, potent, and selective agonist for melanocortin receptor 4 (MC4R).
T12415 PF-00446687 Others
PF-00446687 is a selective agonist of melanocortin-4 receptor (MC4R) (EC50 of 12 ± 1 nM).
T10251 Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA ACTH (1-39) (mouse, rat) TFA Others
Adrenocorticotropic Hormone (ACTH) (1-39), rat (TFA) is a potent melanocortin 2 receptor (MC2) agonist.
T16086 MK-0493 Others
MK-0493 is an effective and selective agonist of the melanocortin receptor 4 (MC4R). It also demonstrated significant reductions in energy intake.
T27986 MCL0129 MCL-0129,MCL 0129
MCL0129, a selective and non-peptidergic melanocortin 4 (MC4) receptor antagonist, is a potential treatment for cachexia.
T12072 ML-00253764 hydrochloride Others
ML-00253764 hydrochloride is an antagonist of nonpeptidic melanocortin receptor 4 (MC4R) (Ki and IC50 of 0.16 µM and 0.103 µM, respectively).
TP1242 1-39-Corticotropin (human)(TFA) Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA)
Adrenocorticotropic Hormone (ACTH) (1-39) human(TFA),a member of the melanocortin family, is a melanocortin receptor agonist. It stimulates production of CS by the adrenals, but melanocortin receptors are also found in t...
T12944 SNT-207707 Others
SNT-207707 is a potent, selective and orally active antagonist of melanocortin MC-4 receptor(IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor).
T10230 MC-4R Agonist 1 Others
MC-4R Agonist 1 is an agonist of human melanocortin-4 receptor (MC-4R) and can be used in the research of sexual dysfunction, obesity, and diabetes.
T69607 Dersimelagon phosphate
Dersimelagon phosphate is a selective melanocortin-1 receptor (MC1R) agonist that increases skin melanin without sun exposure and is being developed to increase light tolerance in EPP/XLP patients.
T12945 SNT-207858 free base Others
SNT-207858 free base is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor(IC50 of 22 nM (binding) and 11 nM (function), on the MC-4 receptor).
T75965 β-Melanocyte Stimulating Hormone (MSH), human TFA
β-Melanocyte Stimulating Hormone (MSH), human TFA, is a 22-residue peptide that functions as an endogenous agonist for the melanocortin-4 receptor (MC4-R) [1].
T12946 SNT-207858 Others
SNT-207858 is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.
T68328 Modimelanotide
Modimelanotide is a melanocortinergic peptide drug derived from α-melanocyte-stimulating hormone (α-MSH) which was under development for the treatment of acute kidney injury. It acts as a non-selective melanocortin recep...
T75977 ACTH (1-17) (TFA)
ACTH (1-17) TFA, an analogue of adrenocorticotropin, serves as a highly effective agonist for the human melanocortin 1 (MC1) receptor, exhibiting a dissociation constant (K i) of 0.21 nM.
TP1010 ACTH (1-17) (TFA) (7266-47-9 free base) α1-17-ACTH TFA,ACTH (1-17) (TFA)
ACTH (1-17) TFA is a corticotrophin analogue and an effective human melanocortin 1 (MC1) receptor agonist with Ki value of 0.21 nM.
TP1893 [D-Trp8]-γ-MSH
Selective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively). Displays anti-inflammatory efficacy.
TP1003 Beta-MSH (1-22) human TFA (17908-57-5 free base) Beta-MSH (1-22) human TFA,β-Melanocyte Stimulating Hormone (MSH), human TFA
β-Melanocyte Stimulating Hormone (MSH), human (Synonyms: Beta-MSH (1-22) (human)) β-Melanocyte Stimulating Hormone (MSH), human, a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist.
T10568 BMS-470539 dihydrochloride Others
BMS-470539 dihydrochloride is a highly potent and selective agonist of the melanocortin-1 receptor (MC-1R; IC50: 120 nM; EC50: 28 nM) with anti-inflammatory properties. It does not activate MC-3R and is a very weak parti...
T70838 RO27-3225 TFA
RO27-3225, also known as RO273225 is a melanocortin type 4 receptor agonist with EC50 = 1 nM. It may alleviate intestinal dysfuntion and brain damage. It has been investigated for an anti-obesity medication. Ro 27-3225...
T12882 Setmelanotide BIM-22493,IRC-022493,RM-493 Melanocortin Receptor
Setmelanotide (BIM-22493) is a selective agonist of melanocortin 4 receptor (MC4R)(human and rat MC4R with EC50s of 0.27 nM and 0.28 nM, respectively).
TP1011 ACTH (1-17) α1-17-ACTH
ACTH (1-17), an adrenocorticotropin analogue, is a potent human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM. Adrenocorticotropic hormone (ACTH), also known as corticotropin, is produced and secreted by the...
T75848 PG106 TFA
PG106 TFA is a potent, selective antagonist of the human melanocortin 3 (hMC3) receptor, displaying an IC50 value of 210 nM, while exhibiting negligible activity at the hMC4 receptors (EC50 = 9900 nM) and hMC5 receptor [...
TP1892 γ1-MSH
Endogenous melanocortin MC3 receptor agonist (pKi = 7.46) that displays ~ 40-fold selectivity over MC4. Increases the release of extracellular dopamine, which induces grooming and vertical activity (rearing) in rats. Exh...
TP1953 PG-931 PG 931
Potent and selective melanocortin 4 (MC4) receptor agonist (IC50 values are 0.58 and 55 nM for human MC4 and MC3 receptors respectively). Produces a rapid and dose dependent restoration of cardiovascular and respiratory ...

Compounds

THIQ
T8485
Synonym:
Target: Melanocortin Receptor
HS024
TP1898
Synonym: HS 024
Target: Melanocortin Receptor
MCL0020
TP1889
Synonym: MCL 0020
Target: Melanocortin Receptor
Afamelanotide acetate
T7589
Synonym: afamelanotide
Target: Melanocortin Receptor
JNJ-10229570
T5464
Synonym: JNJ10229570,UNII-N9IX402L35,JNJ 10229570
Target: Melanocortin Receptor
Bremelanotide Acetate
T7608
Synonym: bremelanotide,PT-141 Acetate
Target: Melanocortin Receptor
Melanotan I
TP1097
Synonym: [Nle4,D-Phe7]-α-MSH,Afamelanotide,MT-I
Target: Others
α-MSH
T7813
Synonym: MSH, amide,CZEN-002,α-Melanocyte-Stimulating Hormone (MSH), amide
Target: Melanocortin Receptor, Adenylyl cyclase
Nonapeptide-1
T7769
Synonym: Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-,Melanostatine™ 5
Target: Others
Adrenocorticotropic Hormone (ACTH) (4-10), human
T7627
Synonym: Adrenocorticotropic Hormone (ACTH) (4-10),ACTH (4-10), human,Acth (4-10)
Target: Melanocortin Receptor
Adrenocorticotropic Hormone (ACTH) (1-39), human
T8231
Synonym: ACTH (1-39), human
Target: Others
Adrenocorticotropic Hormone (ACTH) (4-10) TFA
T7627L
Synonym: Adrenocorticotropic Hormone (ACTH) (4-10) TFA(4037-01-8(free base)),Acth (4-10)
Target: Melanocortin Receptor
PF-07258669
T69526
Synonym:
Target:
ACTH (1-17) acetate
TP1011L
Synonym:
Target: Melanocortin Receptor
Melanotan (MT)-II
TP1324
Synonym:
Target: Melanocortin Receptor
Beta-MSH (1-22) (human) acetate
TP1004L
Synonym: Beta-MSH (1-22) (human) acetate (17908-57-5 Free base)
Target: Melanocortin Receptor
[D-Trp8]-γ-MSH acetate(321351-81-9 free base)
TP1893L1
Synonym:
Target: Melanocortin Receptor
Setmelanotide Acetate(920014-72-8 free base)
T12882L
Synonym: RM-493 Acetate,IRC-022493 Acetate,BIM-22493 Acetate
Target: Melanocortin Receptor
PG 106 acetate
TP1952L
Synonym: PG 106 acetate(944111-22-2 Free base)
Target: Melanocortin Receptor
a-MSH, amide Acetate(581-05-5 free base)
TP2212L
Synonym:
Target: Melanocortin Receptor
HS 014 acetate(207678-81-7 free base)
TP2015L
Synonym:
Target: Melanocortin Receptor
Dersimelagon
T25310
Synonym: MT-7117
Target: Melanocortin Receptor
ML 00253764 hydrochloride
T22989
Synonym:
Target: Others
MPCI
T24495
Synonym:
Target:
RY764
T28635
Synonym: RY 764,RY-764
Target:
MK-0493 HCl
T33419
Synonym: MK 0493,MK-0493,MK0493
Target:
PF-00446687
T12415
Synonym:
Target: Others
Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA
T10251
Synonym: ACTH (1-39) (mouse, rat) TFA
Target: Others
MK-0493
T16086
Synonym:
Target: Others
MCL0129
T27986
Synonym: MCL-0129,MCL 0129
Target:
ML-00253764 hydrochloride
T12072
Synonym:
Target: Others
1-39-Corticotropin (human)(TFA)
TP1242
Synonym: Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA)
Target:
SNT-207707
T12944
Synonym:
Target: Others
MC-4R Agonist 1
T10230
Synonym:
Target: Others
Dersimelagon phosphate
T69607
Synonym:
Target:
SNT-207858 free base
T12945
Synonym:
Target: Others
β-Melanocyte Stimulating Hormone (MSH), human TFA
T75965
Synonym:
Target:
SNT-207858
T12946
Synonym:
Target: Others
Modimelanotide
T68328
Synonym:
Target:
ACTH (1-17) (TFA)
T75977
Synonym:
Target:
ACTH (1-17) (TFA) (7266-47-9 free base)
TP1010
Synonym: α1-17-ACTH TFA,ACTH (1-17) (TFA)
Target:
[D-Trp8]-γ-MSH
TP1893
Synonym:
Target:
Beta-MSH (1-22) human TFA (17908-57-5 free base)
TP1003
Synonym: Beta-MSH (1-22) human TFA,β-Melanocyte Stimulating Hormone (MSH), human TFA
Target:
BMS-470539 dihydrochloride
T10568
Synonym:
Target: Others
RO27-3225 TFA
T70838
Synonym:
Target:
Setmelanotide
T12882
Synonym: BIM-22493,IRC-022493,RM-493
Target: Melanocortin Receptor
ACTH (1-17)
TP1011
Synonym: α1-17-ACTH
Target:
PG106 TFA
T75848
Synonym:
Target:
γ1-MSH
TP1892
Synonym:
Target:
PG-931
TP1953
Synonym: PG 931
Target:
1 2

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-01117 MRAP Protein, Human, Recombinant (hFc) Human HEK293
MRAP (Melanocortin 2 Receptor Accessory Protein) is a Protein Coding gene. This gene encodes a melanocortin receptor-interacting protein. It belongs to the MRAP family. MRAP, which contains a single transmembrane domain,...
TMPY-01369 AGRP Protein, Human, Recombinant (His) Human HEK293
Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist ...
TMPY-01725 Leptin Receptor Protein, Human, Recombinant (His) Human HEK293
Leptin Receptor or CD295 belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-spe...
TMPY-00434 AGRP Protein, Mouse, Recombinant (hFc) Mouse HEK293
Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist ...
TMPY-02269 AGRP Protein, Mouse, Recombinant (His) Mouse HEK293
Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist ...
TMPY-00661 AGRP Protein, Human, Recombinant (hFc) Human HEK293
Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist ...
TMPY-00630 AGRP Protein, Rhesus, Recombinant (mFc) Rhesus HEK293
Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist ...
TMPY-00874 Leptin Receptor Protein, Human, Recombinant (His & hFc) Human HEK293
Leptin Receptor or CD295 belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-spe...
TargetMol