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Cat No. | Product Name | Synonyms | Targets |
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T8485 | THIQ | Melanocortin Receptor | |
THIQ is a selective melanocortin-4 receptor (MC4R) agonist (hMC4R and rMC4R with IC50 of 1.2 nM and 0.6 nM , respectively). | |||
TP1898 | HS024 | HS 024 | Melanocortin Receptor |
HS024 is a highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-... | |||
TP1889 | MCL0020 | MCL 0020 | Melanocortin Receptor |
MCL0020 is a potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no e... | |||
T7589 | Afamelanotide acetate | afamelanotide | Melanocortin Receptor |
Afamelanotide acetate is a synthetic α-melanocyte stimulating hormone analogue and first-in-class melanocortin-1 receptor agonist, used to for Erythropoietic Protoporphyria. | |||
T5464 | JNJ-10229570 | JNJ10229570,UNII-N9IX402L35,JNJ 10229570 | Melanocortin Receptor |
JNJ-10229570 (UNII-N9IX402L35) is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. | |||
T7608 | Bremelanotide Acetate | bremelanotide,PT-141 Acetate | Melanocortin Receptor |
Bremelanotide Acetate (PT-141 Acetate) is an agonist of melanocortin receptor (MCR) . | |||
TP1097 | Melanotan I | [Nle4,D-Phe7]-α-MSH,Afamelanotide,MT-I | Others |
Melanotan I (Afamelanotide) has the amino acid sequence of Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val and a molecular weight of 1647.4 Dalton. | |||
T7813 | α-MSH | MSH, amide,CZEN-002,α-Melanocyte-Stimulating Hormone (MSH), amide | Melanocortin Receptor , Adenylyl cyclase |
α-MSH (MSH, amide) is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase. | |||
T7769 | Nonapeptide-1 | Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-,Melanostatine™ 5 | Others |
Nonapeptide-1 (Melanostatine™ 5) can inhibit the synthesis of melanin, which makes it of interest for treating certain skin conditions. | |||
T7627 | Adrenocorticotropic Hormone (ACTH) (4-10), human | Adrenocorticotropic Hormone (ACTH) (4-10),ACTH (4-10), human,Acth (4-10) | Melanocortin Receptor |
Adrenocorticotropic Hormone (ACTH) (4-10) is an agonist of potent melanocortin(MC4R) receptor . | |||
T8231 | Adrenocorticotropic Hormone (ACTH) (1-39), human | ACTH (1-39), human | Others |
Adrenocorticotropic Hormone (ACTH) (1-39), human (ACTH (1-39), human) is an agonist of melanocortin receptor. | |||
T7627L | Adrenocorticotropic Hormone (ACTH) (4-10) TFA | Adrenocorticotropic Hormone (ACTH) (4-10) TFA(4037-01-8(free base)),Acth (4-10) | Melanocortin Receptor |
Adrenocorticotropic Hormone (ACTH) (4-10) TFA (Acth (4-10)) is an agonist of potent melanocortin(MC4R) receptor . | |||
T69526 | PF-07258669 | ||
PF-07258669, a melanocortin-4 receptor (MC4) antagonist, is utilized in researching cachexia, anorexia, or anorexia nervosa. | |||
TP1011L | ACTH (1-17) acetate | Melanocortin Receptor | |
ACTH (1-17) acetate is a potent agonist at the human melanocortin 1 (MC1) receptor with high affinity(Ki = 0.21 nM). | |||
TP1324 | Melanotan (MT)-II | Melanocortin Receptor | |
Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH). | |||
TP1004L | Beta-MSH (1-22) (human) acetate | Beta-MSH (1-22) (human) acetate (17908-57-5 Free base) | Melanocortin Receptor |
Beta-MSH (1-22) (human) acetate (Beta-MSH (1-22) (human) acetate (17908-57-5 Free base)) , is an endogenous melanocortin-4 receptor (MC4-R) agonist. | |||
TP1893L1 | [D-Trp8]-γ-MSH acetate(321351-81-9 free base) | Melanocortin Receptor | |
Selective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively). Displays anti-inflammatory efficacy. | |||
T12882L | Setmelanotide Acetate(920014-72-8 free base) | RM-493 Acetate,IRC-022493 Acetate,BIM-22493 Acetate | Melanocortin Receptor |
Setmelanotide Acetate(920014-72-8 free base) (RM-493 Acetate) is a selective agonist of melanocortin 4 receptor (MC4R)(human and rat MC4R with EC50s of 0.27 nM and 0.28 nM, respectively). | |||
TP1952L | PG 106 acetate | PG 106 acetate(944111-22-2 Free base) | Melanocortin Receptor |
PG 106 acetate is an effective and selective antagonist of the human melanocortin 3 (hMC3) receptor with an IC50 of 210 nM. PG 106 acetate has no activity with the hMC5 receptor and hMC4 receptors with an EC50 of 9900 nM... | |||
TP2212L | A-MSH, amide Acetate(581-05-5 free base) | Melanocortin Receptor | |
a-MSH, amide Acetate as an endogenous neuropeptide. It is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelano... | |||
TP2015L | HS 014 acetate(207678-81-7 free base) | Melanocortin Receptor | |
HS 014 acetate is a potent and selective melanocortin MC4 receptor antagonist (Ki values are 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake in rats and no... | |||
T25310 | Dersimelagon | MT-7117 | Melanocortin Receptor |
Dersimelagon (MT-7117) is an orally active, selective agonist for the melanocortin 1 receptor (MC1R), demonstrating EC50 values of 8.16 nM (h), 3.91 nM (cm), 1.14 nM (m), and 0.251 nM (r) across species such as human, cy... | |||
T22989 | ML 00253764 hydrochloride | Others | |
melanocortin MC4 receptor antagonist | |||
T24495 | MPCI | ||
MPCI is a selective melanocortin-4 receptor antagonist. | |||
T28635 | RY764 | RY 764,RY-764 | |
RY764 is a potent and selective agonist of melanocortin subtype-4 receptor. | |||
T33419 | MK-0493 HCl | MK 0493,MK-0493,MK0493 | |
MK-0493 is a novel, potent, and selective agonist for melanocortin receptor 4 (MC4R). | |||
T12415 | PF-00446687 | Others | |
PF-00446687 is a selective agonist of melanocortin-4 receptor (MC4R) (EC50 of 12 ± 1 nM). | |||
T10251 | Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA | ACTH (1-39) (mouse, rat) TFA | Others |
Adrenocorticotropic Hormone (ACTH) (1-39), rat (TFA) is a potent melanocortin 2 receptor (MC2) agonist. | |||
T16086 | MK-0493 | Others | |
MK-0493 is an effective and selective agonist of the melanocortin receptor 4 (MC4R). It also demonstrated significant reductions in energy intake. | |||
T27986 | MCL0129 | MCL-0129,MCL 0129 | |
MCL0129, a selective and non-peptidergic melanocortin 4 (MC4) receptor antagonist, is a potential treatment for cachexia. | |||
T12072 | ML-00253764 hydrochloride | Others | |
ML-00253764 hydrochloride is an antagonist of nonpeptidic melanocortin receptor 4 (MC4R) (Ki and IC50 of 0.16 µM and 0.103 µM, respectively). | |||
TP1242 | 1-39-Corticotropin (human)(TFA) | Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA) | |
Adrenocorticotropic Hormone (ACTH) (1-39) human(TFA),a member of the melanocortin family, is a melanocortin receptor agonist. It stimulates production of CS by the adrenals, but melanocortin receptors are also found in t... | |||
T12944 | SNT-207707 | Others | |
SNT-207707 is a potent, selective and orally active antagonist of melanocortin MC-4 receptor(IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor). | |||
T10230 | MC-4R Agonist 1 | Others | |
MC-4R Agonist 1 is an agonist of human melanocortin-4 receptor (MC-4R) and can be used in the research of sexual dysfunction, obesity, and diabetes. | |||
T69607 | Dersimelagon phosphate | ||
Dersimelagon phosphate is a selective melanocortin-1 receptor (MC1R) agonist that increases skin melanin without sun exposure and is being developed to increase light tolerance in EPP/XLP patients. | |||
T12945 | SNT-207858 free base | Others | |
SNT-207858 free base is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor(IC50 of 22 nM (binding) and 11 nM (function), on the MC-4 receptor). | |||
T75965 | β-Melanocyte Stimulating Hormone (MSH), human TFA | ||
β-Melanocyte Stimulating Hormone (MSH), human TFA, is a 22-residue peptide that functions as an endogenous agonist for the melanocortin-4 receptor (MC4-R) [1]. | |||
T12946 | SNT-207858 | Others | |
SNT-207858 is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor. | |||
T68328 | Modimelanotide | ||
Modimelanotide is a melanocortinergic peptide drug derived from α-melanocyte-stimulating hormone (α-MSH) which was under development for the treatment of acute kidney injury. It acts as a non-selective melanocortin recep... | |||
T75977 | ACTH (1-17) (TFA) | ||
ACTH (1-17) TFA, an analogue of adrenocorticotropin, serves as a highly effective agonist for the human melanocortin 1 (MC1) receptor, exhibiting a dissociation constant (K i) of 0.21 nM. | |||
TP1010 | ACTH (1-17) (TFA) (7266-47-9 free base) | α1-17-ACTH TFA,ACTH (1-17) (TFA) | |
ACTH (1-17) TFA is a corticotrophin analogue and an effective human melanocortin 1 (MC1) receptor agonist with Ki value of 0.21 nM. | |||
TP1893 | [D-Trp8]-γ-MSH | ||
Selective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively). Displays anti-inflammatory efficacy. | |||
TP1003 | Beta-MSH (1-22) human TFA (17908-57-5 free base) | Beta-MSH (1-22) human TFA,β-Melanocyte Stimulating Hormone (MSH), human TFA | |
β-Melanocyte Stimulating Hormone (MSH), human (Synonyms: Beta-MSH (1-22) (human)) β-Melanocyte Stimulating Hormone (MSH), human, a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist. | |||
T10568 | BMS-470539 dihydrochloride | Others | |
BMS-470539 dihydrochloride is a highly potent and selective agonist of the melanocortin-1 receptor (MC-1R; IC50: 120 nM; EC50: 28 nM) with anti-inflammatory properties. It does not activate MC-3R and is a very weak parti... | |||
T70838 | RO27-3225 TFA | ||
RO27-3225, also known as RO273225 is a melanocortin type 4 receptor agonist with EC50 = 1 nM. It may alleviate intestinal dysfuntion and brain damage. It has been investigated for an anti-obesity medication. Ro 27-3225... | |||
T12882 | Setmelanotide | BIM-22493,IRC-022493,RM-493 | Melanocortin Receptor |
Setmelanotide (BIM-22493) is a selective agonist of melanocortin 4 receptor (MC4R)(human and rat MC4R with EC50s of 0.27 nM and 0.28 nM, respectively). | |||
TP1011 | ACTH (1-17) | α1-17-ACTH | |
ACTH (1-17), an adrenocorticotropin analogue, is a potent human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM. Adrenocorticotropic hormone (ACTH), also known as corticotropin, is produced and secreted by the... | |||
T75848 | PG106 TFA | ||
PG106 TFA is a potent, selective antagonist of the human melanocortin 3 (hMC3) receptor, displaying an IC50 value of 210 nM, while exhibiting negligible activity at the hMC4 receptors (EC50 = 9900 nM) and hMC5 receptor [... | |||
TP1892 | γ1-MSH | ||
Endogenous melanocortin MC3 receptor agonist (pKi = 7.46) that displays ~ 40-fold selectivity over MC4. Increases the release of extracellular dopamine, which induces grooming and vertical activity (rearing) in rats. Exh... | |||
TP1953 | PG-931 | PG 931 | |
Potent and selective melanocortin 4 (MC4) receptor agonist (IC50 values are 0.58 and 55 nM for human MC4 and MC3 receptors respectively). Produces a rapid and dose dependent restoration of cardiovascular and respiratory ... |
Cat No. | Product Name | Species | Expression System |
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TMPY-01117 | MRAP Protein, Human, Recombinant (hFc) | Human | HEK293 |
MRAP (Melanocortin 2 Receptor Accessory Protein) is a Protein Coding gene. This gene encodes a melanocortin receptor-interacting protein. It belongs to the MRAP family. MRAP, which contains a single transmembrane domain,... | |||
TMPY-01369 | AGRP Protein, Human, Recombinant (His) | Human | HEK293 |
Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist ... | |||
TMPY-01725 | Leptin Receptor Protein, Human, Recombinant (His) | Human | HEK293 |
Leptin Receptor or CD295 belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-spe... | |||
TMPY-00434 | AGRP Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist ... | |||
TMPY-02269 | AGRP Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist ... | |||
TMPY-00661 | AGRP Protein, Human, Recombinant (hFc) | Human | HEK293 |
Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist ... | |||
TMPY-00630 | AGRP Protein, Rhesus, Recombinant (mFc) | Rhesus | HEK293 |
Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist ... | |||
TMPY-00874 | Leptin Receptor Protein, Human, Recombinant (His & hFc) | Human | HEK293 |
Leptin Receptor or CD295 belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-spe... |