Search Result

Search Results for " molt-4 "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T9104	TJ191		Apoptosis
	TJ191 is a selective anti-cancer agent, targeting low TβRIII-expressing malignant T-cell leukemia/lymphoma cells.		Apoptosis
T6603	Nelarabine	GW 506U78,Nelzarabine,506U78	Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
	Nelarabine (GW 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.
T35569	CTA 056		Apoptosis
	CTA 056 is an interleukin-2 induced T cell kinase (ITK) inhibitor, inhibits the growth of MOLT-4 xenograft tumors in mice, induces apoptosis in Jurkat cells, and can be used in the study of autoimmune disorders and T cel...		Apoptosis
T41163	ZNL 02-096	Pomalidomide-C3-adavosertib	Apoptosis , Wee1
	ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar concentrations without damaging PLK1, a secondary target of AZD 1775.ZNL ...		Apoptosis , Wee1
T17225	Vercirnon	CCX282-B,GSK-1605786,Traficet-EN	CCR
	Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.		CCR
T6748	A-1155463	A 1155463,A1155463	BCL
	A-1155463, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related proteins BCL-W(Ki=19 nM) and MCL-1(Ki>440 nM).		BCL
T2383	Panobinostat	NVP-LBH589,LBH589	Apoptosis , HIV Protease , HDAC , Autophagy
	Panobinostat (NVP-LBH589) is a broad-spectrum HDAC inhibitor (IC50=5 nM) with oral activity and non-selectivity. Panobinostat has antitumor activity and induces apoptosis and autophagy.		Apoptosis , HIV Protease , HDAC , Autophagy
T35476	BSJ-04-132
	Selective Cdk4 degrader. Degrades Cdk4 in Molt-4 cells, with no effect on Cdk6 levels. Displays cereblon-dependent degradation. Jiang et al (2019) Development of dual and selective degraders of cyclin-dependent kinases 4...
T39909	XZ739	XZ739
	XZ739 is a Cereblon-dependent PROTAC BCL-XL degrader, targeting a member of the Bcl-2 family, with a DC50 value of 2.5 nM in MOLT-4 cells after 16 hours of treatment. Additionally, XZ739 elicits cell death via caspase-me...
T35810	C24 dihydro Ceramide (d18:0/24:0)	Cer(d18:0/24:0)
	C24 dihydro Ceramide is a sphingolipid that has been found in the stratum corneum of human skin.[1] It is found in higher concentrations in female sebum compared to male sebum.[2] C24 dihydro Ceramide levels positively c...
T79451	WES-1		Carbonic Anhydrase
	WES-1 (Compound 8g), a carbonic anhydrase IX inhibitor (Ki: 55.9 μM), exhibits broad-spectrum antiproliferative activity against various cancer cell lines, including leukemia (K-562 and MOLT-4), non-small cell lung cance...		Carbonic Anhydrase
T41016	Vercirnon sodium	GSK-1605786 sodium,CCX282-Bsodium,Traficet-ENsodium
	Vercirnon (GSK1605786A) sodium is an orally bioavailable, selective, and potent CCR9 antagonist. It effectively inhibits CCR9-mediated calcium mobilization and chemotaxis in Molt-4 cells, exhibiting IC50 values of 5.4 nM...
T37560	Nidulin
	Nidulin is a depsidone originally isolated from A. nidulans. It is active against the bacteria M. tuberculosis and M. ranoe, as well as the fungi T. tonsurans and M. audouini. It also inhibits the growth of methicillin-r...
T36894	5-Bromouridine
	5-Bromouridine is a brominated analog of the nucleoside uridine .1It can be incorporated into RNA and subsequently detected by antibodies against bromodeoxyuridine .25-Bromouridine decreases the viability of HL-60 and MO...
T37419	Zetomipzomib
	KZR-616, a first-in-class inhibitor of the immunoproteasome, selectively targets the LMP7 (IC50: 39/57 nM=hLMP7/mLMP7) and LMP2 (IC50: 131/179 nM=hLMP7/mLMP7) subunits of the immunoproteasome. KZR-616 has the potential f...

Compounds

Synonym: GW 506U78,Nelzarabine,506U78

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Synonym: Pomalidomide-C3-adavosertib

Target: Apoptosis, Wee1

Vercirnon

T17225

Synonym: CCX282-B,GSK-1605786,Traficet-EN

Target: CCR

A-1155463

T6748

Synonym: A 1155463,A1155463

Target: BCL

Panobinostat

T2383

Synonym: NVP-LBH589,LBH589

Target: Apoptosis, HIV Protease, HDAC, Autophagy

C24 dihydro Ceramide (d18:0/24:0)

T35810

Synonym: Cer(d18:0/24:0)

Target: Carbonic Anhydrase

Vercirnon sodium

T41016

Synonym: GSK-1605786 sodium,CCX282-Bsodium,Traficet-ENsodium

Cat No.	Product Name	Synonyms	Targets
T9715	Aplidine		SARS-CoV , DNA/RNA Synthesis
	Aplidine possesses antiviral activity against SARS-CoV-2(IC90 = 0.88 nM). Aplidine is a potent anti-cancer agent by targeting eukaryotic translation elongation factor 1 Alpha 2(EEF1A2, Kd = 80 nM).		SARS-CoV , DNA/RNA Synthesis
T1511	Daunorubicin hydrochloride	Daunomycin HCl,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin	Apoptosis , DNA/RNA Synthesis , Topoisomerase , Antibacterial , Antibiotic , Autophagy
	Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein synthesis.
TN2755	2-Desoxy-4-epi-pulchellin		Anti-infection
	2-Desoxy-4-epi-pulchellin has potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with IC50 values ranging from 0.10 to 46.7uM, while it shows sig...		Anti-infection
T83561	(2S)-4'-Hydroxy-7-methoxyflavan
	(2S)-4'-Hydroxy-7-methoxyflavan, a flavan, demonstrated significant cytotoxic effects on human leukemic Molt 4 cells [1].
TN4837	Pseudotaraxasterol		AChR
	Pseudotaraxasterol shows cytotoxic activity against MOLT-4 cells.		AChR

Natural Products

Aplidine

T9715

Synonym:

Target: SARS-CoV, DNA/RNA Synthesis

Daunorubicin hydrochloride

T1511

Synonym: Daunomycin HCl,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin

Target: Apoptosis, DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic, Autophagy

2-Desoxy-4-epi-pulchellin

TN2755

Synonym:

Target: Anti-infection

(2S)-4'-Hydroxy-7-methoxyflavan

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00864	VEGF165 Protein, Human, Recombinant	Human	Human Cells
	Human Vascular endothelial growth factor (VEGF), also known as VEGF-A and vascular permeability factor (VPF), belongs to the platelet-derived growth factor family of cysteine-knot growth factors. It is a potent activator...
TMPK-00823	VEGF165 Protein, Human, Recombinant (His & Avi)	Human	HEK293
	Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most a...
TMPY-04911	VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated	Human,Cynomolgus	HEK293
	Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-...
TMPY-00749	FGF-2 Protein, Human, Recombinant	Human	E. coli
	Basic fibroblast growth factor (bFGF), also known as FGF2, is a member of the fibroblast growth factor (FGF) family. It is a highly specific chemotactic and mitogenic factor for many cell types, appears to be involved in...
TMPY-01822	PTK9 Protein, Human, Recombinant (His & GST)	Human	E. coli
	Twinfilin-1, also known as Protein A6, Protein tyrosine kinase 9, TWF1 and PTK9, is a cytoplasm protein that belongs to the actin-binding proteins ADF family and Twinfilin subfamily. Twinfilin-1 (TWF1 / PTK9 ) is a highl...
TMPK-00423	CD45 Protein, Human, Recombinant (His & Avi)	Human	HEK293
	PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) com...
TMPY-02893	NT5C3A/NT5C3 Protein, Human, Recombinant	Human	E. coli
	NT5C3A (5'-Nucleotidase, Cytosolic IIIA) is a Protein Coding gene. This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded prot...
TMPK-00822	VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled	Human	HEK293
	Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most a...
TMPY-04754	CASK Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	Peripheral plasma membrane protein CASK, also known as calcium/calmodulin-dependent serine protein kinase, CASK and LIN2, is a nucleus, cytoplasm and cell membrane protein which belongs to theMAGUK family. CASK / LIN2...
TMPY-04471	APEG1 Protein, Human, Recombinant (His)	Human	E. coli
	Striated muscle preferentially expressed protein kinase, also known as aortic preferentially expressed protein 1, APEG-1, SPEG and KIAA1297, is a protein that belongs to the protein kinase superfamily and CAMK Ser/Thr pr...
TMPY-00380	ANTXR2 Protein, Human, Recombinant (hFc)	Human	HEK293
	Loss-of-function mutations in capillary morphogenesis gene 2 (CMG2/ANTXR2), a transmembrane surface protein, cause hyaline fibromatosis syndrome (HFS), a severe genetic disorder that is characterized by large subcutaneou...
TMPJ-00410	CD45R0 Protein, Human, Recombinant (His)	Human	Human Cells
	Protein tyrosine phosphatase, receptor type C (CD45), also known as PTPRC is a member of the protein tyrosine phosphatase (PTP) family which is known for its function to serve as signaling molecules and to regulate a var...
TMPJ-00782	Amyloid Precursor Protein, Human, Recombinant (hFc)	Human	Human Cells
	Amyloid precursor protein (APP) is a type I membrane protein with several isoforms due to alternative splicing, performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and...
TMPK-00424	CD45 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) com...
TMPY-05598	Siglec-2/CD22 Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	HEK293
	CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesi...
TMPJ-00233	CD200R1/CRTR2 Protein, Human, Recombinant (His)	Human	Human Cells
	Cell surface glycoprotein CD200 Receptor 1 (CD200R1) is the receptor for the CD200 (OX-2) membrane glycoprotein. CD200R1 contains one C2- type Ig-like domain and one V-type Ig-like domain within its extracellular domain ...
TMPY-01033	IL-32 Protein, Human, Recombinant (isoform alpha, His)	Human	HEK293
	IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathw...
TMPY-01117	MRAP Protein, Human, Recombinant (hFc)	Human	HEK293
	MRAP (Melanocortin 2 Receptor Accessory Protein) is a Protein Coding gene. This gene encodes a melanocortin receptor-interacting protein. It belongs to the MRAP family. MRAP, which contains a single transmembrane domain,...
TMPY-04563	CASK Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Peripheral plasma membrane protein CASK, also known as calcium/calmodulin-dependent serine protein kinase, CASK and LIN2, is a nucleus, cytoplasm and cell membrane protein which belongs to theMAGUK family. CASK / LIN2...
TMPY-00711	CD45 Protein, Human, Recombinant (hFc)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-01933	CHI3L2 Protein, Human, Recombinant (His)	Human	HEK293
	Chondrocyte protein 39 (YKL-39), also known as Chitinase 3-like 2 (CHI3L2), is a secretory protein of articular chondrocytes belonging to the glycosyl hydrolase 18 family. Its highest expression is in chondrocytes, follo...
TMPK-00702	ANTXR2 Protein, Human, Recombinant (His)	Human	HEK293
	The Capillary Morphogenesis Gene 2 (CMG2) gene encodes an Anthrax toxin receptor (ANTXR2),ANTXR2/CMG2 was originally identified as a result of up-regulation during capillary morphogenesis of endothelial cells (ECs) cultu...
TMPJ-01188	CORO6 Protein, Human, Recombinant (His)	Human	E. coli
	Coronin 6, a newly identified member of the coronin family, is highly enriched at adult NMJs and regulates AChR clustering via modulating the interaction between receptors and the actin cytoskeletal network. Coronins are...
TMPJ-01333	TEM8/ANTXR1 Protein, Human, Recombinant (His)	Human	Human Cells
	Anthrax Toxin Receptor 1 (ANTXR1) is a single-pass type I membrane protein that belongs to the ATR family. ANTXR1 contains one VWFA domain and binds PA through the VWA domain. ANTXR1 is highly expressed in tumor endothel...
TMPY-04565	SRPK3 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Serine / threonine-protein kinase SRPK3, also known as Muscle-specific serine kinase 1, Serine/arginine-rich protein-specific kinase 3, SR-protein-specific kinase 3, Serine / threonine-protein kinase 23, MSSK-1, SRPK3 an...
TMPY-01823	PTK9 Protein, Human, Recombinant	Human	E. coli
	Twinfilin-1, also known as Protein A6, Protein tyrosine kinase 9, TWF1 and PTK9, is a cytoplasm protein that belongs to the actin-binding proteins ADF family and Twinfilin subfamily. Twinfilin-1 (TWF1 / PTK9 ) is a highl...
TMPY-00119	FLT1 Protein, Human, Recombinant (hFc)	Human	HEK293
	Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor and FLT1, is a si...
TMPJ-01256	Caspase-10 Protein, Human, Recombinant (His)	Human	E. coli
	Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granz...
TMPY-00225	CLEC9A Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	CLEC9A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 52.1 kDa. Accession number: Q8BRU4-4
TMPK-01356	SIRP alpha V4 Protein, Human, Recombinant (His & Avi)	Human	HEK293
	Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadl...
TMPK-01362	SIRP alpha V4 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadl...