Home Tools
Log in
Cart

Search Result

Search Results for " mcf7 "

Targets

39

Compounds

13

Natural Products

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T9122 XL177A DUB
XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.
T9636 Dalpiciclib SHR-6390 CDK
Dalpiciclib (SHR-6390) is a highly selective, orally bioavailable, and comparable potency inhibitor of CDK4 and CKD6 with IC50s of 12.4 nM and 9.9 nM, respectively. Dalpiciclib exerts potent antitumor activity in esophag...
T16745 Rhosin hydrochloride Apoptosis , Rho , Ras
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin hydrochloride does not interact with Cdc42 o...
T9629 BRD4 Inhibitor-24 Epigenetic Reader Domain
BRD4 Inhibitor-24 is a BRD4 small molecule inhibitor with antitumor activity.
T2679 BMS-265246 BMS265246 CDK
BMS-265246 is a potent and selective CDK1/2 inhibitor.
T9205 NCGC00378430 Phosphatase , Others
NCGC00378430 is a potent SIX1/EYA2 interaction inhibitor that disrupts the SIX1/EYA2 complex, EMT, and Metastasis.
T60002 DC-S239 DC-S239 Histone Methyltransferase
DC-S239 (DC-S239) is a selective inhibitor of histone methyltransferase SETD7 (IC50 = 4.59 μM) with anticancer activity.
T12134 MYCMI-6 NSC354961 Apoptosis , c-Myc
MYCMI-6 (NSC-354961) is a potent and selective inhibitor of endogenous MYC:MAX protein interactions,reduces proliferation and induces massive apoptosis in tumor tissue from a MYC-driven xenograft tumor model without seve...
T8334 CADD522 MFCD00167693 Others
CADD522 (MFCD00167693) is a potent inhibitor of runt-related transcription factor-2 (RUNX2)-DNA binding with an IC50 of 10 nM, with antitumor activity
T4459 PK11000 DNA Alkylator/Crosslinker
PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53.
T8649 TMBIM6 antagonist-1 BAX-inhibitor-1,BIA mTOR
TMBIM6 antagonist-1 (BAX-inhibitor-1) is a bax inhibitor
T6018 Zosuquidar trihydrochloride Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride P-gp
Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.
T9078 LY3405105 1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester CDK
LY3405105 (1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester) is a novel CDK7 inhibitors.
T7311 Oxyphenisatin acetate Autophagy
Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468.
TQ0232 UNC0646 UNC 0646 Histone Methyltransferase
UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646(UNC 0646) potently blocks G9a/GLP methyltransferase activity in cells ...
T69860 PSB-15160
PSB-15160 is a compound that inhibits the growth of MCF7 (breast), NCI-H460 (lung) and SF-268 (NCS) cells in the treatment of estrogen-dependent tumours.
T77657 MSNBA transporter
MSNBA is a selective and potent inhibitor of fructose transport through GLUT5 and also acts as a probe of the GLUT5 transporter. MSNBA inhibited GLUT5 fructose uptake in MCF7 cells with KI of 3.2±0.4 μM.
T7018 WZB117 transporter
WZB117 is a Glucose Transporter 1 (GLUT1) inhibitor. when IC50 of WZB117 approximate 10 μM, it inhibits lung cancer A549 cells and breast cancer MCF7 cells proliferation.
T16923 SPP-86 c-RET
SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine kinase with an IC50 of 8 nM.
T81054 T-1-MCPAB VEGFR
T-1-MCPAB, a VEGFR-2 inhibitor with an IC50 of 0.135 µM, effectively suppresses MCF7 cell migration and has applications in cancer research [1].
T68378 PRMT4-IN-1 Histone Methyltransferase
PRMT4-IN-1 is a selective inhibitor of PRMT4, demonstrating an IC50 value of 3.2 nM, and has been shown to reduce the relative viability of MCF7 cells [1].
T61280 Colletotrichalactones A
Colletotrichalactones A is a polyketide with moderate-to-potent cytotoxic activity against MCF7 cells, exhibiting an IC50 value of 35.06 μM [1].
T63401 EGFR/HER2/TS-IN-1
EGFR/HER2/TS-IN-1 are EGFR, HER2 and TS (Thymidylate synthase) inhibitors with IC50 values of 0.203, 0.088 and 0.168 μM, respectively, and have the ability to induce apoptosis (MCF7 cell death).
T79083 HSP90-IN-22 HSP
HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor exhibiting antiproliferative activity, with IC50 values of 3.65 μM in MCF7 breast cancer cells and 2.71 μM in SKBr3 breast cancer cells.
T81740 Multi-kinase-IN-6 Trk receptor
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. It exhibits antiproliferative effects on MCF7, HCT116, and EKVX ca...
T72844 EGFR/CDK2-IN-1
EGFR/CDK2-IN-1 is an EGFR/CDK2 inhibitor. EGFR/CDK2-IN-1 shows good cytotoxicity against MCF7 and HepG2 cells. EGFR/CDK2-IN-1 can be used in cancer research .
T60849 PIN1 inhibitor 2
PIN1 inhibitor 2 (compound 12) is a potent inhibitor of PIN1 that has the potential in the breast cancer research. PIN1 inhibitor 2 exhibits antitumor activity with an IC 50 of 9.55 μM against MCF7 cells [1].
T63045 (1S,3R)-GNE-502
(1S,3R)-GNE-502 (compound 179) is a potent degradation agent of Erα and is able to degrade ERα in MCF7 HCS cells (EC50: 13 nM). (1S,3R)-GNE-502 can be used in the study of estrogen receptor-related cancers.
T36968 ARN-21934 Topoisomerase
ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II α over β. ARN-21934 inhibits DNA relaxation with an IC50 of 2 μM as compared to the anticancer agent Etopo...
T18605 PROTAC ERα Degrader-2 Others
PROTAC ERα Degrader-2 comprises a cIAP1 ligand binding group, a linker and an estrogen receptor α (ERα) binding group. PROTAC ERα Degrader-2 is an ERα degrader. Maximal ERα degradation at 30 μM concentration in human mam...
T61229 VEGFR-2/DHFR-IN-2
VEGFR-2/DHFR-IN-2 (compound 5b) is a dual inhibitor targeting VEGFR-2 and DHFR, with respective IC50 values of 0.623 μM and 9.085 μM. It demonstrates potent cytotoxicity against C26, HepG2, and MCF7 cancer cell lines, wi...
T81962 Lactate transportor 1 Monocarboxylate transporter
Lactate Transporter 1 (Compound 1) serves as an active lactate transporter within living cells and exerts cytotoxic effects, exhibiting IC50 values of 3.36 μM in HeLa, 3.27 μM in CAL27, 5.58 μM in MCF7, and 7.66 μM in MC...
T70345 JAS239
JAS239 is a novel carbocyanine dye that binds and competitively inhibits choline kinase (ChoK) intracellularly. JAS239 attenuated choline phosphorylation and viability in a panel of human breast cancer cell lines. Antibo...
T78773 Tubulin inhibitor 38
Tubulin Inhibitor 38 (Compound 14), a tetrazole-based agent, demonstrates significant antiproliferative effects by inducing mitotic arrest and blocking the cell cycle at the G2/M phase, ultimately triggering apoptosis. A...
T82492 EGFR/HER2/DHFR-IN-3 EGFR
EGFR/HER2/DHFR-IN-3 (compound 4c) serves as an efficacious dual inhibitor specifically targeting EGFR/HER2, exhibiting IC50 values of 0.138 μM for EGFR and 0.092 μM for HER2, respectively. Moreover, it demonstrates inhi...
T82493 EGFR/HER2/DHFR-IN-2 EGFR
EGFR/HER2/DHFR-IN-2 (Compound 4b) serves as an inhibitor for EGFR, HER2, and DHFR, with IC50 values of 0.248, 0.156, and 0.138 μM, respectively. It exhibits anticancer activity, displaying IC50 values of 9.14, 7.33, 14.1...
T69403 AZD-3409
AZD-3409 is a potent prenyl transferase inhibitor. AZD-3409 showed higher potency than lonafarnib. The mean IC(50) for cytotoxicity of AZD3409 was 510 in MEF cells, 10,600 in A549 cells and 6,170 in MCF7 cells, respectiv...
T36308 PF-06843195
PF-06843195 is a highly selective PI3Kα inhibitor with an IC50 of 18 nM in Rat1 fibroblasts. The Kis of PF-06843195 for PI3Kα and PI3Kδ in biochemical kinase assay are less than 0.018 nM and 0.28 nM, respectively. PF-068...
T61489 VEGFR-2/DHFR-IN-1
VEGFR-2/DHFR-IN-1 (compound 8b) is an inhibitor of VEGFR-2 and DHFR with IC 50 s of 0.384 and 7.881 μM, respectively. VEGFR-2/DHFR-IN-1 shows good antibacterial activities against Escherichia coli, Streptococcus faecalis...

Compounds

XL177A
T9122
Synonym:
Target: DUB
Dalpiciclib
T9636
Synonym: SHR-6390
Target: CDK
Rhosin hydrochloride
T16745
Synonym:
Target: Apoptosis, Rho, Ras
BRD4 Inhibitor-24
T9629
Synonym:
Target: Epigenetic Reader Domain
BMS-265246
T2679
Synonym: BMS265246
Target: CDK
NCGC00378430
T9205
Synonym:
Target: Phosphatase, Others
DC-S239
T60002
Synonym: DC-S239
Target: Histone Methyltransferase
MYCMI-6
T12134
Synonym: NSC354961
Target: Apoptosis, c-Myc
CADD522
T8334
Synonym: MFCD00167693
Target: Others
PK11000
T4459
Synonym:
Target: DNA Alkylator/Crosslinker
TMBIM6 antagonist-1
T8649
Synonym: BAX-inhibitor-1,BIA
Target: mTOR
Zosuquidar trihydrochloride
T6018
Synonym: Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride
Target: P-gp
LY3405105
T9078
Synonym: 1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester
Target: CDK
Oxyphenisatin acetate
T7311
Synonym:
Target: Autophagy
UNC0646
TQ0232
Synonym: UNC 0646
Target: Histone Methyltransferase
PSB-15160
T69860
Synonym:
Target:
MSNBA
T77657
Synonym:
Target: transporter
WZB117
T7018
Synonym:
Target: transporter
SPP-86
T16923
Synonym:
Target: c-RET
T-1-MCPAB
T81054
Synonym:
Target: VEGFR
PRMT4-IN-1
T68378
Synonym:
Target: Histone Methyltransferase
Colletotrichalactones A
T61280
Synonym:
Target:
EGFR/HER2/TS-IN-1
T63401
Synonym:
Target:
HSP90-IN-22
T79083
Synonym:
Target: HSP
Multi-kinase-IN-6
T81740
Synonym:
Target: Trk receptor
EGFR/CDK2-IN-1
T72844
Synonym:
Target:
PIN1 inhibitor 2
T60849
Synonym:
Target:
(1S,3R)-GNE-502
T63045
Synonym:
Target:
ARN-21934
T36968
Synonym:
Target: Topoisomerase
PROTAC ERα Degrader-2
T18605
Synonym:
Target: Others
VEGFR-2/DHFR-IN-2
T61229
Synonym:
Target:
Lactate transportor 1
T81962
Synonym:
Target: Monocarboxylate transporter
JAS239
T70345
Synonym:
Target:
Tubulin inhibitor 38
T78773
Synonym:
Target:
EGFR/HER2/DHFR-IN-3
T82492
Synonym:
Target: EGFR
EGFR/HER2/DHFR-IN-2
T82493
Synonym:
Target: EGFR
AZD-3409
T69403
Synonym:
Target:
PF-06843195
T36308
Synonym:
Target:
VEGFR-2/DHFR-IN-1
T61489
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T5755 Aloesin Tyrosinase
Aloesin is a C-glycosylated chromone compound found in aloe (Liliaceae) that inhibits tyrosinase (IC50 = 0.9 mM), an enzyme responsible for catalyzing the first step of the conversion of tyrosine to melanin.
T9605 Sangivamycin BA-90912,NSC 65346 Nucleoside Antimetabolite/Analog , PKC
Sangivamycin (NSC-65346) is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers.
T17155 Trabectedin Ecteinascidin 743,ET-743 Apoptosis , Reactive Oxygen Species
Trabectedin (Ecteinascidin 743) has potent antitumor activity and the potential for soft tissue sarcoma and ovarian cancer research. Trabectedin inhibits cell growth of MX-1, MCF7 and MCF7/DXR cells with IC50 values of 0...
T5132 9-dihydro-13-acetylbaccatin III 13-Acetyl-9-dihydrobaccatin III,9-DHAB III Apoptosis
9-dihydro-13-acetylbaccatin III (9-DHAB III)is an apoptosis inducer. It shows cytotoxicity against the MCF7 cell line and drug-resistant cell line MCF7-ADR.
TN1018 Angeloylgomisin H PPAR
Angeloylgomisin H shows moderate cytotoxic activities with IC50 values ranging from 100 to 200 ug/mL against MCF7, HEK293 and CAL27 cell lines.
TN1222 26-Deoxyactein 27-Deoxyactein,23-epi-26-Deoxyactein NOS , CDK , NO Synthase
23-epi-26-Deoxyactein (27-Deoxyactein) has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. It also has anti-cancer activity, it can in...
TN6569 Cis-Moschamine
cis-Moschamine exerts antitumour effects on HeLa, MCF7 and A431 cells.
TN4321 Isopteleine Others
Isopteleine shows weak cytotoxic activities against human breast cancer cells (MCF7).
T81688 Neohelmanthicin B
Neohelmanthicin B, a phenylpropanoid isolated from Thapsia garganica, demonstrates cytotoxic properties against EL4, S180, and MCF7 cell lines, with respective IC50 values of 10, 5, and 12 μM [1].
TN3834 Derrone Antifection
Derrone may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens. It is also a novel Aurora kinase inhibitor, it can significantly inhibit the formation and growth of MCF7 t...
T81689 Neohelmanthicin A
Neohelmanthicin A (compound 3A), a phenylpropanoid with antitumor properties, exhibits IC50 values of 0.13 μM, 7 μM, and 23 μM against leukemia cell line EL4, breast cancer cell line S180, and breast cancer cell line MCF...
T72742 (-)-Pinocembrin (-)-乔松素
(-)-Pinocembrin exhibits anti-mycobacterium activity against mycobacteriuum tuberculosis H37Ra with an IC 50 value of 1.11 mg/mL in dormant phase and 1.21 mg/mL in active phase, respectively. (-)-Pinocembrin has potent a...
TN5153 Torilin MMP , ERK , IκB/IKK , p38 MAPK , NF-κB , Tyrosinase , Reductase , DNA/RNA Synthesis , JNK
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic acid (IC50 = 160.3 +/- 24.62 microM) but is weaker than fi...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPK-00785 ANXA2 Protein, Mouse, Recombinant (His) Mouse E. coli
ANXA2, highly expressed in invasive breast cancer cells, is closely related with poor prognosis, and acts as a molecular switch to EGFR activation. ANXA2 expression is inversely correlated with cell sensitivity to gefiti...
TMPK-00784 ANXA2 Protein, Human, Recombinant (His) Human E. coli
ANXA2, highly expressed in invasive breast cancer cells, is closely related with poor prognosis, and acts as a molecular switch to EGFR activation. ANXA2 expression is inversely correlated with cell sensitivity to gefiti...
TargetMol