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Search Results for " liver-x-receptor "

Targets

36

Compounds

6

Natural Products

5

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T5178 AZ876 Liver X Receptor
AZ876 is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively.
T16930 SR9238 Liver X Receptor
SR9238 is a synthetic agonist of liver X receptor inverse (IC50s: 214 nM and 43 nM for LXRα and LXRβ, respectively).
T1801 SR9243 Liver X Receptor
SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect.
T15427 GSK2033 Liver X Receptor
GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively).
T27478 GSK3987 Liver X Receptor
GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM.
T7768 RGX-104 RGX-104 free Acid Liver X Receptor
RGX-104 (RGX-104 free Acid) free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR)
T1783 LXR-623 LXR623,WAY 252623 Liver X Receptor
LXR-623 (WAY 252623) is an orally bioavailable and highly specifical synthetic modulator of LXR.
T6310 GW3965 hydrochloride GW3965 HCl Liver X Receptor
GW3965 hydrochloride (GW3965 HCl) is an effective and specific LXR agonist for hLXRα/β (EC50: 190/30 nM).
T2601 Vidofludimus SC12267,4sc-101 Dehydrogenase , DNA/RNA Synthesis , Interleukin
Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).
T5128 RGX-104 hydrochloride SB742881,RGX-104 HCl Liver X Receptor
RGX-104 hydrochloride (SB742881) is a liver X receptor (LXR) agonist with potential immunomodulating and antineoplastic activities. It modulates innate immunity via transcriptional activation of the ApoE gene.
T3970 BMS-779788 XL652,EXEL04286652,XL 652,XL-652,BMS-788 Liver X Receptor
BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM).
T6690 T0901317 Apoptosis , FXR , Liver X Receptor , ROR
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
T16792 Rovazolac ALX-101 Liver X Receptor
Rovazolac (ALX-101) is a liver x receptor (LXR) modulator used in the study of immune system disorders and atopic dermatitis.
T63896 BE1218 Liver X Receptor
BE1218 is a liver X receptor (LXR) inverse agonist active on LXRα and LXRβ with an IC50 of 9 nM and 7 nM, respectively.
T27496 GSK9772 GSK-9772,GSK 9772
GSK9772 is a transrepression-selective liver X receptor modulators with anti-inflammatory activity.
T71756 24(S),25-Epoxycholesterol
24(S),25-Epoxycholesterol is an oxysterol agonist of the liver X receptor.
T27229 E-4177 E4177
E-4177 is an angiotensin type 1 receptor antagonist. In rat adrenal cortex and liver, E4177 competitively inhibited the specific binding of 125I-[Sar1,Ile8]Ang II, with IC50 being (5.2 +/- 1.0) x 10(-8) M for the adrenal...
T11899 LXRβ agonist-2 Others
LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM.
T25528 IMB-808
IMB-808 is an effective partial dual agonist of liver X receptor α and β (LXRα/β) that promotes the expression of genes related to reverse cholesterol transport (including ABCA1 and ABCG1).
T35076 VTP-766
VTP-766 is an effective orally active and selective liver X receptor β (lxrβ) agonist, targeted to treat atopic dermatitis and acute coronary syndrome.
T37414 CAY10771
CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 μM, respectively)...
T64148 LXR agonist 2
LXR agonist 2 is a potent agonist of the LXR (liver X receptor). LXR agonist 2 stabilises NCOA1 (coactivator), which in turn agonises the LXR.
T6310L GW3965
GW3965 is a potent, selective agonist of liver X receptor (LXR) with EC 50 s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively [1] [2] [3].
T69724 Cilofexor tromethamine
Cilofexor, also known as GS-9674, is a farnesoid X receptor (FXR) agonist. The nonsteroidal FXR agonist cilofexor (GS-9674) improves markers of cholestasis and liver injury in patients with PSC. In clinical study, cilof...
T63723 LXR agonist 1
LXR (Liver X receptor) agonist 1 is a potent agonist of LXR, capable of acting on LXR-α (AC50: 1.5 nM) and LXR-β (AC50: 12 nM). LXR agonist 1 has shown research potential in atherosclerosis.
T63989 LXRβ agonist-3
LXRβ agonist-3 is a potent and selective LXRβ (liver X receptor β) agonist (EC50: 0.095 μM). LXRβ agonist-3 effectively inhibits U87EGFRvIII cells (IC50: 3.75 μM). .
T83858 Tauro-Obeticholic Acid sodium Tauro-6-Ethylchenodeoxycholic Acid,Tauro-6-Ethyl-CDCA,Obeticholic Acid Taurine Conjugate,Tauro-OCA,T-ECDCA
Tauro-obeticholic acid, a farnesoid X receptor (FXR) agonist and semisynthetic derivative of chenodeoxycholic acid, is an active metabolite of obeticholic acid. This compound undergoes taurine conjugation in the liver to...
T75388 FITC-GW3965
FITC-GW3965 is a fluorescence-labelled liver X receptor β ( LXRβ ) agonist GW3965 . FITC-GW3965 is a tracer, that can be designed by replacing the trifluoromethyl of GW3965 with an amide to link the FITC. FITC-GW3965 can...
T74147 Larsucosterol (trimethylamine)
Larsucosterol (DUR-928) trimethylamine, a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol trimethylamine as a potent endogenous regulator decreases lipogenesis. Larsucosterol trimethy...
T70899 Vidofludimus hemicalcium 4sc-101 hemicalcium,SC12267 hemicalcium,4sc-101 hemicalcium ; SC12267 hemicalcium
Vidofludimus (4sc-101 ; SC12267) hemicalcium is an orally active inhibitor for dihydroorotate dehydrogenase (DHODH) and also is a novel modulator for farnesoid X receptor (FXR) . Vidofludimus hemicalcium, as an immuno...
T64171 LXR antagonist 2
LXR antagonist 2 (compound 10rr) is a potent LXR (liver X receptor) inverse agonist, acting on LXRβ (IC50: 0.36 μM) and LXRα (IC50: 2.25 μM). LXR antagonist 2 is an adipogenesis inhibitor that downregulates LXR target ge...
T69671 SR1903 TFA
SR-1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR). It is an inverse agonist of RORγ and an agonist of LXR. It also binds to peroxisome proliferator-activated rec...
T35638 SR 1903
SR 1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR).1 It is an inverse agonist of RORγ (IC50 = ~100 nM in a cell-based reporter assay) and an agonist of LXR. It al...
T36130 22(S)-hydroxy Cholesterol 22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol
22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatoc...
T83765 Dendrogenin A ​DDA
Dendrogenin A (DDA) is a compound acting as a selective liver X receptor (LXR) modulator, cholesterol epoxide hydrolase inhibitor (Ki = 120 nM), and a metabolic product of cholesterol, originating from 5,6α-epoxy cholest...
T35463 (±)14(15)-EET (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET
(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) i...

Compounds

AZ876
T5178
Synonym:
Target: Liver X Receptor
SR9238
T16930
Synonym:
Target: Liver X Receptor
SR9243
T1801
Synonym:
Target: Liver X Receptor
GSK2033
T15427
Synonym:
Target: Liver X Receptor
GSK3987
T27478
Synonym:
Target: Liver X Receptor
RGX-104
T7768
Synonym: RGX-104 free Acid
Target: Liver X Receptor
LXR-623
T1783
Synonym: LXR623,WAY 252623
Target: Liver X Receptor
GW3965 hydrochloride
T6310
Synonym: GW3965 HCl
Target: Liver X Receptor
Vidofludimus
T2601
Synonym: SC12267,4sc-101
Target: Dehydrogenase, DNA/RNA Synthesis, Interleukin
RGX-104 hydrochloride
T5128
Synonym: SB742881,RGX-104 HCl
Target: Liver X Receptor
BMS-779788
T3970
Synonym: XL652,EXEL04286652,XL 652,XL-652,BMS-788
Target: Liver X Receptor
T0901317
T6690
Synonym:
Target: Apoptosis, FXR, Liver X Receptor, ROR
Rovazolac
T16792
Synonym: ALX-101
Target: Liver X Receptor
BE1218
T63896
Synonym:
Target: Liver X Receptor
GSK9772
T27496
Synonym: GSK-9772,GSK 9772
Target:
24(S),25-Epoxycholesterol
T71756
Synonym:
Target:
E-4177
T27229
Synonym: E4177
Target:
LXRβ agonist-2
T11899
Synonym:
Target: Others
IMB-808
T25528
Synonym:
Target:
VTP-766
T35076
Synonym:
Target:
CAY10771
T37414
Synonym:
Target:
LXR agonist 2
T64148
Synonym:
Target:
GW3965
T6310L
Synonym:
Target:
Cilofexor tromethamine
T69724
Synonym:
Target:
LXR agonist 1
T63723
Synonym:
Target:
LXRβ agonist-3
T63989
Synonym:
Target:
Tauro-Obeticholic Acid sodium
T83858
Synonym: Tauro-6-Ethylchenodeoxycholic Acid,Tauro-6-Ethyl-CDCA,Obeticholic Acid Taurine Conjugate,Tauro-OCA,T-ECDCA
Target:
FITC-GW3965
T75388
Synonym:
Target:
Larsucosterol (trimethylamine)
T74147
Synonym:
Target:
Vidofludimus hemicalcium
T70899
Synonym: 4sc-101 hemicalcium,SC12267 hemicalcium,4sc-101 hemicalcium ; SC12267 hemicalcium
Target:
LXR antagonist 2
T64171
Synonym:
Target:
SR1903 TFA
T69671
Synonym:
Target:
SR 1903
T35638
Synonym:
Target:
22(S)-hydroxy Cholesterol
T36130
Synonym: 22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol
Target:
Dendrogenin A
T83765
Synonym: ​DDA
Target:
(±)14(15)-EET
T35463
Synonym: (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET
Target:
Cat No. Product Name Synonyms Targets
T7529 Yamogenin 山药 Others
Yamogenin is a diastereomer of diosgenin, which we have identified as the compound responsible for the anti-hyperlipidemic effect of fenugreek.
T2768 Saikosaponin A NF-κB , Antibacterial , Liver X Receptor
Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropath...
T2810 (20S)-Protopanaxatriol 20(S)-APPT,g-PPT Apoptosis , Estrogen Receptor/ERR , Glucocorticoid Receptor , Estrogen/progestogen Receptor , Liver X Receptor
(20S)-Protopanaxatriol (g-PPT)(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.
TQ0274 27-Hydroxycholesterol 25(R)-27-hydroxy Cholesterol Estrogen/progestogen Receptor , Liver X Receptor
27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
T16264 Nagilactone B Others
Nagilactone B is extracted from the root bark of Podocarpus nagi and it also is a liver X receptor (LXR) agonist.
TN5431 Icariside E4 Antioxidant , AMPK , Liver X Receptor , Lipid , Fatty Acid Synthase
Icariside E4 is a natural compound derived from Ulmus minor that acts via AMPK phosphorylation and inhibition of MID1IP2 hypolipidation in HepG1 cells.Icariside E4 has anti-injurious, antioxidant, anti-Alzheimer's and an...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-00382 P-selectin Protein, Mouse, Recombinant (Avi & His), Biotinylated Mouse Human Cells
P-selectin/CD62P is a single-pass type I membrane protein which is a member of the Selectin family. It consists 768 amino acid (aa). P-selectin is a cell surface glycoprotein expressed by activated platelets and endothel...
TMPY-04512 SMPDL3A Protein, Mouse, Recombinant (His) Mouse HEK293
SMPDL3A gene is a novel liver X receptor (LXR) -regulated gene, with an LXR response element within its promoter. The induction of SMPDL3A is LXR-dependent and is restricted to human blood cells with no induction observe...
TMPY-03278 SMPDL3A Protein, Human, Recombinant (His) Human HEK293
SMPDL3A gene is a novel liver X receptor (LXR) -regulated gene, with an LXR response element within its promoter. The induction of SMPDL3A is LXR-dependent and is restricted to human blood cells with no induction observe...
TMPJ-00952 CXCL12 Protein, Mouse, Recombinant Mouse E. coli
Mouse Cxcl12 is a secreted and highly conserved protein which belongs to the intercrine alpha (chemokine CxC) family.CXCL12 is widely expressed in various organs including brain, kidney, skeletal muscle, heart, liver, an...
TMPY-02001 RTN4 Protein, Human, Recombinant (GST) Human E. coli
Reticulon-4, also known as Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5 and RTN4, is a multi-pass membrane protein that...
TargetMol