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Search Result

Search Results for " kappa opioid receptor "

Targets

Opioid Receptor

28

Compounds

1

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T11909 LY2444296 FP3FBZ Opioid Receptor
LY2444296 (FP3FBZ) is an orally active and selective antagonist of kappa opioid receptor(Ki = 1 nM).
TQ0082 Aticaprant LY-2456302,CERC-501 Opioid Receptor
Aticaprant (LY-2456302) (CERC-501) is a potent and centrally-penetrant antagonist of the kappa-opioid receptor (Ki: 0.807 nM).
TP2501 Difelikefalin acetate Difelikefalin acetate(1024828-77-0 free base),CR 845 acetate,FE 202845 acetate Opioid Receptor
Difelikefalin acetate (CR 845 acetate) is a peripherally restricted kappa opioid receptor agonist. CR845 exhibit low P450 CYP inhibition and low penetration into the brain.
T28094 MR2034
MR2034 is an agonist of kappa-Opioid receptor. MR2034 stimulates hypothalamic-pituitary-adrenal axis.
T24035 Eptazocine hydrobromide MCV 4169,ST-2121,MCV-4169,sT 2121, l-,l-ST-2121
Eptazocine hydrobromide is an agonist of the Opioid receptor and is a kappa-Opioid receptor agonist. It is also an Opioid analgesic and an Opioid receptor antagonist.
T69799 4-Me-PDTic
4-Me-PDTic is a potent and selective kappa opioid receptor antagonist.
T69818 GNTI TFA
GNTI TFA is a selective kappa opioid receptor antagonist.
T71523 Norbinaltorphimine
nor-Binaltorphimine dihydrochloride is a long-acting potent and highly selective kappa opioid receptor antagonist.
T73339 Anrikefon HSK21542
Anrikefon (HSK21542) is a kappa opioid receptor agonist with analgesic effect .
T25354 Dup 747 Dup-747,Dup747
Dup 747 is an analgesic that binds with high affinity and selectivity to the kappa-opioid receptor.
T79848 Icalcaprant Opioid Receptor
Icalcaprant is a kappa-opioid receptor antagonist [1].
T71370 ICI-204879 HCl
ICI-204879 HCl is a potent and selective agonists at the opioid kappa-receptor.
T69851 Riminkefon
Riminkefon is a kappa opioid receptor agonist .
T81938 Leumorphin, human Opioid Receptor
Leumorphin, human, is a potent agonist of the kappa opioid receptor (κ opioid receptor) and inhibits the contraction of the guinea pig ileum's myenteric plexus-longitudinal muscle preparation [1].
T38419 Difelikefalin CR-845,FE-202845
Difelikefalin (CR-845; FE-202845) is a peripherally restricted, selective agonist of the kappa opioid receptor (KOR). It exhibits anti-inflammatory properties and holds promise for modulating pruritus in conditions assoc...
T27027 CJ-15208 CJ15,208,CJ-15,208,CJ 15,208.c[Phe-D-Pro-Phe-Trp]
CJ-15208 is a potent and selective κ-opioid receptor antagonist from a fungus, Ctenomyces serratus ATCC15502 (IC50 are 47 nM for kappa, 260 nM for mu, and 2,600 nM for delta respectly). In the electrically-stimulated twi...
T28495 R-84760 hydrochloride R84760,R 84760,R 86436,R-86436,R86436
R-84760 is a κ-opioid receptor agonist. R-84760 produces an extremely potent antinociceptive effect against tonic pain through the kappa-opioid receptors; the sites of action of subcutaneously administered R-84760 are th...
T73522 CR 665 FE 200665,JNJ 38488502 ; FE 200665,JNJ 38488502
CR 665 (JNJ 38488502) is a peripherally selective κ-opioid agonist, capable of activating the kappa opioid receptor with an EC50 value of 10.9 nM. It is utilized in the research of peripheral pain.
T36372 U-54494A hydrochloride
U-54494A hydrochloride is a benzamide derivative related to kappa opioid receptor agonists. U-54494A hydrochloride has anticonvulsant activity.
T27934 LY255582 LY-255582,LY 255582 Opioid Receptor
LY255582 is a selective centrally active opioid receptor antagonist with high affinity for mu, delta and kappa receptors with Ki of 0.4 nM, 5.2, 2.0 nM, respectively. LY255582 inhibits diet-associated increases in mesoli...
T76631 (N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8)
E-2078, known chemically as (N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8), is a stable analog of Dynorphin A (1–8) and functions as a kappa opioid receptor (KOR) agonist [1].
T69798 4-Me-PDTic HCl
4-Me-PDTic is a potent and selective Kappa Opioid Receptor Antagonist. 4-Me-PDTic had a Ke = 0.37 nM in a [35S]GTPγS binding assay and was 645- and >8100-fold selective for the κ relative to the μ and δ opioid receptors,...
T75916 Dynorphin A TFA
Dynorphin A TFA, an endogenous opioid peptide, plays a role in inhibitory neurotransmission within the central nervous system (CNS). It acts as a highly potent kappa opioid receptor (KOR) agonist and also stimulates othe...
T72423 Endomorphin 1 acetate
Endomorphin-1 acetate is a highly selective and high-affinity μ-opioid receptor agonist (K i: 1.11 nM) that also demonstrates moderate affinity for kappa 3 binding sites (K i: 20-30 nM). This compound exhibits antinocice...
T4633 Asimadoline EMD-61753 Opioid Receptor
Asimadoline (EMD-61753) is a proprietary small molecule therapeutic, originally discovered by Merck KGaA of Darmstadt, Germany. Asimadoline was originally developed to treat peripheral pain such as arthritis. Asimadoline...
T71491 Enadoline (Free Base)
Enadoline (Free Base) is a kappa-opioid receptor agonist; PD 129290 (CAM 570; CI 977) is the S,S(-)-enantiomer; PD 129289 (CAM 569) is the corresponding R,R(+)-enantiomer. In human studies, it produced visual distortions...
T80421 CSD-CH2(1,8)-NH2 Opioid Receptor
CSD-CH2(1,8)-NH2 is a selective and competitive kappa-opioid receptor (KOR) antagonist with a K i of 6.8 nM. It inhibits calcium mobilization in dorsal root ganglion (DRG) neurons and antagonizes the antinociceptive effe...
T37013 (+/-)-PPCC oxalate
Selective sigma (σ) receptor ligand. Displays high affinity for σ1; also binds at σ2 sites (Ki = 1.5 nM and 50.8 nM respectively). Selective over a range of receptor types including dopaminergic and muscarinic receptors,...

Compounds

LY2444296
T11909
Synonym: FP3FBZ
Target: Opioid Receptor
Aticaprant
TQ0082
Synonym: LY-2456302,CERC-501
Target: Opioid Receptor
Difelikefalin acetate
TP2501
Synonym: Difelikefalin acetate(1024828-77-0 free base),CR 845 acetate,FE 202845 acetate
Target: Opioid Receptor
MR2034
T28094
Synonym:
Target:
Eptazocine hydrobromide
T24035
Synonym: MCV 4169,ST-2121,MCV-4169,sT 2121, l-,l-ST-2121
Target:
4-Me-PDTic
T69799
Synonym:
Target:
GNTI TFA
T69818
Synonym:
Target:
Norbinaltorphimine
T71523
Synonym:
Target:
Anrikefon
T73339
Synonym: HSK21542
Target:
Dup 747
T25354
Synonym: Dup-747,Dup747
Target:
Icalcaprant
T79848
Synonym:
Target: Opioid Receptor
ICI-204879 HCl
T71370
Synonym:
Target:
Riminkefon
T69851
Synonym:
Target:
Leumorphin, human
T81938
Synonym:
Target: Opioid Receptor
Difelikefalin
T38419
Synonym: CR-845,FE-202845
Target:
CJ-15208
T27027
Synonym: CJ15,208,CJ-15,208,CJ 15,208.c[Phe-D-Pro-Phe-Trp]
Target:
R-84760 hydrochloride
T28495
Synonym: R84760,R 84760,R 86436,R-86436,R86436
Target:
CR 665
T73522
Synonym: FE 200665,JNJ 38488502 ; FE 200665,JNJ 38488502
Target:
U-54494A hydrochloride
T36372
Synonym:
Target:
LY255582
T27934
Synonym: LY-255582,LY 255582
Target: Opioid Receptor
(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8)
T76631
Synonym:
Target:
4-Me-PDTic HCl
T69798
Synonym:
Target:
Dynorphin A TFA
T75916
Synonym:
Target:
Endomorphin 1 acetate
T72423
Synonym:
Target:
Asimadoline
T4633
Synonym: EMD-61753
Target: Opioid Receptor
Enadoline (Free Base)
T71491
Synonym:
Target:
CSD-CH2(1,8)-NH2
T80421
Synonym:
Target: Opioid Receptor
(+/-)-PPCC oxalate
T37013
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T2870 Matrine Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.

Natural Products

Matrine
T2870
Synonym: Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine
Target: Mitophagy, Ferroptosis, Opioid Receptor, Autophagy

Recombinant Proteins

Species：
Human (1)
Expression System：
Human Cells (1)
Tag：
C-6His (1)
Cat No. Product Name Species Expression System
TMPJ-00737 PDYN Protein, Human, Recombinant (His) Human Human Cells
Proenkephalin-B(PDYN), belongs to the opioid neuropeptide precursor family. The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. Leu-enkephalins, which is a ...
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