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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T15551 | IDH889 | Dehydrogenase | |
IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt). | |||
T15550 | IDH-305 | Dehydrogenase | |
IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor. IDH-305 shows greater than 200 fold selectivity for mutant IDH1 isoforms vs. WT (IC50s: 27 nM (IDH1R132H), 28 nM (IDH1R132C), 6.14 µM (... | |||
T16161 | Mutant IDH1 inhibitor | Dehydrogenase , Isocitrate Dehydrogenase (IDH) | |
Mutant IDH1 inhibitor is an effective inhibitor of mutant IDH1 R132H (IC50: < 72 nM). | |||
T2104 | AGI-5198 | IDH-C35 | Dehydrogenase , Isocitrate Dehydrogenase (IDH) |
AGI-5198 (IDH-C35) is a highly effective and specific inhibitor of IDH1 R132H/R132C mutants (IC50: 0.07/0.16 μM). | |||
TQ0042 | BAY-1436032 | Dehydrogenase , Isocitrate Dehydrogenase (IDH) | |
BAY-1436032 is a novel, selective and orally available inhibitor of pan-mutant isocitrate dehydrogenase 1 (IDH1). | |||
T7741 | DS-1001b | Dehydrogenase , Isocitrate Dehydrogenase (IDH) | |
DS-1001b is an inhibitor of mutant IDH-1 (Isocitrate Dehydrogenase-1) | |||
T12128 | Mutant IDH1-IN-2 | Isocitrate Dehydrogenase (IDH) | |
Mutant IDH1-IN-2 is a mutant Isocitrate dehydrogenase (IDH) proteins inhibitor | |||
T2346 | Enasidenib | AG-221 | Dehydrogenase , Isocitrate Dehydrogenase (IDH) |
Enasidenib (AG-221) is an orally available inhibitor of specific mutant forms of the mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2), with potential antineoplastic activity. | |||
T1809 | AGI-6780 | Dehydrogenase , Isocitrate Dehydrogenase (IDH) | |
AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant. | |||
T16384 | Olutasidenib | FT-2102 | Dehydrogenase , Isocitrate Dehydrogenase (IDH) |
Olutasidenib (FT-2102) is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Olutasidenib is a highly effective, brain penetrant, and selective inhibitor of the mutant Iso... | |||
T2043 | Mutant IDH1-IN-1 | IDH1-IN-1 | Dehydrogenase , Isocitrate Dehydrogenase (IDH) |
Mutant IDH1-IN-1 is a potent mutant IDH1 R132 h inhibitor with IC50 < 0.1 uM. | |||
T3617 | Ivosidenib | AG-120 | Dehydrogenase , Isocitrate Dehydrogenase (IDH) |
Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhi... | |||
T7307 | Vorasidenib | PVM/MA,AG-881 | Isocitrate Dehydrogenase (IDH) |
Vorasidenib (PVM/MA) is an inhibitor of mutant isocitrate dehydrogenase (IDH; IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q, respectively) | |||
T12129 | Mutant IDH1-IN-4 | Others | |
Mutant IDH1-IN-4 is an mutant Isocitrate dehydrogenase 1 (IDH 1) inhibitor. | |||
T39716 | Mutant IDH1-IN-6 | Mutant IDH1-IN-6 | |
Mutant IDH1-IN-6 is an orally active compound that effectively inhibits mutant isocitrate dehydrogenase (IDH) enzymes. It demonstrates potency and selectivity, with IC50 values of 6.27, 3.71, 36.9, and 11.5 nM for IDH1 R... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02413 | Isocitrate dehydrogenase/IDH1 Protein, Human, Recombinant (His) | Human | E. coli |