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Search Results for " isocitrate dehydrogenase (idh) "

Targets

15

Compounds

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T15551 IDH889 Dehydrogenase
IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt).
T15550 IDH-305 Dehydrogenase
IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor. IDH-305 shows greater than 200 fold selectivity for mutant IDH1 isoforms vs. WT (IC50s: 27 nM (IDH1R132H), 28 nM (IDH1R132C), 6.14 µM (...
T16161 Mutant IDH1 inhibitor Dehydrogenase , Isocitrate Dehydrogenase (IDH)
Mutant IDH1 inhibitor is an effective inhibitor of mutant IDH1 R132H (IC50: < 72 nM).
T2104 AGI-5198 IDH-C35 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
AGI-5198 (IDH-C35) is a highly effective and specific inhibitor of IDH1 R132H/R132C mutants (IC50: 0.07/0.16 μM).
TQ0042 BAY-1436032 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
BAY-1436032 is a novel, selective and orally available inhibitor of pan-mutant isocitrate dehydrogenase 1 (IDH1).
T7741 DS-1001b Dehydrogenase , Isocitrate Dehydrogenase (IDH)
DS-1001b is an inhibitor of mutant IDH-1 (Isocitrate Dehydrogenase-1)
T12128 Mutant IDH1-IN-2 Isocitrate Dehydrogenase (IDH)
Mutant IDH1-IN-2 is a mutant Isocitrate dehydrogenase (IDH) proteins inhibitor
T2346 Enasidenib AG-221 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
Enasidenib (AG-221) is an orally available inhibitor of specific mutant forms of the mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2), with potential antineoplastic activity.
T1809 AGI-6780 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant.
T16384 Olutasidenib FT-2102 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
Olutasidenib (FT-2102) is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Olutasidenib is a highly effective, brain penetrant, and selective inhibitor of the mutant Iso...
T2043 Mutant IDH1-IN-1 IDH1-IN-1 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
Mutant IDH1-IN-1 is a potent mutant IDH1 R132 h inhibitor with IC50 < 0.1 uM.
T3617 Ivosidenib AG-120 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhi...
T7307 Vorasidenib PVM/MA,AG-881 Isocitrate Dehydrogenase (IDH)
Vorasidenib (PVM/MA) is an inhibitor of mutant isocitrate dehydrogenase (IDH; IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q, respectively)
T12129 Mutant IDH1-IN-4 Others
Mutant IDH1-IN-4 is an mutant Isocitrate dehydrogenase 1 (IDH 1) inhibitor.
T39716 Mutant IDH1-IN-6 Mutant IDH1-IN-6
Mutant IDH1-IN-6 is an orally active compound that effectively inhibits mutant isocitrate dehydrogenase (IDH) enzymes. It demonstrates potency and selectivity, with IC50 values of 6.27, 3.71, 36.9, and 11.5 nM for IDH1 R...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-02413 Isocitrate dehydrogenase/IDH1 Protein, Human, Recombinant (His) Human E. coli
TargetMol