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Immunology/Inflammation IL Receptor

IL Receptor

Interleukin receptors are a family of cytokine receptors for interleukins. They belong to the immunoglobulin superfamily.There are two main families of Interleukin receptors, Type 1 and Type 2.
Cat No. product name
T1076 DexamethasoneHOT Dexamethasone is a glucocorticoid receptor agonist and an IL receptor modulator.Dexamethasone inhibits production of exosomes containing inflammatory microRNA-15...
TN6739 Angoline Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene e...
TN1493 Chrysosplenol D Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.
TN1894 Luteolin-4'-O-glucoside Luteolin 4'-O-glucoside as a IL-5 inhibitor, it has anti-complementary,and anti-oxdiant activities.
TN1806 Isotetrandrine Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity of...
TN1778 Isoformononetin Isoformononetin shows fungitoxic activity against Cladosporium sphaerospermum; it also has immunomodulatory activity, it inhibits the differentiation of Th17 cel...
TN1579 Dihydrocucurbitacin B Dihydrocucurbitacin B has anti-cancer activity, it reduces cell proliferation due to a decrease in the expression of cyclins, mainly cyclin-B1 and disruption of ...
TN1576 Diallyl disulfide Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.
TN1549 Damnacanthal Damnacanthal possesses anti-cancer, immunomodulatory, antinociceptive and anti-inflammatory actions, it can treat or prevent hepatocellular carcinoma through its...
TN1543 Cynaropicrin Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, and could therefore be applied to prevention of UVB-induced photo aging; it may be a potential a...
TN1416 Ayanin Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma.The IC(50) value of Ayanin (quercetin-3,7,4'-O-trimethylethe...
TN1933 Mitraphylline Mitraphylline has antiproliferative effects on human glioma and neuroblastoma cell lines. It also has anti-inflammatory activity, it inhibits lipopolysaccharide-...
TN1412 Astringin Astringinin is a potent antiarrhythmic agent with cardioprotective activity in ischemic and ischemic-reperfused rat heart, the beneficial effects of astringinin ...
TN1407 Artocarpin Artocarpin has anti- bactericidal effect, can reduce the viability of pneumococci by a factor of >1000, without obvious harm to lung epithelial cells.
TN1403 Arjunolic acid Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the devel...
TN1374 Alpha-Chaconine Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. Al...
TN1295 5-O-Caffeoylshikimic acid 5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of...
TN1266 3-O-Methylquercetin 3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value; it inhibits total cAMP- and cGMP-phosp...
TN1232 (2R)-5,7-Dimethoxyflavanone 5,7-Dimethoxyflavanone has anti-inflammatory activity.
TN1150 Procyanidin B3 Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.
TN1923 Mesaconine Mesaconine has cardiac effect, it also has anti-NF-κB activity. Mesaconine may be part of material basis of Mahuang Fuzi Xixin decoction on anti-inflammation an...
TN1936 Mogroside IIIe Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury i...
TN1132 Procyanidin A2 Procyanidin A2 is a potential precursor of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, exhibits antioxidant, anti-inflammary, anti-hyperglycemia, and anti-type 2...
TN2223 Soyacerebroside I Soyacerebroside I demonstrates a potent tyrosinase inhibitory activity.
T12706 Reslizumab Reslizumab is humanized monoclonal antibodies that target interleukin-5 (IL-5) for the treatment of eosinophilic asthma.
T13666 Dupilumab Dupilumab (RegN-668) can inhibit IL-4 and IL-13 signaling pathways and significantly improve moderate to severe atopic dermatitis.It is a human monoclonal antibo...
T11034 Di-O-methyldemethoxycurcumin Di-O-methyldemethoxycurcumin is a Curcumin analog isolated from medicinal plant turmeric di-orthomethyldemethoxycurcumin, anti-inflammatory and antioxidant prope...
T12245 Nosantine racemate Nosantine racemate is the racemate of Nosantine which is a IL-2 inducer or enhancer of IL-2 induction by phytohemagglutinin (PHA).
T19480 NO-prednisolone NO-prednisolone is a potently stimulates IL-10 production in vivo, and isnitric oxide (NO)-releasing derivative of Prednisolone.
T12218 NFAT Transcription Factor Regulator-1 NFAT Transcription Factor Regulator-1 is an synthesis inhibitor of IL-2 (IC50 of 182 nM).
TN2243 Sugiol Sugiol has antioxidant efficacy, it has significant scavenging activities of 1,1-diphenyl-2-picryl hydrazyl, nitric oxide, superoxide and hydroxyl free radicals....
TN2180 Sappanchalcone Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.
TN1953 Morusinol Morusinol may significantly inhibit arterial thrombosis in vivo due to antiplatelet activity, may exert beneficial effects on transient ischemic attacks or strok...
TN2178 Sanggenone H Sanggenone H may have antiphlogistic activity, it attenuated the secretion of TNF-α± and IL-1α² and inhibited the NF-κB nuclear translocation in LPS-stimula...
TN2169 Saikogenin D Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation of...
TN2088 Platycodin D2 Platycodin D2 , a less hemolytic saponin, can improve specific cellular and humoral responses to hepatitis B surface antigen in mice, it could be safely used as ...
TN2082 Pinostrobin Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiti...
TN2010 Ombuin Ombuin has anti-inflammary activity, it inhibits some macrophage functions involved in the inflammatory process.
TN1996 Nothofagin Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of CAMs, and adhes...
TN1983 Neoisoastilbin Neoisoastilbin may have antioxidant and anti-inflammatory activities.
TN1960 Mussaenoside Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB.
TN1141 Isodeoxyelephantopin Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation. It enhances apopt...
TN1110 Shanzhiside Shanzhiside has immunosuppressive activity, it shows significant inhibition of IL-2 secretion by phorbol myristate acetate and anti-CD28 monoclonal antibody co-s...
T14778 BRD6989 BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant C...
T0122 Bengenin Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
T1246 Bornyl acetate Bornyl acetate has an anti-inflammatory effect. It is the primary volatile ingredient in some Chinese traditional herbs and numerous conifer oils.
T1639 Amlexanox Amlexanox is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast...
T1813 VGX1027 VGX-1027(GIT27) is an isoxazole compound with various immunomodulatory properties.
T2932 Ginsenoside Rh1 Ginsenoside Rg1, one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect.
T6465 Dexamethasone Sodium Phosphate Dexamethasone, an interleukin receptor modulator, has anti-inflammatory and immunosuppressant effects. It belongs to a potent glucocorticoid class of steroid syn...
T2018 Apilimod Apilimod inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis.
T3416 Aucubin Aucubin is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.
T3614 Isoprinosine Isoprinosine has a number of immunomodulatory effects, including inducing T-lymphocyte differentiation, augmenting macrophage and NK cell functions, and stimulat...
T3533 Apilimod mesylate Apilimod mesylate is a potent IL-12/IL-23 inhibitor.
T1846 Y320 Y-320 is a new phenylpyrazoleanilide immunomodulator.
T3332 Isosteviol Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolysi...
T3133 YM90709 YM-90709 is a new-type antagonist inhibiting the binding of interleukin-5 to the interleukin-5 receptor.
T1273 Diacerein Diacerein is a prodrug which is metabolized to rhein. It is currently approved in France for the treatment of osteoarthritis although the use of diacerein is res...
T1347 2-Benzothiazolamine 2-Aminobenzothiazole is an organic compound.
T3910 Anemoside B4 Anemoside B4 inhibits the secretion of IL-10.
T0947 Dexamethason acetate Dexamethasone Acetate is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to bind...
T6761 AS101 AS101, a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.
T3830 20R-Ginsenoside Rg2 20R-Ginsenoside Rg2 is a compound with anti-oxidant and anti-apoptosis.
T3280 Disodium clodronate tetrahydrate Disodium clodronate tetrahydrate inhibits bone resorption and soft tissue calcification.
TN1093 Ginsenoside F4 Ginsenoside F4 has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis, the mechanism is related to the mitochondrial dysfunction and the i...
T5788 XYLOBIOSE XYLOBIOSE ia a natural product,and exhibited therapeutic potential for treating obesity which involved suppression of fat deposition and obesity-related metaboli...
TN1088 3,3',4',5,6,7,8-heptamethoxyflavone 3,3',4',5,6,7,8-Heptamethoxyflavone(HMF) has neuroprotective, chemopreventive, anti-allergic, anti-inflammatory, immunomodulatory, anti-aging and photoprotective...
TN1059 Ganoderic acid B Ganoderic acid B is a chemical marker in quality control of G. lucidum and related products. Ganoderic acid B-containing herbs has potential influence towards th...
TN1035 Irisolidone Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
TN1013 Cucurbitacin D Cucurbitacin D has anticancer effects, it induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells.
TN1012 Febrifugine Febrifugine is an effective coccidiostat, possesses schizonticide props; it and its derivatives shows high degree of antimalarial activity but use limited by tox...
T8280 Desacetyl asperulosidic acid Deacetylasperulosidic acid is a natural compound of Morinda citrifolia fruit. It has antioxidant activity by increasing superoxide dismutase activity. It also pr...
T5779 MOSLOFLAVONE MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and  7.8 μM, respectively.
T5680 ALOIN ALOIN Inhibits Interleukin (IL)-1β-Stimulated IL-8 Production in KB Cells.
T0117 Suplatast tosilate Suplatast Tosilate is a novel capsular anti-asthmatic drug. It ( IC50 above 100 μM) inhibits both IgE production, IL-4 and IL-5 synthesis.
T5660 Menthone Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor ne...
T9911 Tocilizumab Tocilizumab anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor
T5S0167 Atractylenolide I 1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reducti...
T3S0364 L-Arginine 1. L-Arginine exhibits anti-atherosclerotic effect. 2. L-Arginine and soy enriched diet are effective in prevention of osteoporosis associated with diabetes mell...
T2S0843 Negletein 1. Negletein has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the acti...
T4S0795 Berberrubine 1. Berberrubine has antitumor activity. 2. Berberrubine has antidiabetic activity. 3. Berberrubine dose-dependently inhibits IL-8 and MCP-1 protein levels in the...
T4450 GIBH130 GIBH-130 markedly inhibits the IL-1β secretion by activated microglia (IC50: 3.4 nM). GIBH-130 is an effective inhibitor of neuroinflammation.
T4279 Esonarimod Esonarimod is an antirheumatic drug.
T10317 Anakinra Anakinra (Raleukin) is an antagonist of recombinant, nonglycosylated human IL-1R. It is the first biological agent to block the pro-inflammatory effects.
T12982 SP4206 SP4206 is an interaction inhibitor of IL-2/IL-2Rα (IL-2 and IL-2Rα with Kd of 70 nM and 10 nM,respectively)
T9057 Norbergenin Norbergenin is a chemical compound. It is the O-demethylated derivative of bergenin. It can be isolated from rhizomes of Bergenia stracheyi.
TN4288 Isoferulic acid Isoferulic acid is an effective natural antioxidant in both lipid and aqueous media, it may be a new promising anti-glycation agent for the prevention of diabeti...
TN4471 Lysicamine Lysicamine shows significant antioxidant capacity in the ORAC(FL) assay and it is active against S. epidermidis and C. dubliniensis, with MIC values in the range...
TN4437 Licorisoflavan A Licorisoflavan A shows weak scavenging activity against superoxide anion radical, it and licoricidin have potential for the development of novel host-modulating ...
TN4420 Latifolin Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latif...
TN4392 Koaburaside Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase. Koaburaside may have...
TN4383 Kazinol U Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduce...
TN4374 Kaerophyllin Kaerophyllin has anti-fibrotic effects, it can protect the rat liver from TAA-caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting H...
TN4291 Isofuranodiene Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver dise...
TMA1777 Hydrangenol 8-O-glucoside Hydrangenol 8-O-glucoside may have anti-inflammary activity.
TN4583 Moringin Moringin is a modulator of neuroinflammation via the β-catenin-PPARγ axis, it can activate Wnt canonical pathway by inhibiting GSK3β in a mouse model of exper...
TN4213 Hirsutenone Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
TN4194 Heliangin Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cel...
TN4190 Hedycoronen A Hedycoronen A and hedycoronen B have the potential anti-inflammatory benefits, they are potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, w...
TN4171 Grossamide Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflammat...
TN4130 Germacrone 4,5-epoxide (4S,5S)-(+)-Germacrone-4,5-epoxide inhibits certain subtypes of cytochrome P450 (CYP).
TN4094 Gallocatechin gallate Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation throu...
TN4064 Flavoglaucin Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
TN4013 Esculentic acid Esculentic acid has anti-inflammatory effect, it has protective effects against LPS-induced endotoxic shock may be mediated, at least in part, by regulation the ...
TN4561 Methylnissolin Methylnissolin is a natural product from A. membranaceus.
TN4584 Morolic acid Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent change...
TN3914 Echinatine Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant and...
TN5033 Skullcapflavone I Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and...
TP2008L Lyn peptide inhibitor acetate(222018-18-0 free base) Lyn peptide inhibitor acetate is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn p...
T8867 RO2959 Hydrochloride RO2959 hydrochloride is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2.
T8828 CP 424174 CP 424174 is an inhibitor of IL-1β post-translational processing with IC50 of 210 nM. Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active...
TN5238 Viscidulin II Viscidulin II can be potential therapeutic agents against P. acnes-induced skin inflammation, it can significantly suppress P. acnes-induced IL-8 and IL-1β prod...
TN5187 Triptoquinone B Triptoquinone B is a novel interleukin-1 inhibitor, shows extremely potent inhibitory activities against interleukin-lα and β releases for human peripheral mon...
TN5186 Triptoquinone A Triptoquinone A may be a useful candidate for the development of a drug as a potent inhibitor of iNOS gene over-expression. Triptoquinone A has anti-inflammatory...
TN5164 Trans-Hinokiresinol Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphyla...
TN5147 Tilifodiolide Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreas...
TN5011 Shizukaol B Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
TN4592 Murrangatin Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the hig...
TMA1570 Sappanone A Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 ...
TN4879 Questinol Questinol exhibits significant anti-obesity activity. It shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit th...
TN4819 (-)-Praeruptorin A (-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings depen...
TN4683 Nyasol Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory ...
TN4679 Nudiposide Nudiposide has significant neuroprotective activities against glutamate-injured neurotoxicity in HT22 cells. It also exhibits protective effect against sepsis in...
TN4675 Nortrachelogenin Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth ...
TN4661 Nodosin Nodosin has anti-inflammatory function of Nodosin via inhibition of IL-2. Nodosin perfusion provides a potential protective effect through inducing HO-1 expressi...
TN4648 Nepetoidin B Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly via modulation of iNOS mediated ...
TMA2576 Episappanol Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis f...
TN3839 Desoxo-narchinol A Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
T11357 Gamma-glutamylcysteine (TFA) Gamma-glutamylcysteine (TFA) also upregulates the level of the anti-inflammatory cytokine IL-10 and reduces the levels of the pro-inflammatory cytokines (TNF-α,...
T2S1040 Jolkinolide B Jolkinolide B has potent anti-inflammatory, and antitumor activities, it is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part, ...
T9113 Myristicin Myristicin is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, antibacterial, and hepatoprotective effects, it also ...
T7009 Soyacerebroside II Soyacerebroside II exhibits ionophoretic activity for Ca2+ ion. Soyacerebrosides I and II have modulating the cellular immune response effects, they show obvious...
T5S1988 Isorhamnetin-3-O-glucoside Isorhamnetin-3-O-glucoside  inhibits the activity of alpha-glucosidase from rat intestine; it exhibits a potent rat lens aldose reductase (RLAR) inhibition in v...
T4S1057 Tripdiolide Tripdiolide has cytotoxic, and anti-rheumatic activities, it suppresses pro-inflammatory gene expression, may be effective therapy for lupus nephritis.
T4A2399 Cinobufotalin Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide pr...
T3S0006 Methyl ferulate Methyl ferulate is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflammatory agent isolated for the first ...
T2S2363 Corydine Corydine is the adrenolytic and weak cholinergic agent, it shows antimicrobial, and antineoplastic activities. Corydine shows irritant and respiratory stimulant ...
T2S0606 Bakkenolide A Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
TN2511 1,6-O,O-Diacetylbritannilactone 1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
T2S0501 Ilexgenin A Ilexgenin A is a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr
Fr14115 Terpineol Terpineol possesses antifungal activity against Trichophyton mentagrophytes, it also exhibits strong antimicrobial activity against periodontopathic and cariogen...
T11742 K-7174 K-7174 is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α.
T13377 (Z)-10-Hydroxy Nortriptyline (Z)-10-Hydroxy Nortriptyline is a Nortriptyline metabolite, and is a tricyclic antidepressant,and is used to relieve the symptoms of depression.
T11636 IL-17A antagonist 3 IL-17A antagonist 3 is an IL-17A antagonist.
T11635 IL-17A antagonist 1 IL-17A antagonist 1 is an IL-17A antagonist (Kd: 0.66 μM; IC50: 1.14 μM).
T11634 IL-15-IN-1 IL-15-IN-1 is a selective and potent Interleukin 15 (IL-15) inhibitor, inhibiting the proliferation of IL-15-dependent cells (IC50: 0.8 μM).
T10497 Benralizumab Benralizumab (MEDI-563) is an IL-5Rα-directed cytolytic monoclonal antibody that induces rapid, direct and nearly complete depletion of eosinophils via enhanced...
TJS1779 Protosappanin A Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infla...
TN2539 1beta-Hydroxyalantolactone 1beta-Hydroxyalantolactone has protective effect against AD-like skin inflammation, can as a potential therapeutic agent for AD.
TN3802 Dehydrodiconiferyl alcohol Dehydrodiconiferyl alcohol shows anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts. Dehydrodiconiferyl alcohol c...
TN3483 Bakkenolide D Bakkenolide D has anti-allergic effect, it and bakkenolide D demonstrates inhibitory effect on the trachea contraction induced by histamine in vitro, they have o...
TN3779 De-O-methyllasiodiplodin De-O-methyllasiodiplodin exhibits radical scavenging, moderate antibacterial, and potential anti-inflammatory effects, it shows moderate suppression effects on i...
TN3635 Chlojaponilactone B Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264...
TN3609 Catalposide Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. Catalposide is a potent inducer of HO-1 and HO...
TN3603 Carpinontriol B Carpinontriol B has antimicrobial activity, it at 40 ug/disk caused the formation of zones of inhibition. It also has anti-inflammatory activity, it shows consid...
TN3587 Capillarisin Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TN3539 Broussonin A Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, tra...
TN3537 Braylin Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation and by inhibition ...
TN3517 Bisacurone Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressi...
TN3410 Anatabine Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
TN2641 15-Methoxypinusolidic acid 15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
TN3366 Ailanthoidol Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potentia...
TN3364 Agrimonolide Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation of...
TN3325 9-O-Feruloyl-5,5'-dimethoxylariciresinol (+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol may have anti-allergic inflammatory effect, it can inhibit release of histamine from mast cells. It shows cyt...
TN3144 6,4'-Dihydroxy-7-methoxyflavanone 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. It shows inhibition of osteoclasts differentiation and function...
TN3119 5-Hydroxy-7,8-dimethoxyflavanone 5-Hydroxy-7,8-dimethoxyflavanone shows anti-inflammatory activity, it can significantly decrease TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2), and ...
TN2974 3-O-Methylquercetin tetraacetate Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiv...
TN2911 3,9-Dihydroeucomin (+/-)-3,9-Dihydroeucomin has immunomodulatory effects, it shows inhibitory effects on PBMC proliferation activated by PHA with the IC(50) value of 19.4 microM.
TN2895 3,5-Dicaffeoyl-epi-quinic acid 3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases.
T0694 Pranlukast Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to...
Dexamethasone HOT
T1076CAS 50-02-2
Dexamethasone is a glucocorticoid receptor agonist and an IL receptor modulator.Dexamethasone inhibits production of exosomes containing inflammatory microRNA-15...
Angoline
TN6739CAS 21080-31-9
Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene e...
Chrysosplenol D
TN1493CAS 14965-20-9
Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.
Luteolin-4'-O-glucoside
TN1894CAS 6920-38-3
Luteolin 4'-O-glucoside as a IL-5 inhibitor, it has anti-complementary,and anti-oxdiant activities.
Isotetrandrine
TN1806CAS 477-57-6
Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity of...
Isoformononetin
TN1778CAS 486-63-5
Isoformononetin shows fungitoxic activity against Cladosporium sphaerospermum; it also has immunomodulatory activity, it inhibits the differentiation of Th17 cel...
Dihydrocucurbitacin B
TN1579CAS 13201-14-4
Dihydrocucurbitacin B has anti-cancer activity, it reduces cell proliferation due to a decrease in the expression of cyclins, mainly cyclin-B1 and disruption of ...
Diallyl disulfide
TN1576CAS 2179-57-9
Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.
Damnacanthal
TN1549CAS 477-84-9
Damnacanthal possesses anti-cancer, immunomodulatory, antinociceptive and anti-inflammatory actions, it can treat or prevent hepatocellular carcinoma through its...
Cynaropicrin
TN1543CAS 35730-78-0
Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, and could therefore be applied to prevention of UVB-induced photo aging; it may be a potential a...
Ayanin
TN1416CAS 572-32-7
Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma.The IC(50) value of Ayanin (quercetin-3,7,4'-O-trimethylethe...
Mitraphylline
TN1933CAS 509-80-8
Mitraphylline has antiproliferative effects on human glioma and neuroblastoma cell lines. It also has anti-inflammatory activity, it inhibits lipopolysaccharide-...
Astringin
TN1412CAS 29884-49-9
Astringinin is a potent antiarrhythmic agent with cardioprotective activity in ischemic and ischemic-reperfused rat heart, the beneficial effects of astringinin ...
Artocarpin
TN1407CAS 7608-44-8
Artocarpin has anti- bactericidal effect, can reduce the viability of pneumococci by a factor of >1000, without obvious harm to lung epithelial cells.
Arjunolic acid
TN1403CAS 465-00-9
Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the devel...
alpha-Chaconine
TN1374CAS 20562-03-2
Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. Al...
5-O-Caffeoylshikimic acid
TN1295CAS 73263-62-4
5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of...
3-O-Methylquercetin
TN1266CAS 1486-70-0
3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value; it inhibits total cAMP- and cGMP-phosp...
(2R)-5,7-Dimethoxyflavanone
TN1232CAS 1277188-85-8
5,7-Dimethoxyflavanone has anti-inflammatory activity.
Procyanidin B3
TN1150CAS 23567-23-9
Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.
Mesaconine
TN1923CAS 6792-09-2
Mesaconine has cardiac effect, it also has anti-NF-κB activity. Mesaconine may be part of material basis of Mahuang Fuzi Xixin decoction on anti-inflammation an...
Mogroside IIIe
TN1936CAS 88901-37-5
Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury i...
Procyanidin A2
TN1132CAS 41743-41-3
Procyanidin A2 is a potential precursor of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, exhibits antioxidant, anti-inflammary, anti-hyperglycemia, and anti-type 2...
Soyacerebroside I
TN2223CAS 114297-20-0
Soyacerebroside I demonstrates a potent tyrosinase inhibitory activity.
Reslizumab
T12706CAS 241473-69-8
Reslizumab is humanized monoclonal antibodies that target interleukin-5 (IL-5) for the treatment of eosinophilic asthma.
Dupilumab
T13666CAS 1190264-60-8
Dupilumab (RegN-668) can inhibit IL-4 and IL-13 signaling pathways and significantly improve moderate to severe atopic dermatitis.It is a human monoclonal antibo...
Di-O-methyldemethoxycurcumin
T11034CAS 824951-60-2
Di-O-methyldemethoxycurcumin is a Curcumin analog isolated from medicinal plant turmeric di-orthomethyldemethoxycurcumin, anti-inflammatory and antioxidant prope...
Nosantine racemate
T12245CAS 75166-67-5
Nosantine racemate is the racemate of Nosantine which is a IL-2 inducer or enhancer of IL-2 induction by phytohemagglutinin (PHA).
NO-prednisolone
T19480CAS 327610-87-7
NO-prednisolone is a potently stimulates IL-10 production in vivo, and isnitric oxide (NO)-releasing derivative of Prednisolone.
NFAT Transcription Factor Regulator-1
T12218CAS 245747-71-1
NFAT Transcription Factor Regulator-1 is an synthesis inhibitor of IL-2 (IC50 of 182 nM).
Sugiol
TN2243CAS 511-05-7
Sugiol has antioxidant efficacy, it has significant scavenging activities of 1,1-diphenyl-2-picryl hydrazyl, nitric oxide, superoxide and hydroxyl free radicals....
Sappanchalcone
TN2180CAS 94344-54-4
Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.
Morusinol
TN1953CAS 62949-93-3
Morusinol may significantly inhibit arterial thrombosis in vivo due to antiplatelet activity, may exert beneficial effects on transient ischemic attacks or strok...
Sanggenone H
TN2178CAS 86450-80-8
Sanggenone H may have antiphlogistic activity, it attenuated the secretion of TNF-α± and IL-1α² and inhibited the NF-κB nuclear translocation in LPS-stimula...
Saikogenin D
TN2169CAS 5573-16-0
Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation of...
Platycodin D2
TN2088CAS 66663-90-9
Platycodin D2 , a less hemolytic saponin, can improve specific cellular and humoral responses to hepatitis B surface antigen in mice, it could be safely used as ...
Pinostrobin
TN2082CAS 480-37-5
Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiti...
Ombuin
TN2010CAS 529-40-8
Ombuin has anti-inflammary activity, it inhibits some macrophage functions involved in the inflammatory process.
Nothofagin
TN1996CAS 11023-94-2
Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of CAMs, and adhes...
Neoisoastilbin
TN1983CAS 54141-72-9
Neoisoastilbin may have antioxidant and anti-inflammatory activities.
Mussaenoside
TN1960CAS 64421-27-8
Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB.
Isodeoxyelephantopin
TN1141CAS 38927-54-7
Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation. It enhances apopt...
Shanzhiside
TN1110CAS 29836-27-9
Shanzhiside has immunosuppressive activity, it shows significant inhibition of IL-2 secretion by phorbol myristate acetate and anti-CD28 monoclonal antibody co-s...
BRD6989
T14778CAS 642008-81-9
BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant C...
Bengenin
T0122CAS 477-90-7
Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
Bornyl acetate
T1246CAS 76-49-3
Bornyl acetate has an anti-inflammatory effect. It is the primary volatile ingredient in some Chinese traditional herbs and numerous conifer oils.
Amlexanox
T1639CAS 68302-57-8
Amlexanox is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast...
VGX1027
T1813CAS 6501-72-0
VGX-1027(GIT27) is an isoxazole compound with various immunomodulatory properties.
Ginsenoside Rh1
T2932CAS 63223-86-9
Ginsenoside Rg1, one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect.
Dexamethasone Sodium Phosphate
T6465CAS 55203-24-2
Dexamethasone, an interleukin receptor modulator, has anti-inflammatory and immunosuppressant effects. It belongs to a potent glucocorticoid class of steroid syn...
Apilimod
T2018CAS 541550-19-0
Apilimod inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis.
Aucubin
T3416CAS 479-98-1
Aucubin is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.
Isoprinosine
T3614CAS 36703-88-5
Isoprinosine has a number of immunomodulatory effects, including inducing T-lymphocyte differentiation, augmenting macrophage and NK cell functions, and stimulat...
Apilimod mesylate
T3533CAS 870087-36-8
Apilimod mesylate is a potent IL-12/IL-23 inhibitor.
Y320
T1846CAS 288250-47-5
Y-320 is a new phenylpyrazoleanilide immunomodulator.
Isosteviol
T3332CAS 27975-19-5
Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolysi...
YM90709
T3133CAS 163769-88-8
YM-90709 is a new-type antagonist inhibiting the binding of interleukin-5 to the interleukin-5 receptor.
Diacerein
T1273CAS 13739-02-1
Diacerein is a prodrug which is metabolized to rhein. It is currently approved in France for the treatment of osteoarthritis although the use of diacerein is res...
2-Benzothiazolamine
T1347CAS 136-95-8
2-Aminobenzothiazole is an organic compound.
Anemoside B4
T3910CAS 129741-57-7
Anemoside B4 inhibits the secretion of IL-10.
Dexamethason acetate
T0947CAS 1177-87-3
Dexamethasone Acetate is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to bind...
AS101
T6761CAS 106566-58-9
AS101, a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.
20R-Ginsenoside Rg2
T3830CAS 80952-72-3
20R-Ginsenoside Rg2 is a compound with anti-oxidant and anti-apoptosis.
Disodium clodronate tetrahydrate
T3280CAS 88416-50-6
Disodium clodronate tetrahydrate inhibits bone resorption and soft tissue calcification.
Ginsenoside F4
TN1093CAS 181225-33-2
Ginsenoside F4 has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis, the mechanism is related to the mitochondrial dysfunction and the i...
XYLOBIOSE
T5788CAS 6860-47-5
XYLOBIOSE ia a natural product,and exhibited therapeutic potential for treating obesity which involved suppression of fat deposition and obesity-related metaboli...
3,3',4',5,6,7,8-heptamethoxyflavone
TN1088CAS 1178-24-1
3,3',4',5,6,7,8-Heptamethoxyflavone(HMF) has neuroprotective, chemopreventive, anti-allergic, anti-inflammatory, immunomodulatory, anti-aging and photoprotective...
Ganoderic acid B
TN1059CAS 81907-61-1
Ganoderic acid B is a chemical marker in quality control of G. lucidum and related products. Ganoderic acid B-containing herbs has potential influence towards th...
Irisolidone
TN1035CAS 2345-17-7
Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
Cucurbitacin D
TN1013CAS 3877-86-9
Cucurbitacin D has anticancer effects, it induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells.
Febrifugine
TN1012CAS 24159-07-7
Febrifugine is an effective coccidiostat, possesses schizonticide props; it and its derivatives shows high degree of antimalarial activity but use limited by tox...
Desacetyl asperulosidic acid
T8280CAS 14259-55-3
Deacetylasperulosidic acid is a natural compound of Morinda citrifolia fruit. It has antioxidant activity by increasing superoxide dismutase activity. It also pr...
MOSLOFLAVONE
T5779CAS 740-33-0
MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and  7.8 μM, respectively.
ALOIN
T5680CAS 8015-61-0
ALOIN Inhibits Interleukin (IL)-1β-Stimulated IL-8 Production in KB Cells.
Suplatast tosilate
T0117CAS 94055-76-2
Suplatast Tosilate is a novel capsular anti-asthmatic drug. It ( IC50 above 100 μM) inhibits both IgE production, IL-4 and IL-5 synthesis.
Menthone
T5660CAS 10458-14-7
Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor ne...
Tocilizumab
T9911CAS 375823-41-9
Tocilizumab anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor
Atractylenolide I
T5S0167CAS 73069-13-3
1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reducti...
L-Arginine
T3S0364CAS 74-79-3
1. L-Arginine exhibits anti-atherosclerotic effect. 2. L-Arginine and soy enriched diet are effective in prevention of osteoporosis associated with diabetes mell...
Negletein
T2S0843CAS 29550-13-8
1. Negletein has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the acti...
Berberrubine
T4S0795CAS 15401-69-1
1. Berberrubine has antitumor activity. 2. Berberrubine has antidiabetic activity. 3. Berberrubine dose-dependently inhibits IL-8 and MCP-1 protein levels in the...
GIBH130
T4450CAS 1252608-59-5
GIBH-130 markedly inhibits the IL-1β secretion by activated microglia (IC50: 3.4 nM). GIBH-130 is an effective inhibitor of neuroinflammation.
Esonarimod
T4279CAS 101973-77-7
Esonarimod is an antirheumatic drug.
Anakinra
T10317CAS 143090-92-0
Anakinra (Raleukin) is an antagonist of recombinant, nonglycosylated human IL-1R. It is the first biological agent to block the pro-inflammatory effects.
SP4206
T12982CAS 515846-21-6
SP4206 is an interaction inhibitor of IL-2/IL-2Rα (IL-2 and IL-2Rα with Kd of 70 nM and 10 nM,respectively)
norbergenin
T9057CAS 79595-97-4
Norbergenin is a chemical compound. It is the O-demethylated derivative of bergenin. It can be isolated from rhizomes of Bergenia stracheyi.
Isoferulic acid
TN4288CAS 25522-33-2
Isoferulic acid is an effective natural antioxidant in both lipid and aqueous media, it may be a new promising anti-glycation agent for the prevention of diabeti...
Lysicamine
TN4471CAS 15444-20-9
Lysicamine shows significant antioxidant capacity in the ORAC(FL) assay and it is active against S. epidermidis and C. dubliniensis, with MIC values in the range...
Licorisoflavan A
TN4437CAS 129314-37-0
Licorisoflavan A shows weak scavenging activity against superoxide anion radical, it and licoricidin have potential for the development of novel host-modulating ...
Latifolin
TN4420CAS 10154-42-4
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latif...
Koaburaside
TN4392CAS 41653-73-0
Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase. Koaburaside may have...
Kazinol U
TN4383CAS 1238116-48-7
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduce...
Kaerophyllin
TN4374CAS 75590-33-9
Kaerophyllin has anti-fibrotic effects, it can protect the rat liver from TAA-caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting H...
Isofuranodiene
TN4291CAS 57566-47-9
Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver dise...
Hydrangenol 8-O-glucoside
TMA1777CAS 67600-94-6
Hydrangenol 8-O-glucoside may have anti-inflammary activity.
Moringin
TN4583CAS 73255-40-0
Moringin is a modulator of neuroinflammation via the β-catenin-PPARγ axis, it can activate Wnt canonical pathway by inhibiting GSK3β in a mouse model of exper...
Hirsutenone
TN4213CAS 41137-87-5
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
Heliangin
TN4194CAS 13323-48-3
Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cel...
Hedycoronen A
TN4190CAS 1383441-73-3
Hedycoronen A and hedycoronen B have the potential anti-inflammatory benefits, they are potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, w...
Grossamide
TN4171CAS 80510-06-1
Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflammat...
Germacrone 4,5-epoxide
TN4130CAS 92691-35-5
(4S,5S)-(+)-Germacrone-4,5-epoxide inhibits certain subtypes of cytochrome P450 (CYP).
Gallocatechin gallate
TN4094CAS 5127-64-0
Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation throu...
Flavoglaucin
TN4064CAS 523-73-9
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
Esculentic acid
TN4013CAS 103974-74-9
Esculentic acid has anti-inflammatory effect, it has protective effects against LPS-induced endotoxic shock may be mediated, at least in part, by regulation the ...
Methylnissolin
TN4561CAS 733-40-4
Methylnissolin is a natural product from A. membranaceus.
Morolic acid
TN4584CAS 559-68-2
Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent change...
Echinatine
TN3914CAS 480-83-1
Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant and...
Skullcapflavone I
TN5033CAS 41060-16-6
Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and...
Lyn peptide inhibitor acetate(222018-18-0 free base)
TP2008LCAS TP2008L
Lyn peptide inhibitor acetate is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn p...
RO2959 Hydrochloride
T8867CAS 1219927-22-6
RO2959 hydrochloride is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2.
CP 424174
T8828CAS 210825-31-3
CP 424174 is an inhibitor of IL-1β post-translational processing with IC50 of 210 nM. Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active...
Viscidulin II
TN5238CAS 92519-93-2
Viscidulin II can be potential therapeutic agents against P. acnes-induced skin inflammation, it can significantly suppress P. acnes-induced IL-8 and IL-1β prod...
Triptoquinone B
TN5187CAS 142937-50-6
Triptoquinone B is a novel interleukin-1 inhibitor, shows extremely potent inhibitory activities against interleukin-lα and β releases for human peripheral mon...
Triptoquinone A
TN5186CAS 142950-86-5
Triptoquinone A may be a useful candidate for the development of a drug as a potent inhibitor of iNOS gene over-expression. Triptoquinone A has anti-inflammatory...
trans-Hinokiresinol
TN5164CAS 17676-24-3
Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphyla...
Tilifodiolide
TN5147CAS 126724-95-6
Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreas...
Shizukaol B
TN5011CAS 142279-40-1
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
Murrangatin
TN4592CAS 37126-91-3
Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the hig...
Sappanone A
TMA1570CAS 102067-84-5
Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 ...
Questinol
TN4879CAS 35688-09-6
Questinol exhibits significant anti-obesity activity. It shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit th...
(-)-Praeruptorin A
TN4819CAS 14017-71-1
(-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings depen...
Nyasol
TN4683CAS 96895-25-9
Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory ...
Nudiposide
TN4679CAS 62058-46-2
Nudiposide has significant neuroprotective activities against glutamate-injured neurotoxicity in HT22 cells. It also exhibits protective effect against sepsis in...
Nortrachelogenin
TN4675CAS 34444-37-6
Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth ...
Nodosin
TN4661CAS 10391-09-0
Nodosin has anti-inflammatory function of Nodosin via inhibition of IL-2. Nodosin perfusion provides a potential protective effect through inducing HO-1 expressi...
Nepetoidin B
TN4648CAS 55486-06-1
Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly via modulation of iNOS mediated ...
Episappanol
TMA2576CAS 111254-18-3
Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis f...
Desoxo-narchinol A
TN3839CAS 53859-06-6
Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
Gamma-glutamylcysteine (TFA)
T11357CAS 283159-88-6
Gamma-glutamylcysteine (TFA) also upregulates the level of the anti-inflammatory cytokine IL-10 and reduces the levels of the pro-inflammatory cytokines (TNF-α,...
Jolkinolide B
T2S1040CAS 37905-08-1
Jolkinolide B has potent anti-inflammatory, and antitumor activities, it is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part, ...
Myristicin
T9113CAS 607-91-0
Myristicin is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, antibacterial, and hepatoprotective effects, it also ...
Soyacerebroside II
T7009CAS 115074-93-6
Soyacerebroside II exhibits ionophoretic activity for Ca2+ ion. Soyacerebrosides I and II have modulating the cellular immune response effects, they show obvious...
Isorhamnetin-3-O-glucoside
T5S1988CAS 5041-82-7
Isorhamnetin-3-O-glucoside  inhibits the activity of alpha-glucosidase from rat intestine; it exhibits a potent rat lens aldose reductase (RLAR) inhibition in v...
Tripdiolide
T4S1057CAS 38647-10-8
Tripdiolide has cytotoxic, and anti-rheumatic activities, it suppresses pro-inflammatory gene expression, may be effective therapy for lupus nephritis.
Cinobufotalin
T4A2399CAS 1108-68-5
Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide pr...
Methyl ferulate
T3S0006CAS 22329-76-6
Methyl ferulate is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflammatory agent isolated for the first ...
Corydine
T2S2363CAS 476-69-7
Corydine is the adrenolytic and weak cholinergic agent, it shows antimicrobial, and antineoplastic activities. Corydine shows irritant and respiratory stimulant ...
Bakkenolide A
T2S0606CAS 19906-72-0
Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
1,6-O,O-Diacetylbritannilactone
TN2511CAS 1286694-67-4
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
Ilexgenin A
T2S0501CAS 108524-94-3
Ilexgenin A is a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr
Terpineol
Fr14115CAS 98-55-5
Terpineol possesses antifungal activity against Trichophyton mentagrophytes, it also exhibits strong antimicrobial activity against periodontopathic and cariogen...
K-7174
T11742CAS 191089-59-5
K-7174 is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α.
(Z)-10-Hydroxy Nortriptyline
T13377CAS 47132-19-4
(Z)-10-Hydroxy Nortriptyline is a Nortriptyline metabolite, and is a tricyclic antidepressant,and is used to relieve the symptoms of depression.
IL-17A antagonist 3
T11636CAS 2230780-65-9
IL-17A antagonist 3 is an IL-17A antagonist.
IL-17A antagonist 1
T11635CAS 2205034-18-8
IL-17A antagonist 1 is an IL-17A antagonist (Kd: 0.66 μM; IC50: 1.14 μM).
IL-15-IN-1
T11634CAS 1831830-20-6
IL-15-IN-1 is a selective and potent Interleukin 15 (IL-15) inhibitor, inhibiting the proliferation of IL-15-dependent cells (IC50: 0.8 μM).
Benralizumab
T10497CAS 1044511-01-4
Benralizumab (MEDI-563) is an IL-5Rα-directed cytolytic monoclonal antibody that induces rapid, direct and nearly complete depletion of eosinophils via enhanced...
Protosappanin A
TJS1779CAS 102036-28-2
Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infla...
1beta-Hydroxyalantolactone
TN2539CAS 68776-47-6
1beta-Hydroxyalantolactone has protective effect against AD-like skin inflammation, can as a potential therapeutic agent for AD.
Dehydrodiconiferyl alcohol
TN3802CAS 4263-87-0
Dehydrodiconiferyl alcohol shows anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts. Dehydrodiconiferyl alcohol c...
Bakkenolide D
TN3483CAS 18456-03-6
Bakkenolide D has anti-allergic effect, it and bakkenolide D demonstrates inhibitory effect on the trachea contraction induced by histamine in vitro, they have o...
De-O-methyllasiodiplodin
TN3779CAS 32885-82-8
De-O-methyllasiodiplodin exhibits radical scavenging, moderate antibacterial, and potential anti-inflammatory effects, it shows moderate suppression effects on i...
Chlojaponilactone B
TN3635CAS 1449382-91-5
Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264...
Catalposide
TN3609CAS 6736-85-2
Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. Catalposide is a potent inducer of HO-1 and HO...
Carpinontriol B
TN3603CAS 473451-73-9
Carpinontriol B has antimicrobial activity, it at 40 ug/disk caused the formation of zones of inhibition. It also has anti-inflammatory activity, it shows consid...
Capillarisin
TN3587CAS 56365-38-9
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
Broussonin A
TN3539CAS 73731-87-0
Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, tra...
Braylin
TN3537CAS 6054-10-0
Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation and by inhibition ...
Bisacurone
TN3517CAS 120681-81-4
Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressi...
Anatabine
TN3410CAS 581-49-7
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
15-Methoxypinusolidic acid
TN2641CAS 769928-72-5
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
Ailanthoidol
TN3366CAS 156398-61-7
Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potentia...
Agrimonolide
TN3364CAS 21499-24-1
Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation of...
9-O-Feruloyl-5,5'-dimethoxylariciresinol
TN3325CAS 166322-14-1
(+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol may have anti-allergic inflammatory effect, it can inhibit release of histamine from mast cells. It shows cyt...
6,4'-Dihydroxy-7-methoxyflavanone
TN3144CAS 189689-32-5
6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. It shows inhibition of osteoclasts differentiation and function...
5-Hydroxy-7,8-dimethoxyflavanone
TN3119CAS 113981-49-0
5-Hydroxy-7,8-dimethoxyflavanone shows anti-inflammatory activity, it can significantly decrease TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2), and ...
3-O-Methylquercetin tetraacetate
TN2974CAS 1486-69-7
Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiv...
3,9-Dihydroeucomin
TN2911CAS 887375-68-0
(+/-)-3,9-Dihydroeucomin has immunomodulatory effects, it shows inhibitory effects on PBMC proliferation activated by PHA with the IC(50) value of 19.4 microM.
3,5-Dicaffeoyl-epi-quinic acid
TN2895CAS 879305-14-3
3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases.
Pranlukast
T0694CAS 103177-37-3
Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to...