Histone Acetyltransferase

Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl-CoA to form ε-N-acetyllysine. DNA is wrapped around histones, and, by transferring an acetyl group to the histones, genes can be turned on and off. In general, histone acetylation increases gene expression.

Cat. No.	Product name	CAS No.	Purity
T27083	Crebinostat	1092061-61-4	98%
T27083	Crebinostat is a potent histone deacetylase (HDAC) inhibitor, inhibiting HDAC1, HDAC2, HDAC3, and HDAC6 with IC50s of 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM, respect...
T11563	Histone Acetyltransferase Inhibitor II	932749-62-7	98%
T11563	Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 µM).with anti-acetylase activity in...
T15216	EML 425	1675821-32-5	98%
T15216	EML 425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively).
T4679	WM-1119	2055397-28-7	98%
T4679	WM-1119 is a highly potent, selective KAT6A/B inhibitor
T9102	WM-3835	2229025-70-9	98%
T9102	WM-3835 is a novel and high-specific small molecule inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) , able to potently suppressed OS cell proliferati...
T1516	Curcumin	458-37-7	98%
T1516	Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin bl...
T28471	PU139	158093-65-3	98%
T28471	PU139 is a novel inhibitor of histone acetyltransferase (HAT).
T9373	DCH36_06	593273-05-3	98%
T9373	DCH36_06 as a bona fide is a potent p300/CBP inhibitor
T14073	A-485	1889279-16-6	98%
T14073	A-485 is a potent and selective catalytic p300/CBP inhibitor(IC50s of 9.8 nM and 2.6 nM for p300 and CBP, respectively).
T8658	NEO2734	2081072-29-7	98%
T8658	NEO2734 is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).
T11366	Garcinol	78824-30-3	98%
T11366	Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-...
T11807	L002	321695-57-2	98%
T11807	L002 binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain, blocks histone acetylation and p53 acetylation, and inhibits STAT3 acti...
T3217	PF-CBP1 hydrochloride	2070014-93-4	98%
T3217	PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM r...
T6668	SGC-CBP30	1613695-14-9	98%
T6668	SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
T3969	I-CBP112	1640282-31-0	98%
T3969	I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
T6584	MG 149	1243583-85-8	98%
T6584	MG149 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).
T12345	CBP/p300-IN-3	2299226-01-8	98%
T12345	P300/CBP-IN-3 is an inhibitor of p300/CBP histone acetyltransferase.
T5468	YF-2	1311423-89-8	98%
T5468	YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM...
T2452	C646	328968-36-1	98%
T2452	C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
T9167	PF-9363	2569009-58-9	98%
T9167	PF-9363 is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.