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Histone Acetyltransferase

Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl-CoA to form ε-N-acetyllysine. DNA is wrapped around histones, and, by transferring an acetyl group to the histones, genes can be turned on and off. In general, histone acetylation increases gene expression.
Cat. No. Product name CAS No. Purity Chemical Structure
T27083 Crebinostat 1092061-61-4 98%
Crebinostat is a potent histone deacetylase (HDAC) inhibitor, inhibiting HDAC1, HDAC2, HDAC3, and HDAC6 with IC50s of 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM, respect...
T11563 Histone Acetyltransferase Inhibitor II 932749-62-7 98%
Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 µM).with anti-acetylase activity in...
T15216 EML 425 1675821-32-5 98%
EML 425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively).
T4679 WM-1119 2055397-28-7 98%
WM-1119 is a highly potent, selective KAT6A/B inhibitor
T9102 WM-3835 2229025-70-9 98%
WM-3835 is a novel and high-specific small molecule inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) , able to potently suppressed OS cell proliferati...
T1516 Curcumin 458-37-7 98%
Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin bl...
T28471 PU139 158093-65-3 98%
PU139 is a novel inhibitor of histone acetyltransferase (HAT).
T9373 DCH36_06 593273-05-3 98%
DCH36_06  as a bona fide is a potent p300/CBP inhibitor
T14073 A-485 1889279-16-6 98%
A-485 is a potent and selective catalytic p300/CBP inhibitor(IC50s of 9.8 nM and 2.6 nM for p300 and CBP, respectively).
T8658 NEO2734 2081072-29-7 98%
NEO2734 is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).
T11366 Garcinol 78824-30-3 98%
Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-...
T11807 L002 321695-57-2 98%
L002 binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain, blocks histone acetylation and p53 acetylation, and inhibits STAT3 acti...
T3217 PF-CBP1 hydrochloride 2070014-93-4 98%
PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM r...
T6668 SGC-CBP30 1613695-14-9 98%
SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
T3969 I-CBP112 1640282-31-0 98%
I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
T6584 MG 149 1243583-85-8 98%
MG149 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).
T12345 CBP/p300-IN-3 2299226-01-8 98%
P300/CBP-IN-3 is an inhibitor of p300/CBP histone acetyltransferase.
T5468 YF-2 1311423-89-8 98%
YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM...
T2452 C646 328968-36-1 98%
C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
T9167 PF-9363 2569009-58-9 98%
PF-9363 is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.
Crebinostat
T27083
Crebinostat is a potent histone deacetylase (HDAC) inhibitor, inhibiting HDAC1, HDAC2, HDAC3, and HDAC6 with IC50s of 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM, respect...
Histone Acetyltransferase Inhibitor II
T11563
Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 µM).with anti-acetylase activity in...
EML 425
T15216
EML 425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively).
WM-1119
T4679
WM-1119 is a highly potent, selective KAT6A/B inhibitor
WM-3835
T9102
WM-3835 is a novel and high-specific small molecule inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) , able to potently suppressed OS cell proliferati...
Curcumin
T1516
Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin bl...
PU139
T28471
PU139 is a novel inhibitor of histone acetyltransferase (HAT).
DCH36_06
T9373
DCH36_06  as a bona fide is a potent p300/CBP inhibitor
A-485
T14073
A-485 is a potent and selective catalytic p300/CBP inhibitor(IC50s of 9.8 nM and 2.6 nM for p300 and CBP, respectively).
NEO2734
T8658
NEO2734 is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).
Garcinol
T11366
Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-...
L002
T11807
L002 binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain, blocks histone acetylation and p53 acetylation, and inhibits STAT3 acti...
PF-CBP1 hydrochloride
T3217
PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM r...
SGC-CBP30
T6668
SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
I-CBP112
T3969
I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
MG 149
T6584
MG149 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).
CBP/p300-IN-3
T12345
P300/CBP-IN-3 is an inhibitor of p300/CBP histone acetyltransferase.
YF-2
T5468
YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM...
C646
T2452
C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
PF-9363
T9167
PF-9363 is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.
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